The ultimate aim in the examination a stochastic process is to create a definitive process. ...a seemingly random body of data can be refined to a more organized state.
Biomarkers: Another grail quest? Lumb, Philip D., MB, BS, MCCM
Journal of critical care,
10/2012, Letnik:
27, Številka:
5
Journal Article
Recenzirano
The Journal continues its mandate to represent the World Federation of Societies of Intensive and Critical Care Medicine and the Society for Complexity in Acute Illness, and I look forward to an ...upcoming issue in which abstracts from the Society for Complexity in Acute Illness Annual meeting will be published.
The X-ray astronomical telescopes in use today, such as Chandra and XMM-Newton, use X-ray grating spectrometers to probe the high energy physics of the Universe. These instruments typically use ...reflective optics for focussing onto gratings that disperse incident X-rays across a detector, often a Charge-Coupled Device (CCD). The X-ray energy is determined from the position that it was detected on the CCD. Improved technology for the next generation of X-ray grating spectrometers has been developed and will be tested on a sounding rocket experiment known as the Off-plane Grating Rocket Experiment (OGRE). OGRE aims to capture the highest resolution soft X-ray spectrum of Capella, a well-known astronomical X-ray source, during an observation period lasting between 3 and 6 minutes whilst proving the performance and suitability of three key components. These three components consist of a telescope made from silicon mirrors, gold coated silicon X-ray diffraction gratings and a camera that comprises of four Electron-Multiplying (EM)-CCDs that will be arranged to observe the soft X-rays dispersed by the gratings. EM-CCDs have an architecture similar to standard CCDs, with the addition of an EM gain register where the electron signal is amplified so that the effective signal-to-noise ratio of the imager is improved. The devices also have incredibly favourable Quantum Efficiency values for detecting soft X-ray photons. On OGRE, this improved detector performance allows for easier identification of low energy X-rays and fast readouts due to the amplified signal charge making readout noise almost negligible. A simulation that applies the OGRE instrument performance to the Capella soft X-ray spectrum has been developed that allows the distribution of X-rays onto the EM-CCDs to be predicted. A proposed optical model is also discussed which would enable the missions minimum success criteria's photon count requirement to have a high chance of being met with the shortest possible observation time. These results are compared to a Chandra observation to show the overall effectiveness of the new technologies. The current optical module is shown to narrowly meet the minimum success conditions whilst the proposed model comfortably demonstrates the effectiveness of the technologies if a larger effective area is provided.
The World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM) is helping sponsor initiatives that will highlight not only a global awareness and understanding of the importance ...of early public recognition of sepsis symptomatology but also requests global intensive care unit (ICU) participation in the ICON study.
2011 in Review Lumb, Philip D., MB, BS, MCCM
Journal of critical care,
04/2012, Letnik:
27, Številka:
2
Journal Article
Recenzirano
The Journal of Critical Care (JCC) Editorial Board reviewed the Journal's 2011 activities at its meeting on February 5, 2012, at the Society of Critical Care Medicine (SCCM) Annual Congress in ...Houston, Texas; the results are interesting and provide information about how the Journal is perceived by authors and readers alike.
...I disagree with the perception that we are attempting the impossible; rather, it is a matter of professionalism and integrity for legitimate conflicts of interest to be recognized and for the ...aware reader to consider the implications of information derived from a variety of sources; these may include extramural grants from independent agencies and research studies from industrial sponsors.
2011—year in review Lumb, Philip D., MB, BS, FCCM
Journal of critical care,
02/2012, Letnik:
27, Številka:
1
Journal Article
Recenzirano
...it is not only appropriate and fitting but also a pleasure and responsibility to thank the Journal's nine hundred fifty-eight completed reviews (out of 2024 invitations) 2011 reviewers for their ...expert commentaries, unstinting commitment to excellence, and selfless dedication to the concept that peer review is one of the highest forms of academic commitment and a bastion of journalistic integrity. Authors must regard the process as arbitrary at best and unenlightened and callous in the least favorable interpretation. ...perhaps it is wise to initiate the 2012 publication cycle with a brief description of the manuscript selection process and priorities for inclusion.
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