Observations of the X‐ray sky after the next decade will most likely be dominated by Athena (Advanced Telescope for High ENergy Astrophysics), the second large mission of ESA's Cosmic Vision ...2015–2035 programme. Athena has been conceived to address the “Hot and Energetic Universe” science theme, which focuses on the assembly and evolution of hot baryons in cosmic structures as well as the physics and energetic output generated by accreting super‐massive black holes, along with the relationship between the two processes, dubbed cosmic feedback. Thanks to its transformational capabilities, Athena will enable bringing all of today's XMM‐Newton's hot science topics to a new stage. In this paper, we summarize the Athena science case, science requirements, as well as the expected mission performance, mission concept, and its status.
Acute hypertension during cardiac surgery can be difficult to manage and may adversely affect patient outcomes. Clevidipine is a novel, rapidly acting dihydropyridine L-type calcium channel blocker ...with an ultrashort half-life that decreases arterial blood pressure (BP). The Evaluation of CLevidipine In the Perioperative Treatment of Hypertension Assessing Safety Events trial (ECLIPSE) was performed to compare the safety and efficacy of clevidipine (CLV) with nitroglycerin (NTG), sodium nitroprusside (SNP), and nicardipine (NIC) in the treatment of perioperative acute hypertension in patients undergoing cardiac surgery.
We analyzed data from three prospective, randomized, open-label, parallel comparison studies of CLV to NTG or SNP perioperatively, or NIC postoperatively in patients undergoing cardiac surgery at 61 medical centers. Of the 1964 patients enrolled, 1512 met postrandomization inclusion criteria of requiring acute treatment of hypertension based on clinical criteria. The patients were randomized 1:1 for each of the three parallel comparator treatment groups. The primary outcome was the incidence of death, myocardial infarction, stroke or renal dysfunction at 30 days. Adequacy and precision of BP control was evaluated and is reported as a secondary outcome.
There was no difference in the incidence of myocardial infarction, stroke or renal dysfunction for CLV-treated patients compared with the other treatment groups. There was no difference in mortality rates between the CLV, NTG or NIC groups. Mortality was significantly higher, though, for SNP-treated patients compared with CLV-treated patients (P=0.04). CLV was more effective compared with NTG (P=0.0006) or SNP (P=0.003) in maintaining BP within the prespecified BP range. CLV was equivalent to NIC in keeping patients within a prespecified BP range; however, when BP range was narrowed, CLV was associated with fewer BP excursions beyond these BP limits compared with NIC.
CLV is a safe and effective treatment for acute hypertension in patients undergoing cardiac surgery.
Peer Review Lumb, Philip D., M.B., B.S., Master FCCM
Journal of critical care,
04/2016, Letnik:
32
Journal Article
Recenzirano
...it is apparent that the increasing interest in the Journal is fueled by opportunities for electronic access rather than reliance on specific society membership that includes a journal ...subscription. ...our content, while potentially limited to organizations with library subscriptions, nonetheless readership is global and interest international.
Reflections, October 2015 Lumb, Philip D., MB, BS, MCCM
Journal of critical care,
10/2015, Letnik:
30, Številka:
5
Journal Article
Recenzirano
Globalization of disease with rapidly increasing technologic sophistication in multiple sites; wide diversity of pharmacologic availability and use; varying government regulation and evolution of ...practice; increasing recognition of multicultural prerogatives in end-of-life care and organ donation policies; reserve about overly enthusiastic integration and adoption of inadequately validated protocols; general availability of advanced resuscitative techniques with unknown long-term survival impact; and a variety of exciting, innovative, and promising interventions and support strategies must make the specialty vibrant; global; and, of necessity, more scrutinized by and responsible to societal and cultural prerogatives.
Welcome to Seoul Lumb, Philip D., MB, BS, MCCM
Journal of critical care,
08/2015, Letnik:
30, Številka:
4
Journal Article
Recenzirano
(Please refer to the Congress Abstract Introduction prepared by Professors Younsuck Koh, MD, PhD, FCCM, Chairman Organizing Committee, and Chae-Man Lim, MD, PhD, FCCM, Scientific Program ...Chair/Organizing Committee.) The Congress theme--One Step Further; The Pursuit of Excellence in Critical Care--is an appropriate platform from which to highlight the important content in the August issue beginning with several manuscripts dealing with early mobilization and the important benefits such strategies accrue for inhospital patient well-being and ultimate post intensive care unit discharge health, both mental and physical.
Critical care transitions Lumb, Philip D., MB, BS, MCCM
Journal of critical care,
06/2015, Letnik:
30, Številka:
3
Journal Article
Recenzirano
The journal has published manuscripts focusing on education in the past; however, in this issue, manuscripts dealing with practice (Outcomes of an emergency department ICU in a tertiary medical ...center in Taiwan), prediction (Basal functional status predicts functional recovery in critically ill patients with multiple organ failure), engineering science (Engineering control into medicine), and education per se (Innovative strategies in critical care education) vie for pride of place among more conventional fare.
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