Prostate cancer has high metastatic potential. Men with higher urinary levels of the sleep hormone melatonin are much less likely to develop advanced prostate cancer compared with men with lower ...levels of melatonin. Melatonin has shown anticancer activity in experimental investigations. Nevertheless, the therapeutic effect of melatonin in metastatic prostate cancer has largely remained a mystery. Analyses of Gene Expression Omnibus data and human tissue samples indicated that levels of matrix metallopeptidase 13 (MMP‐13) expression are higher in prostate cancer patients than in healthy cancer‐free individuals. Mechanistic investigations revealed that melatonin inhibits MMP‐13 expression and the migratory and invasive capacities of prostate cancer cells via the MT1 receptor and the phospholipase C, p38, and c‐Jun signaling cascades. Importantly, tumor growth rate and metastasis to distant organs were suppressed by melatonin in an orthotopic prostate cancer model. This is the first demonstration showing that melatonin impedes metastasis of prostate cancer by suppressing MMP‐13 expression in both in vitro and in vivo models. Thus, melatonin is promising in the management of prostate cancer metastasis and deserves to undergo clinical investigations.
Melatonin acts on the MT1 receptor and inhibits phospholipase C (PLC) and p38 signal cascades, subsequently suppresses matrix metallopeptidase 13 (MMP‐13) expression through the c‐Jun‐dependent pathway, leading to the reduction of prostate cancer metastasis. This is the first indication that melatonin impedes metastasis via the targeting of MMP‐13 in prostate cancer cells, based on evidence from basic and clinical studies.
The immune checkpoint proteins were reported to involve to host resistance to Mycobacteria tuberculosis (Mtb). Here, we evaluated 11 single nucleotide polymorphisms (SNPs) in PDCD1, CTLA4, and HAVCR2 ...genes between participants with and without TB infection. Genomic DNA isolated from 285 patients with TB and 270 controls without TB infection were used to perform the genotyping assay. Odds ratios were used to characterize the association of 11 SNPs with TB risk. In this study, the various genotypes of the 11 SNPs did not differ significantly in frequency between the non-TB and TB groups. When patients were stratified by sex, however, men differed significantly from women in genotype frequencies at HAVCR2 rs13170556. Odds ratios indicated that rs2227982, rs13170556, rs231775, and rs231779 were sex-specifically associated with TB risk. In addition, the combinations of rs2227982/rs13170556 GA/TC in men and the A-C-C haplotype of rs231775-rs231777-rs231779 in women were significantly associated with TB risk. Our results indicate that rs2227982 in PDCD1 and rs13170556 in HAVCR2 are associated with increased TB susceptibility in men and that the CTLA4 haplotype appears protective against TB in women.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The purpose of this study is to examine the factors influencing China's new retail industry on corporate performance. We mainly design the adjustment effect of the internationalization of its new ...retail industry on corporate performance and proprietary assets.
The framework is based on dynamic panel data of 590 listed companies in China's new retail industry from 2007 to 2019.
We apply the concept of big data for the analysis and investigation, including the DOI explanatory variable for the degree of internationalization, Tobin's Q explained variable, and adjusted variable of proprietary assets (R&D intensity RDI, marketing intensity MI, and capital intensity CI). We found that the degree of internationalization of the new retail industry has a positive impact on corporate performance.
The resultant findings only reflect the setting of China's new retail marketplace. With the research model developed here in, future research can target cross-country studies of various forms of online and offline market sites to determine regional differences in the development of new retail activities.
The results show that the major new retail industry is a multi-channel concept that affects overall corporate performance. The authors focus on corporate performance, which is a moderating effect based on proprietary assets.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A star-shaped 1,3,5-triazine/cyano hybrid molecule CN-T2T was designed and synthesized as a new electron acceptor for efficient exciplex-based OLED emitter by mixing with a suitable electron donor ...(Tris-PCz). The CN-T2T/Tris-PCz exciplex emission shows a high ΦPL of 0.53 and a small ΔE T‑S = −0.59 kcal/mol, affording intrinsically efficient fluorescence and highly efficient exciton up-conversion. The large energy level offsets between Tris-PCz and CN-T2T and the balanced hole and electron mobility of Tris-PCz and CN-T2T, respectively, ensuring sufficient carrier density accumulated in the interface for efficient generation of exciplex excitons. Employing a facile device structure composed as ITO/4% ReO3:Tris-PCz (60 nm)/Tris-PCz (15 nm)/Tris-PCz:CN-T2T(1:1) (25 nm)/CN-T2T (50 nm)/Liq (0.5 nm)/Al (100 nm), in which the electron–hole capture is efficient without additional carrier injection barrier from donor (or acceptor) molecule and carriers mobilities are balanced in the emitting layer, leads to a highly efficient green exciplex OLED with external quantum efficiency (EQE) of 11.9%. The obtained EQE is 18% higher than that of a comparison device using an exciplex exhibiting a comparable ΦPL (0.50), in which TCTA shows similar energy levels but higher hole mobility as compared with Tris-PCz. Our results clearly indicate the significance of mobility balance in governing the efficiency of exciplex-based OLED. Exploiting the Tris-PCz:CN-T2T exciplex as the host, we further demonstrated highly efficient yellow and red fluorescent OLEDs by doping 1 wt % Rubrene and DCJTB as emitter, achieving high EQE of 6.9 and 9.7%, respectively.
Prostate cancer is a major cause of cancer-related mortality in men in developed countries. The compound, 4-acetylantroquinonol B (4AAQB), is isolated from
(commonly known as Niu-Chang-Chih), which ...has been shown to inhibit cancer growth. However, the anticancer activity of 4AAQB has not previously been examined in prostate cancer. This study aimed to investigate the effect of 4AAQB on cancer and angiogenesis, as well as to explore its mechanism of action. Human prostate cancer cells (PC3) and human umbilical vein endothelial cells (HUVEC) were used in cell viability, cell migration, and cell cycle functional assays to evaluate the anticancer and antiangiogenic efficacy of 4AAQB in vitro. The effects of 4AAQB in vivo were determined using xenograft and angiogenesis models. The signaling events downstream of 4AAQB were also examined. The 4AAQB compound inhibited PC3 cell growth and migration, and reduced in vivo cancer growth, as shown in a subcutaneous xenograft model. Furthermore, 4AAQB inhibited HUVEC migration, tube formation, and aortic ring sprouting; it also reduced neovascularization in a Matrigel implant angiogenesis assay in vivo. The 4AAQB compound also decreased metastasis in the PC3 prostate cancer model in vivo. Serum or vascular endothelial growth factor (VEGF)-induced VEGF receptor 2 (VEGFR2), phosphoinositide 3-kinase (PI3K)/Ak strain transforming (Akt), and extracellular signal-regulated kinase ½ (ERK ½) phosphorylation were attenuated by 4AAQB in both PC3 and HUVEC. In conclusion, 4AAQB is a potential candidate for prostate cancer therapy.
Support vector machine (SVM) is a popular pattern classification method with many diverse applications. Kernel parameter setting in the SVM training procedure, along with the feature selection, ...significantly influences the classification accuracy. This study simultaneously determines the parameter values while discovering a subset of features, without reducing SVM classification accuracy. A particle swarm optimization (PSO) based approach for parameter determination and feature selection of the SVM, termed PSO
+
SVM, is developed.
Several public datasets are employed to calculate the classification accuracy rate in order to evaluate the developed PSO
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SVM approach. The developed approach was compared with grid search, which is a conventional method of searching parameter values, and other approaches. Experimental results demonstrate that the classification accuracy rates of the developed approach surpass those of grid search and many other approaches, and that the developed PSO
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SVM approach has a similar result to GA
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SVM. Therefore, the PSO
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SVM approach is valuable for parameter determination and feature selection in an SVM.
•This paper is the first research to solve the distributed hybrid flowshop scheduling problem.•The proposed SIG algorithm provides a practical means of solving this problem.•This study contributes ...significantly to expand the research on distributed scheduling problems.
The trend of globalization has recently seen the study of distributed scheduling problems. This study attempts to solve the distributed hybrid flowshop scheduling problem with multiprocessor tasks, and is the first attempt to address this problem. To solve this strongly NP-hard problem, a mixed integer linear programming formulation and self-tuning iterated greedy (SIG) algorithm that incorporates an adaptive cocktail decoding mechanism are presented to minimize the makespan. Comprehensive computational results demonstrate that the proposed SIG algorithm is extremely efficient and effective. This paper successfully expands the research area of distributed scheduling problems.
Blockchain technology, while still challenged with key limitations, is a transformative Information and Communications Technology (ICT) that has changed our notion of trust. Improved efficiencies for ...agricultural sustainable development has been demonstrated when ICT-enabled farms have access to knowledge banks and other digital resources. UN FAO-recommended ICT e-agricultural infrastructure components are a confluence of ICT and blockchain technology requirements. When ICT e-agricultural systems with blockchain infrastructure are immutable and distributed ledger systems for record management, baseline agricultural environmental data integrity is safeguarded for those who participate in transparent data management. This paper reviewed blockchain-based concepts associated with ICT-based technology. Moreover, a model ICT e-agriculture system with a blockchain infrastructure is proposed for use at the local and regional scale. To determine context specific technical and social requirements of blockchain technology for ICT e-agriculture systems, an evaluation tool is presented. The proposed system and tool can be evaluated and applied to further developments of e-agriculture systems.
Protein Function Module (PFM) identification in Protein-Protein Interaction Networks (PPINs) is one of the most important and challenging tasks in computational biology. The quick and accurate ...detection of PFMs in PPINs can contribute greatly to the understanding of the functions, properties, and biological mechanisms in research on various diseases and the development of new medicines. Despite the performance of existing detection approaches being improved to some extent, there are still opportunities for further enhancements in the efficiency, accuracy, and robustness of such detection methods. Based on the uniqueness of the network-clustering problem in the context of PPINs, this study proposed a very effective and efficient model based on the Lin-Kernighan-Helsgaun algorithm for detecting PFMs in PPINs. To demonstrate the effectiveness and efficiency of the proposed model, computational experiments are performed using three different categories of species datasets. The computational results reveal that the proposed model outperforms existing detection techniques in terms of two key performance indices, i.e., the degree of polymerization inside PFMs (cohesion) and the deviation degree between PFMs (separation), while being very fast and robust. The proposed model can be used to help researchers decide whether to conduct further expensive and time-consuming biological experiments and to select target proteins from large-scale PPI data for further detailed research.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Critical shoulder angle (CSA) is the angle between the superior and inferior bone margins of the glenoid and the most lateral border of the acromion and is potentially affected during a rotator cuff ...tear (RCT). Acromioplasty is generally performed to rectify the anatomy of the acromion during RCT repair surgery. However, limited information is available regarding the changes in the CSA after anterolateral acromioplasty. We hypothesized that CSA can be decreased after anterolateral acromioplasty. Data were retrospectively collected from 712 patients with RCTs and underwent arthroscopic rotator cuff repair between January 2012 and December 2018, of which 337 patients were included in the study. The presurgical and postsurgical CSA were then determined and compared using a paired samples t test. Because previous study mentioned CSA more than 38 degrees were at risk of rotator cuff re-tear, patients were segregated into two groups: CSA < 38° and CSA greater than or equal to 38°; these groups were compared using an independent-samples t test. These 337 participants (160 male and 177 female) presented a CSA of 38.4° ± 6.0° before anterolateral acromioplasty, which significantly decreased to 35.8° ± 5.9° after surgery (P < .05). Before surgery, 172 patients were present in the CSA greater than or equal to 38° group and 57 were preset in the CSA < 38° group after surgery. The CSA decreased significantly in the CSA greater than or equal to 38° group rather than in the CSA < 38° group (P < .05). In conclusion, the CSA can be effectively decreased through anterolateral acromioplasty, and this reduction in the CSA is more significant among individuals with CSA greater than or equal to 38° than among those with CSA < 38°, indicating that acromioplasty is recommended along with RCT repair especially among individuals with a wide presurgical CSA.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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