We present a Chandra observation of the recurrent nova U Scorpii, done with the High Resolution camera-S (HRC-S) detector and the Low Energy Transmission Grating (LETG) on day 18 after the observed ...visual maximum of 2010, and compare it with XMM-Newton observations obtained on days 23 and 35 after maximum. The total absorbed flux was in the range 2.2-2.6 × 10−11 erg cm−2 s−1, corresponding to unabsorbed luminosity 7-8.5 × 1036 ×(d/12 kpc)2 for N(H) = 2-2.7 × 1021 cm−2. On day 18, 70 per cent of the soft X-tray flux was in a continuum typical of a very hot white dwarf (WD) atmosphere, which accounted for about 80 per cent of the flux on days 23 and 35. In addition, all spectra display very broad emission lines, due to higher ionization stages at later times. With Chandra we observed apparent P Cygni profiles. We find that these peculiar profiles are not due to blueshifted absorption and redshifted emission in photoionized ejecta, like the optical P Cyg of novae, but they are rather a superposition of WD atmospheric absorption features reflected by the already discovered Thomson scattering corona, and emission lines due to collisional ionization in condensations in the ejecta. On days 23 and 35, the absorption components were no longer measurable, having lost the initial large blueshift that displaced them from the core of the broad emission lines. We interpret this as an indication that mass-loss ceased between day 18 and day 23. On day 35, the emission line spectrum became very complex, with several different components. Model atmospheres indicate that the WD atmospheric temperature was about 730 000 K on day 18 and reached 900 000-1000 000 K on day 35. This peak temperature is consistent with a WD mass of at least 1.3 M.
Adult-born granule cells (abGCs) have been implicated in memory discrimination through a neural computation known as pattern separation. Here, using in vivo Ca
imaging, we examined how chronic ...ablation or acute chemogenetic silencing of abGCs affects the activity of mature granule cells (mGCs). In both cases, we observed altered remapping of mGCs. Rather than broadly modulating the activity of all mGCs, abGCs promote the remapping of place cells' firing fields while increasing rate remapping of mGCs that represent sensory cues. In turn, these remapping deficits are associated with behavioral impairments in animals' ability to correctly identify new goal locations. Thus, abGCs facilitate pattern separation through the formation of non-overlapping representations for identical sensory cues encountered in different locations. In the absence of abGCs, the dentate gyrus shifts to a state that is dominated by cue information, a situation that is consistent with the overgeneralization often observed in anxiety or age-related disorders.
Dioctophymosis is caused by Dioctophyme renale, nematode with indirect life cycle. Its intermediate host is a freshwater oligochaete and its definitive host is a wild or household carnivore. The ...adult nematode develops in the definite host, generally locating itself in the kidney. This article was meant to describe the first nephrectomy performed in a domestic cat due to renal dioctophymosis in Argentina. The subject showed a non-specific appearance of generally feeling ill, hematuria and mild diarrhea. It was diagnosed through abdominal ultrasound, followed by exploratory celiotomy and nephrectomy. After verifying absence of free specimens, the right kidney was removed. This organ was found to be enlarged in a spheroidal manner in contrast to the left kidney, with significant thickening of the renal capsule, excessive congestion of vessels and adhesions involving the caudal vena cava. An adult nematode was removed from the right kidney and identified as Dioctophyme renale. Reports of feline dioctophymosis are scarce being most of them necropsy findings. In this we are presenting a confirmed case of D. renale removed by surgery from a live cat. The results presented here reinforces the fact that cats are also appropriate definitive hosts for this parasite.
•This is the first report of a diagnosed and genetically confirmed case of dioctophymosis in a domestic cat in Argentina•The renal localization of the adult parasite and eggs in urine makes the domestic cat an appropriate host•Cats might be considered as another source of egg dissemination
Daytime restricted feeding promotes the re‐alignment of the food entrained oscillator (FEO). Endocrine cues which secretion is regulated by the transition of fasting and feeding cycles converge in ...the FEO. The present study aimed to investigate the ghrelin, growth hormone (GH) and insulin‐like growth factor (IGF)‐1 system because their release depends on rhythmic and nutritional factors, and the output from the system influences feeding and biochemical status. In a daily sampling approach, rats that were fed ad lib. were compared with rats on a reversed (daytime) and restricted feeding schedule by 3 weeks (dRF; food access for 2 h), also assessing the effect of acute fasting and refeeding. We undertook measurements of clock protein BMAL1 and performed somatometry of peripheral organs and determined the concentration of total, acylated and unacylated ghrelin, GH and IGF‐1 in both serum and in its main synthesising organs. During dRF, BMAL1 expression was synchronised to mealtime in hypophysis and liver; rats exhibited acute hyperphagia, stomach distension with a slow emptying, a phase shift in liver mass towards the dark period and decrease in mass perigonadal white adipose tissue. Total ghrelin secretion during the 24‐h period increased in the dRF group as a result of elevation of the unacylated form. By contrast, GH and IGF‐1 serum concentration fell, with a modification of GH daily pattern after mealtime. In the dRF group, ghrelin content in the stomach and pituitary GH content decreased, whereas hepatic IGF‐1 remained equal. The daily patterns and synthesis of these hormones had a rheostatic adaptation. The endocrine adaptive response elicited suggests that it may be associated with the regulation of metabolic, behavioural and physiological processes during the paradigm of daytime restricted feeding and associated FEO activity.
Status of the GEO600 detector Lück, H; Hewitson, M; Ajith, P ...
Classical and quantum gravity,
04/2006, Letnik:
23, Številka:
8
Journal Article, Conference Proceeding
Background:
In a disease that has only existed for 18 months, it is difficult to be fully informed of the long-term sequelae of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. ...Evidence is growing that most organ systems can be affected by the virus, causing severe disabilities in survivors. The extent of the aftermath will declare itself over the next 5–10 years, but it is likely to be substantial with profound socio-economic impact on society.
Methods:
This is an international multi-center, prospective long-term follow-up study of patients who developed severe coronavirus disease-2019 (COVID-19) and were admitted to Intensive Care Units (ICUs). The study will be conducted at international tertiary hospitals. Patients will be monitored from time of ICU discharge up to 24 months. Information will be collected on demographics, co-existing illnesses before ICU admission, severity of illness during ICU admission and post-ICU quality of life as well as organ dysfunction and recovery. Statistical analysis will consist of patient trajectories over time for the key variables of quality of life and organ function. Using latent class analysis, we will determine if there are distinct patterns of patients in terms of recovery. Multivariable regression analyses will be used to examine associations between baseline characteristics and severity variables upon admission and discharge in the ICU, and how these impact outcomes at all follow-up time points up to 2 years.
Ethics and Dissemination:
The core study team and local principal investigators will ensure that the study adheres to all relevant national and local regulations, and that the necessary approvals are in place before a site may enroll patients.
Clinical Trial Registration:
anzctr.org.au
: ACTRN12620000799954.
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