Injectable scaffolds are of great interests for skin regeneration because they can fill irregularly shaped defects through minimally invasive surgical treatments. In this study, an injectable ...hydrogel from biopolymers is developed and its application as wound dressings is examined. Gelatin-based hydrogels were successfully prepared at body temperature upon blending with low content of gellan, and the synergetic effect on the gel formation was carefully characterized through rheological methods. The electrostatic complexation between gelatin and gellan was confirmed to contribute a continuous hydrogel network. The obtained blend hydrogel demonstrates remarkable shear-thinning and self-recovering properties. For antibacterial purpose, tannic acid was incorporated into the blend hydrogel. In addition, tannic acid-loaded blend hydrogel was verified to accelerate the wound healing on the mice model, significantly than the control groups. Thus, this paper presents a facile approach without chemical modification to construct injectable gelatin-based hydrogels, which have great potential as a wound dressing or tissue scaffold at body temperature.
The hydrogen evolution reaction is a huge challenge for CO
2
electroreduction. Herein, an inside-mode indium oxide/carbon nanotube compound (MWCNTs@In
2
O
3
) is developed to maximize the catalytic ...effect and suppress hydrogen evolution, its HCOOH selectivity can reach up to 92.2% at −16.8 mA cm
−2
, which is more efficient than In
2
O
3
.
An inside-mode MWCNTs@In
2
O
3
compound was developed to improve the catalytic effect and suppress hydrogen evolution. The HCOOH selectivity reaches up to 92.2%.
Electronic storage devices assembled from traditional hydrogel electrolytes (HEs) lose most of their capacity due to low-temperature effects and fail at high temperatures due to the water evaporation ...or accelerated hydrolysis of metal salt ions. Here, organohydrogel electrolytes (OHEs) are prepared by swelling freeze-dried hydrogels of poly(2-acrylamido-2-methylpropanesulfonic acid)/polyacrylamide in a binary solvent electrolyte of ethylene glycol and water (EG/H2O, water content 10% v/v) containing ZnCl2/NH4Cl. Owing to the synergistic solvation of ZnCl2, EG, and H2O, the OHE possesses a lower freezing point (<−60 °C) than the control HE. The flexible zinc||polyaniline (Zn||PANI) battery assembled by the OHE exhibits high rate performance (122.1 mA h/g, 5 A/g) and excellent cycle stability (81.5%, 4000 cycles) at room temperature. The Zn||PANI battery shows good electrochemical stability against the process of bending, heavy pressure, hammering, and soaking. More importantly, the battery has a wide operating temperature (−30 to 80 °C) with outstanding capacity retentions of 88.8% after 1500 cycles at −30 °C and 44.8% after 1000 cycles at 80 °C. Especially, the OHE can alleviate the problems of corrosion, zinc dendrite, and other side reactions of the zinc anode by generating an EG interphase on the surface of the zinc foil.
A platinum( ii ) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, ...followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent anti-tumour activities in two independent mouse models via an immunogenic cell death pathway.
Silver/carbon (Ag/C) core–shell nanospheres synthesized by a hydrothermal method were used as templates for fabricating silver nanoparticle-decorated Ag/C (Ag/C/AgNps) nanospheres. The particle size ...of Ag nanoparticles can be tuned by varying the concentration of Ag precursor. Detection of melamine molecules at concentrations as low as 5.0×10–8 M shows that the Ag/C/AgNps nanosphere is a good SERS-active substrate. The effect of heavy metal ions on the detection of melamine is also investigated. It was found that the SERS spectrum profile of melamine is very sensitive to the presence of heavy metal ions: the peak positions of the SERS bands exhibit some apparent change with the kind of metal ion, showing a blue or red shift compared with those in the SERS spectrum of melamine; the SERS signal intensity decrease with increasing the concentration of metal ion.
A multifunctional platform based on two-dimensional nanomaterials for combined antibacterial and anti-inflammatory therapy is developed. Bi2Se3 nanodiscs selectively eradicate Gram-positive bacteria ...with a low risk of drug resistance. Moreover, Bi2Se3 nanodiscs with antioxidant activity relieve intracellular oxidative stress of macrophages to suppress inflammation caused by bacterial infections.
Highlights
2D Sn nanosheets (SnNSs) were prepared through the combination of cryogenic exfoliation and liquid-phase exfoliation.
The functionalized 2D SnNSs have good stability, superior ...biocompatibility, high photothermal conversion efficiency, and multimode imaging capability.
Stanene (Sn)-based materials have been extensively applied in industrial production and daily life, but their potential biomedical application remains largely unexplored, which is due to the absence of the appropriate and effective methods for fabricating Sn-based biomaterials. Herein, we explored a new approach combining cryogenic exfoliation and liquid-phase exfoliation to successfully manufacture two-dimensional (2D) Sn nanosheets (SnNSs). The obtained SnNSs exhibited a typical sheet-like structure with an average size of ~ 100 nm and a thickness of ~ 5.1 nm. After PEGylation, the resulting PEGylated SnNSs (SnNSs@PEG) exhibited good stability, superior biocompatibility, and excellent photothermal performance, which could serve as robust photothermal agents for multi-modal imaging (fluorescence/photoacoustic/photothermal imaging)-guided photothermal elimination of cancer. Furthermore, we also used first-principles density functional theory calculations to investigate the photothermal mechanism of SnNSs, revealing that the free electrons in upper and lower layers of SnNSs contribute to the conversion of the photo to thermal. This work not only introduces a new approach to fabricate 2D SnNSs but also establishes the SnNSs-based nanomedicines for photonic cancer theranostics. This new type of SnNSs with great potential in the field of nanomedicines may spur a wave of developing Sn-based biological materials to benefit biomedical applications.
Agents with multiple modes of tumor cell death can be effective chemotherapeutic drugs. One example of a bimodal chemotherapeutic approach is an agent that can induce both apoptosis and autophagic ...death. Thus far, no clinical anticancer drug has been shown to simultaneously induce both these pathways. Mono-functional platinum complexes are potent anticancer drug candidates which act through mechanisms distinct from cisplatin. Here, we describe the synthesis and characterize of two mono-functional platinum complexes containing 8-substituted quinoline derivatives as ligands, PtL1ClCl L1 = (Z)-1-(pyridin-2-yl)-N-(quinolin-8-ylmethylene) methanamine (Mon-Pt-1) and PtL2ClCl L2 = (Z)-2-(pyridin-2-yl)-N-(quinolin-8-ylmethylene) ethanamine (Mon-Pt-2). In comparison to cisplatin, Mon-Pt-2 exhibited a greater in vitro cytotoxicity, was more effective in resistant cells and elicited a better anticancer effect. Mechanistic experiments indicate that Mon-Pt-2 mainly accumulates in mitochondria, and stimulates significant TrxR inhibition ROS release and an ER stress response, mediated by mitochondrial dysfunction, ultimately resulting in a simultaneous induction of apoptosis and autophagy. Importantly, compared to cisplatin, Mon-Pt-2 exhibits lower acute toxicity and better anticancer activity in a murine tumor model. To the best of our knowledge, Mon-Pt-2 is the first mono-functional platinum complex inducing pro-death autophagy and apoptosis of cancer cells.
We synthesized two mono-functional platinum complexes, which target the mitochondria and exhibit high cytotoxicity, including in cisplatin-resistant cells. Mon-Pt-2 induced a significant ROS release and ER stress response mediated by mitochondrial dysfunction, ultimately resulting in simultaneous apoptosis and pro-autophagy in A549 cells. Importantly, compared to cisplatin, Mon-Pt-2 exhibits lower toxicity and better anticancer activity in a murine tumor model. Display omitted
•Two novel mono-functional platinum complexes were synthesized.•The complexes exhibited better anticancer activity than that of cisplatin.•The antitumor activity was resulted from the occurrence of apoptosis and autophagy.•ER-stress response mediated the occurrence of apoptosis and autophagy.
Transition metal carbides (TMCs) have been used extensively as catalysts for hydrogenation reactions. However, TMC catalysts suffer from low activity for H2 activation, which is vital to their ...hydrogenation performance. Herein, we report a feasible strategy to improve the ability of TMCs (e. g., Mo2C) for H2 activation by modulation of the metal‐support interaction (MSI). The MSI can be tuned by introducing N element into carbon supports. Specifically, N can modulate the orbital structure of Mo to promote H2 activation. Experimental and theoretical results reveal that H2 activation ability of the metal sites can be altered by loading them onto carbon supports, and optimized by doping N into the corresponding carbon matrices. Consequently, N‐doped carbon‐supported Mo2C (Mo2C/NC) catalyst, possessing improved H2 activation ability, displays remarkably enhanced catalytic hydrogenation performance for the reduction of nitro compounds. The conversion and selectivity over Mo2C/NC are nearly 100 % under mild conditions.
Thanks for your support: Hydrogenation performance of transition metal carbides can be improved by enhancing their H2 activation ability, which can be achieved by introducing and modulating the metal‐support interaction (MSI). Compared with Mo2C and Mo2C/C, Mo2C/NC performs better in hydrogenating nitro compounds into amino compounds.
Carbon capture, storage, and utilization (CCSU) is recognized as an effective method to reduce the excessive emission of CO2. Absorption by amine aqueous solutions is considered highly efficient for ...CO2 capture from the flue gas because of the large CO2 capture capacity and high selectivity. However, it is often limited by the equipment corrosion and the high desorption energy consumption, and adsorption of CO2 using solid adsorbents has been receiving more attention in recent years due to its simplicity and high efficiency. More recently, a great number of porous organic polymers (POPs) have been designed and constructed for CO2 capture, and they are proven promising solid adsorbents for CO2 capture due to their high Brunauer-Emmett-Teller (BET) surface area (SBET), adjustable pore size and easy functionalization. In particular, they usually have rigid skeleton, permanent porosity, and good physiochemical stability. In this review, we have a detailed review for the different POPs developed in recent years, not only the design strategy, but also the special structure for CO2 capture. The outlook of the opportunities and challenges of the POPs is also proposed.
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