The CYGNO/INITIUM experiment Amaro, F. D.; Baracchini, Elisabetta; Benussi, L. ...
SciPost physics proceedings,
07/2023
12
Journal Article
Recenzirano
Odprti dostop
The CYGNO project for the development of a high precision optical readout gaseous TPC for directional Dark Matter search and solar neutrino spectroscopy will be presented. It is to be hosted at ...Laboratori Nazionali del Gran Sasso. CYGNO peculiar features are the use of sCMOS cameras and PMTs coupled to GEMs amplification of a helium-based gas mixture at atmospheric pressure, in order to achieve 3D tracking with head tail capability and background rejection down to O(keV) energy, to boost sensitivity to low WIMP masses. The latest R&D results within the CYGNO project will be discussed along with the underground installation and operation of a 50 l prototype, soon to be followed by a O(1) m3 experiment demonstrator in 2024-2026. The latest results on the negative ion drift operation at atmospheric pressure within CYGNO optical readout approach will be illustrated, which is the aim of the ERC Consolidator Grant project INITIUM.
Optical readout of Gas Electron Multipliers (GEM) provides very interesting performance and has been proposed for different applications in particle physics. In particular, thanks to its good ...efficiency in the keV energy range, it is being developed for low-energy and rare event studies, such as Dark Matter searches. So far, the optical approach has only exploited the light produced during the avalanche processes in GEM channels. Further luminescence in the gas can be induced by electrons accelerated by a suitable electric field. The CYGNO collaboration studied this process with a combined use of a triple-GEM structure and a grid in an He/CF4 (60/40) gas mixture at atmospheric pressure. Results reported in this paper allow to conclude that with an electric field of about 11 kV/cm a photon production mean free path of about 1.0 cm was found.
The performances of an optical readout of Time Projection Chambers (TPCs) with multiple Gas Electron Multipliers (GEMs) amplification stages are presented. The detector is characterized by using 55Fe ...photons converting inside a 7 litre sensitive volume detector in different electric field configurations. This prototype is developed as part of the R&D for the CYGNO project for an application to direct Dark Matter search by detection of tracks of nuclear recoils in the gas within the keV energy range.
The INFN Cloud project was launched at the beginning of 2020, aiming to build a distributed Cloud infrastructure and provide advanced services for the INFN scientific communities. A Platform as a ...Service (PaaS) was created inside INFN Cloud that allows the experiments to develop and access resources as a Software as a Service (SaaS), and CYGNO is the betatester of this system. The aim of the CYGNO experiment is to realize a large gaseous Time Projection Chamber based on the optical readout of the photons produced in the avalanche multiplication of ionization electrons in a GEM stack. To this extent, CYGNO exploits the progress in commercial scientific Active Pixel Sensors based on Scientific CMOS for Dark Matter search and Solar Neutrino studies. CYGNO, like many other astroparticle experiments, requires a computing model to acquire, store, simulate and analyze data typically far from High Energy Physics (HEP) experiments. Indeed, astroparticle experiments are typically characterized by being less demanding of computing resources with respect to HEP ones but have to deal with unique and unrepeatable data, sometimes collected in extreme conditions, with extensive use of templates and montecarlo, and are often re-calibrated and reconstructed many times for a given data set. Moreover, the varieties and the scale of computing models and requirements are extremely large. In this scenario, the Cloud infrastructure with standardized and optimized services offered to the scientific community could be a useful solution able to match the requirements of many small/medium size experiments. In this work, we will present the CYGNO computing model based on the INFN cloud infrastructure where the experiment software, easily extendible to similar experiments to similar applications on other similar experiments, provides tools as a service to store, archive, analyze, and simulate data.
Enantiomeric pairs of 11 dansyl derivatives of α-amino acids were used as analytes in electrokinetic chromatography to test the ability as chiral selectors of two pure derivatives of β-cyclodextrin: ...the ethylendiamine derivative in primary position (CDen) and a member of a new class of receptors, the cysteamine-bridged hemispherodextrin THCMH. The selectivity obtained by the presence of the hemispherodextrin, appears particularly promising as shown by the large values of resolution obtained. The importance of a detailed analysis of these data is discussed in terms of suggestions for a rational approach to separation science.
The enantioseparation of the enantiomeric pairs of 10 Dns derivatives of α-amino acids was successfully carried out by using for the first time the 3-amino derivative of the γ-cyclodextrin. The ...effects of pH and selector concentration on the migration times and the resolutions of analytes were studied in detail. 3-Deoxy-3-amino-2(S),3(R)-γ-cyclodextrin (GCD3AM) shows very good chiral recognition ability even at very low concentrations at all the three investigated values of pH, as shown by the very large values of selectivity and resolution towards several pairs of amino acids. The role played by the cavity, the substitution site and the protonation equilibria on the observed properties of chiral selectivity, on varying the specific amino acid involved, is discussed.
Major depressive disorder (MDD) is one of the leading causes of global disability. It is a risk factor for noncompliance with medical treatment, with about 40% of patients not responding to currently ...used antidepressant drugs. The identification and clinical implementation of biomarkers that can indicate the likelihood of treatment response are needed in order to predict which patients will benefit from an antidepressant drug. While analyzing the blood plasma proteome collected from MDD patients before the initiation of antidepressant medication, we observed different fibrinogen alpha (FGA) levels between drug responders and nonresponders. These results were replicated in a second set of patients. Our findings lend further support to a recently identified association between MDD and fibrinogen levels from a large-scale study.
The realization and characterization of a high quality factor resonator composed of two hollow-dielectric cylinders with its pseudo-TM030 mode resonating at 10.9 GHz frequency is discussed. The ...quality factor was measured at the temperatures 300 K and 4 K obtaining Q300K=(150,000±2,000) and Q4K=(720,000±10,000)respectively, the latter corresponding to a gain of one order of magnitude with respect to a traditional copper cylindrical-cavity with the corresponding TM010 mode resonating at the same frequency. The implications to dark-matter axion-searches with cavity experiments are discussed showing that the gain in quality factor is not spoiled by a reduced geometrical coupling C030 of the cavity mode to the axion field. This reduction effect is estimated to be at most 20%. Numerical simulations show that frequency tuning of several hundreds MHz is feasible.
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