This study focuses on the potential of generative artificial intelligence tools in education, particularly through the practical application of the 4PADAFE instructional design matrix. The objective ...was to evaluate how these tools, in combination with the matrix, can enhance education and improve the teaching–learning process. Through surveys conducted with teachers from the University of ESPE Armed Forces who participated in the MOOC course “Generative Artificial Intelligence Tools for Education: GPT Chat Techniques”, the study explores the impact of these tools on education. The findings reveal that generative artificial intelligence tools are crucial in developing massive MOOC virtual classrooms when integrated with an instructional design matrix. The results demonstrate the potential of generative artificial intelligence tools in university education. By utilizing these tools in conjunction with an instructional design matrix, educators can design and deliver personalized and enriching educational experiences. The devices offer opportunities to enhance the teaching–learning process and tailor educational materials to individual needs, ultimately preparing students for the demands of the 21st century. The study concludes that generative artificial intelligence tools have significant potential in education. They provide innovative ways to engage students, adapt content, and promote personalized learning. Implementing the 4PADAFE instructional design matrix further enhances the effectiveness and coherence of educational activities. By embracing these technological advancements, education can stay relevant and effectively meet the digital world’s challenges.
Mongolia has the world's highest incidence of hepatocellular carcinoma (HCC), with ∼100 cases/100,000 inhabitants, although the reasons for this have not been thoroughly delineated.
We performed a ...molecular characterization of Mongolian (n = 192) compared with Western (n = 187) HCCs by RNA sequencing and whole-exome sequencing to unveil distinct genomic and transcriptomic features associated with environmental factors in this population.
Mongolian patients were younger, with higher female prevalence, and with predominantly HBV-HDV coinfection etiology. Mongolian HCCs presented significantly higher rates of protein-coding mutations (121 vs. 70 mutations per tumor in Western), and in specific driver HCC genes (i.e., APOB and TSC2). Four mutational signatures characterized Mongolian samples, one of which was novel (SBS Mongolia) and present in 25% of Mongolian HCC cases. This signature showed a distinct substitution profile with a high proportion of T>G substitutions and was significantly associated with a signature of exposure to the environmental agent dimethyl sulfate (71%), a 2A carcinogenic associated with coal combustion. Transcriptomic-based analysis delineated three molecular clusters, two not present in Western HCC; one with a highly inflamed profile and the other significantly associated with younger female patients.
Mongolian HCC has unique molecular traits with a high mutational burden and a novel mutational signature associated with genotoxic environmental factors present in this country.
Purpose: Mongolia has the world’s highest incidence of hepatocellular carcinoma (HCC), with ~100 cases/105 inhabitants, although the reasons for this feature have not been thoroughly delineated. ...Experimental Design: We performed a molecular characterization of Mongolian (n=192) compared to Western HCCs (n=187) by RNA-seq and WES to unveil distinct genomic and transcriptomic features associated with environmental factors in this population. Results: Mongolian patients were younger, with higher female prevalence, and with predominantly HBV-HDV co-infection etiology. Mongolian HCCs presented significantly higher rates of protein-coding mutations (121 vs 70 mutations per tumor in Western), and in specific driver HCC genes (i.e. APOB, TSC2). Four mutational signatures characterized Mongolian samples, one of which was novel (SBS Mongolia) and present in 25% of Mongolian HCC cases. This signature showed a distinct substitution profile with a high proportion of T>G substitutions and was significantly associated with exposure to the environmental agent dimethyl sulfate (DMS, 71%), a 2A carcinogenic associated with coal combustion. Transcriptomic-based analysis delineated two molecular clusters, one with a highly inflamed profile, not present in Western HCC, and that were significantly associated with HBV-HDV etiology and female gender. Conclusions: Mongolian HCC has unique molecular traits with a high mutational burden and a novel mutational signature associated with genotoxic environmental factors present in this country.
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