In addition to exhibited antioxidant and anti-inflammatory activity, fullerene C60 is a promising wound healing agent. An important stage in the production of fullerene-based ointments is the ...stability of the aqueous fullerene dispersion (AFD) with minimum size of colloidal fullerene aggregates and sufficiently high concentration. To achieve these parameters tangential flow filtration of fullerene C60 was used (“green technology”).
As estimated by small-angle neutron scattering and dynamic light scattering purified AFDs with narrow-size distribution nanoclusters have a size of 6 nm and are assembled into agglomerates which reach a size of 150 nm.
The ability of the AFD to exhibit regenerative activity was studied using the animal wound model. This study shows for the first time that the fullerene-based composition stimulates the healing of wounds of various origins. We assume that the mechanism of the AFD wound-healing activity is associated with the aryl hydrocarbon receptor and macrophages activity.
The aqueous dispersion of fullerene C60 (AFD)–based ointment demonstrated a high wound healing activity on animal model. AFD produced by diafiltration in the presence of the biocompatible nonionic stabilizer Pluronic F-127. As estimated by small-angle neutron scattering and dynamic light scattering, AFD contains nanoparticles (~6 nm) with narrow size distribution formed branched aggregates up to 150 nm. Display omitted
•The presence of spatial spin-modulated structure (SSMS) in Bi1-yLayFeO3 is confirmed.•The SSMS is characterised by a positive magnetic anisotropy constant Κu > 0 at 4.2 K.•At 300 K Κu > 0 for y = 0 ...– 0.03 while Κu < 0 for higher La content.•At 300 K for y = 0.03 – 0.05 the SSMS is close to harmonic.•A high-frequency peak proportional to La content was observed in 57Fe NMR spectra.
In this paper we present study of the magnetic structure of multiferroic series Bi1-yLayFeO3 (y = 0, 0.015, 0.03, 0.05 and 0.10) using nuclear magnetic resonance (NMR) at 4.2 K and Mössbauer spectroscopy at room temperature on 57Fe nuclei. We observed the presence of cycloid type spatial spin-modulated structure (SSMS) in the whole range of compositions. The study of the concentration dependence of the anharmonicity parameter m revealed that at the temperature of liquid helium in the composition region y = 0 – 0.10 as well as at room temperature for y = 0.03 the magnetic state of multiferroics is described by cycloid type SSMS with a positive effective uniaxial constant of magnetic anisotropy Κu > 0 (“easy axis” model). The study at room temperature in turn revealed that magnetic state of the multiferroics with y = 0 – 0.03 is described by cycloid type SSMS with a positive effective uniaxial constant of magnetic anisotropy Κu > 0 (“easy axis” model). In contrast, the magnetic state of multiferroics with y = 0.05 and 0.10 is described by a negative effective uniaxial constant of magnetic anisotropy Κu < 0 (“easy plane” model). Anharmonicity parameter m at room temperature for y = 0.03 – 0.05 is close to zero, which means that SSMS in this range of compositions is close to harmonic.
Throughout history, humans have been attempting to develop the ornamental features of domestic animals in addition to their productive qualities. Many chicken breeds have developed tufts of elongated ...feathers that jut out from the sides and bottom of the beak, leading to the phenotype known as muffs and beard. It is an incomplete autosomal dominant phenotype determined by the Mb locus localised on chromosome GGA27. This project aimed to analyse the genetic diversity of chicken breeds using full genomic genotyping with the Chicken 60K BeadChip. A total of 53,313 Single Nucleotide Polymorphisms were analysed. DNA was obtained from breeds with the muffs and beard as a marker phenotype: Faverolles (n = 20), Ukrainian Muffed (n = 18), Orloff (n = 20), Novopavlov White (n = 20), and Novopavlov Coloured (n = 15). The Russian White (n = 20) was selected as an alternative breed without the muffs and beard phenotype. The chickens are owned by the Centre of Collective Use "Genetic Collection of Rare and Endangered Breeds of Chickens" (St. Petersburg region, Pushkin), and are also included in the Core Shared Research Facility (CSRF) and/or Large-Scale Research Facility (LSRF). Multidimensional scaling revealed that the Novopavlov White and the Novopavlov Coloured populations formed a separate group. The Ukrainian Muffed and the Orloff have also been combined into a separate group. Based on cluster analysis, with the cross-validation error and the most probable number of clusters K = 4 taken into account, the Orloff was singled out as a separate group. The Ukrainian Muffed exhibited a notable similarity with the Orloff under the same conditions. At K = 5, the populations of the Novopavlov White and the Novopavlov Coloured diverged. Only at K = 6, a distinct and separate cluster was formed by the Ukrainian Muffed. The Russian White had the greatest number of short (1-2 Mb) homozygous regions. If the HOXB8 gene is located between 3.402 and 3.404 Mb on chromosome GGA27, homozygous regions are rarely found in the chickens with the muffs and beard phenotype. Scanning the chicken genome with the Chicken 60K BeadChip provided enough information about the genetic diversity of the chicken breeds for the peculiarities of the development of the ornamental muffs and beard phenotypes in them to be understood. For example, Phoenix bantams, whose tail feathers grow throughout their lives, require greater consideration of husbandry conditions.
Due to the physical, chemical, biological characteristics and high biocompatibility, the hydrogels based on plant polysaccharides and proteins became a sought-after material in many fields. Such ...hydrogels are the water swelling biopolymer matrices that react reversibly on minor changes in composition and in the external environment. However, the mechanical and electrical properties of "pure" hydrogels inhibit their wide practical application. One of approachs to improve their properties is the usage of carbon nanotubes, which provide good electrical conductivity and can significantly improve the characteristics of materials. The effects of carbon nanotubes on electric conductivity and mechanic properties of hydrogels based on natural biopolymers (gelatin and κ-carrageenan) of different composition were investigated. The electrical conductivity of the gels was studied using InoLab Cond 7310 SET1 conductometer. The rheological properties of hydrogels were investigated by Anton Paar MCR 302 rheometer. Such characteristics as temperature, frequency and amplitude dependencies of the storage modulus and the loss modulus of hydrogels were obtained. It was found that the addition of carbon nanotubes led to the increase in electrical conductivity of hydrogels. The morphology and rheological properties of studied hydrogels alter significantly in the presence of carbon nanotubes. The obtained data indicate the possibility of a purposeful change in electrical and mechanical properties of hydrogels by the addition of carbon nanotubes.
•Magnetic H-T phase diagram of a Fe/Gd ferrimagnetic superlattice is obtained.•Collinear, twisted and surface twist magnetic states are identified.•Two spectral branches of ferromagnetic resonance ...are observed.•The observed modes correspond to different types of non-uniform precession in Gd.
Static and dynamic magnetic properties of a ferrimagnetic Fe(35Å)/Gd(50Å)12 superlattice were investigated in a wide 4–300 K temperature range using magneto-optical Kerr effect (MOKE) and ferromagnetic resonance (FMR) techniques. The multilayer structure was sputtered on a transparent glass substrate which made it possible to perform MOKE measurements on both Fe and Gd terminated sides of the superlattice. These experiments allowed us to detect a transition between field-aligned and canted magnetic states on both sides of the film and to distinguish between the bulk and surface twisted phases of the superlattice. As a result, the experimental H-T magnetic phase diagram of the system was obtained. FMR studies at frequencies 7–36 GHz demonstrated a complex evolution of absorption spectra as temperature decreased from room down to 4 K. Two spectral branches were detected in the sample. Theoretical simulations show that the observed spectral branches correspond to different types of inhomogeneous resonance modes in the multilayer with non-uniform magnetization precession inside Gd layers.
Sleep Disorders in Patients after COVID-19 Ahmet’yanov, M. A.; Reikhert, L. I.; Kicherova, O. A. ...
Neuroscience and behavioral physiology,
06/2022, Letnik:
52, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Healthy sleep is required to ensure the body’s homeostatic stability, the consistency of immunological reactions, and optimum functioning of the internal organs, the nervous system, and cognitive ...functions. Patterns of changes to the circadian rhythms have been studied in many diseases, though infection with SARS-CoV-2 is a new reality and the basic mechanisms of functioning of the body in this pathology require deeper investigation. Despite the difficulty of analytical investigations in pandemic conditions, experience of the diagnosis of COVID-19 has now been acquired and treatment algorithms have been developed for different clinical situations; vaccines have been developed. Least studied are questions of the long-term sequelae of COVID-19. At the same time, there are good grounds for suggesting that patients need long-term rehabilitation in the post-covid period of SARS-CoV-2, for reasons including damage to the nervous system. Analysis of publications – from descriptions of clinical cases to literature reviews – allows empirical experience to be accumulated, providing the opportunity for future identification of prognostic markers for the disease for effective prevention of long-term sequelae. The results of current prospective studies draw attention to the occurrence of dyssomnia and obstructive sleep apnea not only as a common consequence of coronavirus infection, but also as a factor significantly worsening the prognosis in the acute period of illness. It has repeatedly been shown that sleep deprivation has adverse influences on the body’s resistance, including to SARS-CoV-2, and requires correction to improve prognoses in the acute and long-term periods of illness in COVID-19 patients.
According to WHO, cancer is the cause of ~5 million deaths annually. To date, there is no universal solution to fight cancer despite outstanding achievements of radiotherapy, chemotherapy, and ...immunotherapy. In this regard, there is a need to develop new approaches to antitumor therapy, in particular based on the search and use of targeted molecules that allow killing tumor cells of various types with high efficiency without significant toxic effects on healthy organs and tissues. This review presents the characteristics of the main proteins of the heat shock proteins (HSP) family, the features of their expression in tumor cells, and the possibility of using monoclonal antibodies against these proteins as a guiding vector for antitumor immunotherapy.
Method of carbon nanotubes disaggregation with the help of protein material, gelatin, has been proposed which facilitate to disperse evenly nanotubes in hydrogels based on gelatin and polysaccharides ...(sodium alginate or κ-carrageenan). In the obtained composite hydrogels carbon nanotubes are located in the biopolymer matrix, i.e. being in biocompatible form without losing their unique properties. The removal of water from the pores of the hydrogel by means of freeze drying allowed to obtain materials having high porosity and with included carbon nanotubes. The produced hydrogels can be used to create eco-friendly composite materials for biomedical and technical purposes. Depending on the tasks the developed systems can also be used in the forms of xerogel (films), cryogel, aerogel, and even in the form of powder, containing carbon nanotubes.
The associative behavior of
n
-alkanes in petroleum dispersed systems and its changes under different temperature conditions were studied using dynamic light scattering, as well as optical, electron, ...and atomic force microscopy. Within the framework of the previously proposed hypothesis about the presence of associates (coacervates) of
n
-alkanes in crude oil systems,
i.e.
, microparticles with a shell and a specific internal composition and structure, studies of the sizes of the existing structures were carried out at two different temperatures. It was shown that in the studied paraffinic oil system the associates remained even at elevated temperatures.
Modern technologies are constantly evolving, almost continuously various innovations aimed at improving life appear in various branches. In addition to the rapidly growing number of inventions, the ...amount of information in public access is also growing. To store and process large volumes of information, BIG DATA technologies are used, which help improve the quality of urban planning studies. The article discusses the possibilities of using BIG DATA in urban planning, lists possible areas for using geographic information systems in economics, medicine, transport, environmental management, construction, municipal and state administration, science, and investment activities. There is identified possible users of GIS at various levels of management. The authors define the role of the federal universities in the creation, management of GIS, and training in this area.
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