The purpose of this review was to evaluate the strength of evidence for a relationship between risk of mortality and frequent and ongoing insomnia using a meta-analytic strategy.
Seventeen studies, ...including a total of 36,938,981 individuals followed up for a mean of 11.6 y, reporting the investigation of the association between mortality and frequent (≥3 nights/wk), ongoing (≥1 mo) insomnia were identified.
There was no difference in the odds of mortality for those individuals with symptoms of insomnia when compared to those without symptoms (OR = 1.06, 95%CI = 0.61–1.84, p = .84). This finding was echoed in the assessment of the rate of mortality in those with and without symptoms of insomnia using the outcomes of multivariate models, with the most complete adjustment for potential confounders, as reported by the individual studies included in this meta-analysis (HR = 1.07, 95%CI = .96–.1.19, p = .22). Additional analyses revealed a tendency for an increased risk of mortality associated with hypnotic use.
The current evidence reinforces the use of cognitive therapy, within a CBTi framework, as a frontline non-pharmacological treatment for insomnia to reassure patients their longevity will not be impacted as a consequence of suffering from insomnia.
Despite being one of the founding members of the European Community and the third largest economy in the EU, Italy does not stand out as a particularly influential negotiator when it comes to ...day‐to‐day EU decision‐making. Why is it that a country with Italy's political weight, economic resources and administrative capacity has such a patchy record in terms of negotiation success? Examining Italy's negotiation of two key EU policies (2008–16) and relying on an original set of interviews with EU officials and Italian politicians, this paper contends that the answer lies in a set of domestic factors that have largely been neglected by negotiation theory: namely, political, administrative and individual domestic constraints.
This contribution explains Italy's inconsistent performance in EU negotiations, while also developing a broader theoretical framework accounting for the ways in which domestic factors moderate member states' bargaining power and, ultimately, their likelihood of achieving negotiation success.
Aim:
Pharyngodynia, nasal congestion, rhinorrhea, smell, and taste dysfunctions could be the presenting symptoms of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome ...coronavirus 2. The aim was to perform a systematic review of current evidences on clinical presentation of COVID-19, focusing on upper airway symptoms in order to help otolaryngologists identifying suspected cases.
Methods:
We searched PubMed and Web of Science electronic databases.
Results:
We included 5 retrospective clinical studies for a total of 1556 hospitalized patients with COVID-19, 57.5% were male and mean age was 49.1 years. Pooled data revealed that pharyngodynia was present in 12.4% of patients, nasal congestion in 3.7%, and rhinorrhea was rare. No reports on COVID-19 and olfactory/gustative disorders matched inclusion criteria but preliminary evidences suggested they could be present. Common symptoms were fever (85.6%), cough (68.7%), and fatigue (39.4%). Frequent comorbidities were hypertension (17.4%), diabetes (3.8%), and coronary heart disease (3.8%); 83% of patients had alterations on chest computed tomography that were bilateral in 89.5% of cases. Ground-glass opacity was the most common finding (50%). Lymphopenia (77.2%) and leucopenia (30.1%) were common. Critical cases with complications were 9%, intensive care unit admission was required in 7.3%, invasive ventilation in 3.4%, and mortality was 2.4%.
Conclusion:
Otolaryngologists should know that pharyngodynia, nasal congestion, olfactory, and gustative disorders could be the presenting symptoms of COVID-19. Clinical presentation together with radiological and laboratory findings could help to identify suspected cases.
A third-order substrate integrated waveguide (SIW) integrated filter/antenna is presented in this letter. The filter/antenna is composed of two cavity resonators with a slot antenna in the second ...cavity. The slot antenna excites two modes in the slot cavity, creating a third-order filtering response while preserving the radiating characteristics. A transmission zero can be arbitrarily placed below or above the passband. The filter/antenna operates at a center frequency of 3.71 GHz and has an 8.29% fractional bandwidth with a 5.10 dBi antenna gain.
In recent years, the combination of precise quantum Monte Carlo (QMC) methods with realistic nuclear interactions and consistent electroweak currents, in particular those constructed within effective ...field theories (EFTs), has led to new insights in light and medium-mass nuclei, neutron matter, and electroweak reactions. For example, with the same chiral interactions, QMC calculations can reproduce binding energies and radii for light nuclei,
n
-α scattering phase shifts, and the neutron matter equation of state. This compelling new body of work has been made possible both by advances in QMC methods for nuclear physics, which push the bounds of applicability to heavier nuclei and to asymmetric nuclear matter, and by the development of local chiral EFT interactions up to next-to-next-to-leading order and minimally nonlocal interactions including Δ degrees of freedom. In this review, we discuss these recent developments and give an overview of the exciting results for nuclei, neutron matter and neutron stars, and electroweak reactions.
A
bstract
The effective cross section of double parton scattering in proton collisions has been measured by many experiments with rather different results. Motivated by this fact, we assumed that the ...parton correlations in the transverse plane are different whether we have valence or sea partons. With this simple approach, we were able to fit the available data and found that sea parton pairs are more correlated in the transverse plane than valence-sea parton pairs.
Statements about building walls, deportation and denying services to undocumented immigrants made during President Trump's presidential campaign and presidency may induce fear in Latino populations ...and create barriers to their health care access. To assess how these statements relate to undocumented Latino immigrants' (UDLI) and Latino legal residents/citizens' (LLRC) perceptions of safety and their presentations for emergency care, we conducted surveys of adult patients at three county emergency departments (EDs) in California from June 2017 to December 2018. Of 1,684 patients approached, 1,337 (79.4%) agreed to participate: 34.3% UDLI, 36.9% LLRC, and 29.8% non-Latino legal residents/citizens (NLRC). The vast majority of UDLI (95%), LLRC (94%) and NLRC (85%) had heard statements about immigrants. Most UDLI (89%), LLRC (88%) and NLRC (87%) either thought that these measures were being enacted now or will be enacted in the future. Most UDLI and half of LLRC reported that these statements made them feel unsafe living in the US, 75% (95% CI 70-80%) and 51% (95% CI 47-56%), respectively. More UDLI reported that these statements made them afraid to come to the ED (24%, 95% CI 20-28%) vs LLRC (4.4%, 95% CI 3-7%) and NLRC (3.5%, 95% CI 2-6%); 55% of UDLI with this fear stated it caused them to delay coming to the ED (median delay 2-3 days). The vast majority of patients in our California EDs have heard statements during the 2016 presidential campaign or from President Trump about measures against undocumented immigrants, which have induced worry and safety concerns in both UDLI and LLRC patients. Exposure to these statements was also associated with fear of accessing emergency care in some UDLIs. Given California's sanctuary state status, these safety concerns and ED access fears may be greater in a nationwide population of Latinos.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Intraspecific trait variation has been singled out as an important mechanism by which individuals can cope with environmental variations and avoid local extinctions. Here we evaluate variation in ...metamer traits (i.e., traits associated with internodes, petioles and their corresponding leaves) and parameters of chlorophyll fluorescence within and among populations of a neotropical tree, Copaifera langsdorffii. We also evaluated phenotypic plasticity in natural settings comparing traits between shade and sun-exposed metamers. We selected six populations along a climatic gradient ranging from semi-arid to humid and representing three different biomes (Caatinga, Cerrado, and Atlantic Forest). Local climatic conditions significantly affected the morphological and physiological traits of populations. Trait variation among populations was explained mainly by aridity index and evapotranspiration. Individuals from drier regions had lower specific leaf area (SLA), lower investment in leaf area per total dry mass of metamer (LARm), lower specific petiole length (SPL) and lower potential quantum yield (Fv/Fm, only for sun-exposed metamers). Populations from locations with greater environmental heterogeneity (interannual variation) had greater plasticity in response to light for Fv/Fm and electron transport rate (ETR) and morphological traits related to the hydraulic and biomechanical aspects of the leaves (petiole length, internode length and SPL). High intraspecific variation in metamer traits in C. langsdorffii coupled with its ability to modify these traits in response to different climate conditions can explain the success of the species over a range of different habitats and represent important factors for the persistence of this species in the face of climate change.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The accurate estimation of sleep onset is required for many purposes, including the administration of a behavioural treatment for insomnia called Intensive Sleep Retraining, facilitating power naps, ...and conducting objective daytime sleepiness tests. Specialised equipment and trained individuals are presently required to administer these applications in the laboratory: a costly and impractical procedure which limits their utility in practice. A wearable device could be used to administer these applications outside the laboratory, increasing accessibility. This systematic review aimed to identify practical wearable devices that accurately estimate sleep onset. The search strategy identified seventy-one articles which compared estimations of sleep onset latency from wearable devices against polysomnography (PSG). Actigraphy devices produced average estimations of sleep onset latency that were often not significantly different from PSG, but there was large inter-individual variability depending on participant characteristics. As expected, electroencephalography-based devices produced more accurate and less variable estimates. Devices that measured behavioural aspects of sleep onset consistently overestimated PSG-determined sleep onset latency, but to a comparatively low degree. This sleep measurement method could be deployed in a simple wearable device to accurately estimate sleep onset and administer Intensive Sleep Retraining, power naps, and objective daytime sleepiness tests outside the laboratory setting.
The formalism based on factorization and nuclear spectral functions has been generalized to treat transition matrix elements involving two-nucleon currents, whose contribution to the nuclear ...electromagnetic response in the transverse channel is known to be significant. We report the results of calculations of the inclusive electron-carbon cross section, showing that the inclusion of processes involving two-nucleon currents appreciably improves the agreement between theory and data in the dip region, between the quasielastic and Δ-production peaks. The relation to approaches based on the independent particle of the nucleus and the implications for the analysis of flux-integrated neutrino-nucleus cross sections are discussed.
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