The paper presents a current status of the simulation of the pure CsI crystal calorimeter of the detector of charm-tau factory project in Novosibirsk. The calorimeter employs the scheme with the ...crystals focusing at the beams interaction point to obtain the optimal energy and coordinate resolutions. We present a detailed description of the calorimeter design, optimized using the specially developed parametrized crystal geometry generator. The report also presents the results for the coordinate and energy correction functions calculation. After application of these corrections the estimation of the photon energy and coordinate resolutions for the ideal conditions of negligibly small stochastic, electronic and pileup noises was performed. The π0 reconstruction efficiency and mass resolution depending on it's momentum were also determined.
Abstarct
In
Drosophila melanogaster
differentiation of the male germ cells is accompanied by chromatin rearrangement and activation of the specific genes. These processes are regulated by few ...transcription factors that belong to two classes,
can
and
aly
that form distinct functional complexes. Mechanisms of action of
aly
and
can
class transcription factors on gene expression and chromatin state remain unclear. To investigate this question we have built the whole genome binding profile of transcription factor Comr belonging to
aly
class using the tissue-specific DamID method. Resulting data were correlated with gene expression in
comr
(
aly
class) and
can
(
can
class) mutant testes. It was shown that Comr is a direct activator for about 300 testis-specific genes. Furthermore a set of genes revealed decreased expression in
comr
mutants but did not bind Comr protein, suggesting the existence of secondary regulation. Indeed, among the Comr gene targets we found a gene coding an uncharacterized transcription factor that could be a secondary participant in the genetic pathway in spermatocytes. These date allowed us to advance a model of gene activation needed for male gametes differentiation in
D. melanogaster
.
The ratio of the electron and muon widths of the J/ psi J/ psi meson has been measured using direct J/ psi J/ psi decays in the KEDR experiment at the VEPP-4M electron-positron collider. The result ...Gamma e+e-(J/ psi )/ Gamma mu + mu -(J/ psi )=1.0022 plus or minus 0.0044 plus or minus 0.0048(0.65%) is in good agreement with the lepton universality. The experience collected during this analysis will be used for J/ psi J/ psi lepton width determination with up to 1% accuracy.
Measurement of parameters Anashin, V V; Aulchenko, V M; Baldin, E M ...
Physics letters. B,
05/2012, Letnik:
711, Številka:
3-4
Journal Article
Recenzirano
We report the final results of a study of the psi ( 3770 ) meson using a data sample collected with the KEDR detector at the VEPP-4M electron-positron collider. The data analysis takes into account ...interference between the resonant and nonresonant D D macr production, where the latter is related to the nonresonant part of the energy-dependent form factor F D . The vector dominance approach and several empirical parameterizations have been tried for the nonresonant F D N R ( s ) . Our results for the mass and total width of psi ( 3770 ) are M = 3779.2 - 1.7 + 1.8 - 0.7 + 0.5 - 0.3 + 0.3 MeV , Gamma = 24.9 - 4.0 + 4.6 - 0.6 + 0.5 - 0.9 + 0.2 MeV , where the first, second and third uncertainties are statistical, systematic and model, respectively. For the electron partial width two possible solutions have been found: ( 1 ) Gamma e e = 154 - 58 + 79 - 9 + 17 - 25 + 13 eV , ( 2 ) Gamma e e = 414 - 80 + 72 - 26 + 24 - 10 + 90 eV . Our statistics are insufficient to prefer one solution to another. The Solution (2) mitigates the problem of non- D D macr decays but is disfavored by potential models. It is shown that taking into account the resonance-continuum interference in the near-threshold region affects resonance parameters, thus the results presented cannot be directly compared with the corresponding PDG values obtained ignoring this effect.
A high-precision determination of the main parameters of the psi ( 2 S ) resonance has been performed with the KEDR detector at the VEPP-4M e + e - collider in three scans of the psi ( 2 S ) - psi ( ...3770 ) energy range. Fitting the energy dependence of the multihadron cross section in the vicinity of the psi ( 2 S ) we obtained the mass value M = 3686.114 plus or minus 0.007 plus or minus 0.011 - 0.012 + 0.002 MeV and the product of the electron partial width by the branching fraction into hadrons Gamma e e B h = 2.233 plus or minus 0.015 plus or minus 0.037 plus or minus 0.020 keV . The first and second uncertainties are statistical and systematic, respectively. The third uncertainty quoted is an estimate of the model dependence of the result due to assumptions on the interference effects in the cross section of the single-photon e + e - annihilation to hadrons explicitly considered in this work. Implicitly, the same assumptions were employed to obtain the charmonium leptonic width and the absolute branching fractions in many experiments. Using the result presented and the world average values of the electron and hadron branching fractions, one obtains the electron partial width and the total width of the psi ( 2 S ) : Gamma e e = 2.282 plus or minus 0.015 plus or minus 0.038 plus or minus 0.021 keV , Gamma = 296 plus or minus 2 plus or minus 8 plus or minus 3 keV . These results are consistent with and more than two times more precise than any of the previous experiments.
We report results of a search for narrow resonances in e super(+e) super(-) annihilation at center-of-mass energies between 1.85 and 3.1 GeV performed with the KEDR detector at the VEPP-4M e ...super(+e) super(-) collider. The upper limit on the leptonic width of a narrow resonance inline image has been obtained (at 90% C.L.).
Cytochrome (CYP) 450 isoenzymes are the basic enzymes involved in Phase I biotransformation. The most important role in biotransformation belongs to CYP3A4, CYP2D6, CYP2C9, CYP2C19 and CYP1A2. ...Inhibition and induction of CYP isoenzymes caused by drugs are important and clinically relevant pharmacokinetic mechanisms of drug interaction. Investigation of the activity of CYP isoenzymes by using phenotyping methods (such as the determination of the concentration of specific substrates and metabolites in biological fluids) during drug administration provides the prediction of negative side effects caused by drug interaction. In clinical practice, the process of phenotyping of CYP isoenzymes and some endogenous substrates in the ratio of cortisol to 6β-hydroxycortisol in urine for the evaluation of CYP3A4 activity has been deemed to be a quite promising, safe and minimally invasive method for patients nowadays.
Antimicrobial therapy, especially inactivation of multi-antibiotic-resistant strains, requires creating new approaches for drug action and targeted delivery in different environmental conditions. In ...this work, detonation nanodiamonds (DNDs) were used to deliver polycationic zinc phthalocyanines to E. coli cells. It is shown that in aqueous solutions, zinc phthalocyanines with cholinyl peripheral substituents form complexes with negatively charged DND based on electrostatic interactions. About 40–70 phthalocyanine molecules can bind to a single DND particle, depending on the number of charged groups of the dye molecule. During the complex formation, quenching of phthalocyanine fluorescence and a decrease in its ability to generate reactive oxygen species were observed. In the presence of bacterial cells, phthalocyanine left the complex and induced a photodynamic effect, the magnitude of which depended on the phthalocyanine charge, the molarity of the buffer solution, and the stoichiometry of the phthalocyanine-DND complex. It was found that at physiological values of the ionic strength of the solution, the photodynamic effect of phthalocyanine with a charge of 8+ in combination with a DND is higher than that of the initial phthalocyanine. Thus, nanodiamonds are a promising platform for the delivery of photosensitizers in antimicrobial therapy.
•Polycationic Pcs form hybrid complex (HC) with negatively charged DND.•HCs with Pc:DND > 10 are positively charged and bind to bacterial cell wall.•Pcs are released from the HC due to interaction with bacterial cell.•HC formation enhances photodynamic activity of Pc in highly buffered solutions.
Targeted delivery of photosensitizers is one of the main problems of the photodynamic therapy of cancer. Nanodiamonds hold much promise as a delivery platform because of their good sorption ...properties, functionally modifiable surfaces, and low biological toxicity of carbon. In this work, we present a rational design of nanodiamonds for targeted delivery of boronated derivative of e6 chloride to human A431 epidermoid carcinoma cells. Formation of hybrid complexes in aqueous solution is accompanied by deactivation of the excited states of the dye. This prevents generation of reactive oxygen species until the complex reaches the target. In the presence of lipid membranes, the photosensitizers leave the complex and exhibit their photodynamic activity. Modification of the nanodiamond surface by transferrin leads to an additional increase in the efficiency of photodynamic inactivation of cancer cells.
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•Nanodiamond (ND) and photosensitizer BACE form a complex in aqueous solution.•Complex formation prevents photobleaching of BACE.•In the presence of lipid membranes BACE leaves the complex and generates ROS.•Modification of the ND with transferrin enhance photodynamic effect on A431 cells.
Enhancement of optical properties of photosensitizers by additional light-harvesting antennas is promising for the improvement of the photodynamic therapy. However, large number of parameters ...determine interactions of nanoparticles and photosensitizers in complex and, thus the photodynamic efficacy of the hybrid structure. In order to achieve high efficiency of energetic coupling and photodynamic activity of such complexes it is important to know the location of the photosensitizer molecule on the nanoparticle, because it affects the spectral properties of the photosensitizer and the stability of the hybrid complex in vitro/in vivo. In this work complexes of polycationic aluminum phthalocyanines and CdSe/ZnS quantum dots were obtained. We used quantum dots which outer shell consists of polymer with carboxyl groups and provides water solubility and the negative charge of the nanoparticle. We found that phthalocyanine molecules could penetrate deeply into the polymer shell of quantum dot, leading thereby to significant changes in the spectral and photodynamic properties of phthalocyanines. We also showed that noncovalent interactions between phthalocyanine and quantum dot provide possibility for a release of the phthalocyanine from the hybrid complex and its binding to both Gram-positive and Gram-negative bacterial cells. Also, detailed characterization of the nanoparticle core and shell sizes was carried out.
•Binding to QDs affects spectral and photodynamic characteristics of Pcs•Upon binding Pcs can penetrate deeply into the polymer shell of QD•Pcs could be released from the hybrid complex due to interaction with bacterial cell
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