To support cellular homeostasis and mitigate chemotherapeutic stress, cancer cells must gain a series of adaptive intracellular processes. Here we identify that NUPR1, a tamoxifen (Tam)-induced ...transcriptional coregulator, is necessary for the maintenance of Tam resistance through physical interaction with ESR1 in breast cancers. Mechanistically, NUPR1 binds to the promoter regions of several genes involved in autophagy process and drug resistance such as BECN1, GREB1, RAB31, PGR, CYP1B1, and regulates their transcription. In Tam-resistant ESR1 breast cancer cells, NUPR1 depletion results in premature senescence in vitro and tumor suppression in vivo. Moreover, enforced-autophagic flux augments cytoplasmic vacuolization in NUPR1-depleted Tam resistant cells, which facilitates the transition from autophagic survival to premature senescence. Collectively, these findings suggest a critical role for NUPR1 as a transcriptional coregulator in enabling endocrine persistence of breast cancers, thus providing a vulnerable diagnostic and/or therapeutic target for endocrine resistance.
Quasi-brittleness is an important factor affecting the size effect of concrete, and the addition of steel fiber can effectively change this effect in concrete. The size effect on the fracture energy ...of steel fiber reinforced high-strength concrete was investigated in this paper. A total of 156 concrete single-edge notched beams (SENB) of various span-to-depth ratios, crack-to-depth ratios and steel fiber contents were tested to study the size effect of fracture energy of the high-strength concrete added steel fibers. The parameters of fracture in the boundary effect model (BEM) and size effect law (SEL) were deeply analyzed. The results show that the addition of steel fiber will generate significant influence on the parameter values obtained from both BEM and SEL. Based on the BEM, the relationship among Gf (experimental test fracture energy), gf (local fracture energy), and GF (fracture energy unaffected by specimen boundary) could be obtained. Thus, a method for analyzing the influence of steel fiber on GF was proposed using small-size SENB specimens at laboratory. In addition, based on the SEL, the impact of size effect on the fracture energy was effectively mitigated by the addition of steel fibers in high-strength concrete to a certain extent.
Carbon dioxide is one of the greenhouse gases responsible for global warming, and how to reduce the amount of carbon dioxide in the air is a major issue. Scholars have found that herbaceous flowers ...can fix 12.16 g•m
-2
• D
-1
carbon dioxide per unit leaf area in green space, which has a good ecological benefit of carbon sequestration. Therefore, how to further improve the ecological benefits of carbon sequestration has become a concern of landscape architecture industry. This paper summarizes seven kinds of garden green land carbon ecological concrete approaches to improve, including selecting high carbon sequestration ability of plant species, increase high carbon sequestration ability of plant population, rich garden plant hierarchy, increase use native plants, increasing the vertical greening, choose low maintenance plants landscape, choose the appropriate maintenance management way, In order to deal with global warming phenomenon on the full play of green landscape fixed carbon dioxide capacity.
The Baeyer–Villiger oxidation (BVO) of ketone and aldehyde can produce ester and formate, which both have wide applications in many areas. In this work, a series of Sn-containing silicates were ...prepared through the sol-gel process by using structure-directing and crystallizing agents and post-synthetic coordinated modification of binaphthol. Characterizations revealed that loading of (L)-sodium lactate as the crystallizing agent decreased the crystal size of the synthesized catalyst, and there were SnO2 nanoparticles with sizes of 17–19 nm on the catalyst. Furthermore, quite differently from the 3D mesoporous structure of classical Sn-beta zeolites, the synthesized catalysts had a silt-like mesoporous structure. In the catalysis, when cyclic aliphatic ketones were used as the substrate, only BVO-type products and corresponding ring-opening products were obtained. BVO of aliphatic aldehyde produced both an aerobic oxidation product (carboxylic acid) and a BVO-type product. The presented transformation of aromatic aldehyde (benzaldehyde) only gave an aerobic oxidation product (benzoic acid). The post-synthetic coordinating attachment of (S)-binaphthol to the Sn-containing silicate backbone worsened the BVO of aliphatic ketones but improved the BVO of aliphatic aldehyde and the aerobic oxidation of aromatic aldehyde. In addition, this work also developed two new routes for the synthesis of high-value-added 6-hydroxyhexanoic acid and cyclohexylformate under catalytic BVO conditions.
A new fault detection scheme for aircraft Inertial Measurement Unit (IMU) sensors is developed in this paper. This scheme adopts a deep neural network with a CNN-LSTM-fusion architecture (CNN: ...convolution neural network; LSTM: long short-term memory). The fault detection network (FDN) developed in this paper is irrelative to aircraft model or flight condition. Flight data is reformed into a 2D format for FDN input and is mapped via the net to fault cases directly. We simulate different aircrafts with various flight conditions and separate them into training and testing sets. Part of the aircrafts and flight conditions appears only in the testing set to validate robustness and scalability of the FDN. Different architectures of FDN are studied, and an optimized architecture is obtained via ablation studies. An average detecting accuracy of 94.5% on 20 different cases is achieved.
Green roofs can improve urban ecological conditions by mitigating the heat island effect and absorbing harmful gases. Soil additives can improve roof soil properties and promote the stability of the ...urban ecosystem. As soil additives, biochar and sludge are widely used in the ground, but their application on roofs is still scarce. This study examined the carbon storage potential of green roofs amended with sludge and biochar. The roof soil was composed of soil and varying proportions of the additives (0%, 5%, 10%, 15%, and 20%, v/v); Sedum lineare was then planted. The carbon contents of the soils and plants were measured for one year. The influence of biochar or sludge on the carbon content of the roof soil and the factors affecting the roof carbon storage potential were analyzed. The results showed that the carbon storage potential of a biochar green roof (9.3 kg C m−2) was significantly higher than that of a sludge green roof (7.9 kg C m−2). Biochar increased the carbon content of the green roof by improving the physical properties of the roof soil and promoting plant growth, whereas sludge increased the carbon content of the green roof by improving the chemical properties of the roof soil. Moreover, biochar could not only store large amounts of stable carbon, but also reduce the weight of the green roof, improve soil moisture, and provide a resourceful utilization of municipal sludge. Thus, biochar can be considered a material for promoting carbon storage on green roofs.
The transverse leakage of leaky surface acoustic waves (LSAWs) occurs on 42°YX-lithium tantalate substrates (42LT), which increases the insertion loss, narrows the bandwidth and flattens the roll-off ...of band 40/41 SAW filters and duplexers. In this work, LSAW characteristics with different metal materials and thicknesses are calculated by the finite element method (FEM), which determines the IDT material and thickness used for band 40/41 SAW filter design. To deeply understand transverse leakage and suppress it, the effects of different gap and dummy lengths on transverse leakage are simulated and discussed. Then, a new technique of using a wider dummy without any additional lithographic or depositing processes is proposed to suppress the leakage. Its effectiveness is validated by both simulations and experiments. Then, the technique is extended to applications of band 40 and 41 SAW filters. The experimental results show that with the wider dummy structure, the band 40 and 41 SAW filters achieve a more than 0.2 dB improvement in the insertion loss, a wider bandwidth and a steeper roll-off characteristic. This technique may also be extended to the other band SAW filter applications.
SAW devices with a multi-layered piezoelectric substrate have excellent performance due to advantages such as a high quality factor, Q, low loss insertion, large bandwidth, etc. Prior to ...manufacturing, a comprehensive analysis and proper design are essential to evaluating the device’s key performance indicators, including the Bode Q value, bandwidth, and transverse mode suppression. This study explored the performance of SAW resonators employing a 42°Y-X LiTaO3 (LT) thin-plate-based multi-layered piezoelectric substrate. The thicknesses for each layer of the 42°Y-X LT/SiO2/poly-Si/Si substrate were optimized according to the index of phase velocity, Bode Q value, and bandwidth. The effect of the device structure parameters on the dispersion curve and slowness curve was studied, and a flat slowness curve was found to be favorable for transverse mode suppression. In addition, the design of the dummy configuration was also optimized for the suppression of spurious waves. Based on the optimized design, a one-port resonator on the 42°Y-X LT/SiO2/poly-Si/Si substrate was fabricated. The simulation results and measurements are presented and compared, which provides guidelines for the design of new types of SAW devices configured with complex structures.
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