The Ozone Monitoring Instrument (OMI) was launched on 15 July 2004, with an expected mission lifetime of 5 years. After more than 17 years in orbit the instrument is still functioning satisfactorily ...and in principle can continue doing so until the expected decommissioning of its platform Aura in 2025. In order to continue the datasets acquired by OMI and the Microwave Limb Sounder, the mission was extended up to at least 2023.
Actions have been taken to ensure the proper functioning of the OMI operations, the data processing, and the calibration monitoring system until the eventual end of the mission. For the data processing a new level-0 (L0) to level-1b (L1b) data processor was built based on the recent developments for the TROPOspheric Monitoring Instrument (TROPOMI). With corrections for the degradation of the instrument now included, it is feasible to generate a new data collection to
supersede the current collection-3 data products and reprocess the data of the entire mission up to now.
This paper describes the differences between the collection-3 and collection-4 data. It will be shown that the collection-4 L1b data comprise a clear improvement with respect to the previous collections. By correcting for the gentle optical and electronic aging that has occurred over the past 17 years, OMI’s ability to make trend-quality ozone measurements has further improved.
Analysis of protein-protein interactions (PPIs) is a valuable approach for characterizing proteins of unknown function. Here, we have developed a strategy combining library and matrix yeast ...two-hybrid screens to generate a highly connected PPI network for Huntington's disease (HD). The network contains 186 PPIs among 35 bait and 51 prey proteins. It revealed 165 new potential interactions, 32 of which were confirmed by independent binding experiments. The network also permitted the functional annotation of 16 uncharacterized proteins and facilitated the discovery of GIT1, a G protein-coupled receptor kinase-interacting protein, which enhances huntingtin aggregation by recruitment of the protein into membranous vesicles. Coimmunoprecipitations and immunofluorescence studies revealed that GIT1 and huntingtin associate in mammalian cells under physiological conditions. Moreover, GIT1 localizes to neuronal inclusions, and is selectively cleaved in HD brains, indicating that its distribution and function is altered during disease pathogenesis.
Environmental cues transduced by an endocrine network converge on Caenorhabditis elegans nuclear receptor DAF-12 to mediate arrest at dauer diapause or continuous larval development. In adults, ...DAF-12 selects long-lived or short-lived modes. How these organismal choices are molecularly specified is unknown. Here we show that coregulator DIN-1 and DAF-12 physically and genetically interact to instruct organismal fates. Homologous to human corepressor SHARP, DIN-1 comes in long (L) and short (S) isoforms, which are nuclear localized but have distinct functions. DIN-1L has embryonic and larval developmental roles. DIN-1S, along with DAF-12, regulates lipid metabolism, larval stage-specific programs, diapause, and longevity. Epistasis experiments reveal that din-1S acts in the dauer pathways downstream of lipophilic hormone, insulin/IGF, and TGFbeta signaling, the same point as daf-12. We propose that the DIN-1S/DAF-12 complex serves as a molecular switch that implements slow life history alternatives in response to diminished hormonal signals.
We study Bragg scattering at one-dimensional (1D) optical lattices. Cold atoms are confined by the optical dipole force at the antinodes of a standing wave generated inside a laser-driven ...high-finesse cavity. The atoms arrange themselves into a chain of pancake-shaped layers located at the antinodes of the standing wave. Laser light incident on this chain is partially Bragg reflected. We observe an angular dependence of this Bragg reflection which is different from what is known from crystalline solids. In solids, the scattering layers can be taken to be infinitely spread (three-dimensional limit). This is not generally true for an optical lattice consistent of a 1D linear chain of pointlike scattering sites. By an explicit structure factor calculation, we derive a generalized Bragg condition, which is valid in the intermediate regime. This enables us to determine the aspect ratio of the atomic lattice from the angular dependance of the Bragg scattered light.
Food habits of moose (Alces alces ) (Belovsky, 1981; Joyal, 1976; Oldenmeyer, 1974; Peek et al., 1976; Peterson, 1955) and white-tailed deer (Odocoileus virginianus ) (Banasiak, 1961; Crawford, 1982; ...Huot, 1974) are well-documented. However, these species tend not to concentrate in the same areas during winter (Irwin, 1975; Telger, 1970, 1972); thus, information on their diets in zones of overlap are sparse. The purpose of this study was to quantify the winter diets of sympatric populations of moose and white-tailed deer.
We study the widths of interspecies Feshbach resonances in a mixture of the fermionic quantum gases 6Li and 40K. We develop a model to calculate the width and position of all available Feshbach ...resonances for a system. Using the model, we select the optimal resonance to study the {6}Li/{40}K mixture. Experimentally, we obtain the asymmetric Fano line shape of the interspecies elastic cross section by measuring the distillation rate of 6Li atoms from a potassium-rich 6Li/{40}K mixture as a function of magnetic field. This provides us with the first experimental determination of the width of a resonance in this mixture, DeltaB=1.5(5) G. Our results offer good perspectives for the observation of universal crossover physics using this mass-imbalanced fermionic mixture.
The present study is discussing the question of possible negative effects of early physiotherapy on the mother-child-relationship. Mothers and children in Vojta-physiotherapy are compared with ...mother-child-pairs in Bobath-therapy on the basis of the hypothesis that Vojta-treatment is more apt to stress the mother-child-relationship. Indicators here were the physical and emotional stress in mothers as well as their attitudes towards their children, expressed in a questionnaire. Results indicate the special stress of the Vojta-technique at the beginning of the therapy while with ongoing treatment no differences between Vojta- and Bobath-therapy were found. Generally it is claimed that psychological information and support should be provided for the concerned families.
Repeated-measures analysis of variance.
To examine the effect of 2 different orthotic posting designs on first metatarsophalangeal (first MTP) joint kinematics during gait.
Common orthotic designs ...used to control abnormal pronation incorporate the use of a medial post in the forefoot and/or rearfoot locations. Although this design may favorably alter rearfoot and lower-limb kinematics, the incorporation of a forefoot post has been theorized to negatively impact first MTP joint function by limiting hallux dorsiflexion during push off. An alternative design that has been proposed to be more favorable for function of the hallux and first metatarsal is the medial arch support.
Eighteen subjects with a mean age of 28.2 years (SD, 8.3 years) completed the study. All subjects were judged to have excessive pronation based on a clinical orthopaedic examination. Two different pairs of orthoses were custom molded for each subject. One design incorporated an extrinsic rearfoot and forefoot post and the second design had a high medial longitudinal arch in combination with an extrinsic rearfoot post. The "Flock of Birds" electromagnetic tracking device was used to collect 3-dimensional position and orientation data of 3 body segments (hallux, first metatarsal, and calcaneus) during the stance phase of walking for 3 conditions (no orthosis and each of the 2 different orthotic designs). A repeated-measures analysis of variance was used to assess differences in first MTP joint dorsiflexion at midstance and during the push-off period of gait, as well as metatarsal declination angle changes during relaxed stance. An exploratory regression analysis was used to investigate factors that related to the change in peak dorsiflexion for the orthotic conditions.
Peak first MTP joint dorsiflexion averaged between 38 degrees and 40 degrees across all conditions. Although slight increases in first MTP joint dorsiflexion values were noted with both types of orthotic designs, these differences were not significant at either phase of the stance cycle (P = .50). The metatarsal declination angle in relaxed stance significantly increased (P = .001) under both orthotic conditions. Considerable individual variability was present. For the rearfoot-forefoot posted orthosis, a change in the declination angle of the first metatarsal during relaxed stance with the orthosis was a significant nonlinear predictor of change in peak dorsiflexion during push off.
Foot orthoses that incorporate a medial forefoot post do not have a consistent negative effect of reducing first MTP joint dorsiflexion during walking.
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