The abundance of satellite dwarf galaxies has long been considered a crucial test for the current model of cosmology leading to the well-known missing satellite problem. Recent advances in ...simulations and observations have allowed the study of dwarf galaxies around host galaxies in more detail. Using the Dark Energy Camera we surveyed a 72 deg
2
area of the nearby Sculptor group, also encompassing the two low-mass Local Volume galaxies NGC 24 and NGC 45 residing behind the group, to search for as yet undetected dwarf galaxies. Apart from the previously known dwarf galaxies we found only two new candidates down to a 3
σ
surface brightness detection limit of 27.4
r
mag arcsec
−2
. Both systems are in projection close to NGC 24. However, one of these candidates could be an ultra-diffuse galaxy associated with a background galaxy. We compared the number of known dwarf galaxy candidates around NGC 24, NGC 45, and five other well-studied low-mass spiral galaxies (NGC 1156, NGC 2403, NGC 5023, M 33, and the LMC) with predictions from cosmological simulations, and found that for the stellar-to-halo mass models considered, the observed satellite numbers tend to be on the lower end of the expected range. This could mean either that there is an overprediction of luminous subhalos in ΛCDM or that we are missing some of the satellite members due to observational biases.
Context. The study of dwarf galaxies and their environments provides crucial test beds for predictions of cosmological models and insights into the structure formation on small cosmological scales. ...In recent years, many problems on the scale of groups of galaxies has challenged the current standard model of cosmology. Aims. Our aim is to increase the sample of known galaxies in the Leo-I group, which contains the M 96 subgroup and the Leo Triplet. This galaxy aggregate is located at the edge of the Local Volume at a mean distance of 10.7 Mpc. Methods. We employed image enhancing techniques to search for low surface brightness objects in publicly available gr images taken by the Sloan Digital Sky Survey within 500 square degrees around the Leo-I group. Once detected, we performed surface photometry and compared their structural parameters to other known dwarf galaxies in the nearby universe. Results. We found 36 new dwarf galaxy candidates within the search area. Their morphology and structural parameters resemble known dwarfs in other groups. Among the candidates five or six galaxies are considered as ultra diffuse galaxy candidates. If confirmed, they would be some of the closest examples of this galaxy type. We assessed the luminosity function of the Leo-I group and find it to be considerably rich in dwarf galaxies, with twice the number of galaxies as the Local Group at a limiting magnitude of MV = −10 and a steeper faint-end slope.
Herein we report the synthesis of a crystalline graphitic carbon nitride, or g‐C3N4, obtained from the temperature‐induced condensation of dicyandiamide (NH2C(NH)NHCN) by using a salt melt of ...lithium chloride and potassium chloride as the solvent. The proposed crystal structure of this g‐C3N4 species is based on sheets of hexagonally arranged s‐heptazine (C6N7) units that are held together by covalent bonds between C and N atoms which are stacked in a graphitic, staggered fashion, as corroborated by powder X‐ray diffractometry and high‐resolution transmission electron microscopy.
Melting into shape: Crystalline graphitic carbon nitride (see graphic for structure) has been prepared by temperature‐induced condensation in a salt melt of lithium chloride and potassium chloride. The structure was studied by powder X‐ray diffraction and high‐resolution transmission electron spectroscopy.
Nada nuevo: la plaga del plagio Müller, Oliver
Avances en psicología latinoamericana,
09/2022, Letnik:
40, Številka:
2
Journal Article
Odprti dostop
Lo que escribiré en este editorial es, en cierto sentido, nada nuevo. ¿Pero es plagio? La definición corta que se me ha quedado es: usar las palabras o ideas de otra persona sin darle crédito. La ...verdad es que no recordaba dónde la había leído por primera vez y, hasta ahora, no podía indicar su fuente. Hice una búsqueda en Internet y las otras personas que la usan así, o de manera similar, indican que es del diccionario Merriam-Webster.
BACKGROUND—In patients with acute pulmonary embolism, systemic thrombolysis improves right ventricular (RV) dilatation, is associated with major bleeding, and is withheld in many patients at risk. ...This multicenter randomized, controlled trial investigated whether ultrasound-assisted catheter-directed thrombolysis (USAT) is superior to anticoagulation alone in the reversal of RV dilatation in intermediate-risk patients.
METHODS AND RESULTS—Fifty-nine patients (63±14 years) with acute main or lower lobe pulmonary embolism and echocardiographic RV to left ventricular dimension (RV/LV) ratio ≥1.0 were randomized to receive unfractionated heparin and an USAT regimen of 10 to 20 mg recombinant tissue plasminogen activator over 15 hours (n=30; USAT group) or unfractionated heparin alone (n=29; heparin group). Primary outcome was the difference in the RV/LV ratio from baseline to 24 hours. Safety outcomes included death, major and minor bleeding, and recurrent venous thromboembolism at 90 days. In the USAT group, the mean RV/LV ratio was reduced from 1.28±0.19 at baseline to 0.99±0.17 at 24 hours (P<0.001); in the heparin group, mean RV/LV ratios were 1.20±0.14 and 1.17±0.20, respectively (P=0.31). The mean decrease in RV/LV ratio from baseline to 24 hours was 0.30±0.20 versus 0.03±0.16 (P<0.001), respectively. At 90 days, there was 1 death (in the heparin group), no major bleeding, 4 minor bleeding episodes (3 in the USAT group and 1 in the heparin group; P=0.61), and no recurrent venous thromboembolism.
CONCLUSIONS—In patients with pulmonary embolism at intermediate risk, a standardized USAT regimen was superior to anticoagulation with heparin alone in reversing RV dilatation at 24 hours, without an increase in bleeding complications.
CLINICAL TRIAL REGISTRATION—URLhttp://www.clinicaltrials.gov. Unique identifierNCT01166997.
The clinical use of the chemotherapeutic doxorubicin (Dox) is limited by cardiotoxic side-effects. One of the early Dox effects is induction of a sarcoplasmic reticulum (SR) Ca2+ leak. The chaperone ...Glucose regulated protein 78 (GRP78) is important for Ca2+ homeostasis in the endoplasmic reticulum (ER)-the organelle corresponding to the SR in non-cardiomyocytes-and has been shown to convey resistance to Dox in certain tumors. Our aim was to investigate the effect of cardiac GRP78 gene transfer on Ca2+ dependent signaling, cell death, cardiac function and survival in clinically relevant in vitro and in vivo models for Dox cardiotoxicity.By using neonatal cardiomyocytes we could demonstrate that Dox induced Ca2+ dependent Ca2+ /calmodulin-dependent protein kinase II (CaMKII) activation is one of the factors involved in Dox cardiotoxicity by promoting apoptosis. Furthermore, we found that adeno-associated virus (AAV) mediated GRP78 overexpression partly protects neonatal cardiomyocytes from Dox induced cell death by modulating Ca2+ dependent pathways like the activation of CaMKII, phospholamban (PLN) and p53 accumulation. Most importantly, cardiac GRP78 gene therapy in mice treated with Dox revealed improved diastolic function (dP/dtmin) and survival after Dox treatment. In conclusion, our results demonstrate for the first time that Ca2+ dependent CaMKII activation fosters Dox cardiomyopathy and provide additional insight into possible mechanisms by which GRP78 overexpression protects cardiomyocytes from Doxorubicin toxicity.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Este año se cumplen 40 años de existencia de nuestra revista Avances en Psicología Latinoamericana (APL), fundada por el Dr. Rubén Ardila en 1982 con el nombre Avances en Psicología Clínica ...Latinoamericana (ACPL), como cuenta él mismo (Ardila, 1986). Felicitamos y agradecemos al Dr. Ardila por haber creado esta revista, que es solo uno de sus aportes a la promoción de la psicología en Latinoamérica y en el mundo.
Quiero empezar dando gracias. Gracias a Miguel Gutiérrez y a Luisa Fernanda Ramírez, por ofrecerme la oportunidad de liderar esta revista y entregármela en un excelente estado. Además, felicitaciones ...por los grandes logros que alcanzaron durante su gestión y que documentaron en el anterior editorial (Gutiérrez-Peláez & Ramírez, 2020). También deseo agradecer que me siguen apoyando como parte del comité editorial, al igual que Andrés Pérez-Acosta y Sara Cadavid, quienes están a mi lado con Rat und Tat (consejo y acción, como se dice en alemán). Dicho esto, quiero aclarar que el retraso en la publicación de este primer número del 2021 y los procesos editoriales, se debe únicamente a mis desafíos en aprender cómo manejar las nuevas funciones en la revista y combinar estas con aquella situación del covid-19, que nos ha azotado más tiempo del que pensábamos.
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