•Uveitis is a vision-threatening inflammation and can be elicited by vaccination.•We describe a case of uveitis that occurred after BNT162b2 COVID-19 vaccination.•After treatment with topical ...steroids, visual acuity was completely restored.
Uveitis is a vision-threatening inflammation and is considered an ophthalmic emergency. It generally arises as a result of autoimmune conditions, infections, or ocular trauma, but it may also occur as an isolated disorder. Over the past decades, several cases of vaccine-associated uveitis have been described, with the hepatitis B virus vaccine being the leading cause.
A case of anterior uveitis in a 23-year-old male, with onset 14 days after the second dose of BNT162b2 COVID-19 vaccine, is reported here. Initial symptoms were pain, photophobia, and red eye. Ocular examination showed pericheratic and conjunctival hyperaemia, posterior synechiae, and anterior chamber cells ± keratic precipitates in the lower quadrants. The posterior segment did not show any alteration, and optical coherence tomography ruled out the presence of cystoid macular oedema. After a 10-day treatment course of topical steroids and cycloplegic eye drops, the ocular inflammatory signs disappeared and visual acuity was completely restored. Even if causality remains presumed, a warning should be given to physicians about the possibility of eye inflammation following SARS-CoV-2 vaccination.
Due to the stochastic nature of the source, wind turbines operate under non-stationary conditions and the extracted power depends non-trivially on ambient conditions and working parameters. It is ...therefore difficult to establish a normal behavior model for monitoring the performance of a wind turbine and the most employed approach is to be driven by data. The power curve of a wind turbine is the relation between the wind intensity and the extracted power and is widely employed for monitoring wind turbine performance. On the grounds of the above considerations, a recent trend regarding wind turbine power curve analysis consists of the incorporation of the main working parameters (as, for example, the rotor speed or the blade pitch) as input variables of a multivariate regression whose target is the power. In this study, a method for multivariate wind turbine power curve analysis is proposed: it is based on sequential features selection, which employs Support Vector Regression with Gaussian Kernel. One of the most innovative aspects of this study is that the set of possible covariates includes also minimum, maximum and standard deviation of the most important environmental and operational variables. Three test cases of practical interest are contemplated: a Senvion MM92, a Vestas V90 and a Vestas V117 wind turbines owned by the ENGIE Italia company. It is shown that the selection of the covariates depends remarkably on the wind turbine model and this aspect should therefore be taken in consideration in order to customize the data-driven monitoring of the power curve. The obtained error metrics are competitive and in general lower with respect to the state of the art in the literature. Furthermore, minimum, maximum and standard deviation of the main environmental and operation variables are abundantly selected by the feature selection algorithm: this result indicates that the richness of the measurement channels contained in wind turbine Supervisory Control And Data Acquisition (SCADA) data sets should be exploited for monitoring the performance as reliably as possible.
This work is devoted to the formulation of innovative SCADA-based methods for wind turbine performance analysis and interpretation. The work is organized as an academia–industry collaboration: three ...test cases are analyzed, two with hydraulic pitch control (Vestas V90 and V100) and one with electric pitch control (Senvion MM92). The investigation is based on the method of bins, on a polynomial regression applied to operation curves that have never been analyzed in detail in the literature before, and on correlation and causality analysis. A key point is the analysis of measurement channels related to the blade pitch control and to the rotor: pitch manifold pressure, pitch piston traveled distance and tower vibrations for the hydraulic pitch wind turbines, and blade pitch current for the electric pitch wind turbines. The main result of this study is that cases of noticeable under-performance are observed for the hydraulic pitch wind turbines, which are associated with pitch pressure decrease in time for one case and to suspected rotor unbalance for another case. On the other way round, the behavior of the rotational speed and blade pitch curves is homogeneous and stable for the wind turbines electrically controlled. Summarizing, the evidence collected in this work identifies the hydraulic pitch as a sensible component of the wind turbine that should be monitored cautiously because it is likely associated with performance decline with age.
BNT162b2 and mRNA-1273 are the two recently approved mRNA-based vaccines against COVID-19 which has shown excellent safety and efficacy. Preliminary data about specific and neutralizing antibodies is ...available covering the first 100 days after vaccination.
We reviewed all the publications regarding the immunologic consequences of BNT162b2 and mRNA-1273 vaccination. A summary of specific antibodies concentration and neutralizing antibodies titers elicited by each vaccine is provided.
BNT162b2 and mRNA-1273 displayed a reassuring safety and efficacy profile, with the latter above 94%. They can elicit specific antibodies titers and neutralizing antibodies concentrations that are far superior from those observed among COVID-19 human convalescent serum, across a wide span of age, for at least 100 days after vaccination. Moreover, the vaccine-induced T cellular response is oriented toward a T
1 response and no evidence of vaccine-enhanced disease have been reported.
BNT162b2 and mRNA-1273 can elicit specific antibodies titers and neutralizing antibodies concentrations above those observed among COVID-19 human convalescent serum in the first 100 days after vaccination. Data about vaccine efficacy in those with previous COVID-19 or immunocompromised is still limited.
Roland Barthes (2004) designa o estilo como esplendor e prisão do escritor: sua solidão. O presente artigo pretende refletir sobre esta visão barthesiana de estilo na obra do poeta, crítico de arte e ...tradutor italiano Emilio Villa, a partir de poemas plurilíngues ou traduzidos pelo próprio poeta italiano para o português brasileiro e de algumas de suas obras pictóricas. O conceito de tradução torna-se central para análise da obra de Emilio Villa, através da leitura de Walter Benjamin, Henri Meschonnic e outros teóricos e, também, pelas diversas traduções por ele realizadas: a Odisseia, partes do Gênesis, uma escolha das tabuletas mesopotâmicas. Villa escreveu não unicamente em italiano, mas seu plurilinguismo se confirmou em textos escritos em latim, grego, francês e outras línguas.
Roland Barthes (2004) designates style as the writer's splendor and prison: his loneliness. This paper intends to reflect on this barthesian thought of style in the work of the italian poet, art critic and translator Emilio Villa, based on plurilingual or translated poems into Brasilian Portuguese by the italian poet himself and some of his pictorial works. The concept of translation becomes central to analysing Emilio Villa's work, through reading Walter Benjamin, Henri Meschonnic and other theorists, and also through the various translations he made: the Odyssey, parts of Genesis, a selection of Mesopotamian tablets. Villa wrote not only in Italian, but his plurilingualism was confirmed in texts written in Latin, Greek, French and other languages.
Roland Barthes (2004) designa lo stile come splendore e prigione dello scrittore: la sua solitudine. Il presente articolo si propone di riflettere su questo pensiero barthesiano dello stile nell´opera del poeta, critico d'arte e traduttore italiano Emilio Villa, attraverso poesie plurilingui o tradotte in portoghese brasiliano dallo stesso poeta italiano e alcune delle sue opere pittoriche.
Immune exhaustion is a condition associated with chronic infections and cancers, characterized by the inability of antigen-specific T cells to eliminate the cognate antigen. Exhausted T cells display ...a peculiar phenotypic profile and exclusive functional characteristics. Immune exhaustion has been described in patients with
infection, and cases of tuberculosis reactivation have been reported in those treated with immune checkpoint inhibitors, drugs able to re-establish T-cells' function. Exhausted T CD8
cells' profile has also been described in patients with infection due to nontuberculous mycobacteria. In this review, we initially provide an overview of the mechanisms leading to immune exhaustion in patients infected by
and nontuberculous mycobacteria. We then dissect the therapeutic perspectives related to immune checkpoint blockade in patients with these infections.
An increasing amount of wind turbines, especially in Europe, are reaching the end of their expected lifetimes; therefore, long data sets describing their operation are available for scholars to ...analyze the performance trends. On these grounds, the present work is devoted to test case studies for the evaluation and the interpretation of wind turbine performance decline with age. Two wind farms were studied, featuring widely employed wind turbine models: the former is composed of 6 Senvion MM92 and the latter of 11 Vestas V52 wind turbines, owned by the ENGIE Italia company. SCADA data spanning, respectively, 10 and 7 years were analyzed for the two test cases. The effect of aging on the performance of the test case wind turbines was studied by constructing a data-driven model of appropriate operation curves, selected depending on the working region. For the Senvion MM92, we found that it is questionable to talk about performance aging because there is no evident trend in time: the performance variation year by year is in the order of a few kW and is therefore irrelevant for practical applications. For the Vestas V52 wind turbines, a much wider variability is observed: two wind turbines are affected by a remarkable performance drop, after which the behavior is stable and under-performing with respect to the rest of the wind farm. Particular attention is devoted to the interpretation of the results: the comparative discussion of the two test cases indicates that the observed operation curves are compatible with the hypothesis that the worsening with age of the two under-performing Vestas V52 can be ascribed to the behavior of the hydraulic blade pitch. Furthermore, for both test cases, it is estimated that the gearbox-aging contributes negligibly to the performance decline in time.
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase responsible for the development of different tumor types. Despite the remarkable clinical activity of crizotinib (Xalkori), the first ...ALK inhibitor approved in 2011, the emergence of resistance mutations and of brain metastases frequently causes relapse in patients. Within our ALK drug discovery program, we identified compound 1, a novel 3-aminoindazole active on ALK in biochemical and in cellular assays. Its optimization led to compound 2 (entrectinib), a potent orally available ALK inhibitor active on ALK-dependent cell lines, efficiently penetrant the blood–brain barrier (BBB) in different animal species and highly efficacious in in vivo xenograft models. Moreover, entrectinib resulted to be strictly potent on the closely related tyrosine kinases ROS1 and TRKs recently found constitutively activated in several tumor types. Entrectinib is currently undergoing phase I/II clinical trial for the treatment of patients affected by ALK-, ROS1-, and TRK-positive tumors.
The widespread availability of wind turbine operation data has considerably boosted the research and the applications for wind turbine monitoring. It is well established that a systematic ...misalignment of the wind turbine nacelle with respect to the wind direction has a remarkable impact in terms of down-performance, because the extracted power is in first approximation proportional to the cosine cube of the yaw angle. Nevertheless, due to the fact that in the wind farm practice the wind field facing the rotor is estimated through anemometers placed behind the rotor, it is challenging to robustly detect systematic yaw errors without the use of additional upwind sensory systems. Nevertheless, this objective is valuable because it involves the use of data that are available to wind farm practitioners at zero cost. On these grounds, the present work is a two-steps test case discussion. At first, a new method for systematic yaw error detection through operation data analysis is presented and is applied for individuating a misaligned multi-MW wind turbine. After the yaw error correction on the test case wind turbine, operation data of the whole wind farm are employed for an innovative assessment method of the performance improvement at the target wind turbine. The other wind turbines in the farm are employed as references and their operation data are used as input for a multivariate Kernel regression whose target is the power of the wind turbine of interest. Training the model with pre-correction data and validating on post-correction data, it is estimated that a systematic yaw error of 4 ∘ affects the performance up to the order of the 1.5% of the Annual Energy Production.
Fungal infections represent a relevant issue in agri-food and biomedical fields because they could compromise quality of food and humans' health. Natural extracts represent a safe alternative to ...synthetic fungicides and in the green chemistry and circular economy scenario, agro-industrial wastes and by-products offer an eco-friendly source of bioactive natural compounds. In this paper, phenolic-rich extracts from
L. de-oiled pomace,
Mill. wood,
L. peel, and
L. pomace and seeds were characterized by HPLC-MS-DAD analysis. Finally, these extracts were tested as antimicrobial agents against pathogenic filamentous fungi and dermatophytes such as
,
sp.,
, and
. The experimental results evidenced that all extracts exhibited a significant growth inhibition for
.
L.,
Mill., and
L. extracts showed a high activity against
sp. and
. These data are promising for the potential applications of some of these extracts as antifungal agents in the food and biomedical fields.
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