Compost-bedded pack barns (CBP) are receiving increasing attention as a housing system for dairy cows that has potential to improve animal welfare. This article reviews current scientific knowledge ...about CBP with the aim of providing a comprehensive tool for producers and researchers using this housing system. In CBP, cows are provided with an open bedded pack area rather than the individual stalls and concrete alleys found in freestall systems. The bedded pack, a mixture of organic bedding and cattle excreta, is cultivated frequently (1–3 times per day) to incorporate fresh manure and air into the pack, thus promoting an aerobic composting process. To function well, CBP generally require a large area per cow. Optimal animal densities over the bedded area range from 7.4 to more than 15 m2/cow depending on several factors, including climate, bedding, pack management, and cow characteristics. Studies have indicated that CBP, compared with conventional systems such as freestall barns, have the potential to improve the welfare of dairy cows. In particular, the main reported benefits include improved comfort during resting, better foot and leg health, and more natural animal behavior. Research has also indicated that adequate udder health can be achieved in CBP. However, because the bedded pack has been shown to contain high bacterial concentrations, proper management is essential to maintain adequate cow cleanliness and reduce the risk of mastitis. Controlling pack moisture is consistently indicated as the most important issue with CBP. Especially under cold and humid weather conditions, large amounts of bedding may be necessary to keep the pack adequately dry and comfortable for the cows. Nevertheless, the improvements in cow health may offset the higher costs of bedding.
Polyphenol-rich diets have been associated with reduced risk of cardiovascular disease (CVD). However, few prospective epidemiological studies have examined the relationship between classes of ...ingested polyphenols and risk of CVD. Our aim was to evaluate the association between polyphenol intake and risk of major cardiovascular events in a prospective Spanish cohort.
We included 17,065 university graduates (60.7% women, mean age: 37.2 years, age range: 20–89) followed-up for a mean of 10.1 years. Polyphenol intake was assessed at baseline using a validated semi-quantitative 136-item food frequency questionnaire and matching food consumption data with the Phenol-Explorer database. Cox proportional hazards models were used to estimate the adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for incident cardiovascular events (myocardial infarction, stroke or cardiovascular death). Cherries, chocolate, coffee, apples, and olives were the major sources of variability in polyphenol intake. Participants with higher flavonoids intake (fifth quintile) had a 47% lower incidence of cardiovascular events compared to those in the lowest quintile (HR: 0.53, 95% CI: 0.29–0.98; P for trend = 0.09) after adjusting for potential confounders. The results were non-significant for other polyphenol types.
The intake of flavonoids showed an inverse association with risk of cardiovascular events in a prospective cohort of Spanish middle-aged adult university graduates.
NCT02669602 in Clinical Trials.
•Intake of flavonoids was associated with a lower risk of cardiovascular events.•Med-Diet is characterized by a high intake of polyphenols.•A diet rich in polyphenols, mainly flavonoids, should be encouraged even among young-middle aged populations.
•Algae constitute a source of phenolic compounds, which show bioactive properties.•Extraction process is critical for phenolic compounds’ conservation and stability.•Phenolics show bioactivities such ...as antioxidant, antitumoral or antimicrobial.•Phenolics from algae can be applied as natural ingredients in different industries.•Further research about structure–activity relationships is required.
Given the growing tendency of consumers to choose products with natural ingredients, food industries have directed scientific research in this direction. In this regard, algae are an attractive option for the research, since they can synthesize a group of secondary metabolites, called phenolic compounds, associated with really promising properties and bioactivities. The objective of this work was to classify the major phenolic compounds, compare the effectiveness of the different extractive techniques used for their extraction, from traditional systems (like heat assisted extraction) to the most advance ones (such as ultrasound, microwave or supercritical fluid extraction); the available methods for identification and quantification; the stability of the enriched extract in phenolic compounds and the main bioactivities described for these secondary metabolites, to offer an overview of the situation to consider if it is possible and/or convenient an orientation of phenolic compounds from algae towards an industrial application.
The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, ...which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.
Xenon dual-phase time projection chambers designed to search for weakly interacting massive particles have so far shown a relative energy resolution which degrades with energy above
∼
200 keV due to ...the saturation effects. This has limited their sensitivity in the search for rare events like the neutrinoless double-beta decay of
136
Xe
at its
Q
value,
Q
β
β
≃
2.46
MeV
. For the XENON1T dual-phase time projection chamber, we demonstrate that the relative energy resolution at
1
σ
/
μ
is as low as (
0.80
±
0.02
) % in its one-ton fiducial mass, and for single-site interactions at
Q
β
β
. We also present a new signal correction method to rectify the saturation effects of the signal readout system, resulting in more accurate position reconstruction and indirectly improving the energy resolution. The very good result achieved in XENON1T opens up new windows for the xenon dual-phase dark matter detectors to simultaneously search for other rare events.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
We present results from the direct search for dark matter with the XENON100 detector, installed underground at the Laboratori Nazionali del Gran Sasso of INFN, Italy. XENON100 is a two-phase ...time-projection chamber with a 62 kg liquid xenon target. Interaction vertex reconstruction in three dimensions with millimeter precision allows the selection of only the innermost 48 kg as the ultralow background fiducial target. In 100.9 live days of data, acquired between January and June 2010, no evidence for dark matter is found. Three candidate events were observed in the signal region with an expected background of (1.8 ± 0.6) events. This leads to the most stringent limit on dark matter interactions today, excluding spin-independent elastic weakly interacting massive particle (WIMP) nucleon scattering cross sections above 7.0 × 10(-45) cm(2) for a WIMP mass of 50 GeV/c(2) at 90% confidence level.
Exposure to Zika virus in utero has been associated with neurodevelopmental abnormalities. In this letter, the results of long-term follow-up of Brazilian children exposed to ZIKV in utero are ...reported.
We present UV, optical, and near-infrared (NIR) photometry of the first electromagnetic counterpart to a gravitational wave source from Advanced Laser Interferometer Gravitational-wave Observatory ...(LIGO)/Virgo, the binary neutron star merger GW170817. Our data set extends from the discovery of the optical counterpart at 0.47-18.5 days post-merger, and includes observations with the Dark Energy Camera (DECam), Gemini-South/FLAMINGOS-2 (GS/F2), and the Hubble Space Telescope (HST). The spectral energy distribution (SED) inferred from this photometry at 0.6 days is well described by a blackbody model with T 8300 K, a radius of R 4.5 × 10 14 cm (corresponding to an expansion velocity of v 0.3 c ), and a bolometric luminosity of L bol 5 × 10 41 erg s−1. At 1.5 days we find a multi-component SED across the optical and NIR, and subsequently we observe rapid fading in the UV and blue optical bands and significant reddening of the optical/NIR colors. Modeling the entire data set, we find that models with heating from radioactive decay of 56Ni, or those with only a single component of opacity from r-process elements, fail to capture the rapid optical decline and red optical/NIR colors. Instead, models with two components consistent with lanthanide-poor and lanthanide-rich ejecta provide a good fit to the data; the resulting "blue" component has M ej blue 0.01 M and v ej blue 0.3 c , and the "red" component has M ej red 0.04 M and v ej red 0.1 c . These ejecta masses are broadly consistent with the estimated r-process production rate required to explain the Milky Way r-process abundances, providing the first evidence that binary neutron star (BNS) mergers can be a dominant site of r-process enrichment.
This work describes an economic analysis of the inclusion of pumped storage in a small island system that has abundant renewable energy available but that at times cannot accept all of this power ...because of limits imposed by security criteria. The question of whether or how much pumped storage to include is addressed by formulating a linear programming optimization problem. The stochastic nature of load and renewable production is addressed using scenarios developed through fuzzy clustering. Both the unit capacity in MW and the reservoir storage capacity in MWh are optimized, and optimal operating strategies for the scenarios are produced. Results showed that including pumped storage can be an effective means of allowing larger penetration of intermittent renewable energy sources, improving both the dynamic security and the economic operation of a test system. Including the dynamic security criteria in the economic question of dimensioning the pumped storage unit proved to make a significant difference in the optimal pumped storage capacity.
Purpose
The aim of this study was to analyze the relationship between adiposity, cardiometabolic risk and cardiorespiratory fitness (CRF) according to different groups of adiponectin concentration.
...Methods
255 adolescents of both sexes, aged 11–17 years old, participated. Anthropometric and biochemical parameters such as body mass, height, abdominal circumference (AC), waist circumference (WC), fat mass, fat-free mass, total cholesterol (TC), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), triglycerides (TG), glucose, insulin, adiponectin, blood pressure, peak oxygen consumption (VO
2peak
) were measured. Body mass index (BMI), z-score BMI (BMI-z), triponderal mass index (TMI), waist-to-height ratio (WHtR), homeostasis model to assessment insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI) were calculated. Adiponectin was categorized: low adiponectin concentration (LAC ≤ 5.18 µg/mL
−1
), intermediate (IAC = 5.18 and 7.63 µg/mL
−1
) and high (HAC ≥ 7.63 µg/ml
−1
).
Results
LAC showed higher BMI, BMI-z and TMI than the other groups (
p
< 0.05) and higher AC, WC and WHtR that the HAC (
p
< 0.05). IAC showed lower values of TC, LDL-c and TG, and the LAC presented the highest values of insulin, HOMA-IR and QUICKI (
p
< 0.05) to the IAC and HAC. HAC presented the lower VO
2peak
than the other groups (
p
< 0.01). BMI, TMI, glucose, insulin, HOMA-IR showed inverse, and QUICKI a direct and weak correlation with adiponectin (
p
< 0.05). No significant association was found between adiponectin and VO
2peak
(
p
> 0.05).
Conclusion
The LAC group had higher means in the anthropometric variables and the worst results related to insulin resistance and sensitivity. Thus, adiponectin may play an important role in obesity and reduced concentration may be a factor in the development of obesity-associated morbidities.
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