The efficient and selective capture of toxic oxo-anions is highly desirable for environmental retrieval and hazardous waste disposal. This has remained an important task and gained considerable ...scientific attention due to their harmful effects on the ecosystem and human health. Herein, a porous cationic metal-organic framework (MOF), namely, Cu
3
Cl(L)(H
2
O)
2
·Cl·4DMA·8H
2
O (
1
), was synthesized (H
4
L = 1,4,8,11-tetrazacyclotetradecane-
N
,
N
′,
N
′′,
N
′′′-tetramethylenecinnamic acid and DMA =
N
,
N
′-dimethylacetamide).
1
shows high stability in aqueous solution and represents an extraordinary example that is capable of efficiently capturing environmentally toxic Cr
2
O
7
2−
and MnO
4
−
anions. Moreover, the removal of Cr
2
O
7
2−
and MnO
4
−
anions from water was also explored in the presence of other competing anions.
A porous cationic metal-organic framework was rationally achieved with nanosized channels, and it exhibited the capability to efficiently capture environmentally toxic Cr
2
O
7
2−
and MnO
4
−
anions.
We perform a perturbative QCD analysis of the gluonic gravitational form factors (GFFs) of the proton and pion at large momentum transfer. We derive the explicit factorization formula of the GFFs in ...terms of the distribution amplitudes of hadrons. At the leading power, we find that the gluon GFFs Ag and Cg scale as Agπ(t)=Cgπ(t)∼1/(−t) for pion, Agp(t)∼1/(−t)2 and Cgp(t)∼ln2(−t/Λ2)/(−t)3 for proton, respectively, where t is the momentum transfer and Λ a non-perturbative scale to regulate the endpoint singularity in Cgp calculation. Our results provide a unique perspective of the momentum dependence of the GFFs and will help to improve our understanding of the internal pressure distributions of hadrons.
Diabetic retinopathy (DR) is a common eye complication of diabetes, and the pathogenic mechanism of DR is still under investigation. The canonical Wnt signaling pathway is an evolutionarily conserved ...pathway that plays fundamental roles in embryogenesis and adult tissue homeostasis. Wnt signaling regulates expression of multiple genes that control retinal development and eye organogenesis, and dysregulated Wnt signaling plays pathophysiological roles in many ocular diseases, including DR. This review highlights recent progress in studies of Wnt signaling in DR. We discuss Wnt signaling regulation in the retina and dysregulation of Wnt signaling associated with ocular diseases with an emphasis on DR. We also discuss the therapeutic potential of modulating Wnt signaling in DR. Continued studies in this field will advance our current understanding on DR and contribute to the development of new treatments.
Two C2H6‐selective metal‐organic framework (MOF) adsorbents with ultrahigh stability, high surface areas, and suitable pore size have been designed and synthesized for one‐step separation of ...ethane/ethylene (C2H6/C2H4) under humid conditions to produce polymer‐grade pure C2H4. Experimental results reveal that these two MOFs not only adsorb a high amount of C2H6 but also display good C2H6/C2H4 selectivity verified by fixed bed column breakthrough experiments. Most importantly, the good water stability and hydrophobic pore environments make these two MOFs capable of efficiently separating C2H6/C2H4 under humid conditions, exhibiting the benchmark performance among all reported adsorbents for separation of C2H6/C2H4 under humid conditions. Moreover, the affinity sites and their static adsorption energies were successfully revealed by single crystal data and computation studies. Adsorbents described in this work can be used to address major chemical industrial challenges.
Two highly robust microporous metal–organic frameworks with high ethane uptake and selectivity, ultrahigh water stability, high chemical stability, and low ethane/ethene adsorption enthalpy were designed and synthesized, which could realize one‐step C2H4 purification from binary C2H6/C2H4 mixtures under both dry and humid conditions.
Two Cu(
i
)-based inorganic-organic complexes, namely, H
3
O·CuL·0.5Mo
10
O
32
·H
2
O (
1
) and CuL·0.5HPW
12
O
40
·EtOH·H
2
O (
2
), were designed by combining polyoxometalate, Cu(
i
) ions and ...tetra-2-mercaptopyrimidine-thiacalix4arene (L
1
). In both
1
and
2
, each Cu(
i
) is bridged by two different L ligands to form a chain. The polyoxometalate anions are free and balance the network charge. Significantly, the oxidation desulfurization and cycloaddition reactions were studied with
1
and
2
as heterogeneous catalysts, respectively. Moreover, the two complexes featured chemical stability and catalytic recyclability, and are easy to separate from the solvents.
Two Cu(
i
)-based inorganic-organic complexes were synthesized, which can be used as high-efficiency heterogeneous catalysts for ODS and AAC reactions, respectively.
Long-lived superhydrophobic surfaces Xue, Chao-Hua; Ma, Jian-Zhong
Journal of materials chemistry. A, Materials for energy and sustainability,
01/2013, Letnik:
1, Številka:
13
Journal Article
Background Ferroptosis is a novel form of regulated cell death that plays a critical role in tumorigenesis. The purpose of this study was to establish a ferroptosis-associated gene (FRG) signature ...and assess its clinical outcome in gastric cancer (GC). Methods Differentially expressed FRGs were identified using gene expression profiles from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. Univariate and least absolute shrinkage and selection operator (LASSO) Cox regression analyses were performed to construct a prognostic signature. The model was validated using an independent GEO dataset, and a genomic-clinicopathologic nomogram integrating risk scores and clinicopathological features was established. Results An 8-FRG signature was constructed to calculate the risk score and classify GC patients into two risk groups (high- and low-risk) according to the median value of the risk score. The signature showed a robust predictive capacity in the stratification analysis. A high-risk score was associated with advanced clinicopathological features and an unfavorable prognosis. The predictive accuracy of the signature was confirmed using an independent GSE84437 dataset. Patients in the two groups showed different enrichment of immune cells and immune-related pathways. Finally, we established a genomic-clinicopathologic nomogram (based on risk score, age, and tumor stage) to predict the overall survival (OS) of GC patients. Conclusions The novel FRG signature may be a reliable tool for assisting clinicians in predicting the OS of GC patients and may facilitate personalized treatment.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Abstract
Zinc (Zn) is an essential micronutrient for both plants and animals, while its deficiency in crops and humans is a global problem that affects both crop productivity and human health. Since ...plants and humans differ in their Zn requirements, it is crucial to balance plant nutrition and human nutrition for Zn. In this review, we focus on the transport system of Zn from soil to grain in rice (Oryza sativa), which is a major dietary source of Zn for people subsiding on rice-based diets. We describe transporters belonging to the different families that are involved in the uptake, vacuolar sequestration, root-to-shoot translocation, and distribution of Zn, and discuss their mechanisms of regulation. We give examples for enhancing Zn accumulation and bioavailability in rice grains through the manipulation of genes that are highly expressed in the nodes, where Zn is deposited at high concentrations. Finally, we provide our perspectives on breeding rice cultivars with both increased tolerance to Zn-deficiency stress and high Zn density in the grains.
This review describes the transporters involved in the uptake, vacuolar sequestration, root-to-shoot translocation, and distribution of zinc in rice, and discusses how to balance optimal plant nutrition and human nutrition for zinc.
Objectives
Large bone defects are a common, debilitating clinical condition that have substantial global health and economic burden. Bone tissue engineering technology has become one of the most ...promising approaches for regenerating defective bones. In this study, we fabricated a naringin‐inlaid composite silk fibroin/hydroxyapatite (NG/SF/HAp) scaffold to repair bone defects.
Materials and Methods
The salt‐leaching technology was used to fabricate the NG/SF/HAp scaffold. The cytocompatibility of the NG/SF/HAp scaffold was assessed using scanning electron microscopy, live/dead cell staining and phalloidin staining. The osteogenic and angiogenic properties were assessed in vitro and in vivo.
Results
The porous NG/SF/HAp scaffold had a well‐designed biomimetic porous structure with osteoinductive and angiogenic activities. A gene microarray identified 854 differentially expressed genes between human umbilical cord‐derived mesenchymal stem cells (hUCMSCs) cultured on SF‐nHAp scaffolds and cells cultured on NG/SF/HAp scaffolds. The underlying osteoblastic mechanism was investigated using hUCMSCs in vitro. Naringin facilitated hUCMSC ingrowth into the SF/HAp scaffold and promoted osteogenic differentiation. The osteogenic and angiogenic capabilities of cells cultured in the NG/SF/HAp scaffold were superior to those of cells cultured in the SF/HAp scaffold.
Conclusions
The data indicate the potential of the SF/HAp composite scaffold incorporating naringin for bone regeneration.
Overall schematic illustration of naringin‐inlaid silk fibroin/hydroxyapatite scaffold enhances human umbilical cord‐derived mesenchymal stem cell‐based bone regeneration.
The widespread use of chemicals has brought serious water pollution threatening human health and environment, which requires green, fast, and low‐cost purification urgently. Here, we build up a novel ...material family of sky‐parking‐like 3D structured graphene oxides (SP‐GOs) with adjustable interlayer‐space of 0.8–1.7 nm via the insertion of different sized diamine compounds as support pillars between GO layers. The assembled 3D SP‐GOs exhibit superior adsorption capacity and short removal time for various aromatic organic compounds in water, achieving record‐breaking maximum adsorption capacity of 535.79 mg g−1 toward the most common water‐pollutant bisphenol A (BPA) at ambient conditions as well as significantly improved removal of other organic pollutants including sulfapyridine, carbamazepine, ketoprofen and 2‐naphthol. The construction of SP‐GO provides a simple approach for evolving the GO material from 2D to 3D and a new avenue for the decontamination of pollutants in environmental remediation.
Good riddance, bisphenol A! A series of sky‐parking‐like 3D graphene oxides with adjustable interlayer space of 0.8 to 1.7 nm were used for water purification, which exhibited record‐breaking maximum bisphenol A adsorption capacity of 535.8 mg g−1 under ambient conditions.
PDF
