Thirty alternative flame retardant compounds and a suite of 17 brominated diphenyl ether (BDE) congeners were determined in the blubber of 21 harbour porpoises stranded or bycaught around UK coasts ...during 2008 using GC-MS/MS. Of the 30 compounds, 19 were not detected. Of the remaining 11 compounds, some fell below the lowest calibration level and so were recorded as less than values, but were certainly present in the blubber samples (examples include tetrabromo-p-xylene (TBX), tetrabromo-o-chlorotoluene (TBCT) and 2,3-dibromopropyl-2,4,6-tribromophenyl ether (TBP-DBPE). Concentrations were low, the highest concentration being only 35μgkg−1 wet weight. This contrasted with those of the BDEs, summed concentrations which ranged from 54.6 to 913μgkg−1 wet weight, although levels in porpoise blubber have been declining since 1998. Both Dechlorane Plus (DDC-CO) isomers were detected in some samples, suggesting either that this product has been used in the UK or that its presence may result from atmospheric transport from source regions. BDE183, a marker for the octa-mix PBDE product, was found at low concentrations (0.63 to 1.7μgkg−1 wet weight) and the four nona- and deca-BDE congeners were not detected in any sample.
•We have determined concentrations of 30 alternative flame retardants in porpoises•Of these, nineteen compounds were not detected•Concentrations were low, the highest being 35μgkg−1 wet weight (pentabromoethylbenzene)•Summed BDE concentrations were up to 1.0mgkg−1 lipid weight•Nona- and deca-BDE congeners were not detected
Harbour seals and harbour porpoises are top predator species from the North Sea, have long life spans and hence, are known to accumulate high levels of anthropogenic contaminants. To gain knowledge ...about the behaviour of naturally-produced compounds in these marine mammals, the biomagnification of naturally-produced methoxylated polybrominated diphenyl ethers (MeO-PBDEs) was assessed. The biomagnification of MeO-PBDEs (2′-MeO-BDE 68 and 6-MeO-BDE 47) was lower in harbour seals (all biomagnification factors (BMFs)
<
1) compared to the same age–gender groups of the harbour porpoises (all BMFs
>
1). This may indicate a better metabolic breakdown of MeO-PBDEs in harbour seals, as was previously suggested for polybrominated diphenyl ethers (PBDEs). In both predators, 6-MeO-BDE 47 had the highest concentrations (range: 45–483 ng/g lw and 2–38 ng/g lw for harbour porpoises and seals, respectively) compared to 2′-MeO-BDE 68 (range: 2–28 ng/g lw and 1–6 ng/g lw for harbour porpoises and seals, respectively). In general, the highest concentrations were found in juveniles, suggesting an increased biotransformation capacity with age or the influence of dilution by growth for both species. Here we show that naturally-produced brominated organic compounds can biomagnify and accumulate in North Sea top predators, although to a lesser extent than anthropogenic lipophilic contaminants, such as polychlorinated biphenyls (PCBs) or PBDEs.
Síndrome de Goldenhar: a propósito de un caso González Calvete, Laura; Ramos Pérez, Alfonso; Lozano Losada, Sara ...
Pediatría Atención Primaria,
03/2016, Letnik:
18, Številka:
69
Journal Article
Recenzirano
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El síndrome de Goldenhar forma parte del espectro de anomalías del primer y segundo arco branquial. Constituye una entidad congénita poco frecuente, caracterizada por la asociación de anomalías ...oculares, auriculares, mandibulares y vertebrales, y cuya etiología permanece aún desconocida. A continuación describimos el caso de un recién nacido que presenta hallazgos clínicos compatibles, que incluyen la asociación de lipodermoide conjuntival unilateral, apéndices preauriculares, hipoplasia hemifacial e hipoplasia de pabellones auriculares. Así mismo, se hace una breve revisión basada en el conjunto de los casos que hasta el presente han aparecido en la literatura científica.
This article shows the complex relationship between picture and word in Chinese art, since the limits between what is painted and what is written, what is contemplated and what is read, are not ...clearly defined. In order to understand the convergence of calligraphy, painting and poetry, the paper studies the Chinese conception of art, world, and human being, and how that conception is reflected in the contents and formal aesthetics of works of art. Finally, it is shown how temporality and spatiality, which may be linked with word and picture, are mixed in each one of the three arts, which may come to life either by themselves or in unison. Publication abstract
This broad introduction to Colonial American literatures brings out the comparative and transatlantic nature of the writing of this period and highlights the interactions between native, non-scribal ...groups, and Europeans that helped to shape early American writing. * Situates the writing of this period in its various historical and cultural contexts, including colonialism, imperialism, diaspora, and nation formation. * Highlights interactions between native, non-scribal groups and Europeans during the early centuries of exploration. * Covers a wide range of approaches to defining and reading early American writing. * Looks at the development of regional spheres of influence in the seventeenth and eighteenth centuries. * Serves as a vital adjunct to Castillo and Schweitzer's 'The Literatures of Colonial America: An Anthology' (Blackwell Publishing, 2001).
Viruses and Skin Cancer Becerril, Sara; Corchado-Cobos, Roberto; García-Sancha, Natalia ...
International journal of molecular sciences,
05/2021, Letnik:
22, Številka:
10
Journal Article
Recenzirano
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Advances in virology and skin cancer over recent decades have produced achievements that have been recognized not only in the field of dermatology, but also in other areas of medicine. They have ...modified the therapeutic and preventive solutions that can be offered to some patients and represent a significant step forward in our knowledge of the biology of skin cancer. In this paper, we review the viral agents responsible for different types of skin cancer, especially for solid skin tumors. We focus on human papillomavirus and squamous cell cancers, Merkel cell polyomavirus and Merkel cell carcinoma, and human herpesvirus 8 and Kaposi’s sarcoma.
Hereditary transthyretin amyloidosis (ATTRv) is a rare genetic disease that negatively affects patients' quality of life through the involvement of various organs and tissues. Despite a large amount ...of research on medical and psychosocial interventions, the impact of occupational therapy (OT) on patients with ATTRv is not well understood. The aim of this study was to develop an OT programme to improve the daily functioning and quality of life of patients with ATTRv. Fourteen patients with ATTRv were interviewed. Together they developed short- and medium-term occupational goals. Patients received the OT intervention for six months. Outcomes were measured using scores for activities of daily living and psychological well-being. The study found that OT can have a positive impact as a complementary intervention to medical and other psychosocial treatments. Of the 14 patients, 12 maintained the same scores in activities of daily living. Two deteriorated and eight improved their psychological scores. This study highlights the need for further research in this area and the importance of OT in the management of patients with ATTRv. Early intervention is of paramount importance and further research is needed to evaluate the long-term effects of OT interventions in patients with ATTRv.
Cohesin is a chromatin-bound complex that mediates sister chromatid cohesion and facilitates long-range interactions through DNA looping. How the transcription and replication machineries deal with ...the presence of cohesin on chromatin remains unclear. The dynamic association of cohesin with chromatin depends on WAPL cohesin release factor (WAPL) and on PDS5 cohesin-associated factor (PDS5), which exists in two versions in vertebrate cells, PDS5A and PDS5B. Using genetic deletion in mouse embryo fibroblasts and a combination of CRISPR-mediated gene editing and RNAi-mediated gene silencing in human cells, here we analyzed the consequences of PDS5 depletion for DNA replication. We found that either PDS5A or PDS5B is sufficient for proper cohesin dynamics and that their simultaneous removal increases cohesin's residence time on chromatin and slows down DNA replication. A similar phenotype was observed in WAPL-depleted cells. Cohesin down-regulation restored normal replication fork rates in PDS5-deficient cells, suggesting that chromatin-bound cohesin hinders the advance of the replisome. We further show that PDS5 proteins are required to recruit WRN helicase-interacting protein 1 (WRNIP1), RAD51 recombinase (RAD51), and BRCA2 DNA repair associated (BRCA2) to stalled forks and that in their absence, nascent DNA strands at unprotected forks are degraded by MRE11 homolog double-strand break repair nuclease (MRE11). These findings indicate that PDS5 proteins participate in replication fork protection and also provide insights into how cohesin and its regulators contribute to the response to replication stress, a common feature of cancer cells.
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