B-cell lymphoma/leukemia 10 (BCL10) is an apoptotic regulatory protein related to advanced TNM stage and disease recurrence in oral squamous cell carcinoma (OSCC). However, the regulatory mechanism ...of BCL10 in OSCC progression is still unknown. Here, we showed that knockdown of endogenous BCL10 could significantly reduce cell migration and invasion abilities, retard cell proliferation by G0/G1 phase accumulation and inhibit tumorigenicity in vivo. In molecular level, we identified S100P as a crucial downstream effector of BCL10-inhibited OSCC progression by high-throughput microarray analysis. S100P messenger RNA and protein expression levels were significantly diminished in silenced-BCL10 clones, and transfected S100P expression plasmids restored migration, invasion, proliferation abilities and tumorigenicity in shBCL10 transfectants. Furthermore, we provided evidence that BCL10 regulated S100P expression through signal transducers and activators of transcription 1 (STAT1) and activating transcription factor 4 (ATF4). Knockdown of BCL10 decreased S100P promoter activity, but showed no effect in truncated STAT1/ATF4 S100P promoter. In addition, we also found that the P50/P65 signaling pathway was involved in BCL10-enhanced OSCC progression. Restored S100P in silenced-BCL10 clones could markedly reverse P65 activation via outside-in signaling. Taken together, we discovered a novel axis of BCL10-regulated OSCC progression via STAT1/ATF4/S100P/P65 signaling, which could predict the prognosis of OSCC and will be beneficial for developing therapeutic strategy against advanced OSCC.
We present Magellan/M2FS, Very Large Telescope/GIRAFFE, and Gemini South/GMOS spectroscopy of the newly discovered Milky Way satellite Reticulum II. Based on the spectra of 25 Ret II member stars ...selected from Dark Energy Survey imaging, we measure a mean heliocentric velocity of 62.8 + or - 0.5 km s super(-1) and a velocity dispersion of 3.3 + or - 0.7 km s super(-1). The mass-to-light ratio of Ret II within its half-light radius is 470 + or - 210 M sub(middot in circle)L sub(middot in circle), demonstrating that it is a strongly dark matter-dominated system. Despite its spatial proximity to the Magellanic Clouds, the radial velocity of Ret II differs from that of the LMC and SMC by 199 and 83 km s super(-1), respectively, suggesting that it is not gravitationally bound to the Magellanic system. The likely member stars of Ret II span 1.3 dex in metallicity, with a dispersion of 0.28 + or - 0.09 dex, and we identify several extremely metal-poor stars with Fe/H < -3. In combination with its luminosity, size, and ellipticity, these results confirm that Ret II is an ultra-faint dwarf galaxy. With a mean metallicity of Fe/H = -2.65 + or - 0.07, Ret II matches Segue 1 as the most metal-poor galaxy known. Although Ret II is the third-closest dwarf galaxy to the Milky Way, the line-of-sight integral of the dark matter density squared is log sub(10) (J) = 18.8 0.6 GeV cm = + or - 2 -5 within 0degrees.2, indicating that the predicted gamma-ray flux from dark matter annihilation in Ret II is lower than that of several other dwarf galaxies.
This study describes the frequency of occurrence of work-related injuries and musculoskeletal disorders (MSDs) among factory workers in Shenzhen, China, and examines the determinants of injuries and ...MSDs.
A cross-sectional survey was conducted with 3479 frontline workers in 60 factories during 2008–2009. We calculated the annual incidence rates of work-related injuries and the prevalence rates of MSD (based on the Nordic Standard Form) for the factory workers. Logistic regression analysis was applied to explore the associations between potential risk factors and occupational injury and MSD.
Among all participating workers, 8.3% reported acute traumatic injuries in the previous 12 months. The event-based incidence rate was 119.6 per 1000 person-years. About half of the frontline workers reported suffering from MSDs during the previous 12 months. The injury risk was reduced for female workers (Odds ratio, OR: 0.48; 95% confidence interval, CI: 0.36–0.66) and those with higher educational levels, but increased in workers with over 55 work hours/week (OR: 1.64; 95% CI: 1.21–2.22), high mental stress at work (OR: 3.50; 95% CI: 1.70–7.19) and previous injury history (OR: 3.94; 95% CI: 2.78–5.58). The MSD risk was increased among female workers (OR: 1.58; 95% CI: 1.34–1.87), and those with over 55 work hours/week (OR: 1.56; 95% CI: 1.28–1.90), high mental stress at work (OR: 3.16; 95% CI: 2.04–4.89) and a past injury history (OR: 3.04; 95% CI: 2.14–4.32).
High proportions of frontline workers were affected by work injuries and MSDs in these factories in China. Long work hours, high mental stress at work and previous injury history were important risk factors for work-related injury and MSD.
We have determined the intrinsic gas transport properties of He, H
2, O
2, N
2, CH
4, and CO
2 for a 6FDA-durene polyimide as a function of pressure, temperature and aging time. The permeability ...coefficients of O
2, N
2, CH
4, and CO
2 decrease slightly with increasing pressure. The pressure-dependent diffusion coefficients and solubility coefficients are consistent with the dual-sorption model and partial immobilization. All the gas permeabilities increase with temperature and their apparent activation energies for permeation increase with increasing gas molecular sizes in the order of CO
2, O
2, N
2, and CH
4.
The percentages of permeability decay after 280 days of aging are 22, 32, 36, 40, 42, and 30% for He, H
2, O
2, N
2, CH
4, and CO
2, respectively. Interestingly, except for H
2 (kinetic diameter of 2.89
Å), the percentages of permeability decay increase exactly in the order of He (kinetic diameter of 2.6
Å), CO
2 (3.30
Å), O
2 (3.46
Å), N
2 (3.64
Å), and CH
4 (3.80
Å). The apparent activation energies of permeation for O
2, N
2, CH
4, and CO
2 increase with aging because of the increases in activation energies of diffusion and the decreases in solubility coefficients. The activation-energy increase for diffusion is probably due to the decrease in polymeric molar volume because of densification during aging. The reduction in solubility coefficient indicates the available sites for sorption decreasing with aging because of the reduction of microvoids and interstitial chain space.
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► Derivation on full-field residual stresses is investigated for thin-film substrate. ► Stress-optical coefficient is measured by 2D photoelasticity under tensional forces. ► Residual ...stresses for thin-film substrate in different orientations are different. ► Slope of stress versus retardation curve describes stress-optical coefficient.
For flexible electronics in manufacture, the full-field stress measurement is an important issue for the film deposited on the flexible substrate. In this work, the two-dimensional photoelasticity is proposed to measure stress-optical coefficients and an analytical derivation is carried out for investigation on full-field residual stresses under tensional forces. In experimental setup, a polarization beam splitter (PBS) is used to connect with two CCD cameras that are used to capture the intensity of right-hand and left-hand circular polarization separately. It has higher measured speed and better uniformity than a direct rotation method. Stress-optical coefficients can be calculated by extracting the slope from tensional stress versus optical retardation curve. Experimental results show that optical retardations for indium-tin-oxide (ITO)-coated PET (polyethylene terephthalate) substrates can be affected more easily than PET substrates under tensional forces. The difference of stress-optical coefficients between 0° and 90° orientations for PEN (polyethylene naphthalate) substrates is smaller than that for PET substrates. Furthermore, it shows residual stresses for ITO-coated PET substrates in 0° and 90° orientations are different under tensional stress.
This paper proposes a laser interferometer for determining the straightness of a moving stage. The optical setup is described and the theory is derived. The results show that this interferometer not ...only overcomes the disadvantages of the conventional interferometers but also provides a higher sensitivity. Two experiments were carried out in this research. The first experiment verifies the validity of the theoretical derivation. The second experiment demonstrates that this interferometer could be adopted for straightness measurements.
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