The Compact Linear Collider (CLIC) is an option for a future
e
+
e
-
collider operating at centre-of-mass energies up to
3
TeV
, providing sensitivity to a wide range of new physics phenomena and ...precision physics measurements at the energy frontier. This paper is the first comprehensive presentation of the Higgs physics reach of CLIC operating at three energy stages:
s
=
350
GeV
, 1.4 and
3
TeV
. The initial stage of operation allows the study of Higgs boson production in Higgsstrahlung (
e
+
e
-
→
Z
H
) and
W
W
-fusion (
e
+
e
-
→
H
ν
e
ν
¯
e
), resulting in precise measurements of the production cross sections, the Higgs total decay width
Γ
H
, and model-independent determinations of the Higgs couplings. Operation at
s
>
1
TeV
provides high-statistics samples of Higgs bosons produced through
W
W
-fusion, enabling tight constraints on the Higgs boson couplings. Studies of the rarer processes
e
+
e
-
→
t
t
¯
H
and
e
+
e
-
→
H
H
ν
e
ν
¯
e
allow measurements of the top Yukawa coupling and the Higgs boson self-coupling. This paper presents detailed studies of the precision achievable with Higgs measurements at CLIC and describes the interpretation of these measurements in a global fit.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A
bstract
The Compact Linear Collider (CLIC) is a proposed future high-luminosity linear electron-positron collider operating at three energy stages, with nominal centre-of-mass energies
s
= 380 GeV, ...1
.
5 TeV, and 3 TeV. Its aim is to explore the energy frontier, providing sensitivity to physics beyond the Standard Model (BSM) and precision measurements of Standard Model processes with an emphasis on Higgs boson and top-quark physics. The opportunities for top-quark physics at CLIC are discussed in this paper. The initial stage of operation focuses on top-quark pair production measurements, as well as the search for rare flavour-changing neutral current (FCNC) top-quark decays. It also includes a top-quark pair production threshold scan around 350 GeV which provides a precise measurement of the top-quark mass in a well-defined theoretical framework. At the higher-energy stages, studies are made of top-quark pairs produced in association with other particles. A study of t
̄
tH production including the extraction of the top Yukawa coupling is presented as well as a study of vector boson fusion (VBF) production, which gives direct access to high-energy electroweak interactions. Operation above 1 TeV leads to more highly collimated jet environments where dedicated methods are used to analyse the jet constituents. These techniques enable studies of the top-quark pair production, and hence the sensitivity to BSM physics, to be extended to higher energies. This paper also includes phenomenological interpretations that may be performed using the results from the extensive top-quark physics programme at CLIC.
Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated ...familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐mutated α1 subunits in voltage‐gated NaV1.1 sodium channels (Scn1aL263V). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature.
The CLIC Tracker Detector (CLICTD) is a monolithic pixel sensor. It is fabricated in a 180 nm CMOS imaging process, modified with an additional deep low-dose n-type implant to obtain full lateral ...depletion. The sensor features a small collection diode, which is essential for achieving a low input capacitance. The CLICTD sensor was designed as a technology demonstrator in the context of the tracking detector studies for the Compact Linear Collider (CLIC). Its design characteristics are of broad interest beyond CLIC, for HL-LHC tracking detector upgrades. It is produced in two different pixel flavours: one with a continuous deep n-type implant, and one with a segmented n-type implant to ensure fast charge collection. The pixel matrix consists of 16 × 128 detection channels measuring 300μm×30μm. Each detection channel is segmented into eight sub-pixels to reduce the amount of digital circuity while maintaining a small collection electrode pitch. This paper presents the characterisation results of the CLICTD sensor in a particle beam. The different pixel flavours are compared in detail by using the simultaneous time-over-threshold and time-of-arrival measurement functionalities. Most notably, a spatial resolution down to (4.6±0.2)μm is measured. A time resolution down to (5.8±0.1)ns is observed, after applying an offline time-walk correction using the pixel-charge information. The hit detection efficiency is found to be well above 99.7% for thresholds of the order of several hundred electrons.
We present our new measurement of the cross-section for charm dimuon production in neutrino–iron interactions based upon the full statistics collected by the NOMAD experiment. After background ...subtraction we observe 15 344 charm dimuon events, providing the largest sample currently available. The analysis exploits the large inclusive charged current sample – about 9×106 events after all analysis cuts – and the high resolution NOMAD detector to constrain the total systematic uncertainty on the ratio of charm dimuon to inclusive Charged Current (CC) cross-sections to ∼2%. We also perform a fit to the NOMAD data to extract the charm production parameters and the strange quark sea content of the nucleon within the NLO QCD approximation. We obtain a value of mc(mc)=1.159±0.075 GeV/c2 for the running mass of the charm quark in the MS¯ scheme and a strange quark sea suppression factor of κs=0.591±0.019 at Q2=20 GeV2/c2.
We have studied the muon neutrino and antineutrino quasi-elastic (QEL) scattering reactions (
ν
μ
n
→
μ
−
p
and
) using a set of experimental data collected by the NOMAD Collaboration. We have ...performed measurements of the cross-section of these processes on a nuclear target (mainly carbon) normalizing it to the total
ν
μ
(
) charged-current cross section. The results for the flux-averaged QEL cross sections in the (anti)neutrino energy interval 3–100 GeV are
and
for neutrino and antineutrino, respectively. The axial mass parameter
M
A
was extracted from the measured quasi-elastic neutrino cross section. The corresponding result is
M
A
=1.05±0.02(stat)±0.06(syst) GeV. It is consistent with the axial mass values recalculated from the antineutrino cross section and extracted from the pure
Q
2
shape analysis of the high purity sample of
ν
μ
quasi-elastic 2-track events, but has smaller systematic error and should be quoted as the main result of this work. Our measured
M
A
is found to be in good agreement with the world average value obtained in previous deuterium filled bubble chamber experiments. The NOMAD measurement of
M
A
is lower than those recently published by K2K and MiniBooNE Collaborations. However, within the large errors quoted by these experiments on
M
A
, these results are compatible with the more precise NOMAD value.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Aims/hypothesis
Glucocorticoids (GCs) are widely used anti-inflammatory agents that frequently induce side effects, including insulin resistance, diabetes and hypertension. Here, we investigated the ...contribution of microvascular dysfunction to the development of these adverse effects in healthy men.
Methods
In a randomised, placebo-controlled, dose–response intervention study, 32 healthy normoglycaemic men (age: 21 ± 2 years; BMI: 21.9 ± 1.7 kg/m
2
) were allocated to receive prednisolone 30 mg once daily (
n
= 12), prednisolone 7.5 mg once daily (
n
= 12) or placebo (
n
= 8) for 2 weeks using block randomisation. A central office performed the treatment allocation, and medication was dispersed by the hospital pharmacy that was also blinded. Treatment allocation was kept in concealed envelopes. Participants, study personnel conducting the measures and assessing the outcome were blinded to group assignment. The study was conducted at a university hospital. Primary endpoint was prednisolone-induced changes in microvascular function, which was assessed by capillary microscopy. Insulin sensitivity was determined by hyperinsulinaemic–euglycaemic clamp and postprandial glycaemic excursions by standardised meal tests.
Results
Compared with placebo, prednisolone 7.5 mg and 30 mg decreased insulin-stimulated capillary recruitment by 9 ± 4% and 17 ± 3%, respectively (
p
< 0.01). In addition, prednisolone 7.5 mg and 30 mg reduced insulin sensitivity (
M
value) by −11.4 ± 4.5 μmol kg
−1
min
−1
and −25.1 ± 4.1 μmol kg
−1
min
−1
(
p
< 0.001) and increased postprandial glucose levels by 11 ± 5% and 27 ± 9% (
p
< 0.001), respectively. Only high-dose prednisolone increased systolic blood pressure (6 ± 1.2 mmHg,
p
= 0.006). Prednisolone-induced changes in insulin-stimulated capillary recruitment were associated with insulin sensitivity (
r
= +0.76;
p
< 0.001), postprandial glucose concentrations (
r
= −0.52;
p
< 0.03) and systolic blood pressure (
r
= −0.62;
p
< 0.001). Prednisolone increased resistin concentrations, which were negatively related to insulin-stimulated capillary recruitment (
r
= −0.40;
p
= 0.03). No effects were noted on adiponectin and leptin concentrations. Prednisolone treatment was well tolerated; none of the participants left the study.
Conclusions/interpretation
Prednisolone-induced impairment of insulin-stimulated capillary recruitment was paralleled by insulin resistance, increased postprandial glucose levels, hypertension and increased circulating resistin concentrations in healthy men. We propose that GC-induced impairments of microvascular function may contribute to the adverse effects of GC treatment on glucose metabolism and blood pressure.
Trial registration
isrctn.org ISRTCN 78149983
Funding
The study was funded by the Dutch Top Institute Pharma T1-106.
OBJECTIVE: Glucocorticoids (GCs) are regarded as diabetogenic because they impair insulin sensitivity and islet-cell function. This study assessed whether treatment with the glucagon-like peptide ...receptor agonist (GLP-1 RA) exenatide (EXE) could prevent GC-induced glucose intolerance. RESEARCH DESIGN AND METHODS: A randomized, placebo-controlled, double-blind, crossover study in eight healthy men (age: 23.5 20.0-28.3 years; BMI: 26.4 24.3-28.0 kg/m²) was conducted. Participants received three therapeutic regimens for 2 consecutive days: 1) 80 mg of oral prednisolone (PRED) every day (q.d.) and intravenous (IV) EXE infusion (PRED+EXE); 2) 80 mg of oral PRED q.d. and IV saline infusion (PRED+SAL); and 3) oral placebo-PRED q.d. and intravenous saline infusion (PLB+SAL). On day 1, glucose tolerance was assessed during a meal challenge test. On day 2, participants underwent a clamp procedure to measure insulin secretion and insulin sensitivity. RESULTS: PRED+SAL treatment increased postprandial glucose levels (vs. PLB+SAL, P = 0.012), which was prevented by concomitant EXE (vs. PLB+SAL, P = NS). EXE reduced PRED-induced hyperglucagonemia during the meal challenge (P = 0.018) and decreased gastric emptying (vs. PRED+SAL, P = 0.028; vs. PLB+SAL, P = 0.046). PRED+SAL decreased first-phase glucose- and arginine-stimulated C-peptide secretion (vs. PLB+SAL, P = 0.017 and P = 0.05, respectively), whereas PRED+EXE improved first- and second-phase glucose- and arginine-stimulated C-peptide secretion (vs. PLB+SAL; P = 0.017, 0.012, and 0.093, respectively). CONCLUSIONS: The GLP-1 RA EXE prevented PRED-induced glucose intolerance and islet-cell dysfunction in healthy humans. Incretin-based therapies should be explored as a potential strategy to prevent steroid diabetes.
A new design of a detector plane of sub-millimetre thickness for an electromagnetic sampling calorimeter is presented. It is intended to be used in the luminometers LumiCal and BeamCal in future ...linear e
+
e
-
collider experiments. The detector planes were produced utilising novel connectivity scheme technologies. They were installed in a compact prototype of the calorimeter and tested at DESY with an electron beam of energy 1–5 GeV. The performance of a prototype of a compact LumiCal comprising eight detector planes was studied. The effective Molière radius at 5 GeV was determined to be (8.1 ± 0.1 (stat) ± 0.3 (syst)) mm, a value well reproduced by the Monte Carlo (MC) simulation (8.4 ± 0.1) mm. The dependence of the effective Molière radius on the electron energy in the range 1–5 GeV was also studied. Good agreement was obtained between data and MC simulation.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Abstract
The CALICE collaboration is developing highly granular
electromagnetic and hadronic calorimeters for detectors at future
energy frontier electron-positron colliders. After successful tests
...of a physics prototype, a technological prototype of the Analog
Hadron Calorimeter has been built, based on a design and
construction techniques scalable to a collider detector. The
prototype consists of a steel absorber structure and active layers
of small scintillator tiles that are individually read out by
directly coupled SiPMs. Each layer has an active area of
72 × 72 cm^2 and a tile size of
3 × 3 cm^2. With 38 active layers, the prototype
has nearly 22,000 readout channels, and its total thickness
amounts to 4.4 nuclear interaction lengths. The dedicated readout
electronics provide time stamping of each hit with an expected
resolution of about 1 ns. The prototype was constructed in
2017 and commissioned in beam tests at DESY. It recorded muons,
hadron showers and electron showers at different energies in test
beams at CERN in 2018. In this paper, the design of the prototype,
its construction and commissioning are described. The methods used
to calibrate the detector are detailed, and the performance achieved
in terms of uniformity and stability is presented.
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