The High Energy Stereoscopic System (H.E.S.S.) is an array of imaging atmospheric Cherenkov telescopes (IACTs) located in Namibia. It was built to detect Very High Energy (VHE, >100 GeV) cosmic gamma ...rays, and consists of four 12 m diameter Cherenkov telescopes (CT1-4), built in 2003, and a larger 28 m telescope (CT5), built in 2012. The larger mirror surface of CT5 permits to lower the energy threshold of the array down to 30 GeV. The cameras of CT1-4 are currently undergoing an extensive upgrade, with the goals of reducing their failure rate, reducing their readout dead time and improving the overall performance of the array. The entire camera electronics has been renewed from ground-up, as well as the power, ventilation and pneumatics systems, and the control and data acquisition software. Technical solutions forseen for the next-generation Cherenkov Telescope Array (CTA) observatory have been introduced, most notably the readout is based on the NECTAr analog memory chip. The camera control subsystems and the control software framework also pursue an innovative design, increasing the camera performance, robustness and flexibility. The CT1 camera has been upgraded in July 2015 and is currently taking data; CT2-4 will upgraded in Fall 2016. Together they will assure continuous operation of H.E.S.S at its full sensitivity until and possibly beyond the advent of CTA. This contribution describes the design, the testing and the in-lab and on-site performance of all components of the newly upgraded H.E.S.S. camera.
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is a key regulatory enzyme of glucose metabolism. This bifunctional enzyme controls glycolysis and gluconeogenesis as well as glucose ...phosphorylation and metabolism. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-2 (PFKFB-2) plays significant role in the glycolysis regulation in the heart as well as in some other organs (kidney, brain and lung). Results of this investigation clearly demonstrated that in the glioma cells as well as in some mouse organs are presented several new unique alternative splice variants of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-2. These PFKFB-2 splice variants are a result of deletions or/and inserts in catalytic regions of 6-phosphofructo-2-kinase and fructose-2,6-bisphosphatase as well as in С-terminal regulatory region. Alternative splice variants of PFKFB-2 from glioma and mouse cells contain different inserts after 2nd exon but mouse splice variant has also deletion in 6-phosphofructo-2-kinase region and insert in C-terminus. Another splice variants of mouse PFKFB-2 have deletions in 6-phosphofructo-2-kinase or fructose-2,6-bisphosphatase regions, since one splice variant has deletion of all catalytic domains. In conclusion, this study provides evidences that alternative splicing of PFKFB-2 mRNA possibly has a significant role in glycolysis regulation via creation of monofunctional isoforms of this enzyme.
The High Energy Stereoscopic System (H.E.S.S.) is one of the currently operating Imaging Atmospheric Cherenkov Telescopes. H.E.S.S. operates in the broad energy range from a few tens of GeV to more ...than 50 TeV reaching its best sensitivity around 1 TeV. In this contribution, we present an analysis technique, which is optimised for the detection at the highest energies accessible to H.E.S.S. and aimed to improve the sensitivity above 10 TeV. It includes the employment of improved event direction reconstruction and gamma-hadron separation. For the first time, also extensive air showers with event offsets up to 4.5\(^{\circ}\) from the camera centre are considered in the analysis, thereby increasing the effective Field-of-View of H.E.S.S. from 5\(^{\circ}\) to 9\(^{\circ}\). Key performance parameters of the new high-energy analysis are presented and its applicability demonstrated for representative hard-spectrum sources in the Milky Way.
A bifunctional PFKFB enzyme is a key regulator of glycolysis. Four different genes encode the synthesis of multiple PFKFB isoforms. We analyzed data concerning structural organization of PFKFB genes ...and alternative splice variants of PFKFB mRNA, as well as expression and molecular mechanisms of regulation of different PFKFB isoforms in malignant tumors and at hypoxia, and mechanisms of hormonal regulation. Hypoxia inducible factor (HIF)-dependent mechanisms of regulation of the expression of different PFKFB variants are presented and discussed.
The detection of an astrophysical flux of high-energy neutrinos by IceCube is a major step forward in the search for the origin of cosmic rays, as this emission is expected to originate in hadronic ...interactions taking place in or near cosmic-ray accelerators. No neutrino point sources, or significant correlation with known astrophysical objects, have been identified in the IceCube data so far. The hadronic interactions responsible for the neutrino emission should also lead to the production of high-energy gamma rays. The search for neutrino sources can then be performed by studying the spatial and temporal correlations between neutrino events and very high energy (VHE, E > 100 GeV) gamma rays. We report here on the search for VHE gamma-ray emission with the H.E.S.S. imaging air Cherenkov telescopes (IACTs) at the reconstructed position of muon neutrino events detected by IceCube. We will provide an up-to-date summary of the extensive program to perform prompt IACT observations of realtime IceCube neutrino event positions. A recent highlight of this program are the H.E.S.S. observations during the broad multi-wavelength campaign that followed the detection of the neutrino event IceCube-170922A arriving from a direction consistent with the location of a flaring gamma-ray blazar TXS 0506+056 in September 2017. We'll present the H.E.S.S. observations obtained within ~4h hours of the neutrino detection as well as a complementary search for gamma-ray emission at longer timescales and put them into the multi-wavelength and multi-messenger context.
The High Energy Stereoscopic System (H.E.S.S.) is one of the three arrays of imaging atmospheric Cherenkov telescopes (IACTs) currently in operation. It is composed of four 12-meter telescopes and a ...28-meter one, and is sensitive to gamma rays in the energy range ~30 GeV - 100 TeV. The cameras of the 12-m telescopes recently underwent a substantial upgrade, with the goal of improving their performance and robustness. The upgrade involved replacing all camera components except for the photomultiplier tubes (PMTs). This meant developing new hardware for the trigger, readout, power, cooling and mechanical systems, and new software for camera control and data acquisition. Several novel technologies were employed in the cameras: the readout is built around the new NECTAr digitizer chip, developed for the next generation of IACTs; the camera electronics is fully controlled and read out via Ethernet using a combination of FPGA and embedded ARM computers; the software uses modern libraries such as Apache Thrift, ZMQ and Protocol buffers. This work describes in detail the design and the performance of the upgraded cameras.
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