Anti-interleukin-17 agents have recently been developed for the treatment of psoriasis. This study evaluated the tolerance and effectiveness of anti-interleukin-17 agents for psoriasis in elderly ...patients in daily practice. A multicentre, retrospective study was performed, involving psoriatic patients aged ≥65 years who had received an anti-interleukin-17 agent, including secukinumab, ixekizumab or brodalumab. A total of 114 patients were included: 72 received secukinumab, 35 ixekizumab, and 7 brodalumab. Treatment was stopped in 32 patients (28.9%), because of relapses in 14 patients (41.2%), primary failures in 11 patients (32.4%), or adverse events in 7 patients (20.6%). The 3 most frequently reported adverse events were injection site reactions (n = 4), oral candidiasis (n = 3), and influenza-like illness (n = 3). Regarding effectiveness, 80 patients (70%) reached a Physician Global Assessment score of 0/1, 6 months after treatment initiation. In conclusion, anti-interleukin-17 therapy appears to be an effective and safe therapeutic option for psoriasis treatment in patients aged ≥ 65 years.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
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•Anisotropic Nd-Fe-B bonded magnets were obtained via Laser Powder Bed Fusion.•Mechanical orientation of elongated anisotropic magnetic particles was explored.•As-printed bonded ...magnets exhibited a mean alignment degree of < cos θ> = 0.73.•Alignment degree can be tailored as a function of the size of the magnetic particles.
Nd-Fe-B bonded magnets are an important class of permanent magnets, employed in many technological sectors. Additive Manufacturing (AM) enables the fabrication of net-shape bonded magnets with complex geometries, allowing to tailor their magnetic stray field specifically for a given application. A crucial challenge is the production of magnetically anisotropic components. Approaches presented in the literature up to now required a post-printing procedure or the complex integration of a magnetic field source into the AM process. Here, we present a technique to fabricate anisotropic bonded magnets via Laser Powder Bed Fusion (LPBF) by utilizing the mechanical alignment of anisotropic particles in a single step, without the need for a magnetic field source. Anisotropic bonded magnets were fabricated using a mixture of anisotropic Nd-Fe-B powder (MQA-38–14) and polyamide-12 (PA12). This magnetic powder consists of ellipsoidal particles, where the easy magnetization axis is distributed perpendicular to their longest side, and the mean aspect ratio of 3:1 can be exploited to generate magnetic texture. Depending on the particle size used as feedstock, the degree of alignment (<cosθ>) can be tailored to a maximum of <cosθ> = 0.78. The fabricated anisotropic bonded magnets exhibited a maximum remanence of Jr = 377 mT and an energy product of (BH)max = 28.6 kJ/m3, respectively.
In order to find a promising trade-off permanent magnet material regarding a performance/cost-ratio, the Ce1−xSmxFe11−yTi1Vy-phase (x = 0–1; y = 0, 1) is analyzed in detail. In the first part, its ...existence range is studied (1000 °C) and the intrinsic magnetic properties are comprehensively determined. Diffraction experiments localize both structure-stabilizing transition metals on 8i-sites, explaining the measured reduction in saturation polarization as V is added. Curie temperatures increase upon Sm-substitution with a negligible dependence on V. Annealings of nanocrystalline material produced via intensive milling and melt-spinning show that V especially raises the obtainable maximum coercivities for Sm-rich phases (924 kA/m).
In the second part, the promising magnetic properties of the nanocrystalline material are successfully transferred to the bulk state via hot-pressing. The isotropic Ce0.5Sm0.5Fe10Ti1V1-magnet (coercivity = 425 kA/m) is characterized by various means. Magnetic measurements, structural investigations and calculations of the elastic constants consider necessary factors for a successful texturing by die-upsetting (as accepted for Nd-Fe-B). The results are fundamental for further considerations in this active field of research.
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A sensitive and reproducible 96-well assay of uronic acid permitting a rapid processing of a number of samples with a very low consumption of reagents is described for the determination of complex ...uronic acid-bearing polyanions such as hyaluronic acid, chondroitin sulfate, dermatan sulfate and heparin. The sensitivity of the reaction was approx. 1 μg for glucuronic acid and 2 μg for complex polysaccharides, with a linear function of glucuronic acid concentration between 1 and 100 μg. The relative coefficient of variations ranged from 1.5 to 8.7% for the assay performed in the 96-well plate. These values were found to be lower than those obtained by the conventional procedure.
Since 1990 our group has been using extracorporeal circulation to ozonate blood by an original method, known as extracorporeal blood oxygenation and ozonation (EBOO), with the aim of amplifying the ...results observed with ozone autohemotherapy.
To verify the hypothesis that EBOO improves the skin lesions typical of peripheral artery disease (PAD) patients.
Twenty-eight patients with PAD were randomized to receive EBOO or intravenous prostacyclin in a controlled clinical trial. The primary efficacy parameters were regression of skin lesions and pain,and improvement in quality of life and vascularisation.
Patients treated with EBOO showed highly significant regression of skin lesions with respect to patients treated with prostacyclin. Other parameters that were significantly different in the two groups of patients were pain,pruritus, heavy legs and well-being. No significant differences in vascularisation of the lower limbs before and after treatment were found in either group. No side effects or complications were recorded during the 210 EBOO treatments.
EBOO was much more effective than prostacyclin for treating skin lesions in PAD patients and also had a positive effect on patient general condition without any apparent change in arterial circulation. This suggests other mechanisms of action of EBOO.
Complex polysaccharides, glycosaminoglycans (GAGs), are a class of ubiquitous macromolecules exhibiting a wide range of biological functions. They are widely distributed as sidechains of ...proteoglycans (PGs) in the extracellular matrix and at cellular level. The recent emergence of enhanced analytical tools for their study has triggered a virtual explosion in the field of glycomics. Analytical electrophoretic separation techniques, including agarose-gel, capillary electrophoresis (HPCE) and fluorophore-assisted carbohydrate electrophoresis (FACE), of GAGs and GAG-derived oligosaccharides have been employed for the structural analysis and quantification of hyaluronic acid (HA), chondroitin sulfate (CS), dermatan sulfate (DS), keratan sulfate (KS), heparan sulfate (HS), heparin (Hep) and acidic bacterial polysaccharides. Furthermore, recent developments in the electrophoretic separation and detection of unsaturated disaccharides and oligosaccharides derived from GAGs by enzymatic or chemical degradation have made it possible to examine alterations of GAGs with respect to their amounts and fine structural features in various pathological conditions, thus becoming applicable for diagnosis. In this paper, the electromigration procedures developed to analyze and characterize complex polysaccharides are reviewed. Moreover, a critical evaluation of the biological relevance of the results obtained by these electrophoresis approaches is presented.
Recent studies have illustrated that systemic medications are underused for treating adult atopic dermatitis (AD) and that dermatologists have concerns regarding the safety profile of cyclosporine in ...AD.
We performed a national online practice survey between March and April 2020.
A total of 305 dermatologists responded, 57% with hospital-based activity and 43% with private practice. Overall, 46.9% prescribed cyclosporine for adult AD. Before initiating treatment, 56.9% did not perform evaluation scoring. Reasons for not prescribing cyclosporine were no eligible patients (24.7%), lack of information (52.6%), need for hospital prescription (31.2%), and lack of experience (79.2%). Fifty-four percent of the dermatologists prescribed methotrexate for adult AD. Before initiating treatment, 50.5% did not perform evaluation scoring. Reasons for not prescribing methotrexate were no eligible patients (46.7%), lack of information (39.3%), lack of experience (25.2%), and not approved for AD (47.4%). A total of 2.1% dermatologists prescribed other systemic treatments for adult AD, 9.8% prescribed corticosteroids and 56.4% prescribed dupilumab.
Systemic treatments for AD are used by half of dermatologists, although cyclosporine and dupilumab must be initiated in hospitals in France. Methotrexate is more frequently used than cyclosporine, although it is not approved for this indication in France. A vast majority of dermatologists do not perform any evaluation scoring before initiating systemic treatment for adult AD.
Purpose: Hidradenitis suppurativa (HS) is an inflammatory skin disease characterized by recurrent or chronic painful and suppurating lesions in the apocrine gland-bearing regions. The lack of ...knowledge about HS and its extremely heterogeneous clinical presentation, in terms of both lesion appearance and sites of involvement, frequently delay its diagnosis for several years. Objectives: in this study, using the latent class analysis, it was demonstrated that severity of HS could be evaluated not only with clinical or surgical characteristics but also with gender specificities. Patients and Methods: Clinical and sociodemographic data of HS patients were retrospectively analysed with the latent class method in order to create a classification tool of disease severity. Results: From the study of 1428 HS patients (544 men and 884 women), two classification models, depending on gender, were developed. Each classification model was composed of three distinct latent classes clearly identified and defined from mild-to- severe cases of HS. These classification models of HS severity were not distorted by patient ages and were coherent with Hurley stages but were more clinically precise. Conclusion: In this study, a convenient classification tool, useful for facilitating decision support in routine practice, has been developed. This tool could be used to define clinical subgroups within a study population. Keywords: hidradenitis suppurativa, classification, severity, latent class, Hurley stage
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