An already existing, sub-critical arrangement made of natural uranium and water moderator has been exposed to a low intensity (≈ 10
9 ppp) proton beam from CERN-PS at several kinetic energies from ...600 MeV to 2.75 GeV. The energy delivered by the hadronic cascade induced by the beam in the device has been measured by the temperature rise of small sampling blocks of uranium located in several different positions inside the device and counting the fissions in thin probe foils of natural uranium. We find typically
G ≈ 30 in reasonable agreement with calculations, where
G is the ratio of the energy produced in the device to the energy delivered by the beam. This result opens the way to the realisation of the so-called Energy Amplifier, a practical device to produce energy from thorium or depleted uranium targets exposed to an intense high energy proton beam. Results show that the optimal kinetic is ≥ 1 GeV, below which
G decreases but is still acceptable in the energy range explored
Fluorescent polymer nanoparticles for long‐term labeling and tracking of living cells with any desired color code are developed. They are built from biodegradable poly(lactic‐co‐glycolic acid) ...polymer loaded with cyanine dyes (DiO, DiI, and DiD) with the help of bulky fluorinated counterions, which minimize aggregation‐caused quenching. At the single particle level, these particles are ≈20‐fold brighter than quantum dots of similar color. Due to their identical 40 nm size and surface properties, these nanoparticles are endocytosed equally well by living cells. Mixing nanoparticles of three colors in different proportions generates a homogeneous RGB (red, green, and blue) barcode in cells, which is transmitted through many cell generations. Cell barcoding is validated on 7 cell lines (HeLa, KB, embryonic kidney (293T), Chinese hamster ovary, rat basophilic leucemia, U97, and D2A1), 13 color codes, and it enables simultaneous tracking of co‐cultured barcoded cell populations for >2 weeks. It is also applied to studying competition among drug‐treated cell populations. This technology enabled six‐color imaging in vivo for (1) tracking xenografted cancer cells and (2) monitoring morphogenesis after microinjection in zebrafish embryos. In addition to a robust method of multicolor cell labeling and tracking, this work suggests that multiple functions can be co‐localized inside cells by combining structurally close nanoparticles carrying different functions.
Structurally close but spectrally distinct fluorescent polymer nanoparticles are prepared through loading of cyanine dyes with the help of bulky hydrophobic counterions, preventing aggregation‐caused quenching. Due to identical internalization, these nanoparticles can be combined together for long‐term labeling and tracking of cells in vitro and in vivo with at least 13 color codes.
In the framework on a study of the acido-basic and sorption properties of iron oxides, a thorough characterization of two types of goethite powders was performed in several laboratories joined in a ...common project. Chemical analysis by ICPAES; high-resolution SEM, TEM, and AFM observations; XRD with line width analysis; and argon and nitrogen sorption isotherms were used for that purpose. The main crystallographic faces of goethite particles could be identified as {001}, {101}, and {121}, and their abundance correlated with the distribution of low-pressure argon adsorption local isotherms. These results will be very useful for further studies on the relationship between surface reactivity in aqueous solution and orientation of solid surfaces.
PDF
