•Wavelet transform, SVM and PLS are used for building the load forecast model.•Sensitivity analysis and correlation analysis are used to select the input variables.•The significant meteorological ...factors to cooling and heating load are obtained.•Dynamic load predictions for different time horizons are evaluated.
Dynamic cooling and heating load forecasting of heating, ventilation and air conditioning (HVAC) systems is a basis for optimizing the operation of HVAC systems and can contribute to achieving the effective management for the HVAC systems. This paper proposes a load forecasting method for office buildings based on artificial intelligence and regression analysis, including wavelet transform, support vector machines (SVM), and partial least squares regression (PLS). An office building located in Tianjin, China is taken as the building case study to validate the proposed model. For selecting the input variables, the methods of sensitivity analysis and correlation analysis are used. The results of different prediction horizons, mainly including 1 h ahead, 2 h ahead, 3 h ahead and 24 h ahead forecasting, are finally provided. In order to illustrate the accuracy improvement of the proposed model, the other three models are built to compare with the proposed model. Further, the influence of weather forecast precision on the proposed model is analyzed in this paper. The results indicate that the proposed method can realize dynamic load forecasting with high accuracy for different time horizons.
In this paper, the relevant information on chemical constituents and quality evaluation of Spina gleditsiae were retrieved and summarized. Modern studies show that Spina gleditsiae mainly contains ...flavonoids, phenols, triterpenoids, coumarins, sterols, lactones, organic acids and other compounds. Then the quality evaluation methods of Spina gleditsiae were introduced. In the future research, it is necessary to explore the extraction and separation technology of its chemical constituents and active constituents, and establish appropriate models to promote its development and application. It provides a reference for the further establishment of scientific and reasonable studies on the effective components of Spina gleditsiae.
Small well spacing tests were carried out in three and four zones of the transitional zone to solve the problems of poor effect of water flooding and low reserves utilization. In order to improve the ...effect of water drive development in the transitional zone of Area A, the two test zones in area a have been reopened and utilized, well pattern is changed from anti-nine-point method to five-point method. Through strengthening the tracking adjustment of oil and water wells, the variation law of production and water cut in the test well area with small well spacing in the development process is understood, and the adaptability of different well patterns and well spacing in three or four zones is verified, it provides a technical reference for the adaptability of water injection in three or four zones of the transition zone.
A large amount of heterogeneous data is generated during the experiments, operations, and simulations of the Experimental Advanced Superconducting Tokamak (EAST). The semantic and formatting ...inconsistencies of these heterogeneous data barrier the automation of data processes in integrated modeling and analysis. Data integration approaches based on a unified data model are an effective way to address this problem. A data integration tool, SpDB, was developed to unify data access for EAST’s integrated modeling process. SpDB unifies access to heterogeneous data sources under a single entry point in a namespace compatible with Integrated Modeling and Analysis Suite (IMAS). Users can access abstract tree data structures through a unified path without worrying about the format of specific data sources. SpDB enables automating integrated modeling workflows by combining multiple data sources into a single data structure that acts as a unified IO interface to the module.
•SpDB is a data integration tool to unify data access for EAST’s integrated modeling.•SpDB uses unified path compatible with IMAS IDS to access heterogeneous data sources.•SpDB combines multiple data sources to simplify integrated modelling workflows.
A novel coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-emerged in humans in Wuhan, China, in December 2019 and has since disseminated globally
. As of April 16, 2020, the ...confirmed case count of coronavirus disease 2019 (COVID-19) had surpassed 2 million. Based on full-genome sequence analysis, SARS-CoV-2 shows high homology to SARS-related coronaviruses identified in horseshoe bats
. Here we show the establishment and characterization of expandable intestinal organoids derived from horseshoe bats of the Rhinolophus sinicus species that can recapitulate bat intestinal epithelium. These bat enteroids are fully susceptible to SARS-CoV-2 infection and sustain robust viral replication. Development of gastrointestinal symptoms in some patients with COVID-19 and detection of viral RNA in fecal specimens suggest that SARS-CoV-2 might cause enteric, in addition to respiratory, infection
. Here we demonstrate active replication of SARS-CoV-2 in human intestinal organoids and isolation of infectious virus from the stool specimen of a patient with diarrheal COVID-19. Collectively, we established the first expandable organoid culture system of bat intestinal epithelium and present evidence that SARS-CoV-2 can infect bat intestinal cells. The robust SARS-CoV-2 replication in human intestinal organoids suggests that the human intestinal tract might be a transmission route of SARS-CoV-2.
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•Hollow tubular g-C3N4 isotype heterojunction (SCN-CN) was synthesized.•SCN-CN performed a high visible-light photodegradation efficiency for TCH and RHB.•This work provides a ...theoretical basis for CN isotype heterojunction.•Electronic, optical, and work function properties were calculated based on DFT.
A highly reactive hollow tubular g-C3N4 isotype heterojunction (SCN-CN) was designed to enhance visible light absorption and manipulate the directed transfer of electrons and holes. The results of UV–vis DRS, XPS valence band and DFT theoretical calculations indicated S doping increases the visible-light absorption capacity and changed the ba nd gap structure of g-C3N4 (CN), resulting in the transfer of electrons from the CN to the SCN and holes from the SCN to the CN under visible light. In addition, the tubular structure of the SCN-CN facilitated the transfer of electrons in the longitudinal direction, which reduced charge carrier recombination. Furthermore, the optical properties, electronic structure, and electron transfer of SCN-CN were also studied by experiments and theoretical calculations. The antibiotic tetracycline hydrochloride (TCH) and dye Rhodamine B (RHB) were subjected to evaluate the photocatalytic performance of SCN-CN. The scavenger tests and ESR data showed that the h+, ·O2− and ·OH worked together in the photocatalytic process. Moreover, the photocatalytic degradation pathway was analyzed by LC-MS. This study synthesized a hollow tubular CN isotype heterojunction with high visible-light photocatalytic performance and provided a theoretical basis for CN isotype heterojunction.
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•Application of carbon nanomaterials for pollutants removal.•Toxicity impact of carbon nanomaterials.•Degradation of carbon nanomaterials.•Future perspectives of graphene based ...adsorbents.
Carbon nanomaterials (CNMs) are novel nanomaterials with excellent physicochemical properties, which are widely used in biomedicine, energy and sensing. Besides, CNMs also play an important role in environmental pollution control, which can absorb heavy metals, antibiotics and harmful gases. However, CNMs are inevitably entering the environment while they are rapidly developing. They are harmful to living organisms in the environment and are difficult to degrade under natural conditions. Here, we systematically describe the toxicity of carbon nanotubes (CNTs), graphene (GRA) and C60 to cells, animals, humans, and microorganisms. According to the current research results, the toxicity mechanism is summarized, including oxidative stress response, mechanical damage and effects on biological enzymes. In addition, according to the latest research progress, we focus on the two major degradation methods of chemical degradation and biodegradation of CNTs, GRA and C60. Meanwhile, the reaction conditions and degradation mechanisms of degradation are respectively stated. Moreover, we have prospects for the limitations of CNM degradation under non-experimental conditions and their potential application.
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•Surfactant-assisted synthesis is a promising method for photocatalyst synthesis.•Surfactant would efficiently enhance the photocatalytic activity of photocatalysts.•Surfactant can ...regulate the morphology and structure of photocatalysts.•Influencing factors and recent advances are highlighted.
The presence of large amounts of contaminants in the environment would result in ecological and health hazards. The photocatalytic technologies have been developed to use sunlight to remove contaminants in recent years. Researchers are primarily focused on developing high-performance photocatalysts. This review discusses the effects of surfactant on the structural morphology, physicochemical properties and contaminant removal performance of photocatalysts. The mechanism and synthesis method of surfactant-assisted photocatalysts are reviewed. Meanwhile, the effects of surfactant type, surfactant concentration, solution pH, synthesis method and calcination temperature on the photocatalysts are also discussed in detail. In addition, we summarized the recent advances and the application of surfactant-assisted photocatalysts in the environmental remediation. Finally, the future researches on surfactant-assisted photocatalysts are also proposed. This review provides new insights into the use of surfactants to prepare photocatalysts with well-defined shape and excellent performance to enhance photocatalytic efficiency for removing pollutants.
As an important biomarker for early cancer diagnostics and a valuable therapeutic target, telomerase has attracted extensive attention concerning its detection and monitoring. Herein, a homogeneous ...electrochemical strategy based on T7 exonuclease-aided target recycling amplification is proposed for a simple, rapid, and highly sensitive assay of human telomerase activity from crude cancer cell extracts. In this strategy, a 5′ methylene blue (MB)-labeled hairpin (HP) probe is designed, which can hybridize with the telomerase reaction products to initiate the subsequent digestion by T7 exonuclease, and a large amount of MB-labeled mononucleotides are released to result in the significantly amplified electrochemical signal. By taking advantage of the high amplification efficiency of T7-aided target recycling, the present assay enables the detection of telomerase activity at the single-cell level, which is superior or comparable to that of the reported literature. Furthermore, the assay was carried out in a homogeneous solution without complex modification or immobilization procedures, which has the merits of simplicity, rapid response, and improved recognition efficiency compared with heterogeneous biosensors. With the ability of fast detection, outstanding sensitivity, and excellent selectivity, this strategy offers a convenient and specific method for telomerase activity detection, which exhibits great potential in the practical application in telomerase-based early stage cancer diagnosis.
Chimeric antigen receptor （CAR） T cell therapy is a promising approach to treat cancer, such as B-cell ma- lignancy 1. However, the current standard treatment requires autologous adoptive cell ...transfer, which is ex- pensive and time-consuming. For newborn and elder patients, it is often difficult to obtain enough T ceils with good quality to generate patient-specific CAR-T cells. To make CAR-T therapy more accessible, it is highly desirable to develop an allogeneic adoptive transfer strategy, in which universal CAR-T cells derived from T cells from healthy donors can be applied to treat multiple patients.
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