The Sounds of Silents Lochner, Jim
BBC music magazine,
08/2019, Letnik:
27, Številka:
11
Magazine Article
Lochner profiles Charlie Chaplin, an Oscar-winning composer. For most people, Charlie Chaplin's musical legacy rests with the classic song Smile. But in a musical career that spanned over 50 years, ...Chaplin wrote over two-dozen published songs and composed nearly 900 minutes of film music -an astonishing achievement for someone who could not read or write music. He relied on a string of musicians to transcribe, arrange and orchestrate his musical vision, but working with Chaplin wasn't easy. In his autobiography, Charles Chaplin Jr. remembered watching'a man who couldn't read a note and knew nothing of the mechanics of the art, work at being a composer - and drive men mad.'
The value of normative models in research and clinical practice relies on their robustness and a systematic comparison of different modelling algorithms and parameters; however, this has not been ...done to date. We aimed to identify the optimal approach for normative modelling of brain morphometric data through systematic empirical benchmarking, by quantifying the accuracy of different algorithms and identifying parameters that optimised model performance. We developed this framework with regional morphometric data from 37 407 healthy individuals (53% female and 47% male; aged 3–90 years) from 87 datasets from Europe, Australia, the USA, South Africa, and east Asia following a comparative evaluation of eight algorithms and multiple covariate combinations pertaining to image acquisition and quality, parcellation software versions, global neuroimaging measures, and longitudinal stability. The multivariate fractional polynomial regression (MFPR) emerged as the preferred algorithm, optimised with non-linear polynomials for age and linear effects of global measures as covariates. The MFPR models showed excellent accuracy across the lifespan and within distinct age-bins and longitudinal stability over a 2-year period. The performance of all MFPR models plateaued at sample sizes exceeding 3000 study participants. This model can inform about the biological and behavioural implications of deviations from typical age-related neuroanatomical changes and support future study designs. The model and scripts described here are freely available through CentileBrain.
PDF