Atypical hemolytic uremic syndrome (aHUS) is associated with significant mortality and morbidity, including acute renal injury, anemia and thrombocytopenia. Rare cases of aHUS in a child with acute ...leukemia before diagnosis or during chemotherapy have been reported. We report a pediatric case of B-cell acute lymphoblastic leukemia complicated by pancreatitis with concomitant aHUS following induction chemotherapy.
The pre- and post-scission neutron multiplicities are measured for the fission of 208Rn, populated with the reactions 30Si+178Hf and 48Ti+160Gd in the excitation energy range of 54.5 - 80.8 MeV. We ...found significant differences in the pre-scission neutron multiplicities of these two systems. Also, both the reactions exhibit an enhancement in the pre-scission multiplicity with respect to the existing data for the 16O+194Pt reaction populating 210Rn. The measured multiplicities are compared with the theoretical predictions obtained from the Langevin dynamical model for fission. Dynamical simulations are also performed to estimate the capture cross-sections. Contribution of the neutrons, emitted during the fusion process, is shown to be crucial in determining the neutron multiplicities for the present systems. Moreover, in case of the 48Ti+160Gd reaction, rapid quasi-fission dynamics prevents neutron emission from the thermalized target-projectile composite. The present measurement helps us to understand the relative importance of fusion and quasi-fission processes and their timescales depending on the entrance channel mass asymmetry.
Background
Medullary sponge kidney (MSK) disease predisposes patients to recurrent nephrolithiasis, which affects one in every 5000 people in the United States.
Methods
We report a rare case of a ...pediatric recipient of a living donor MSK transplant and discuss considerations when discussing risks and benefits of accepting MSK allografts for this population.
Results
The recipient was admitted due to concerns for nephrolithiasis, hydronephrosis, and urinary tract infection at 1‐month post‐transplant. The hydronephrosis was resolved by surgical removal of an encrusted ureteral stent; this was followed by supplementation with oral medications to prevent future episodes of nephrolithiasis. The recipient did not have any further episodes after this as seen at a 1‐year follow‐up. The donor has remained well through this period.
Conclusions
With increasing organ shortages, the use of variety of donors may need to be considered to enlarge the organ pool.
Fission-fragment mass distributions were measured for 225,227Pa nuclei formed in fusion reactions of 19F+206,208Pb around fusion barrier energies. Mass-angle correlations do not indicate any ...quasi-fission like events in this bombarding energy range. Mass distributions were fitted by Gaussian distribution and mass variance extracted. At below-barrier energies, the mass variance was found to increase with decrease in energy for both nuclei. Results from present work were compared with existing data for induced fission of 224,226Th and 228U around barrier energies. Enhancement in mass variance of 225,227Pa nuclei at below-barrier energies shows evidence for presence of asymmetric fission events mixed with symmetric fission events. This is in agreement with the results of mass distributions of nearby nuclei 224,226Th and 228U where two-mode fission process was observed. Two-mode feature of fission arises due to the shell effects changing the landscape of the potential-energy surfaces at low excitation energies. The excitation-energy dependence of the mass variance gives strong evidence for survival of microscopic shell effects in fission of light actinide nuclei 225,227Pa with initial excitation energy ∼30–50 MeV.
Heart transplant recipients frequently require kidney transplantation for concomitant advanced chronic kidney disease. Data on simultaneous (heart and kidney transplants performed simultaneously) ...versus sequential (heart transplant performed before kidney) heart-kidney transplants in children are limited. Herein, we compare kidney transplant outcomes between the two groups.
We used the Scientific Registry of Transplant Recipients to identify all pediatric (age <21 years) heart transplant recipients who also received a kidney transplant within 10 years of the heart transplant. We divided the study cohort into simultaneous heart-kidney and sequential heart-kidney recipients. We compared patient and death-censored graft survival using the Cox regression, adjusting for age at kidney transplant, sex, race, pre-transplant dialysis, donor type, and prior kidney transplant. We evaluated delayed graft function (defined as dialysis within the first week posttransplant) using logistic regression.
Our analysis cohort included 165 recipients (86 simultaneous and 79 sequential). The incidence of delayed graft function was higher in simultaneous recipients (22.4 vs. 7.7%, p=0.017), but the difference lost statistical significance on multivariable analysis. We found no difference in patient survival (aHR 0.97; 95% CI 0.39, 2.41; p=0.95) after kidney transplant but higher death-censored kidney graft survival in sequential heart-kidney recipients compared with simultaneous heart-kidney recipients (aHR 4.26; 95% CI 1.21, 14.9; p=0.02).
Sequential heart-kidney transplants are associated with higher death-censored kidney allograft survival in children compared with simultaneous heart-kidney transplants.
15O(α,γ)19Ne is regarded as one of the most important thermonuclear reactions in type I X-ray bursts. For studying the properties of the key resonance in this reaction using β decay, the existing ...Proton Detector component of the Gaseous Detector with Germanium Tagging (GADGET) assembly is being upgraded to operate as a time projection chamber (TPC) at FRIB. This upgrade includes the associated hardware as well as software and this paper mainly focusses on the software upgrade. The full detector set up is simulated using the ATTPCROOTv 2 data analysis framework for 20Mg and 241Am.
Abstract only Background: The prevalence of clinical HTN in children and adolescents is 3.5%. Measuring BP with an inappropriate cuff is the most common cause of misdiagnosing hypertension. Incorrect ...measurement can result in unnecessary investigations, treatment, and follow-up for the mistaken diagnosis of hypertension, or no treatment for hypertension in individuals mistakenly thought to have normal BP. Methods: A Prospective case control study of healthy children 4-12 years of age visiting Flushing Hospital Medical Center ACC, between Jan-Nov 2018. Data collected included age, gender, ethnicity, body mass index (BMI), arm circumference, and BP values obtained with different size cuffs. Subjects were divided into 4 BMI groups, differentiated as underweight (B1, BMI < 18.5), normal weight (B2,18.5-24.9), overweight (B3,25-29.9), or obese( B4, > 30). Result: The study was conducted with 137 patients with average age of 7.67 ± 2.48 (Median age 7.0). The study sample included 64 (43%) females and 73 (57%) males with 91% were Hispanic. Two patients were obese and given the limited sample size were excluded.The systolic BP was found to be 5 mmHg less with the larger cuff and 5 mmHg more with the smaller cuff. A one-way ANOVA was done to compare the effect of age on changes in systolic BP when a larger cuff was used. These was no statistical significance between changes in systolic BP for the different age groups (F(8,125)=1.318, p =0.2407). A one-way ANOVA was done to compare the effect of BMI on changes in systolic BP when a larger cuff was used. There was no statistical significance between changes in systolic BP for the BMI groups (F(2,131)=2.349, p =0.09). The same was done for the smaller cuff and systolic BP. No statistically significant change was found because of age (F(8,113)=0.7423, p=0.65 ) or BMI (F(2,119)=2.916, p =0.05). No statistical/clinical difference was found when measuring diastolic BP. Conclusions: Systolic BP in children aged 4-12 years was 5 mmHg higher when measured with a smaller cuff and 5 mmHg lower when measured with a larger cuff. Diastolic BP was not clinically significant for different cuff sizes. Age and BMI did not affect the differences in BP measurement.
Statistical model calculations for evaporation residue and fission cross-sections are performed for 210Po nucleus populated by 18O + 192Os system in the excitation energy range of 52.43 - 83.51 MeV. ...Experimental fusion cross-sections are fitted using CCFULL code. Evaporation residue and fission cross-sections are then fitted using Bohr-Wheeler formalism including shell effects in level density and fission barrier by using scaling factor (Kf) in the range of 1.0 to 0.75. The results of the calculations are in good agreement with the experimental data.
While there are increasing reports of acute kidney injury among hospitalized adults with COVID-19, there is still limited information on renal complications associated with COVID-19 in children. The ...cause of kidney involvement in COVID-19 is likely multifactorial, and appears to involve a complex process, including complement dysregulation and thrombotic microangiopathy. We present a pediatric case of COVID-19 and renal failure due to thombotic microangiopathy, successfully treated with eculizumab.
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