Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities. Exploring the ...mechanism of action of AMPs may help in the modification and development of AMPs. Many studies were conducted on the mechanism of AMPs. The present review mainly summarizes the research status on the antimicrobial, anti-inflammatory, and antibiofilm properties of AMPs. This study not only describes the mechanism of cell wall action and membrane-targeting action but also includes the transmembrane mechanism of intracellular action and intracellular action targets. It also discusses the dual mechanism of action reported by a large number of investigations. Antibiofilm and anti-inflammatory mechanisms were described based on the formation of biofilms and inflammation. This study aims to provide a comprehensive review of the multiple activities and coordination of AMPs
, and to fully understand AMPs to realize their therapeutic prospect.
Inflammation is a complex physiological process that poses a serious threat to people's health. However, the potential molecular mechanisms of inflammation are still not clear. Moreover, there is ...lack of effective anti-inflammatory drugs that meet the clinical requirement. Procyanidin A1 (PCA1) is a monomer component isolated from Procyanidin and shows various pharmacological activities. This study further demonstrated the regulatory role of PCA1 on lipopolysaccharide (LPS)-stimulated inflammatory response and oxidative stress in RAW264.7 cells. Our data showed that PCA1 dramatically attenuated the production of pro-inflammatory cytokines such as NO, iNOS, IL-6, and TNF-α in RAW264.7 cells administrated with LPS. PCA1 blocked IκB-α degradation, inhibited IKKα/β and IκBα phosphorylation, and suppressed nuclear translocation of p65 in RAW264.7 cells induced by LPS. PCA1 also suppressed the phosphorylation of JNK1/2, p38, and ERK1/2 in LPS-stimulated RAW264.7 cells. In addition, PCA1 increased the expression of HO-1, reduced the expression of Keap1, and promoted Nrf2 into the nuclear in LPS-stimulated RAW264.7 cells. Cellular thermal shift assay indicated that PCA1 bond to TLR4. Meanwhile, PCA1 inhibited the production of intracellular ROS and alleviated the depletion of mitochondrial membrane potential in vitro. Collectively, our data indicated that PCA1 exhibited a significant anti-inflammatory effect, suggesting that it is a potential agent for the treatment of inflammatory diseases.
Marine debris and plastic pollution affect all coastal habitats, however coastal debris studies are predominantly performed on sandy beaches. Other coastal habitats, such as mangroves, remain ...understudied. Eighteen of the top twenty rivers that contribute the most plastic to the ocean are associated with mangroves, but very few of those forests were investigated in terms of plastic debris pollution. Here we discuss the results of the few available studies on macrodebris conducted in mangroves, which show that mangrove debris research is still in its early stages, with many areas of study to be further investigated. Indeed, the distinct structural complexity of mangroves increases their ability to trap debris from both terrestrial, freshwater and marine sources, resulting in impacts unique to the mangrove ecosystem. Our review highlights a significant lack in standardisation across the performed surveys. Here we suggest standardised guidelines for future integrated macrodebris and microplastic studies in mangroves to facilitate comparisons between studies. Such standardisation should prioritize the use of stratified random sampling, the measurement of the area covered by the debris and the abundance and type of macrodebris and microplastics found, in order to assess the ecological impact of macrodebris and its role as source of microplastics for adjacent ecosystems. We also advocate the use of standard categories across studies, based on those identified for surveying other coastal habitats. This review highlights an alarming knowledge gap in extent, sources and overall impacts of marine macrodebris, mainly constituted by plastic, on mangrove forests, which hinders policy making to address this issue. Standardised, reliable and extended research on this aspect of mangrove pollution is needed to manage and protect these endangered vegetated coastal ecosystems.
Display omitted
•Mangrove distribution overlaps with areas of severe plastic pollution.•Structural features of mangrove forests help them trap marine debris.•Marine debris impacts mangroves in unique ways compared to other coastal habitats.•Standardised sampling and surveys should be implemented in future studies.•More research needed on marine debris to manage and conserve mangroves.
Harnessing the physiochemical properties and enzymatic activities of nanozymes will provide new insights for disease theranostics. Herein, a novel carbon dot (C‐dot) superoxide dismutase (SOD) ...nanozyme that exhibits red fluorescence with emission wavelength of 683 nm and shows high SOD‐like activity of >4000 U mg−1 is reported, which presents the great potential for imaging the biodistribution of nanozyme itself in vivo and ameliorating acute lung injury. Through surface modifications, the mechanism of C‐dot SOD nanozyme activity is revealed to be relied on their surface functional groups which bind with superoxide radicals, promote the electron transfer between C‐dots and superoxide radicals, and finally accelerate the dismutation of superoxide radicals. The absolute quantum yield of ≈14% of red fluorescence C‐dot nanozyme endow it bioimaging in vitro and in vivo. Moreover, the C‐dot nanozyme effectively enters the cells, accumulates at mitochondria, and protects living cells from oxidative damage by scavenging reactive oxygen species (ROS) and reducing the levels of pro‐inflammatory factors. Importantly, in vivo animal experiments demonstrate the accumulation of C‐dots in injure lung and therapeutic effect of C‐dot nanozyme toward acute lung injury in mice. The red fluorescent C‐dot SOD nanozyme shows great potential for in vivo bioimaging and management of ROS‐related diseases.
Red emissive carbon dot nanozyme with high superoxide dismutase (SOD)‐like activity over 4000 U mg−1 is developed. The SOD nanozyme activity is revealed to be relied on their surface functional groups which capture O2•– and then promote the electron transfer between O2•– and π‐system of carbon dot. The C‐dot SOD nanozyme shows great potential in bioimaging and ameliorating acute lung injury.
For all the stable first order plus time delay (FOPTD) systems, a fractional order proportional integral (FOPI) or a traditional integer order proportional integral derivative (IOPID) controller can ...be designed to fulfill a flat phase constraint and two design specifications simultaneously: gain crossover frequency and phase margin. In this paper, a guideline for choosing two feasible or achievable specifications, and a new FOPI/IOPID controller synthesis are proposed for all the stable FOPTD systems. Using this synthesis scheme, the complete feasible region of two specifications can be obtained and visualized in the plane. With this region as the prior knowledge, all combinations of two specifications can be verified before the controller design. Especially, it is interesting to compare the areas of these two feasible regions for the IOPID and FOPI controllers. This area comparison reveals, for the first time, the potential advantages of one controller over the other in terms of achievable performances. A simulation illustration is presented to show the effectiveness and the performance of the designed FOPI controller compared with the optimized integer order PI controller and the IOPID controller designed following the same synthesis for the FOPI in this paper.
This paper proposes a correlation coefficient (CC) and standard deviation (SD) integrated approach for determining the weights of attributes in multiple attribute decision making (MADM) and a global ...sensitivity analysis to the weights determined. The CCSD integrated approach determines the weights of attributes by considering SD of each attribute and their CCs with the overall assessment of decision alternatives, where CCs are determined by removing each attribute from the overall assessment of decision alternatives. If the CC for an attribute turns out to be very high, then the removal of this attribute has little effect on decision making; otherwise, the attribute should be given an important weight. The global sensitivity analysis to the weights of attributes is proposed to ensure the stability of the best decision alternative or alternative ranking. A numerical example about the economic benefit assessment of the industrial economy of China is investigated to illustrate the potential applications of the CCSD method in determining the weights of attributes. Comparisons with existing weight generation methods are also discussed.
A manta ray biomimetic glider is designed and studied with both laboratory experiments and numerical simulations with a new dynamic update method called the motion-based zonal mesh update method ...(MBZMU method) to reveal its hydrodynamic performance. Regarding the experimental study, an ejection gliding experiment is conducted for qualitative verification, and a hydrostatic free-fall experiment is conducted to quantitatively verify the reliability of the corresponding numerical simulation. Regarding the numerical simulation, to reduce the trend of nose-up movement and to obtain a long lasting and stable gliding motion, a series of cases with the center of mass offset forward by different distances and different initial angles of attack have been calculated. The results show that the glider will show the optimal gliding performance when the center of mass is 20mm in front of the center of geometry and the initial attack angle range lies between A0 = -5° to A0 = -2.5° at the same time. The optimal gliding distance can reach six times its body length under these circumstances. Furthermore, the stability of the glider is explained from the perspective of Blended-Wing-Body (BWB) configuration.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A Latin manuscript from the early 16th century, which is conserved in the National Library Vittorio Emmanuel II of Rome with its editor’s signature Michele Ruggieri, is regarded as the earliest Latin ...translation of the Four Books discovered so far. Based on a preliminary study of its handwriting, its date of annotations, the signature of its editor and its different translating styles, this paper focuses on the Latin translation of the Confucian concepts in Daxue, Zhongyong and Lunyu. By comparing it with other officially published Latin translations of the Four Books composed by the Jesuits in China during the 17th-18th century, the paper analyses its characteristics, speculates about its real translator, and tries to present an original understanding of the Jesuits on Confucian works in spite of cross-cultural translation.
The rotation of structures in a target introduces additional frequency modulations on the returned signals and also generates sidebands about the center Doppler frequency of the target. In other ...words, the body image will be contaminated due to the interference from the rotating parts. In this paper, an imaging method for moving targets with rotating parts is presented. The method is simple to implement and is based on the Hough transform (HT), which is widely used in image processing. Using the standard HT and an extended HT, we put forward a separation method by detecting the straight lines and the sinusoids on the spectrogram, respectively. A computer simulation is given to illustrate the effectiveness of the proposed method.
At present, agricultural robots are produced in large quantities and used in agricultural planting, and the traditional agricultural model is gradually shifting to rely on the Internet of Things and ...sensors to accurately detect crop growth information. The scientific and rational design of agricultural robots plays a huge role in planting and production efficiency, however, the factors affecting their design are complex and ambiguous, so it is necessary to use a rational evaluation system to make a preferential decision among multiple design options.
In order to reduce the subjectivity and blindness of program selection in the process of agricultural robot design, make the decision more objective and reasonable, and thus enhance the practicality and scientificity of the program, a new comprehensive evaluation method based on user requirements is proposed.
First, after researching and interviewing users and farming operations, obtaining raw information on requirements, using the Kano model to classify the requirements and establishing an evaluation index system. Secondly, the combination of hierarchical analysis(AHP) and entropy weighting method is used to assign weights to the evaluation index system, calculate the weight value and importance ranking of each index, and carry out various program designs based on the ranking. Finally, the VIKOR method was applied to evaluate and rank the design solutions.
The new evaluation method can better complete the preferential decision of the agricultural robot design scheme and get a more perfect design scheme, which reduces the influence of human subjective thinking in the decision-making process.
The method not only corrects the traditional evaluation method, but also effectively improves the accuracy and comprehensiveness of the design evaluation process. It also provides a reference for designers to preferably select design solutions and promotes the development of small mobile machines in the context of smart agriculture.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
PDF
