In order to accurately analyze and evaluate multi-index and multi-route traffic schemes for comparison and selection, we introduce herein a comprehensive weight and an intelligent selection algorithm ...for traffic scheme optimization to improve upon the shortcomings of common qualitative and quantitative analysis methods. Firstly, we establish an evaluation index system of transportation by traffic scheme considering the factors of technology, ecological environment, social environment, and economy, based on the whole life cycle. Secondly, the comprehensive weight based on subjective and objective factors is constructed. Finally, we establish an optimization method for transportation schemes by using the comprehensive weight and Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) model. The results show that the evaluation index system based on the whole life cycle is more comprehensive and accurate. The comprehensive weight vector avoids the defects of single weight methods and makes full use of subjective data and expert opinions. The comprehensive weight vector is introduced into the decision-maker's preference coefficient, so that analysts can determine the scheme according to the subjective and objective information and to the required accuracy. This method uses a large number of evaluation groups to evaluate the scheme, and the evaluation results show greater objectivity and efficiency.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In recent years, with the higher requirements for the performance of cement-based materials and the call for energy conservation and environmental protection, a wave of research on new materials has ...set off, and various high-performance concrete and more environmentally friendly geopolymers have appeared in the public. With a view to solving the defects of energy consumption, environmental protection and low toughness of traditional cement-based materials. At the same time, nanomaterials have become a focus of current research. Therefore, the research on the properties of cement-based materials and geopolymers modified by graphene and its derivatives has aroused extensive interest of researchers. Graphene-based nanomaterials are one of them. Because of their large specific surface area, excellent physical properties have been favored by many researchers. This paper reviews the research progress of graphene-based nanomaterials in improving the properties of cement-based materials and geopolymer materials, and points out the main challenges and development prospects of such materials in the construction field in the future.
A superconducting interfaceInterfaces between materials can harbor quantum states that belong to neither of the materials. A classic example is the superconducting interface between two insulating ...oxides, LaAlO3 and SrTiO3, with a critical temperature of around 200 millikelvin. Liu et al. observed superconductivity at a different interface—formed between KTaO3 as a substrate and an overlayer of either EuO or LaAlO3—at a considerably higher temperature of about 2 kelvin. Transport measurements displayed anisotropy, which may indicate an unusual superconducting state.Science, this issue p. 716The distinctive electronic structure found at interfaces between materials can allow unconventional quantum states to emerge. Here we report on the discovery of superconductivity in electron gases formed at interfaces between (111)-oriented KTaO3 and insulating overlayers of either EuO or LaAlO3. The superconducting transition temperature, as high as 2.2 kelvin, is about one order of magnitude higher than that of the LaAlO3/SrTiO3 system. Notably, similar electron gases at KTaO3 (001) interfaces remain normal down to 25 millikelvin. The critical field and current-voltage measurements indicate that the superconductivity is two-dimensional. In EuO/KTaO3 (111) samples, a spontaneous in-plane transport anisotropy is observed before the onset of superconductivity, suggesting the emergence of a distinct “stripe”-like phase, which is also revealed near the critical field.
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•The landscape types in the study area are dominated by grassland and bare area.•The optimal grain size for landscape pattern analysis is 150 m, and the optimal scale is ...10 km × 10 km.•Fragmentation decreases, aggregation increases, and spatial heterogeneity increases.•The area of high-risk zones increases and the ecological environment deteriorates.
Amidst swift socioeconomic progress, urbanization is intensifying, necessitating robust methodologies for environmental quality monitoring. Landscape Ecological Risk (LER) has emerged as a pivotal tool in this context. Extensive research has focused on the land utilization rates within watersheds, scrutinizing them through the lens of land use/land cover (LULC) dynamics. This study delves into the LULC attributes of the Bosten Lake Basin (BLB) across three temporal snapshots: 2000, 2010, and 2020. Grasslands and bare ground made up the vast majority area of the BLB. Selected twelve landscape pattern indices, analyzed their response curves with respect to grain size, determined the optimal grain size to be 150 m, and analysed its optimum amplitude of 10 km × 10 km on the basis of the semi-variance function, thus determined the optimal scale for analyzing the landscape pattern. Exploring scale effect facilitates a nuanced examination of the landscape patterns and land use efficacy within BLB. From 2000 to 2020, the landscape pattern showed less fragmented, less aggregated, and more spatially heterogeneous. The landscape ecological risk index model has been constructed for the investigation of the LER change characteristics of the BLB. Lowest-risk zones and lower-risk zones of LER predominate in BLB. In 2000, 2010 and 2020 the combined lower and lowest risk zones represent 62.02 %, 59.37 % and 58.44 % of the catchment area respectively. Finally, analyzed the spatial autocorrelation variation characteristics of LER. The global Moran' I index of BLB for the three periods from 2000 to 2020 exceeded 0.7. This study establishes theoretical and practical foundation for future multi-scale landscape ecological risk studies in eco-fragile regions.
Obesity is a growing epidemic among reproductive-age men, which can cause and exacerbate male infertility by means of associated comorbidities, endocrine abnormalities, and direct effects on the ...fidelity and throughput of spermatogenesis. A prominent consequence of male obesity is a reduction in testosterone levels. Natural products have shown tremendous potential anti-obesity effects in metabolic diseases. This study aimed to investigate the potential of apigenin (AP) to alleviate testicular dysfunction induced by a high-fat diet (HFD) and to investigate the underlying mechanisms, focusing on endoplasmic reticulum stress (ERS) and testosterone synthesis. A murine model of obesity was established using HFD-fed mice. The effects of AP on obesity, lipid metabolism, testicular dysfunction, and ERS were assessed through various physiological, histological, and molecular techniques. Administration of AP (10 mg/kg) ameliorated HFD-induced obesity and testicular dysfunction in a mouse model, as evidenced by decreased body weight, improved lipid profiles and testicular pathology, and restored protein levels related to testosterone. Furthermore, in vitro studies demonstrated that AP relieved ERS and recovered testosterone synthesis in murine Leydig cells (TM3) treated with free fatty acids (FFAs). It was also observed that AP rescued testosterone synthesis enzymes in TM3 cells, similar to that observed with the inhibitor of the PERK pathway (GSK2606414). In addition, ChIP, qPCR, and gene silencing showed that the C/EBP homologous protein (CHOP) bound directly to the promoter region of steroidogenic STAR and negatively modulated its expression. Collectively, AP has remarkable potential to alleviate HFD-induced obesity and testicular dysfunction. Its protective effects are attributable partly to mitigating ERS and restoring testosterone synthesis in Leydig cells.
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•Apigenin relieves obesity-related testicular dysfunction.•Apigenin restores testosterone synthesis by antagonizing the PERK-CHOP pathway.•CHOP directly binds and then negatively modulates steroidogenic STAR in Leydig cells.•Apigenin reduces lipid accumulation and improves lipid metabolism.
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•The construction land and farmland in Jinghe County has changed dramatically.•The farmland increased significantly and expanded along with a “triangle” three sides.•The biodiversity ...of farmland decreased, while the fragmentation degree of forest land increased.•Human factors are the main driving force of landscape pattern change in Jinghe County.
The eco-environment of the arid area is constantly fragile global-wide. The study on the spatial and temporal variation of its landscape pattern can quickly identify the driving factors, which is an effective analysis method of ecological conservation in the arid area. In this study, Jinghe County, Xinjiang, in Northwestern China, is chosen as a case study of understanding the major driving force of the oasis landscape. Landsat satellite images of 1994, 2007, and 2017 are used as the basic data sources for analysis. The moving window method, transition matrix, and factor analysis are selected as the main technical means for this paper to reveal the temporal and spatial variation of landscape pattern in Jinghe County, and to quantitatively describe its driving factors. The results of the analysis show that: (1) The landscape pattern of Jinghe County has changed dramatically, especially the construction land and farmland. Both show an increase of 351.29% and 269.01% respectively between 1994 and 2017. Farmland increased the most, with the proportion of 6.45% in Jinghe County, and expanded along with the “triangle” three sides. The area of forest land increased slightly, the area of grassland and unused land decreased, and the area of water did not change significantly. (2) The dominant obvious regional differences of landscape types in Jinghe County are mainly manifested in farmland and forest land. Taking the unused land as the boundary, the biodiversity of farmland decreased, and the aggregation degree deepened, while the fragmentation degree of forest land increased. (3) The spatial–temporal variation of landscape patterns in Jinghe County is the result of the combination of natural and human factors, but the correlation between human factors and the change of landscape area is significantly greater than that of natural factors. Thus, human factors are the main driving force of landscape pattern change in Jinghe County. The scientific management and planning of the intensity of human activities in Jinghe County should be the focus of ecological environment restoration and protection.
Di(2-ethylhexyl) phthalate (DEHP), as a widespread environmental pollutant and an endocrine disruptor, can disturb the homeostasis of thyroid hormones (THs). In order to elucidate roles of the MAPK ...and PI3K/Akt pathways and hepatic enzymes in thyroid-disrupting effects of DEHP, Sprague-Dawley rats were dosed with DEHP by gavage for 30 consecutive days; Nthy-ori 3-1 cells were treated with DEHP with NAC, k-Ras siRNA or inhibitors (U0126 and wortmannin). Results showed that DEHP led to histopathologic changes in rat thyroid and liver, such as the decrease in thyroid follicular cavity diameter, hepatocyte edema. Triiodothyronine (T3), thyroxine (T4) and thyrotropin releasing hormone (TRH) were reduced. DEHP caused ROS production, oxidative stress and k-Ras upregulation, thereby activating the ERK and Akt pathways in vivo and in vitro. Moreover, TRH receptor (TRHr) level was elevated after the activation of the Akt pathway and was downregulated after the inhibition of the Akt pathway. However, TRHr was not modulated by the ERK pathway. Additionally, hepatic enzymes, including Ugt1a1, CYP2b1, Sult1e1, and Sult2b1, were significantly induced after DEHP exposure. Taken together, DEHP can perturb TH homeostasis and reduce TH levels. The activated Ras/Akt/TRHr pathway and induced hepatic enzymes play vital roles in thyroid-disrupting effects of DEHP.
Active contour models driven by local binary fitting energy can segment images with inhomogeneous intensity, while being prone to falling into a local minima. However, the segmentation result largely ...depends on the location of the initial contour. We propose an active contour model with global and local image information. The local information of the model is obtained by bilateral filters, which can also enhance the edge information while smoothing the image. The local fitting centers are calculated before the contour evolution, which can alleviate the iterative process and achieve fast image segmentation. The global information of the model is obtained by simplifying the C-V model, which can assist contour evolution, thereby increasing accuracy. Experimental results show that our algorithm is insensitive to the initial contour position, and has higher precision and speed.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Background/Aims: Triclosan, as an antimicrobial agent and a potential endocrine disruptor, has been used extensively in diverse products, resulting in widespread human exposure. In recent years, ...studies suggest that triclosan could disturb thyroid functions and decline thyroid hormones (THs). Methods: To verify our hypothesis that the MAPK pathway may function significantly in triclosan-induced hypothyroidism, Sprague-Dawley rats were gavaged with triclosan for 31 consecutive days; Nthy-ori 3-1 cells were treated with triclosan in the presence/absence of NAC, inhibitors (SB203580 and SB202474), or TRHr siRNA. Tissues and/or cells were analyzed by several techniques including transmission electron microscopy, confocal laser scanning microscopy, gene silencing, western blot, and real-time PCR. Results: Triclosan led to histopathologic changes in the thyroid and decreases in triiodothyronine (T3) and thyroxine (T4). Triclosan stimulated ROS production and oxidative stress occurrence, thereby activating the p38 pathway in vivo and in vitro. Thyrotropin releasing hormone receptor (TRHr) was induced when the p38 pathway was activated, and was suppressed when that pathway was inhibited. Moreover, thyroid peroxidase (TPO) was restrained and modulated by the p38/TRHr pathway after triclosan treatment. Furthermore, deiodinase 3 (D3) and hepatic enzymes (Ugt2b1, CYP1a1, CYP1a2, CYP2b1, CYP3a1, and Sult1e1) were also induced by triclosan. Conclusion: Taken together, p38/TRHr-dependent regulation of TPO in thyroid cells contributes to the hypothyroidism of triclosan-treated rats.
In the recent decades, traditional concrete poses a great challenge to the modernization of the construction industry because of low tensile strength, poor toughness, and weak resistance to cracking. ...To overcome these problems, ultra-high performance concrete (UHPC) with superior mechanical properties and durability is developed for broad application prospect in the future engineering construction. However, UHPC is less eco-friendly because it consumes more cement compared with the traditional concrete. The manufacturing of cement produces large amounts of carbon dioxide and therefore leads to the greenhouse effect. Nanomaterials consist of microstructural features that range from 0.1 to 100 nm in size, which exhibit the novel properties different from their bulk counterparts, including filling effect, surface activity, and environmental sustainability. This paper reviews the effect of various nanomaterials used in UHPC to partially replace the cement or as an additive on the microstructures, mechanical properties, and other properties of UHPC. In addition, the limitations and shortcomings of the current research are analyzed and summarized, and development directions are provided for future research on the application of nanomaterials in UHPC.
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