ABSTRACT We give an overview of the Grism Lens Amplified Survey from Space (GLASS), a large Hubble Space Telescope program aimed at obtaining grism spectroscopy of the fields of 10 massive clusters ...of galaxies at redshift z = 0.308-0.686, including the Hubble Frontier Fields (HFF). The Wide Field Camera 3 (WFC3) yields near-infrared spectra of the cluster cores covering the wavelength range 0.81-1.69 m through grisms G102 and G141, while the Advanced Camera for Surveys in parallel mode provides G800L spectra of the infall regions of the clusters. The WFC3 spectra are taken at two almost orthogonal position angles in order to minimize the effects of confusion. After summarizing the scientific drivers of GLASS, we describe the sample selection as well as the observing strategy and data processing pipeline. We then utilize MACS J0717.5+3745, a HFF cluster and the first one observed by GLASS, to illustrate the data quality and the high-level data products. Each spectrum brighter than is visually inspected by at least two co-authors and a redshift is measured when sufficient information is present in the spectra. Furthermore, we conducted a thorough search for emission lines through all of the GLASS WFC3 spectra with the aim of measuring redshifts for sources with continuum fainter than We provide a catalog of 139 emission-line-based spectroscopic redshifts for extragalactic sources, including three new redshifts of multiple image systems (one probable, two tentative). In addition to the data itself, we also release software tools that are helpful to navigate the data.
This paper is the second in a series in which we perform an extensive comparison of various galaxy-based cluster mass estimation techniques that utilize the positions, velocities and colours of ...galaxies. Our aim is to quantify the scatter, systematic bias and completeness of cluster masses derived from a diverse set of 25 galaxy-based methods using two contrasting mock galaxy catalogues based on a sophisticated halo occupation model and a semi-analytic model. Analysing 968 clusters, we find a wide range in the rms errors in log M
200c delivered by the different methods (0.18–1.08 dex, i.e. a factor of ∼1.5–12), with abundance-matching and richness methods providing the best results, irrespective of the input model assumptions. In addition, certain methods produce a significant number of catastrophic cases where the mass is under- or overestimated by a factor greater than 10. Given the steeply falling high-mass end of the cluster mass function, we recommend that richness- or abundance-matching-based methods are used in conjunction with these methods as a sanity check for studies selecting high-mass clusters. We see a stronger correlation of the recovered to input number of galaxies for both catalogues in comparison with the group/cluster mass, however, this does not guarantee that the correct member galaxies are being selected. We do not observe significantly higher scatter for either mock galaxy catalogues. Our results have implications for cosmological analyses that utilize the masses, richnesses, or abundances of clusters, which have different uncertainties when different methods are used.
Minimal residual disease prior to allogeneic hematopoietic cell transplantation has been associated with increased risk of relapse and death in patients with acute myeloid leukemia, but detection ...methodologies and results vary widely. We performed a systematic review and meta-analysis evaluating the prognostic role of minimal residual disease detected by polymerase chain reaction or multiparametric flow cytometry before transplant. We identified 19 articles published between January 2005 and June 2016 and extracted hazard ratios for leukemia-free survival, overall survival, and cumulative incidences of relapse and non-relapse mortality. Pre-transplant minimal residual disease was associated with worse leukemia-free survival (hazard ratio=2.76 1.90-4.00), overall survival (hazard ratio=2.36 1.73-3.22), and cumulative incidence of relapse (hazard ratio=3.65 2.53-5.27), but not non-relapse mortality (hazard ratio=1.12 0.81-1.55). These associations held regardless of detection method, conditioning intensity, and patient age. Adverse cytogenetics was not an independent risk factor for death or relapse. There was more heterogeneity among studies using flow cytometry-based than
polymerase chain reaction-based detection (I
=75.1%
<0.1% for leukemia-free survival, 67.8%
<0.1% for overall survival, and 22.1%
<0.1% for cumulative incidence of relapse). These results demonstrate a strong relationship between pre-transplant minimal residual disease and post-transplant relapse and survival. Outcome heterogeneity among studies using flow-based methods may underscore site-specific methodological differences or differences in test performance and interpretation.
This is the fourth in a series of papers studying the astrophysics and cosmology of massive, dynamically relaxed galaxy clusters. Here, we use measurements of weak gravitational lensing from the ...Weighing the Giants project to calibrate Chandra X-ray measurements of total mass that rely on the assumption of hydrostatic equilibrium. This comparison of X-ray and lensing masses measures the combined bias of X-ray hydrostatic masses from both astrophysical and instrumental sources. While we cannot disentangle the two sources of bias, only the combined bias is relevant for calibrating cosmological measurements using relaxed clusters. Assuming a fixed cosmology, and within a characteristic radius (r
2500) determined from the X-ray data, we measure a lensing to X-ray mass ratio of 0.96 ± 9 per cent (stat) ± 9 per cent (sys). We find no significant trends of this ratio with mass, redshift or the morphological indicators used to select the sample. Our results imply that any departures from hydrostatic equilibrium at these radii are offset by calibration errors of comparable magnitude, with large departures of tens-of-percent unlikely. In addition, we find a mean concentration of the sample measured from lensing data of
$c_{200} = 3.0_{-1.8}^{+4.4}$
. Anticipated short-term improvements in lensing systematics, and a modest expansion of the relaxed lensing sample, can easily increase the measurement precision by 30–50 per cent, leading to similar improvements in cosmological constraints that employ X-ray hydrostatic mass estimates, such as on Ωm from the cluster gas mass fraction.
The nature and origin of the cold interstellar medium (ISM) in early-type galaxies are still a matter of debate, and understanding the role of this component in galaxy evolution and in fuelling the ...central supermassive black holes requires more observational constraints. Here, we present a multiwavelength study of the ISM in eight nearby, X-ray and optically bright, giant elliptical galaxies, all central dominant members of relatively low-mass groups. Using far-infrared spectral imaging with the Herschel Photodetector Array Camera & Spectrometer, we map the emission of cold gas in the cooling lines of C iiλ157 μm, O i λ63 μm and O ib λ145 μm. Additionally, we present Hα+N ii imaging of warm ionized gas with the Southern Astrophysical Research (SOAR) telescope, and a study of the thermodynamic structure of the hot X-ray emitting plasma with Chandra. All systems with extended Hα emission in our sample (6/8 galaxies) display significant C ii line emission indicating the presence of reservoirs of cold gas. This emission is cospatial with the optical Hα+N ii emitting nebulae and the lowest entropy soft X-ray emitting plasma. The entropy profiles of the hot galactic atmospheres show a clear dichotomy, with the systems displaying extended emission-line nebulae having lower entropies beyond r 1 kpc than the cold-gas-poor systems. We show that while the hot atmospheres of the cold-gas-poor galaxies are thermally stable outside of their innermost cores, the atmospheres of the cold-gas-rich systems are prone to cooling instabilities. This provides considerable weight to the argument that cold gas in giant ellipticals is produced chiefly by cooling from the hot phase. We show that cooling instabilities may develop more easily in rotating systems and discuss an alternative condition for thermal instability for this case. The hot atmospheres of cold-gas-rich galaxies display disturbed morphologies indicating that the accretion of clumpy multiphase gas in these systems may result in variable power output of the AGN jets, potentially triggering sporadic, larger outbursts. In the two cold-gas-poor, X-ray morphologically relaxed galaxies of our sample, NGC 1399 and NGC 4472, powerful AGN outbursts may have destroyed or removed most of the cold gas from the cores, allowing the jets to propagate and deposit most of their energy further out, increasing the entropy of the hot galactic atmospheres and leaving their cores relatively undisturbed.
Primary central nervous system lymphomas (PCNSLs) and primary testicular lymphomas (PTLs) are extranodal large B-cell lymphomas (LBCLs) with inferior responses to current empiric treatment regimens. ...To identify targetable genetic features of PCNSL and PTL, we characterized their recurrent somatic mutations, chromosomal rearrangements, copy number alterations (CNAs), and associated driver genes, and compared these comprehensive genetic signatures to those of diffuse LBCL and primary mediastinal large B-cell lymphoma (PMBL). These studies identify unique combinations of genetic alterations in discrete LBCL subtypes and subtype-selective bases for targeted therapy. PCNSLs and PTLs frequently exhibit genomic instability, and near-uniform, often biallelic, CDKN2A loss with rare TP53 mutations. PCNSLs and PTLs also use multiple genetic mechanisms to target key genes and pathways and exhibit near-uniform oncogenic Toll-like receptor signaling as a result of MYD88 mutation and/or NFKBIZ amplification, frequent concurrent B-cell receptor pathway activation, and deregulation of BCL6. Of great interest, PCNSLs and PTLs also have frequent 9p24.1/PD-L1/PD-L2 CNAs and additional translocations of these loci, structural bases of immune evasion that are shared with PMBL.
•PCNSLs and PTLs have a defining genetic signature that differs from other LBCLs and suggests rational targeted therapies.•PCNSLs and PTLs frequently exhibit 9p24.1/PD-L1/PD-L2 copy number alterations and translocations, likely genetic bases of immune evasion.
When innate immune cells such as macrophages are challenged with environmental stresses or infection by pathogens, they trigger the rapid assembly of multi-protein complexes called inflammasomes that ...are responsible for initiating pro-inflammatory responses and a form of cell death termed pyroptosis. We describe here the identification of an intracellular trigger of NLRP3-mediated inflammatory signaling, IL-1β production and pyroptosis in primed murine bone marrow-derived macrophages that is mediated by the disruption of glycolytic flux. This signal results from a drop of NADH levels and induction of mitochondrial ROS production and can be rescued by addition of products that restore NADH production. This signal is also important for host-cell response to the intracellular pathogen Salmonella typhimurium, which can disrupt metabolism by uptake of host-cell glucose. These results reveal an important inflammatory signaling network used by immune cells to sense metabolic dysfunction or infection by intracellular pathogens.
The primary difficulty in measuring dynamical masses of galaxy clusters from galaxy data lies in the separation between true cluster members from interloping galaxies along the line of sight. We ...study the impact of membership contamination and incompleteness on cluster mass estimates obtained with 25 commonly used techniques applied to nearly 1000 mock clusters with precise spectroscopic redshifts. We show that all methods overestimate or underestimate cluster masses when applied to contaminated or incomplete galaxy samples, respectively. This appears to be the main source of the intrinsic scatter in the mass scaling relation. Applying corrections based on a prior knowledge of contamination and incompleteness can reduce the scatter to the level of shot noise expected for poorly sampled clusters. We establish an empirical model quantifying the effect of imperfect membership on cluster mass estimation and discuss its universal and method-dependent features. We find that both imperfect membership and the response of the mass estimators depend on cluster mass, effectively causing a flattening of the estimated–true mass relation. Imperfect membership thus alters cluster counts determined from spectroscopic surveys, hence the cosmological parameters that depend on such counts.
Abstract
We present an HST/Advanced Camera for Surveys (ACS) weak gravitational lensing analysis of 13 massive high-redshift (zmedian = 0.88) galaxy clusters discovered in the South Pole Telescope ...(SPT) Sunyaev–Zel'dovich Survey. This study is part of a larger campaign that aims to robustly calibrate mass–observable scaling relations over a wide range in redshift to enable improved cosmological constraints from the SPT cluster sample. We introduce new strategies to ensure that systematics in the lensing analysis do not degrade constraints on cluster scaling relations significantly. First, we efficiently remove cluster members from the source sample by selecting very blue galaxies in V − I colour. Our estimate of the source redshift distribution is based on Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS) data, where we carefully mimic the source selection criteria of the cluster fields. We apply a statistical correction for systematic photometric redshift errors as derived from Hubble Ultra Deep Field data and verified through spatial cross-correlations. We account for the impact of lensing magnification on the source redshift distribution, finding that this is particularly relevant for shallower surveys. Finally, we account for biases in the mass modelling caused by miscentring and uncertainties in the concentration–mass relation using simulations. In combination with temperature estimates from Chandra
we constrain the normalization of the mass–temperature scaling relation ln (E(z)M500c/1014 M⊙) = A + 1.5ln (kT/7.2 keV) to $A=1.81^{+0.24}_{-0.14}(\mathrm{stat.})\,{\pm }\,0.09(\mathrm{sys.})$, consistent with self-similar redshift evolution when compared to lower redshift samples. Additionally, the lensing data constrain the average concentration of the clusters to $c_\mathrm{200c}=5.6^{+3.7}_{-1.8}$.
ABSTRACT In Hubble Space Telescope (HST) imaging taken on 2014 November 10, four images of supernova (SN) "Refsdal" (redshift z = 1.49) appeared in an Einstein-cross-like configuration (images S1-S4) ...around an early-type galaxy in the cluster MACS J1149.5+2223 (z = 0.54). Almost all lens models of the cluster have predicted that the SN should reappear within a year in a second host-galaxy image created by the cluster's potential. In HST observations taken on 2015 December 11, we find a new source at the predicted position of the new image of SN Refsdal approximately from the previous images S1-S4. This marks the first time the appearance of a SN at a particular time and location in the sky was successfully predicted in advance! We use these data and the light curve from the first four observed images of SN Refsdal to place constraints on the relative time delay and magnification of the new image (SX) compared to images S1-S4. This enables us, for the first time, to test "blind" lens model predictions of both magnifications and time delays for a lensed SN. We find that the timing and brightness of the new image are consistent with the blind predictions of a fraction of the models. The reappearance illustrates the discriminatory power of this blind test and its utility to uncover sources of systematic uncertainty. From planned HST photometry, we expect to reach a precision of 1%-2% on the time delay between S1-S4 and SX.
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