In this paper, we present the first automatically constructed LASCO coronal mass ejection (CME) catalog, a result of the application of the Computer Aided CME Tracking software (CACTus) on the LASCO ...archive during the interval 1997 September-2007 January. We have studied the CME characteristics and have compared them with similar results obtained by manual detection (CDAW CME catalog). On average, CACTus detects less than two events per day during solar minimum, up to eight events during maximum, nearly half of them being narrow (<20°). Assuming a correction factor, we find that the CACTus CME rate is surprisingly consistent with CME rates found during the past 30 years. The CACTus statistics show that small-scale outflow is ubiquitously observed in the outer corona. The majority of CACTus-only events are narrow transients related to previous CME activity or to intensity variations in the slow solar wind, reflecting its turbulent nature. A significant fraction (about 15%) of CACTus-only events were identified as independent events, thus not related to other CME activity. The CACTus CME width distribution is essentially scale invariant in angular span over a range of scales from 20° to 120° while previous catalogs present a broad maximum around 30°. The possibility that the size of coronal mass outflows follow a power-law distribution could indicate that no typical CME size exists, i.e., that the narrow transients are not different from the larger well defined CMEs.
This paper is the first in a series in which we perform an extensive comparison of various galaxy-based cluster mass estimation techniques that utilize the positions, velocities and colours of ...galaxies. Our primary aim is to test the performance of these cluster mass estimation techniques on a diverse set of models that will increase in complexity. We begin by providing participating methods with data from a simple model that delivers idealized clusters, enabling us to quantify the underlying scatter intrinsic to these mass estimation techniques. The mock catalogue is based on a Halo Occupation Distribution (HOD) model that assumes spherical Navarro, Frenk and White (NFW) haloes truncated at R
200, with no substructure nor colour segregation, and with isotropic, isothermal Maxwellian velocities. We find that, above 1014M⊙, recovered cluster masses are correlated with the true underlying cluster mass with an intrinsic scatter of typically a factor of 2. Below 1014M⊙, the scatter rises as the number of member galaxies drops and rapidly approaches an order of magnitude. We find that richness-based methods deliver the lowest scatter, but it is not clear whether such accuracy may simply be the result of using an over-simplistic model to populate the galaxies in their haloes. Even when given the true cluster membership, large scatter is observed for the majority non-richness-based approaches, suggesting that mass reconstruction with a low number of dynamical tracers is inherently problematic.
Although MRI is the gold standard for the diagnosis and monitoring of multiple sclerosis (MS), current conventional MRI techniques often fail to detect cortical alterations and provide little ...information about gliosis, axonal damage and myelin status of lesioned areas. Diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) provide sensitive and complementary measures of the neural tissue microstructure. Additionally, specific white matter tract integrity (WMTI) metrics modelling the diffusion in white matter were recently derived. In the current study we used the well-characterized cuprizone mouse model of central nervous system demyelination to assess the temporal evolution of diffusion tensor (DT), diffusion kurtosis tensor (DK) and WMTI-derived metrics following acute inflammatory demyelination and spontaneous remyelination.
While DT-derived metrics were unable to detect cuprizone induced cortical alterations, the mean kurtosis (MK) and radial kurtosis (RK) were found decreased under cuprizone administration, as compared to age-matched controls, in both the motor and somatosensory cortices. The MK remained decreased in the motor cortices at the end of the recovery period, reflecting long lasting impairment of myelination.
In white matter, DT, DK and WMTI-derived metrics enabled the detection of cuprizone induced changes differentially according to the stage and the severity of the lesion. More specifically, the MK, the RK and the axonal water fraction (AWF) were the most sensitive for the detection of cuprizone induced changes in the genu of the corpus callosum, a region less affected by cuprizone administration. Additionally, microgliosis was associated with an increase of MK and RK during the acute inflammatory demyelination phase. In regions undergoing severe demyelination, namely the body and splenium of the corpus callosum, DT-derived metrics, notably the mean diffusion (MD) and radial diffusion (RD), were among the best discriminators between cuprizone and control groups, hence highlighting their ability to detect both acute and long lasting changes. Interestingly, WMTI-derived metrics showed the aptitude to distinguish between the different stages of the disease. Both the intra-axonal diffusivity (Da) and the AWF were found to be decreased in the cuprizone treated group, Da specifically decreased during the acute inflammatory demyelinating phase whereas the AWF decrease was associated to the spontaneous remyelination and the recovery period.
Altogether our results demonstrate that DKI is sensitive to alterations of cortical areas and provides, along with WMTI metrics, information that is complementary to DT-derived metrics for the characterization of demyelination in both white and grey matter and subsequent inflammatory processes associated with a demyelinating event.
•Diffusion kurtosis imaging detects cuprizone induced cortical demyelination.•Diffusion tensor imaging detects cuprizone induced white matter alterations.•Diffusion kurtosis imaging improves detection of white matter alterations.•White matter tract integrity metrics improve detection of white matter pathology.
Cysteine cathepsins are lysosomal proteases involved in regulation of both normal cellular processes and disease. Biochemical studies with peptide substrates indicate that cathepsins have optimal ...activity at acidic pH and highly attenuated activity at neutral pH. In contrast, there is mounting evidence that cathepsins have biological roles in environments that have non-acidic pH. To further define the specific pH environments where cathepsins act, we designed bifunctional activity-based probes (ABPs) that allow simultaneous analysis of cathepsin protease activity and pH. We use these probes to analyze the steady-state environment of cathepsin activity in macrophages and to measure dynamic changes in activity and pH upon stimulation. We show that Salmonella typhimurium induces a change in lysosomal pH that ultimately impairs cathepsin activity in both infected cells and a fraction of bystander cells, highlighting a mechanism by which Salmonella can simultaneously flourish within host cells and alter the behavior of nearby uninfected cells.
Display omitted
•Synthesis of bifunctional probes that report cathepsin protease activity and pH•Probes used to measure steady-state and dynamic changes in pH and activity•Endosome/lysosome pH changes occur during Salmonella typhimurium infection•Organelles in both Salmonella-infected and bystander cells show elevated pH
Sanman et al. developed bifunctional activity-based probes that facilitate simultaneous analysis of cysteine cathepsin protease activity and pH. Using these probes, they find that an intracellular bacterial pathogen induces acidification defects in cathepsin-containing organelles that occur in both infected and some uninfected bystander cells.
The empirical part of this study is based on a survey of 600 Swedish households and a number of interviews where questions about residential energy behaviour and possible policy instruments for ...change were raised. The study provides insight into current behavioural patterns and gives a bottom-up perspective on the realistic perspective potentials for change and ways to achieve them. Residential energy use accounts for a fifth of the total in Northern nations and patterns of behaviour may influence levels of energy use to the same extent as choice of appliances. The study revealed those behavioural patterns that are efficient and those that need to be improved for energy conservation. Several policy instruments for change were identified in the study and they include combinations of information, economic measures, administrative measures and more user friendly technology as well as equipment with sufficient esthetic quality. Policy instruments that have fostered energy efficient behaviour in Sweden include the massive information campaigns during the oil crises in the 1970s as well as energy labelling of appliances. Still, many households are “energy-unaware” and several energy efficient behaviours are motivated not by energy conservation concern but of a perceived lack of time. This shows that it is important to have a broad perspective in energy conservation, to evaluate trends and to use policy instruments timely to support or discourage them.
There is significant and often heritable variation in cognition and its underlying neural mechanisms, yet specific genetic contributions to such variation are not well characterized. Black‐capped ...chickadees present a good model to investigate the genetic basis of cognition because they exhibit tremendous climate‐related variation in memory, hippocampal morphology and neurogenesis rates throughout the North American continent, and these cognitive traits appear to have a heritable basis. We examined the hippocampal transcriptome profiles of laboratory‐reared chickadees from the two most divergent populations to test whether differential gene expression in the hippocampus is associated with population differences in spatial memory, hippocampal morphology and adult hippocampal neurogenesis rates. Using high‐resolution mRNA sequencing coupled to a de novo transcriptome assembly, we generated 23 295 consensus sequences, which predicted 16 206 protein sequences with 13 982 showing high similarity to known protein sequences or conserved hypothetical proteins in other species. Of these, we identified differential expression in nearly 380 genes, with 47 genes specifically linked to neurogenesis, apoptosis, synaptic function, and learning and memory processes. Many of the other differentially expressed genes, however, may be associated with other functions. Our study presents the first avian hippocampal transcriptome, and it is the first study identifying differential gene expression associated with natural variation in cognition and the hippocampus. Our results provide additional support to the hypothesis that population differences in memory, hippocampal morphology and neurogenesis in chickadees have likely resulted from natural selection that appears to act on memory and its underlying neural mechanisms.
An extensive observational data set, consisting of more than 106 SF6 vertical profiles from MIPAS measurements distributed over the whole globe has been condensed into monthly zonal means of mean age ...of air for the period September 2002 to January 2010, binned at 10° latitude and 1–2 km altitude. The data were analysed with respect to their temporal variation by fitting a regression model consisting of a constant and a linear increase term, 2 proxies for the QBO variation, sinusoidal terms for the seasonal and semi-annual variation and overtones for the correction of the shapes to the observed data set. The impact of subsidence of mesospheric SF6-depleted air and in-mixing into non-polar latitudes on mid-latitudinal absolute age of air and its linear increase was assessed and found to be small. The linear increase of mean age of stratospheric air was found to be positive and partly larger than the trend derived by Engel et al. (2009) for most of the Northern mid-latitudes, the middle stratosphere in the tropics, and parts of the Southern mid-latitudes, as well as for the Southern polar upper stratosphere. Multi-year decrease of age of air was found for the lowermost and the upper stratospheric tropics, for parts of Southern mid-latitudes, and for the Northern polar regions. Analysis of the amplitudes and phases of the seasonal variation shed light on the coupling of stratospheric regions to each other. In particular, the Northern mid-latitude stratosphere is well coupled to the tropics, while the Northern lowermost mid-latitudinal stratosphere is decoupled, confirming the separation of the shallow branch of the Brewer-Dobson circulation from the deep branch. We suggest an overall increased tropical upwelling, together with weakening of mixing barriers, especially in the Northern Hemisphere, as a hypothetical model to explain the observed pattern of linear multi-year increase/decrease, and amplitudes and phase shifts of the seasonal variation.
ABSTRACT
We present an analysis of the X-ray active galactic nucleus (AGN) population in a sample of seven massive galaxy clusters in the redshift range 0.35 < z < 0.45. We utilize high-quality ...Chandra X-ray imaging to robustly identify AGN and precisely determine cluster masses and centroids. Follow-up VIsible Multi-Object Spectrograph optical spectroscopy allows us to determine which AGN are cluster members. Studying the subset of AGN with 0.5–8 keV luminosities >6.8 × 1042 erg s−1, within r ≤ 2r500 (approximately the virial radius), we find that the cluster AGN space density scales with cluster mass as $\sim M^{-2.0^{+0.8}_{-0.9}}$. This result rules out zero mass dependence of the cluster X-ray AGN space density at the 2.5σ level. We compare our cluster X-ray AGN sample to a control field with identical selection and find that the cluster AGN fraction is significantly suppressed relative to the field when considering the brightest galaxies with V < 21.5. For fainter galaxies, this difference is not present. Comparing the X-ray hardness ratios of cluster member AGN to those in the control field, we find no evidence for enhanced X-ray obscuration of cluster member AGN. Lastly, we see tentative evidence that disturbed cluster environments may contribute to enhanced AGN activity.
Family carers of people with profound and multiple intellectual disabilities (PMID) experienced a reduction in healthcare services due to the COVID-19 pandemic. Many subsequently turned to ...Non-Governmental Organisations who worked to support families. However, little research has sought to capture the experiences of family carers or identify effective interventions which might support them. To address these concerns we explored the views of Non-Governmental sector workers across the UK and Ireland who supported families people with PMID during the COVID-19 pandemic. We also sought to explore their views on the characteristics of online support programmes for family carers. METHODS: This study employed a qualitative design using focus groups with participants (n = 24) from five Non-Governmental Organisations across the UK and Ireland. A focus group guide included questions on challenges, supports, coping and resources which helped during lockdown restrictions. Focus groups were held online, were audio recorded and transcribed verbatim. The resulting transcripts were pseudonymised and subjected to thematic analysis.
Four themes were identified (i) 'mental and emotional health', (ii) 'they who shout the loudest' (fighting for services), (iii) 'lack of trust in statutory services' and (iv) 'creating an online support programme'. Mental and emotional health emerged as the most prominent theme and included three subthemes named as 'isolation', 'fear of COVID-19' and 'the exhaustion of caring'.
The COVID-19 pandemic has increased the vulnerability of family carers who were already experiencing difficulties in accessing services and supports for their families. While Non-Governmental Organisations have been a crucial lifeline there is urgent need to design services, including online support programmes, in partnership with family carers which adequately address their needs.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
PDF
