We report two patients that developed severe thrombocytopenia after Zika virus (ZIKV) infection. The first patient had 1000 platelets/μL and died after multiple hemorrhages. The second patient had ...2000 platelets/μL, had melena and ecchymoses, and recovered after receiving intravenous immunoglobulin. ZIKV may be associated with immune-mediated severe thrombocytopenia.
Objective
To study the effect of delivery on the pO2/FiO2 ratio (P/F ratio) in patients with COVID‐19‐related acute respiratory distress syndrome (ARDS) and to compare characteristics between ...delivered and undelivered pregnant patients with COVID‐19.
Design
Retrospective cohort.
Setting
Four hospitals in Houston, Texas.
Population
Pregnant patients admitted to the hospital for COVID‐19.
Methods
Among patients with ARDS who were delivered during their hospitalisation for COVID‐19, linear mixed models were used to investigate time trends before and after delivery of the P/F ratio. Patient characteristics were compared between patients delivered during their hospitalisation for COVID‐19 and those discharged undelivered.
Main outcome measures
The P/F ratio, age, gestational age, length of stay and severity of illness,
Results
Between 4 May 2020 and 26 July 2020, a total of 61 pregnant patients were admitted for COVID‐19. Baseline characteristics were similar between the study groups. Delivery occurred in 21 (34%) of patients during their hospitalisation for COVID‐19. Delivered patients had more severe disease and were admitted at a later gestational age than patients not delivered. Ten of these 21 patients (48%) were delivered preterm; of these, six were delivered due to complications of COVID‐19 and four were delivered for obstetric indications. In patients with ARDS who were delivered (n = 17), the P/F ratio had a negative slope that improved after delivery.
Conclusions
COVID‐19‐related ARDS in pregnancy requires multidisciplinary care and individualised decision‐making, but delivery slows the deterioration of the P/F ratio in these patients.
Tweetable
Delivery improves the P/F ratio in COVID‐19‐related ARDS, though individualised delivery management is needed.
Tweetable
Delivery improves the P/F ratio in COVID‐19‐related ARDS, though individualised delivery management is needed.
ABSTRACT
In this paper, we use photometric data from the Southern Photometric Local Universe Survey Data Release 4 survey to identify isolated galaxy pairs and analyse their characteristics and ...properties. Our results align with previous spectroscopic studies, particularly in luminosity function parameters, suggesting a consistent trait among galaxy systems. Our findings reveal a high fraction of red galaxies across all samples, irrespective of projected distance, velocity difference, or luminosity ratio. We found that the proximity of a neighbour to its central galaxy influences its colour due to environmental effects. We also found that central and neighbour have different behaviours: central galaxies maintain a stable red colour regardless of luminosity, while neighbour colours vary based on luminosity ratios. When the central is significantly brighter, the neighbour tends to be less red. According to our division in red, blue, and mixed pairs, we found evidence of galactic conformity. The red pair fractions increase in closer pairs and in pairs of similar luminosity, indicating shared environments promoting red galaxy formation. Analysing local density, the expected colour–density relation is of course recovered, but it is strongly determined by the stellar mass of the pair. In denser environments, the red pair fractions increase, blue pairs decrease, and for the mixed pairs it depends on their stellar mass: more massive mixed pairs decrease their fraction, whereas the less massive ones increase it. These results shed light on the intricate relationship between galaxy pairs, their characteristics, and environmental influences on colour, providing insights into their evolutionary histories.
The SARS-CoV-2 RNA-dependent RNA polymerase coordinates viral RNA synthesis as part of an assembly known as the replication-transcription complex (RTC)
. Accordingly, the RTC is a target for ...clinically approved antiviral nucleoside analogues, including remdesivir
. Faithful synthesis of viral RNAs by the RTC requires recognition of the correct nucleotide triphosphate (NTP) for incorporation into the nascent RNA. To be effective inhibitors, antiviral nucleoside analogues must compete with the natural NTPs for incorporation. How the SARS-CoV-2 RTC discriminates between the natural NTPs, and how antiviral nucleoside analogues compete, has not been discerned in detail. Here, we use cryogenic-electron microscopy to visualize the RTC bound to each of the natural NTPs in states poised for incorporation. Furthermore, we investigate the RTC with the active metabolite of remdesivir, remdesivir triphosphate (RDV-TP), highlighting the structural basis for the selective incorporation of RDV-TP over its natural counterpart adenosine triphosphate
. Our results explain the suite of interactions required for NTP recognition, informing the rational design of antivirals. Our analysis also yields insights into nucleotide recognition by the nsp12 NiRAN (nidovirus RdRp-associated nucleotidyltransferase), an enigmatic catalytic domain essential for viral propagation
. The NiRAN selectively binds guanosine triphosphate, strengthening proposals for the role of this domain in the formation of the 5' RNA cap
.
Direct electron detectors (DEDs) have revolutionized cryo-electron microscopy (cryo-EM) by facilitating the correction of beam-induced motion and radiation damage, and also by providing ...high-resolution image capture. A new-generation DED, the DE64, has been developed by Direct Electron that has good performance in both integrating and counting modes. The camera has been characterized in both modes in terms of image quality, throughput and resolution of cryo-EM reconstructions. The modulation transfer function, noise power spectrum and detective quantum efficiency (DQE) were determined for both modes, as well as the number of images per unit time. Although the DQE for counting mode was superior to that for integrating mode, the data-collection throughput for this mode was more than ten times slower. Since throughput and resolution are related in single-particle cryo-EM, data for apoferritin were collected and reconstructed using integrating mode, integrating mode in conjunction with a Volta phase plate (VPP) and counting mode. Only the counting-mode data resulted in a better than 3 Å resolution reconstruction with similar numbers of particles, and this increased performance could not be compensated for by the increased throughput of integrating mode or by the increased low-frequency contrast of integrating mode with the VPP. These data show that the superior image quality provided by counting mode is more important for high-resolution cryo-EM reconstructions than the superior throughput of integrating mode.
We describe a revised procedure for the numerical simulation of planetary nebulae luminosity functions (PNLFs), improving on previous work. The procedure is now based on new H-burning post-asymptotic ...giant branch (AGB) evolutionary tracks. For a given stellar mass, the new central stars are more luminous and evolve faster. We have slightly changed the distribution of the O iii 5007 intensities relative to those of and the generation of absorbing factors, while still basing their numerical modeling on empirical information extracted from studies of galactic planetary nebulae (PNs) and their central stars. We argue that the assumption of PNs being completely optically thick to H-ionizing photons leads to conflicts with observations and show that to account for optically thin PNs is necessary. We then use the new simulations to estimate a maximum final mass, clarifying its meaning, and discuss the effect of internal dust extinction as a possible way of explaining the persistent discrepancy between PNLFs and surface brightness fluctuation distances. By adjusting the range of minimum to maximum final mass, it is also possible to explain the observed variety of PNLF shapes at intermediate magnitudes. The new PN formation rates are calculated to be slightly lower than suggested by previous simulations based on older post-AGB evolutionary tracks.
A qualitative study of equine veterinarians and allied staff from Queensland, Australia, showed that veterinarians are ceasing equine practice because of fears related to Hendra virus. Their ...decisions were motivated by personal safety and legal liability concerns.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Context. At least 492 central stars of Galactic planetary nebulae (CSPNs) have been assigned spectral types. Since many CSPNs are faint, these classification efforts are frequently made at low ...spectral resolution. However, the stellar Balmer absorption lines are contaminated with nebular emission; therefore in many cases a low-resolution spectrum does not enable the determination of the H abundance in the CSPN photosphere. Whether or not the photosphere is H deficient is arguably the most important fact we should expect to extract from the CSPN spectrum, and should be the basis for an adequate spectral classification system. Aims. Our purpose is to provide accurate spectral classifications and contribute to the knowledge of central stars of planetary nebulae and stellar evolution. Methods. We have obtained and studied higher quality spectra of CSPNs described in the literature as weak emission-line star (WELS). We provide descriptions of 19 CSPN spectra. These stars had been previously classified at low spectral resolution. We used medium-resolution spectra taken with the Gemini Multi-Object Spectrograph (GMOS). We provide spectral types in the Morgan-Keenan (MK) system whenever possible. Results. Twelve stars in our sample appear to have normal H rich photospheric abundances, and five stars remain unclassified. The rest (two) are most probably H deficient. Of all central stars described by other authors as WELS, we find that at least 26% of them are, in fact, H rich O stars, and at least 3% are H deficient. This supports the suggestion that the denomination WELS should not be taken as a spectral type, because, as a WELS is based on low-resolution spectra, it cannot provide enough information about the photospheric H abundance.
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