Cutaneous manifestations of filovirus infections Nkoghe, Dieudonné; Leroy, Eric Maurice; Toung-Mve, Médard ...
International journal of dermatology,
September 2012, Letnik:
51, Številka:
9
Journal Article
Recenzirano
Ebolavirus and Marburgvirus, two filoviruses belonging to the Filoviridae family, are among the most virulent pathogens for humans and non‐human primates, causing outbreaks of fulminant hemorrhagic ...fever (HF) in Central African countries with case fatality rates of up to 90%. Fruit bats are the likely reservoir, and human infection occurs through contact with bats or infected large‐animal carcasses or by person‐to‐person contact (through body fluids, medical care, and burial practices). Schematically, clinical manifestations occur in three successive phases and include general, gastrointestinal, and mucocutaneous disorders. Death usually results from hemorrhagic complications. Cutaneous manifestations rarely make a major contribution to disease severity but can assist with the diagnosis. Rash, the main cutaneous disorder, is nonspecific and cannot guide the differential diagnosis. Immunohistochemical examination of skin biopsy or necropsy specimens can confirm the diagnosis.
The primary vector at the origin of the 2007 outbreak in Libreville, Gabon is identified as Aedes albopictus, trapped around the nearby French military camp. The Chikungunya virus was isolated from ...mosquitoes and found to be identical to the A226V circulating human strain. This is the first field study showing the role of the recently arrived species Aedes albopictus in Chikungunya virus transmission in Central Africa, and it demonstrates this species' role in modifying the epidemiological presentation of Chikungunya in Gabon.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Tuberculosis is an important public health problem in Gabon, and the DOTS strategy recommended by the World Health Organisation has not been successfully applied. In 2006, 45% of patients abandoned ...treatment during the first phase. A pilot cross-sectional study was thus conducted from September 1 to November 30, 2006, at the Nkembo Tuberculosis Centre in Libreville, Gabon. Thirty patients with positive microscopy results who returned after having interrupted treatment completed a standardised questionnaire. They were mainly young men: their mean age was 33 years old and the male/female ratio was 2.7. Reasons for having abandoned treatment were a lack of money to pay for it (43%) and an impression that they had been cured (23%). The motivations for resuming treatment were the return of symptoms (73%). The risk of drug resistance requires that the Gabonese government play a greater role in the fight against tuberculosis.
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