We report on the discovery and analysis of bursts from nine new repeating fast radio burst (FRB) sources found using the Canadian Hydrogen Intensity Mapping Experiment (CHIME) telescope. These ...sources span a dispersion measure (DM) range of 195-1380 pc cm−3. We detect two bursts from three of the new sources, three bursts from four of the new sources, four bursts from one new source, and five bursts from one new source. We determine sky coordinates of all sources with uncertainties of ∼10′. We detect Faraday rotation measures (RMs) for two sources, with values −20(1) and −499.8(7) rad m−2, that are substantially lower than the RM derived from bursts emitted by FRB 121102. We find that the DM distribution of our events, combined with the nine other repeaters discovered by CHIME/FRB, is indistinguishable from that of thus far non-repeating CHIME/FRB events. However, as previously reported, the burst widths appear statistically significantly larger than the thus far non-repeating CHIME/FRB events, further supporting the notion of inherently different emission mechanisms and/or local environments. These results are consistent with previous work, though are now derived from 18 repeating sources discovered by CHIME/FRB during its first year of operation. We identify candidate galaxies that may contain FRB 190303.J1353+48 (DM = 222.4 pc cm−3).
The standard core accretion model for planetesimal formation in protoplanetary discs (PPDs) is subject to a number of challenges. One is related to the vertical settling of dust to the disc mid-plane ...against turbulent stirring. This is particularly relevant in the presence of the vertical shear instability (VSI), a purely hydrodynamic instability applicable to the outer parts of PPDs, which drives moderate turbulence characterized by large-scale vertical motions. We investigate the evolution of dust and gas in the vicinity of local pressure enhancements (pressure bumps) in a PPD with turbulence sustained by the VSI. Our goal is to determine the morphology of dust concentrations and if dust can concentrate sufficiently to reach conditions that can trigger the streaming instability (SI). We performed a suite of global 2D axisymmetric and 3D simulations of dust and gas for a range of values for Σ
d
∕Σ
g
(ratio of dust-to-gas surface mass densities or metallicity), particle Stokes numbers,
τ
, and pressure bump amplitude,
A
. Dust feedback onto the gas is included. For the first time, we use global 3D simulations to demonstrate the collection of dust in long-lived vortices induced by the VSI. These vortices, which undergo a slow radial inward drift, are the dusty analogs of large long-lived vortices found in previous dust-free simulations of the VSI. Without a pressure bump and for solar metallicity
Z
≈ 0.01 and Stokes numbers
τ
~ 10
−2
, we find that such vortices can reach dust-to-gas density ratios slightly below unity in the discs’ mid-plane, while for
Z
≳ 0.05, long-lived vortices are largely absent. In the presence of a pressure bump, for
Z
≈ 0.01 and
τ
~ 10
−2
, a dusty vortex forms that reaches dust-to-gas ratios of a few times unity, such that the SI is expected to develop, before it eventually shears out into a turbulent dust ring. At intermediate metallicities,
Z
~ 0.03, this occurs for
τ
~ 5 × 10
−3
, but with a weaker and more short-lived vortex, while for larger
τ
, only a turbulent dust ring forms. For
Z
≳ 0.03, we find that the dust ring becomes increasingly axisymmetric for increasing
τ
and dust-to-gas ratios reach order unity for
τ
≳ 5 × 10
−3
. Furthermore, the vertical mass flow profile of the disc is strongly affected by dust for
Z
≳ 0.03, such that gas is transported inward near the mid-plane and outward at larger heights, which is the reversed situation compared to simulations with zero or small amounts of dust. We find viscous
α
-values to drop moderately as ~10
−3
–10
−4
for metallicities increasing as
Z
= 0–0.05. Our results suggest that the VSI can play an active role in the formation of planetesimals through the formation of vortices for plausible values of metallicity and particle size. Also, it may provide a natural explanation for the presence or absence of asymmetries of observed dust rings in PPDs, depending on the background metallicity.
Magnetars are highly magnetized young neutron stars that occasionally produce enormous bursts and flares of X-rays and γ-rays
. Of the approximately thirty magnetars currently known in our Galaxy and ...the Magellanic Clouds, five have exhibited transient radio pulsations
. Fast radio bursts (FRBs) are millisecond-duration bursts of radio waves arriving from cosmological distances
, some of which have been seen to repeat
. A leading model for repeating FRBs is that they are extragalactic magnetars, powered by their intense magnetic fields
. However, a challenge to this model is that FRBs must have radio luminosities many orders of magnitude larger than those seen from known Galactic magnetars. Here we report the detection of an extremely intense radio burst from the Galactic magnetar SGR 1935+2154 using the Canadian Hydrogen Intensity Mapping Experiment (CHIME) FRB project. The fluence of this two-component bright radio burst and the estimated distance to SGR 1935+2154 together imply a burst energy at 400 to 800 megahertz of approximately 3 × 10
erg, which is three orders of magnitude higher than the burst energy of any radio-emitting magnetar detected thus far. Such a burst coming from a nearby galaxy (at a distance of less than approximately 12 megaparsecs) would be indistinguishable from a typical FRB. However, given the large gaps in observed energies and activity between the brightest and most active FRB sources and what is observed for SGR 1935+2154-like magnetars, more energetic and active sources-perhaps younger magnetars-are needed to explain all observations.
We report on the detection of seven bursts from the periodically active, repeating fast radio burst (FRB) source FRB 180916.J0158+65 in the 300-400 MHz frequency range with the Green Bank Telescope ...(GBT). Emission in multiple bursts is visible down to the bottom of the GBT band, suggesting that the cutoff frequency (if it exists) for FRB emission is lower than 300 MHz. Observations were conducted during predicted periods of activity of the source, and had simultaneous coverage with the Low Frequency Array (LOFAR) and the FRB backend on the Canadian Hydrogen Intensity Mapping Experiment (CHIME) telescope. We find that one of the GBT-detected bursts has potentially associated emission in the CHIME band (400-800 MHz) but we detect no bursts in the LOFAR band (110-190 MHz), placing a limit of on the spectral index of broadband emission from the source. We also find that emission from the source is severely band-limited with burst bandwidths as low as ∼40 MHz. In addition, we place the strictest constraint on observable scattering of the source, <1.7 ms at 350 MHz, suggesting that the circumburst environment does not have strong scattering properties. Additionally, knowing that the circumburst environment is optically thin to free-free absorption at 300 MHz, we find evidence against the association of a hyper-compact H ii region or a young supernova remnant (age <50 yr) with the source.
The discovery of a repeating fast radio burst (FRB) source
, FRB 121102, eliminated models involving cataclysmic events for this source. No other repeating FRB has hitherto been detected despite many ...recent discoveries and follow-ups
, suggesting that repeaters may be rare in the FRB population. Here we report the detection of six repeat bursts from FRB 180814.J0422+73, one of the 13 FRBs detected
by the Canadian Hydrogen Intensity Mapping Experiment (CHIME) FRB project
during its pre-commissioning phase in July and August 2018. These repeat bursts are consistent with originating from a single position on the sky, with the same dispersion measure, about 189 pc cm
. This traces approximately twice the expected Milky Way column density, and implies an upper limit on the source redshift of 0.1, at least a factor of about 2 closer than FRB 121102
. In some of the repeat bursts, we observe sub-pulse frequency structure, drifting, and spectral variation reminiscent of that seen in FRB 121102
, suggesting similar emission mechanisms and/or propagation effects. This second repeater, found among the first few CHIME/FRB discoveries, suggests that there exists-and that CHIME/FRB and other wide-field, sensitive radio telescopes will find-a substantial population of repeating FRBs.
Abdominal aortic aneurysm (AAA) is a complex disease which is incompletely accounted for. Basement membrane (BM) Collagen IV (COL4A1/A2) is abundant in the artery wall, and several lines of evidence ...indicate a protective role of baseline COL4A1/A2 in AAA development. Using Col4a1/a2 hemizygous knockout mice (Col4a1/a2
, 129Svj background) we show that partial Col4a1/a2 deficiency augmented AAA formation. Although unchallenged aortas were morphometrically and biomechanically unaffected by genotype, explorative proteomic analyses of aortas revealed a clear reduction in BM components and contractile vascular smooth muscle cell (VSMC) proteins, suggesting a central effect of the BM in maintaining VSMCs in the contractile phenotype. These findings were translated to human arteries by showing that COL4A1/A2 correlated to BM proteins and VSMC markers in non-lesioned internal mammary arteries obtained from coronary artery bypass procedures. Moreover, in human AAA tissue, MYH11 (VSMC marker) was depleted in areas of reduced COL4 as assessed by immunohistochemistry. Finally, circulating COL4A1 degradation fragments correlated with AAA progression in the largest Danish AAA cohort, suggesting COL4A1/A2 proteolysis to be an important feature of AAA formation. In sum, we identify COL4A1/A2 as a critical regulator of VSMC phenotype and a protective factor in AAA formation.
Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from ...intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory responses. The functional significance of chromatin in the cytoplasm is unclear. Here we show that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interferon genes) pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer. The cytoplasmic chromatin-cGAS-STING pathway promotes the senescence-associated secretory phenotype in primary human cells and in mice. Mice deficient in STING show impaired immuno-surveillance of oncogenic RAS and reduced tissue inflammation upon ionizing radiation. Furthermore, this pathway is activated in cancer cells, and correlates with pro-inflammatory gene expression in human cancers. Overall, our findings indicate that genomic DNA serves as a reservoir to initiate a pro-inflammatory pathway in the cytoplasm in senescence and cancer. Targeting the cytoplasmic chromatin-mediated pathway may hold promise in treating inflammation-related disorders.
Relativistic millicharged particles (χq) have been proposed in various extensions to the standard model of particle physics. We consider the scenarios where they are produced at nuclear reactor core ...and via interactions of cosmic rays with the Earth’s atmosphere. Millicharged particles could also be candidates for dark matter and become relativistic through acceleration by supernova explosion shock waves. The atomic ionization cross section of χq with matter are derived with the equivalent photon approximation. Smoking-gun signatures with significant enhancement in the differential cross section are identified. New limits on the mass and charge of χq are derived, using data taken with a point-contact germanium detector with 500 g mass functioning at an energy threshold of 300 eV at the Kuo-Sheng Reactor Neutrino Laboratory.
We report the first results of a light weakly interacting massive particles (WIMPs) search from the CDEX-10 experiment with a 10 kg germanium detector array immersed in liquid nitrogen at the China ...Jinping Underground Laboratory with a physics data size of 102.8 kg day. At an analysis threshold of 160 eVee, improved limits of 8×10^{-42} and 3×10^{-36} cm^{2} at a 90% confidence level on spin-independent and spin-dependent WIMP-nucleon cross sections, respectively, at a WIMP mass (m_{χ}) of 5 GeV/c^{2} are achieved. The lower reach of m_{χ} is extended to 2 GeV/c^{2}.
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