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zadetkov: 89
1.
  • Whole-genome sequencing rev... Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities
    Oben, Bénedith; Froyen, Guy; Maclachlan, Kylee H ... Nature communications, 03/2021, Letnik: 12, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Multiple myeloma (MM) is consistently preceded by precursor conditions recognized clinically as monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). We interrogate ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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2.
  • Are we ready to look beyond... Are we ready to look beyond plasma cells in assessing high-risk smoldering myeloma?
    Maclachlan, Kylee H.; Lesokhin, Alexander M. Cancer cell, 11/2022, Letnik: 40, Številka: 11
    Journal Article
    Recenzirano
    Odprti dostop

    Sklavenitis-Pistofidis et al. report clinical and correlative results of a single-arm phase II trial of elotuzumab, lenalidomide, and dexamethasone in patients with high-risk smoldering myeloma. The ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
3.
  • Copy number signatures pred... Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma
    Maclachlan, Kylee H.; Rustad, Even H.; Derkach, Andriy ... Nature communications, 08/2021, Letnik: 12, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Abstract Chromothripsis is detectable in 20–30% of newly diagnosed multiple myeloma (NDMM) patients and is emerging as a new independent adverse prognostic factor. In this study we interrogate 752 ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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4.
  • Revealing the impact of str... Revealing the impact of structural variants in multiple myeloma
    Rustad, Even H; Yellapantula, Venkata D; Glodzik, Dominik ... Blood cancer discovery, 11/2020, Letnik: 1, Številka: 3
    Journal Article
    Recenzirano
    Odprti dostop

    The landscape of structural variants (SVs) in multiple myeloma remains poorly understood. Here, we performed comprehensive analysis of SVs in a large cohort of 752 multiple myeloma patients by low ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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5.
  • First-in-Human RNA Polymera... First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study
    Khot, Amit; Brajanovski, Natalie; Cameron, Donald P ... Cancer discovery, 08/2019, Letnik: 9, Številka: 8
    Journal Article
    Odprti dostop

    RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of oncogenic pathways, and its dysregulation is a common feature in cancer. We evaluated CX-5461, ...
Celotno besedilo
Dostopno za: UL

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6.
  • The biological and clinical... The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma
    Cirrincione, Anthony M.; Poos, Alexandra M.; Ziccheddu, Bachisio ... Blood, 2024-May-10, Letnik: 144, Številka: 7
    Journal Article
    Recenzirano

    •HY, historically considered an initiating event in MM, can be preceded by deletions involving driver genes.•Deletions within large chromosomal gains represent a novel mechanism that impacts both ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
7.
Celotno besedilo
Dostopno za: EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
8.
Celotno besedilo
Dostopno za: EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
9.
  • Gene interaction network an... Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival
    Simhal, Anish K; Maclachlan, Kylee H; Elkin, Rena ... Blood cancer journal, 11/2023, Letnik: 13, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    The plasma cell cancer multiple myeloma (MM) varies significantly in genomic characteristics, response to therapy, and long-term prognosis. To investigate global interactions in MM, we combined a ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
10.
  • Minimal residual disease in... Minimal residual disease in multiple myeloma: defining the role of next generation sequencing and flow cytometry in routine diagnostic use
    Maclachlan, Kylee H.; Came, Neil; Diamond, Benjamin ... Pathology, April 2021, 2021-Apr, 2021-04-00, 20210401, Letnik: 53, Številka: 3
    Journal Article
    Recenzirano

    For patients diagnosed with multiple myeloma (MM) there have been significant treatment advances over the past decade, reflected in an increasing proportion of patients achieving durable remissions. ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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zadetkov: 89

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