The chemical stage represents important part of radiological mechanism as double strand breaks of DNA molecules represent main damages leading to final biological effect. These breaks are formed ...mainly by water radicals arising in clusters formed by densely ionizing ends of primary or secondary charged particles in neighborhood of a DNA molecule. The given effect may be significantly influenced by other species present in water, which may depend on the size and diffusion of corresponding clusters. We have already proposed a model describing the corresponding process (i.e., the combined effect of cluster diffusion and chemical reactions) running in individual radical clusters and influencing the formation probability of main damages (i.e., DSBs). Now a full number of corresponding species will be considered. With the help of Continuous Petri nets it will then be possible to follow the time evolution of corresponding species in individual clusters, which might be important especially in the case of studying the biological effect of very low-LET radiation. The results in deoxygenated water will be presented; the ratio of final and initial contents of corresponding species being in good agreement with values established experimentally.
The biological effect of ionizing radiation is mediated practically always by the clusters of radicals formed by densely ionizing track ends of primary or secondary particles. In the case of low-LET ...radiation the direct effect may be practically neglected and the radical clusters meet a DNA molecule always some time after their formation. The corresponding damage effect (formation of DSB) depends then on the evolution running in individual clusters, being influenced by present chemical agents. Two main parallel processes influence then final effect: diffusion of corresponding radical clusters (lowering radical concentrations) and chemical reactions of all chemical substances present in the clusters. The processes running in the corresponding radical clusters will be modeled with the help of continuous Petri net, which enables us to study the concurrent influence of both the processes: lowering concentration of radicals due diffusion and due chemical reactions. The given model may be helpful especially when the effect of radicals on DSB formation (DNA damage) at the presence of different substances influencing radiobiological effect is to be studied.
The simplest collision process, the elastic scattering of protons, has been measured at various energies and in a broad interval of scattering angles. Its theoretical description is, however, much ...more delicate, than it may seem at first glance. The widely used eikonal model allowed one to analyze the pp elastic scattering data at an ISR energy of 52.8 GeV and the TOTEM data at a much higher LHC energy of 8 TeV. The results represent the most detailed elaborated impact parameter analysis of pp data which has ever been performed. They have helped to identify several deeper open questions and problems concerning all widely used theoretical frameworks used for the description of the elastic pp scattering. The problems should be further studied and solved to derive some important proton characteristics which may be obtained with the help of the elastic scattering.
We present updated results from the NOvA experiment for νμ→νμ and νμ→νe oscillations from an exposure of 8.85×1020 protons on target, which represents an increase of 46% compared to our previous ...publication. The results utilize significant improvements in both the simulations and analysis of the data. A joint fit to the data for νμ disappearance and νe appearance gives the best-fit point as normal mass hierarchy, Δm322=2.44×10−3 eV2/c4, sin2θ23=0.56, and δCP=1.21π. The 68.3% confidence intervals in the normal mass hierarchy are Δm322∈2.37,2.52×10−3 eV2/c4, sin2θ23∈0.43,0.51∪0.52,0.60, and δCP∈0,0.12π∪0.91π,2π. The inverted mass hierarchy is disfavored at the 95% confidence level for all choices of the other oscillation parameters.
A search for nonresonant Higgs boson pair production in the b (b) over bar gamma gamma final state is performed using 140 fb(-1) of proton-proton collisions at a centre-of-mass energy of 13 TeV ...recorded by the ATLAS detector at the CERN Large Hadron Collider. This analysis supersedes and expands upon the previous nonresonant ATLAS results in this final state based on the same data sample. The analysis strategy is optimised to probe anomalous values not only of the Higgs (H) boson self-coupling modifier kappa(lambda) but also of the quartic HHVV (V = W, Z) coupling modifier kappa(2V). No significant excess above the expected background from Standard Model processes is observed. An observed upper limit mu(HH) < 4.0 is set at 95% confidence level on the Higgs boson pair production cross-section normalised to its Standard Model prediction. The 95% confidence intervals for the coupling modifiers are -1.4 < kappa(lambda) < 6.9 and -0.5 < kappa(2V) < 2.7, assuming all other Higgs boson couplings except the one under study are fixed to the Standard Model predictions. The results are interpreted in the Standard Model effective field theory and Higgs effective field theory frameworks in terms of constraints on the couplings of anomalous Higgs boson (self-)interactions.
The final biological effect of ionizing particles may be influenced often strongly by some chemical substances present in cells during irradiation by low-LET radiation. It may occur during the ...chemical stage of the given process, due to chemical reactions of radicals running in the given process. However, the whole chemical process may be hardly described sufficiently with the help of the usual approach based on the deterministic diffusion-kinetic computations and the stochastic Monte-Carlo simulations. We have proposed already earlier a model describing the processes (i.e., the combined effect of cluster diffusion and chemical reactions) running in individual radical clusters that might be responsible for corresponding damages of DNA molecules (i.e., formation of DSBs). Now a further generalization of the given model (using Continuous Petri nets) will be presented that makes it possible to characterize more detailed behavior of individual radicals in corresponding clusters, which might be useful especially for low-LET radiation when individual radical clusters meet a DNA molecule at different time intervals after their formation; the decreasing presence of individual radicals in corresponding clusters being established. In this paper we shall focus on the design of the corresponding mathematical model and its application; the comparison of corresponding results with experimental data obtained in the case of deoxygenated system will be presented.
•Creation of the mathematical model.•Realization of the model with the help of Continuous Petri nets.•Obtain the time dependence of changes in the concentration of radicals.
Precise knowledge of the beam optics at the LHC is crucial to fulfill the physics goals of the TOTEM experiment, where the kinematics of the scattered protons is reconstructed with near-beam ...telescopes-so-called Roman pots (RP). Before being detected, the protons' trajectories are influenced by the magnetic fields of the accelerator lattice. Thus precise understanding of the proton transport is of key importance for the experiment. A novel method of optics evaluation is proposed which exploits kinematical distributions of elastically scattered protons observed in the RPs. Theoretical predictions, as well as Monte Carlo studies, show that the residual uncertainty of the optics estimation method is smaller than .
This volume of the IOP Conference Series is dedicated to scientific contributions presented at the 16th International Workshop on Advanced Computing and Analysis Techniques in Physics Research (ACAT ...2014), this year the motto was bridging disciplines . The conference took place on September 1-5, 2014, at the Faculty of Civil Engineering, Czech Technical University in Prague, Czech Republic. The 16th edition of ACAT explored the boundaries of computing system architectures, data analysis algorithmics, automatic calculations, and theoretical calculation technologies. It provided a forum for confronting and exchanging ideas among these fields, where new approaches in computing technologies for scientific research were explored and promoted. This year's edition of the workshop brought together over 140 participants from all over the world. The workshop's 16 invited speakers presented key topics on advanced computing and analysis techniques in physics. During the workshop, 60 talks and 40 posters were presented in three tracks: Computing Technology for Physics Research, Data Analysis - Algorithms and Tools, and Computations in Theoretical Physics: Techniques and Methods. The round table enabled discussions on expanding software, knowledge sharing and scientific collaboration in the respective areas. ACAT 2014 was generously sponsored by Western Digital, Brookhaven National Laboratory, Hewlett Packard, DataDirect Networks, M Computers, Bright Computing, Huawei and PDV-Systemhaus. Special appreciations go to the track liaisons Lorenzo Moneta, Axel Naumann and Grigory Rubtsov for their work on the scientific program and the publication preparation. ACAT's IACC would also like to express its gratitude to all referees for their work on making sure the contributions are published in the proceedings. Our thanks extend to the conference liaisons Andrei Kataev and Jerome Lauret who worked with the local contacts and made this conference possible as well as to the program coordinator Federico Carminati and the conference chair Denis Perret-Gallix for their global supervision. Further information on ACAT 2014 can be found at http://www.particle.cz/acat2014
This paper describes the design and the performance of the timing detector developed by the TOTEM Collaboration for the Roman Pots (RPs) to measure the Time-Of-Flight (TOF) of the protons produced in ...central diffractive interactions at the LHC . The measurement of the TOF of the protons allows the determination of the longitudinal position of the proton interaction vertex and its association with one of the vertices reconstructed by the CMS detectors. The TOF detector is based on single crystal Chemical Vapor Deposition (scCVD) diamond plates and is designed to measure the protons TOF with about 50 ps time precision. This upgrade to the TOTEM apparatus will be used in the LHC run 2 and will tag the central diffractive events up to an interaction pileup of about 1. A dedicated fast and low noise electronics for the signal amplification has been developed. The digitization of the diamond signal is performed by sampling the waveform. In conclusion, after introducing the physics studies that will most profit from the addition of these new detectors, we discuss in detail the optimization and the performance of the first TOF detector installed in the LHC in November 2015.
Monitoring setup of Prague T2 site Burdik, M; Chudoba, J; Fiala, L ...
Journal of physics. Conference series,
07/2008, Letnik:
119, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Quality monitoring is a crucial part in struggle for reliability of every Tier 2 site. We present a solution based on Nagios installation in Prague. Our solution includes both third party and ...in-house developed add-ons and plug-ins. We focus on integrating results from grid-wise monitoring tools (such as SAM or Gstat) at one place (our Nagios instance). We also present an automated way to generate configuration files for Nagios from local database of hardware and services.
PDF
