Volume 62, no. 6, p. 2157, Table 1: the sequence for probe Nso1225, 5(prm1)-CGCGATTGTATTACGTGTGA-3(prm1), should read 5(prm1)-CGCCATTGTATTACGTGTGA-3(prm1). This corrects the article on p. 2156 in ...vol. 62..
We report a whole-genome shotgun assembly (called WGSA) of the human genome generated at Celera in 2001. The Celera-generated shotgun data set consisted of 27 million sequencing reads organized in ...pairs by virtue of end-sequencing 2-kbp, 10-kbp, and 50-kbp inserts from shotgun clone libraries. The quality-trimmed reads covered the genome 5.3 times, and the inserts from which pairs of reads were obtained covered the genome 39 times. With the nearly complete human DNA sequence National Center for Biotechnology Information (NCBI) Build 34 now available, it is possible to directly assess the quality, accuracy, and completeness of WGSA and of the first reconstructions of the human genome reported in two landmark papers in February 2001 Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) Science 291, 1304-1351; International Human Genome Sequencing Consortium (2001) Nature 409, 860-921. The analysis of WGSA shows 97% order and orientation agreement with NCBI Build 34, where most of the 3% of sequence out of order is due to scaffold placement problems as opposed to assembly errors within the scaffolds themselves. In addition, WGSA fills some of the remaining gaps in NCBI Build 34. The early genome sequences all covered about the same amount of the genome, but they did so in different ways. The Celera results provide more order and orientation, and the consortium sequence provides better coverage of exact and nearly exact repeats.
Allele frequencies from seven polymorphic red cell antigen loci (ABO, Rh, MN, S, P, Duffy, and Diego) were examined in 144 Native American populations. Mean genetic distances (Nei's D) and the ...fixation index F ST are approximately equal for the North and South American samples but are reduced in the Central American geographic area. The relationship between genetic distance and geographic distance differs markedly across geographic areas. The correlation between geographic distance and genetic distance for the North and Central American data is twice as large as that observed for the South American samples. This geographic difference is confirmed in spatial autocorrelation analyses; no geographic structure is apparent in the South American data but geographic structure is prominent in North and Central American samples. These results confirm earlier observations regarding differences between North and South American gene frequency patterns.
The Convex SPP-1000 is the first commercial implementation of a new generation of scalable shared memory parallel computers with full cache coherence. It employs a hierarchical structure of ...processing communication and memory name-space management resources to provide a scalableNUMA environment. Ensembles of 8 HP PA-RISC7100 microprocessorsemploy an internal cross-bar switch and directory based cache coherence scheme to provide a tightly coupled SMP.Up to 16 processing ensembles are interconnected by a 4 ring network incorporating a full hardware implementation of the SCI protocol for a full system configuration of 128 processors. This paper presents the findings of a set of empirical studies using both synthetic test codes and full applications for the Earth and space sciences to characterize the performance properties of this new architecture. It is shown that overhead and latencies of global primitive mechanisms, while low in absolute time, are significantly more costly than similar functions local to an individual processor ensemble.
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