In heterogeneous catalysis, supports play a crucial role in modulating the geometric and electronic structure of the active metal phase for optimizing the catalytic performance. A γ‐Al2O3 nanosheet ...that contains 27 % pentacoordinate Al3+ sites can nicely disperse and stabilize raft‐like Pt‐Sn clusters as a result of strong interactions between metal and support. Consequently, there are strong electronic interactions between the Pt and Sn atoms, resulting in an increase in the electron density of the Pt sites. When used in the propane dehydrogenation reaction, this catalyst displayed an excellent specific activity for propylene formation with >99 % selectivity, and superior anti‐coking and anti‐sintering properties. Its exceptional ability to maintain the high activity and stability at ultrahigh space velocities further showed that the sheet construction of the catalyst facilitated the kinetic transfer process.
Stable and selective: γ‐Al2O3 nanosheets rich in pentacoordinate Al3+ ions can well disperse and stabilize raft‐like Pt‐Sn clusters, which results in an increase of the electron density of the Pt sites. This material catalyzes the conversion of propane into propylene with >99 % selectivity, and minimizes coke formation and sintering processes.
•Different rock-forming minerals present very different microwave absorption capacity to microwave energy.•The test results can be used to estimate the heating behaviors of rocks to microwave ...irradiation.•SEM-EDX technique was used to determine the elemental distribution and mineralogical composition.•Ferrum may influence the interacting mechanisms between rock-forming minerals and microwaves.
The sample will burst into fragment when the thermal stress induced by thermal expansion greater than the ultimate strength of the rock after microwave irradiation. Microwave-assisted rock fragmentation has been illustrated to be potentially beneficial for mineral processing, mining and geotechnical engineering. In order to have a comprehensive understanding on the influence of microwave on thermo-mechanical properties of rocks, it is necessary to investigate the interaction effect between microwaves and the main rock-forming minerals. In this work, eleven rock-forming minerals were tested in a multimode cavity at 2.45GHz with a power of 2kW, subsequently, the Scanning Electron Microscopy–Energy Dispersive X-ray (SEM-EDX) was used to determine the elemental distribution and mineralogical composition of the tested samples. It was observed that different rock-forming minerals present very different susceptibility induced by microwave treatment. Enstatite presents the strongest microwave absorption capacity by a large margin and most of the rock-forming minerals are weak microwave absorbers. It is significant that the results can be used to predict the heating behaviors of rocks subjected to microwave energy. Furthermore, the SEM-EDX elemental analysis demonstrates that the microwave absorption capacity of rock-forming minerals could link to the contribution of the ferrum, which may influence the interacting mechanisms between microwaves and the rock-forming minerals.
Cortical areas including the anterior cingulate cortex (ACC) play critical roles in different types of chronic pain. Most of previous studies focus on the sensory inputs from somatic areas, and less ...information about plastic changes in the cortex for visceral pain. In this study, chronic visceral pain animal model was established by injection with zymosan into the colon of adult male C57/BL6 mice. Whole cell patch‐clamp recording, behavioral tests, western blot, and Cannulation and ACC microinjection were employed to explore the role of adenylyl cyclase 1 (AC1) in the ACC of C57/BL6 and AC1 knock out mice. Integrative approaches were used to investigate possible changes of neuronal AC1 in the ACC after the injury. We found that AC1, a key enzyme for pain‐related cortical plasticity, was significantly increased in the ACC in an animal model of irritable bowel syndrome. Inhibiting AC1 activity by a selective AC1 inhibitor NB001 significantly reduced the up‐regulation of AC1 protein in the ACC. Furthermore, we found that AC1 is required for NMDA GluN2B receptor up‐regulation and increases of NMDA receptor‐mediated currents. These results suggest that AC1 may form a positive regulation in the cortex during chronic visceral pain. Our findings demonstrate that the up‐regulation of AC1 protein in the cortex may underlie the pathology of chronic visceral pain; and inhibiting AC1 activity may be beneficial for the treatment of visceral pain.
Anterior cingulate cortex (ACC) plays critical roles in different types of chronic pain. Calcium‐stimulated, neuronal selective adenylyl cyclase subtype 1 (AC1) is critical for injury‐triggered cortical plasticity and chronic pain. We demonstrate that AC1 protein was up‐regulated in the ACC for a long‐period of time in a mouse model of chronic visceral pain. AC1 activity is required for the up‐regulation of AC1 protein, suggesting that AC1 may form a positive feedback in the cortex during chronic visceral pain. This is the first time to demonstrate that AC1 protein can undergo long‐term increases in central neurons after peripheral injuries.
A new, high-efficiency technology for fracturing and breaking rocks is required. Due to various advantages including high efficiency, energy-saving, and having no secondary pollution, the technology ...of microwave-induced fracturing of hard rock has been considered as a potential method for rock fracturing and breaking. Aiming at the realisation of two engineering applications: microwave-assisted mechanical rock breaking and stress release from rock masses in deep underground engineering works to prevent geological disasters caused by high-stress concentrations such as rockbursts, a novel (open-type) microwave-induced fracturing apparatus (OMWFA) for fracturing hard rocks was developed. On this basis, the two modes of microwave-induced subsurface fracturing and microwave-induced borehole fracturing of hard rocks were proposed. Due to removal of the restraint of the microwave cavity, OMWFA can be used to fracture large-size rock samples and engineering-scale rock masses. Using the apparatus, the fracturing effects of the two fracturing modes on different dimensions of cuboidal basalt samples were investigated. By combining the microwave-induced fracturing apparatus with a press machine to explore the influence of unidirectional stress on the fracturing effect of microwave treatment on basalt. Moreover, field tests were carried out on rock masses encountered in underground engineering works at Baihetan Hydropower Station in Sichuan Province, China, and the fracturing effects were evaluated by applying a digital borehole televiewer and conducting acoustic wave testing. The results show that the apparatus had favourable fracturing effects on the subsurface and borehole samples of basalt. When no stress was applied, the cracks radially expanded from the approximate centre of the radiant surface and unidirectional stress promoted fracturing. The number and depth of cracks increased with prolonged microwave exposure. After microwave treatment, the P-wave velocity of the samples declined, and the longer the microwave exposure, the more significant the reduction in P-wave velocity was. The results of field test reveal that borehole fracturing can exhibit a favourable effect around boreholes. The sound velocity around the borehole and between the boreholes both declined to some extent. Microwave-induced hard rock fracturing offers guiding significance to those exploring and developing new rock breaking and tunnelling methods, and generally enhances construction safety in deep underground engineering works.
Catalytic dehydrogenation of propane to propylene and by‐product hydrogen is an atom‐economical and environmentally friendly route. PtSn/Al2O3 catalysts have been industrialized in this process, but ...still suffer from platinum sintering and coke deposition under reaction conditions. Herein, we design a calcium‐modified PtSn/Al2O3 catalyst showing a superior propane dehydrogenation performance. The presence of calcium combined with unsaturated aluminum and tin could consist of a new local microenvironment that promotes the dispersion of the platinum species and increases the electron density of the platinum species, which improves the catalytic activity, facilitates propylene desorption and inhibits coke formation. As a result, the achieved PtSnCa/Al2O3 catalyst exhibits a higher propylene formation rate and a lower coke‐accumulation rate compared to the catalyst without Ca addition. Moreover, the size of active phase clusters (∼1 nm) remained almost unchanged after the catalytic test, indicating a superior sintering resistance.
The designed PtSnCa/Al2O3 catalyst with superior propane dehydrogenation performance benefited from the regulation of the platinum active phase microenvironment that consists of unsaturated aluminum, tin, and calcium cations, which promotes the dispersion of the platinum species and increases the electron density of the platinum species.
In heterogeneous catalysis, supports play a crucial role in modulating the geometric and electronic structure of the active metal phase for optimizing the catalytic performance. A γ-Al2O3 nanosheet ...that contains 27% pentacoordinate Al(3+) sites can nicely disperse and stabilize raft-like Pt-Sn clusters as a result of strong interactions between metal and support. Consequently, there are strong electronic interactions between the Pt and Sn atoms, resulting in an increase in the electron density of the Pt sites. When used in the propane dehydrogenation reaction, this catalyst displayed an excellent specific activity for propylene formation with >99% selectivity, and superior anti-coking and anti-sintering properties. Its exceptional ability to maintain the high activity and stability at ultrahigh space velocities further showed that the sheet construction of the catalyst facilitated the kinetic transfer process.
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•Batteries are easily heated up at a rate of more than 10 °C/min by proposed method.•The heat is mainly from ohmic and polarization resistances based on Joule’s law.•A rapid and ...effective method of testing SOH under pulsed heating is proposed.•Pulsing parameters have opposite effects and sensitivity on heating and durability.•Negligible impact on life: only 1% capacity loss after 170 h continuous heating.
Low temperature charging is a major challenge for lithium-ion batteries, since it could lead to dramatic performance degradation and potential safety issues. A pre-heating process is usually applied to overcome above-mentioned challenges. Pulsed operation is adopted as one of established internal pre-heating methods with good temperature uniformity. Herein we employed and investigated bidirectional pulsed current through experimental methods to obtain the main data of the thermal action for comprehensively analyzing heat generation characteristics and thermoelectric coupling model based on second-order RC circuit to verify the basic principle. Battery durability research was then conducted via a continuous heating test method which enables rapid testing of capacity degradation. The results indicated that proposed pulsed heating could not significantly damage the life span from the perspective of long-term applications: the battery has only 1% capacity decay after 170 h continuous heating with a heating rate of 11 °C/min. Parameters, which are beneficial for heating rate, are further found to be detrimental for degradation and vice versa. Nevertheless, based on the outcome of this study, the pulse waveform with a shorter period and a higher amplitude are suggested to give an optimal combination of higher heating rate and lower degradation. Such a pulsed heating method has several potential application scenarios, ranging from electric vehicles and even stationary storage systems.
Chronic pain can lead to anxiety and anxiety can enhance the sensation of pain. Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing interactions. Here we ...characterized two forms of long-term potentiation (LTP) in the anterior cingulate cortex (ACC); a presynaptic form (pre-LTP) that requires kainate receptors and a postsynaptic form (post-LTP) that requires N-methyl-D-aspartate receptors. Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed via a mechanism involving hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Interestingly, chronic pain and anxiety both result in selective occlusion of pre-LTP. Significantly, microinjection of the HCN blocker ZD7288 into the ACC in vivo produces both anxiolytic and analgesic effects. Our results provide a mechanism by which two forms of LTP in the ACC may converge to mediate the interaction between anxiety and chronic pain.
Many COVID-19 patients infected by SARS-CoV-2 virus develop pneumonia (called novel coronavirus pneumonia, NCP) and rapidly progress to respiratory failure. However, rapid diagnosis and ...identification of high-risk patients for early intervention are challenging. Using a large computed tomography (CT) database from 3,777 patients, we developed an AI system that can diagnose NCP and differentiate it from other common pneumonia and normal controls. The AI system can assist radiologists and physicians in performing a quick diagnosis especially when the health system is overloaded. Significantly, our AI system identified important clinical markers that correlated with the NCP lesion properties. Together with the clinical data, our AI system was able to provide accurate clinical prognosis that can aid clinicians to consider appropriate early clinical management and allocate resources appropriately. We have made this AI system available globally to assist the clinicians to combat COVID-19.
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•AI system that can diagnose COVID-19 pneumonia using CT scans•Prediction of progression to critical illness•Potential to improve performance of junior radiologists to the senior level•Can assist evaluation of drug treatment effects with CT quantification
Zhang et al. present an AI-based system, based on hundreds of thousands of human lung CT scan images, that can aid in distinguishing patients NCP versus other common pneumonia and can help to predict the prognosis of COVID-19 patients.
Microwave energy can be used to assist mechanical rock breakage for civil and mining engineering operations. To assess the industrial applicability of this technology, microwave heating of basalt ...specimens in a multi-mode cavity (a microwave chamber) at different power levels was followed by conventional mechanical strength and fragmentation effect tests in the laboratory. X-ray diffraction and scanning electron microscopy/energy-dispersive X-ray spectroscopy were used to determine the mineral composition and distribution of the basalt, to aid interpretation of crack propagation patterns and the associated strength reduction mechanism. These analyses demonstrated that cracks mainly occurred around olivine grains, primarily as intergranular cracks between olivine and plagioclase grains and intragranular cracks within olivine grains. Strength reduction during microwave fracturing of basalt is driven by heat from enstatite (a microwave-sensitive mineral) and volumetric expansion of olivine (a thermally expansive mineral). Uniaxial compressive, Brazilian tensile, and point load strengths all decreased with increasing microwave irradiation time at rates that were positively related to the power level. For a given power level, mechanical strength reduction can be estimated from linear relationships with irradiation time. On the other hand, a power function best described burst time (the irradiation time at which the specimen burst into fragments)
vs
. power level (for a given specimen size) and burst time
vs
. specimen size (for a given power level) relationships. Microwave-induced hard rock fracturing can be an integral part of new methods for rock breakage and tunnel excavation.
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