As a new family of two-dimensional (2D) materials, MXene, with many attractive physicochemical properties, has attracted increasing attentions and been applied for various applications. Here, for the ...first time, ultrathin MXene membranes with thickness down to several tens of nanometers were developed for pervaporation desalination by stacking synthesized atomic-thin MXene nanosheets. Influences such as lateral size of MXene nanosheets and feed temperature on the resulting membrane performance were systematically investigated. Owing to unique 2D interlayer channels as well as high hydrophilicity, the ultrathin MXene membrane with ~60nm exhibited high water flux (85.4Lm−2h−1) and salt rejection (99.5%) with feed concentration of 3.5wt% NaCl at 65°C. In addition, the MXene membrane showed a good long-term stability and performance in synthetic seawater system. The high-performing ultrathin 2D MXene membrane developed here in this work offers great potential for pervaporation applications.
Display omitted
•Ultrathin 2D Ti3C2Tx MXene membrane was designed and fabricated.•MXene membrane was first reported for pervaporation process.•Abundant oxygen-containing groups enabled MXene membranes to be hydrophilic.•High water flux (85.4Lm-2h-1) with high salt rejection (99.5%) was realized.
Recent innovations highlight the great potential of two‐dimensional graphene oxide (GO) films in water‐related applications. However, undesirable water‐induced effects, such as the redispersion and ...peeling of stacked GO laminates, greatly limit their performance and impact their practical application. It remains a great challenge to stabilize GO membranes in water. A molecular bridge strategy is reported in which an interlaminar short‐chain molecular bridge generates a robust GO laminate that resists the tendency to swell. Furthermore, an interfacial long‐chain molecular bridge adheres the GO laminate to a porous substrate to increase the mechanical strength of the membrane. By rationally creating and tuning the molecular bridges, the stabilized GO membranes can exhibit outstanding durability in harsh operating conditions, such as cross‐flow, high‐pressure, and long‐term filtration. This general and scalable stabilizing approach for GO membranes provides new opportunities for reliable two‐dimensional laminar films used in aqueous environments.
Graphene oxide membranes are susceptible to water‐induced effects such as peeling of stacked laminates. A strategy is described for stabilization of graphene oxide membranes with interlaminar short‐chain (amine) and interfacial long‐chain (O=CS) molecular bridges. The bridged membranes demonstrate excellent durability in cross‐flow, high‐pressure, and long‐term filtration and they withstand vibration and sonication treatments.
The recent rise of low‐dimensional Ruddlesden–Popper (RP) perovskites is notable for superior humidity stability, however they suffer from low power conversion efficiency (PCE). Suitable organic ...spacer cations with special properties display a critical effect on the performance and stability of perovskite solar cells (PSCs). Herein, a new strategy of designing self‐additive low‐dimensional RP perovskites is first proposed by employing a glycine salt (Gly+) with outstanding additive effect to improve the photovoltaic performance. Due to the strong interaction between CO and Pb2+, the Gly+ can become a nucleation center and be beneficial to uniform and fast growth of the Gly‐based RP perovskites with larger grain sizes, leading to reduced grain boundary and increased carrier transport. As a result, the Gly‐based self‐additive low‐dimensional RP perovskites exhibit remarkable photoelectric properties, yielding the highest PCE of 18.06% for Gly (n = 8) devices and 15.61% for Gly (n = 4) devices with negligible hysteresis. Furthermore, the Gly‐based devices without encapsulation show excellent long‐term stability against humidity, heat, and UV light in comparison to BA‐based low‐dimensional PSCs. This approach provides a feasible design strategy of new‐type low‐dimensional RP perovskites to obtain highly efficient and stable devices for next‐generation photovoltaic applications.
By employing HOOCCH2NH3+ (Gly+) with its outstanding additive effect, self‐additive low‐dimensional Ruddlesden–Popper perovskites are first designed. As a result, the Gly‐based self‐additive low‐dimensional RP perovskites with large grain sizes exhibit remarkable photoelectric properties, yielding the highest power conversion efficiency of 18.06% with negligible hysteresis. More importantly, Gly‐based devices exhibit markedly improved stability against humidity, heat, and UV light.
Monitoring of human serum albumin (HSA) in a point‐of‐care fashion is urgently needed in particular for elderly or chronically ill patients. Herein, a dual‐state emissive chalcone probe having the ...feature of aggregation‐induced emission was designed and synthesized. The concentration of HSA can be evaluated by the ratios of emission from probes in aggregated and monomeric state, which gives a visually discernible red‐to‐green color change. A simple, portable paper‐based analytical device have been fabricated by integration of the recognition probe in the detection pad and employed for HSA test using the whole blood samples. This paper‐based assay shows the analytical capability comparable to the standard testing methods but is in a point‐of‐care fashion, providing a promising tool for at‐home HSA detection and HSA‐related disease diagnosis.
A paper‐based analytical device integrated with a dual‐state emissive chalcone probe enables ratiometric fluorescence determination of HSA in whole blood samples. This paper‐based assay demonstrates acceptable analytical capability while having compatibility for instrument‐free point‐of‐care testing of HSA in at‐home healthcare settings.
Cytokines are critical mediators that oversee and regulate immune and inflammatory responses via complex networks and serve as biomarkers for many diseases. Quantification of cytokines has ...significant value in both clinical medicine and biology as the levels provide insights into physiological and pathological processes and can be used to aid diagnosis and treatment. Cytokines and their clinical significance are introduced from the perspective of their pro‐ and anti‐inflammatory effects. Factors affecting cytokines quantification in biological fluids, native levels in different body fluids, sample processing and storage conditions, sensitivity to freeze‐thaw, and soluble cytokine receptors are discussed. In addition, recent advances in in vitro and in vivo assays, biosensors based on different signal outputs and intracellular to extracellular protein expression are summarized. Various quantification platforms for high‐sensitivity and reliable measurement of cytokines in different scenarios are discussed, and commercially available cytokine assays are compared. A discussion of challenges in the development and advancement of technologies for cytokine quantification that aim to achieve real‐time multiplex cytokine analysis for point‐of‐care situations applicable for both biomedical research and clinical practice are discussed.
Cytokines are important cellular signaling molecules and immune system mediators. Abnormal cytokine levels may cause cytokine storm and diseases. Consequently, quantification of cytokines is valuable for diseases diagnosisand therapy. The clinical significance of cytokines, factors affecting cytokine quantification, and advances of cytokine detection are summarized, providing a prospective for real‐time quantification of multiplex cytokines in the clinic.
Rapid and point-of-need (PON) detection of bacteria is crucial to directly provide rapid and reliable diagnostics information during on-site tests, allowing more room for taking proactive measures. ...By taking the multifaceted advantages of CRISPR/Cas12a and surface-enhanced Raman scattering (SERS), for the first time, we designed a recombinase polymerase amplification (RPA)-integrated microfluidic paper-based analytical device (μPAD), coined RPA-Cas12a-μPAD for supersensitive SERS detection. Single-stranded DNAs were designed to “pull down” SERS nanoprobes. The amplicons of the invA gene triggered the trans-cleavage of Cas12a, resulting in the indiscriminate shredding of linker ssDNA. Thus, the degree of aggregation of SERS nanoprobes was dependent on the concentration of Salmonella typhimurium (S. typhi), which was determined on a μPAD and monitored by a Raman spectrometer. The limit of detection for S. typhi was approximately 3–4 CFU/mL for spiked milk and meat samples with a dynamic detection range from 1 to 108 CFU/mL. The RPA-Cas12a-μPAD secured accurate tests for food samples in 45 min. This work expands the reach of CRISPR-based diagnostics (CRISPR-Dx) and provides a novel and robust bacterial PON detection platform.
Display omitted
•For the first time, a recombinase polymerase amplification-integrated microfluidic paper-based analytical device (μPAD) was fabricated for SERS detection of pathogenic bacteria.•It was able to supersensitive, specific and quantitative detection of Salmonella typhimurium in less than 45 min.•It was capable of Salmonella typhimurium detection in real food samples, which was comparable or better than the most reported methods.
Graphene, including pristine graphene and its analogues of graphene oxide and reduced graphene oxide, is revolutionizing the way we design high performance devices, particularly in the areas of ...sustainable energy and environmental technologies. From environmental remediation and sensing to energy conversions and storage, there are many successful cases of graphene applications. Instead of being a standalone working material, graphene is almost always coupled with another active material as a composite. With its high surface-to-bulk ratio, efficient heat transfer, and electron conduction, the interfacing with graphene not only helps to overcome such limitations in the bare working material but actually accentuates them. To achieve this, the strategy of surface functionalization of graphene, with either soft matters (e.g., organics, molecular linkers, proteins) or solid inorganic matters (e.g., metal nanoparticles, oxide semiconductors), holds the key to enabling the fabrication of high performance composites. The resultant architectures, in which the graphene is applied to, yield the highest achievable properties and should be unique to the specific applications. This Review provides a bottom-up account encompassing the functionalization of graphene to the design of graphene-based composites and also their selected applications in high performance systems relevant to energy and the environment.
With the potential of achieving high efficiency and low production costs, perovskite solar cells (PSCs) have attracted great attention. However, their unstableness under moist condition has retarded ...the commercial development. Recently, 2D perovskites have received a lot of attention due to their high moisture resistance. In this work, four quasi 2D quasi perovskites are prepared, then their stability under moist condition is investigated. The surface morphology, crystal structure, optical properties, and photovoltaic performance are measured. Among the four quasi‐2D perovskites, (C6H5CH2NH3)2(FA)8Pb9I28 has the best performance: uniform and dense film, extremely well‐oriented crystal structure, strong absorption, and a high power conversion efficiency (PCE) of 17.40%. The aging tests show that quasi‐2D perovskites are more stable under moist conditions than FAPbI3 is. The (C6H5CH2NH3)2(FA)8Pb9I28 quasi‐2D perovskite devices exhibit high humidity stability, maintaining 80% of the starting PCE after 500 h under 80% relative humidity. Compared with other quasi‐2D perovskites, (C6H5CH2NH3)2(FA)8Pb9I28 has the highest humidity stability, due to their strongest hydrophobicity from C6H5CH2NH3+. This work demonstrates that the properties of perovskite materials can be modified by adding different ammonium salts into FAPbI3. Thus, by introducing ammonium salts with high hydrophobic properties the fabrication of highly efficient and stable 2D PSCs may be possible.
Four quasi‐2D perovskites are prepared and used as a light‐absorbing layer. The results demonstrate that (C6H5CH2NH3)2(FA)8Pb9I28 exhibits uniform and dense film, well‐oriented crystal structure, and strong absorption and the device has a high PCE of 17.40% and an excellent moisture resistance. It can be found that introducing an ammonium salt with high hydrophobicity can achieve highly efficient and stable quasi‐2D perovskite devices.
UEBMI covers working and retired employees in cities (i.e., employers and employees from government agencies and institutions, state-owned enterprises, private businesses, social organizations, and ...other private entities), and URBMI covers citizens without employment in cities (i.e., children, students, elderly people, and unemployed residents). ...indicators of osteoporosis such as bone density or imaging information are seldom available in the medical insurance databases. ...consistent with previous publications on hip fracture incidence 8,9,11,16,29, in this study, hip-fracture-related indicators such as the incidence of hip fracture and associated costs in patients aged 55 years and above were used as surrogate indexes for determining the burden of osteoporosis or osteoporotic fractures. Additionally, we included specific symptoms and signs (hip pain, shorting and external rotation of the affected leg), special examination (hip X-ray), and particular treatments (open reduction and internal fixation of femoral neck fracture, open reduction and internal fixation of intertrochanteric fracture). Exclusion criteria for case identification were the following: (1) pathological fracture, (2) old hip fracture, (3) femoral shaft fracture, (4) distal femoral fracture, (5) subtrochanteric fracture, (6) complications and sequelae of hip fracture (non-union, delayed union, malunion, osteomyelitis, osteoarthritis, and anchylosis), (7) prosthesis complications, (8) osteonecrosis of the femoral head, (9) hip dislocation, and (10) removal of internal fixation devices.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
PDF
