Intrinsic variations of the projected density profiles of clusters of galaxies at fixed mass are a source of uncertainty for cluster weak lensing. We present a semi-analytical model to account for ...this effect, based on a combination of variations in halo concentration, ellipticity and orientation, and the presence of correlated haloes. We calibrate the parameters of our model at the 10 per cent level to match the empirical cosmic variance of cluster profiles at
$M_{200m}\approx 10^{14}\ldots 10^{15}\,h^{-1}{\,\mathrm{M}_{\odot }}$
, z = 0.25…0.5 in a cosmological simulation. We show that weak lensing measurements of clusters significantly underestimate mass uncertainties if intrinsic profile variations are ignored, and that our model can be used to provide correct mass likelihoods. Effects on the achievable accuracy of weak lensing cluster mass measurements are particularly strong for the most massive clusters and deep observations (with ≈20 per cent uncertainty from cosmic variance alone at
$M_{200m}\approx 10^{15}\,h^{-1}{\,\mathrm{M}_{\odot }}$
and z = 0.25), but significant also under typical ground-based conditions. We show that neglecting intrinsic profile variations leads to biases in the mass-observable relation constrained with weak lensing, both for intrinsic scatter and overall scale (the latter at the 15 per cent level). These biases are in excess of the statistical errors of upcoming surveys and can be avoided if the cosmic variance of cluster profiles is accounted for.
Due to the COVID-19 pandemic, wearing a face mask has become an essential measure to reduce the rate of virus spreading. The aim of the study was to assess the effect of wearing a surgical face mask ...for a short period on the tear film parameters in subjects with a high body mass index (BMI).
Twenty-five females with a high BMI (31.4 ± 5.5 kg/m2) aged 18-35 years (22.7 ± 4.6 years) participated in the study. In addition, a control group consisting of 25 females (23.0 ± 6.7 years) with a high BMI (29.9 ± 4.1 kg/m2) participated in the study in which no mask was worn. The standardized patient evaluation of eye dryness (SPEED) questionnaire was completed first, followed by the phenol red thread (PRT) and tear ferning (TF) tests, before wearing the face mask. The subjects wore the face mask for 1 hour, and the measurements were performed again immediately after its removal. For the control group, the measurements were performed twice with one hour gap.
Significant (Wilcoxon test, p < 0.05) differences were found between the SPEED scores (p = 0.035) and the PRT measurement (p = 0.042), before and after wearing the surgical face mask. The PRT scores have improved after wearing the surgical face mask, while the dry eye symptoms detected by the SPEED questionnaire have increased. On the other hand, no significant (Wilcoxon test, p = 0.201) differences were found between the TF grades before and after wearing a surgical face mask. For the control group, no significant (Wilcoxon test, p > 0.05) differences were found between the two scores from the SPEED questionnaire and the PRT, and TF tests.
Wearing a surgical face mask for a short duration leads to a change in volume and quality of tears as well as dry eye symptoms in women with a high BMI.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
4.
The role of nicotinamide in acne treatment Walocko, Frances M.; Eber, Ariel E.; Keri, Jonette E. ...
Dermatologic therapy,
September/October 2017, 2017-Sep, 2017-09-00, 20170901, Letnik:
30, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Safe and effective treatment options for acne vulgaris are needed to address side effects and increasing rates of antibiotic resistance from current treatments. Nicotinamide is a vitamin with potent ...anti‐inflammatory properties that could offer a potential treatment option. We aim to summarize the relevant literature on the role of nicotinamide in acne vulgaris and discuss the next steps necessary to move this approach into clinical practice. We searched PubMed for clinical studies using nicotinamide for treatment of acne vulgaris. We summarized the 10 studies that met our search criteria. Six of eight studies using topical nicotinamide led to a significant reduction in acne compared with the patient's baseline or performed similarly to another standard‐of‐care acne treatment. Both studies using an oral supplement containing nicotinamide resulted in a significant reduction in acne compared with baseline. No major adverse side effects were noted. Our review suggests that topical and oral nicotinamide has an unclear effect on acne vulgaris due to the limited nature of the available literature. Additional studies are needed comparing nicotinamide to other first‐line acne treatments and evaluating the efficacy and side effect profile of nicotinamide over an extended period of time.
Tree bark represents an important source of medicinal compounds that may be useful for cancer therapy. In the current study, high-performance liquid chromatography with diode-array detection ...(HPLC-DAD) was used to determine the profile of the phenolic compounds of
, and
bark extracts. The antioxidant and anticancer bioactivities against different cancer cell lines were investigated.
exerted significantly higher antioxidant activities in the diphenyl picrylhydrazine and β-carotene-linoleic acid assays than the other species. In
novel profiles of phenolic acids (ferulic acid was the predominant compound) and catechin were detected. In
, six phenolic acids were detected; the predominant compounds were hydroxycaffeic acid and protocatechuic acid. In
, two phenolic acids and three catechins were detected; catechin was the predominant compound. The three species exerted clear anticancer activity against MCF-7, HeLa, Jurkat, T24, and HT-29 cells, with the strongest activity found in the extracts from
. No antiproliferative activity against normal cells was found. Flow cytometry revealed greater accumulation of necrotic and early/late apoptotic cells in various treated cancer cells than in untreated control cells, and protocatechuic acid induced a similar accumulation of necrotic cells to that of the bark extracts. Caspase-3 and -7 activity was increased in cancer cells treated with different bark extracts; the highest activity was found in the
treatment. Our results suggested that the treatment of cancer cells with bark extracts of
and
, and protocatechuic acid induced apoptosis, suggesting an association between anticancer activities and individual phenolic compounds.
and
natural populations growing in Northern Saudi Arabia might be a valuable source of polyphenols with potent biological activities. Using high-performance liquid chromatography-diode array ...detection (HPLC-DAD), several polyphenols were detected tentatively in considerable amounts in the methanolic leaf extracts of
and
mainly contained rutoside, hyperoside, quercetin 3-glucuronide, gallic acid and
-coumaric acid, whereas those of
contained apigenin 5-glucoside, apigetrin and gallic acid. Strong antioxidant activities were found in the leaf extracts of both species due to the presence of hyperoside, quercetin 3-glucuronide, gallic acid, isoquercetin,
-coumaric acid, quercitrin and rutoside.
and
leaf extracts as well as hyperoside, apigenin 5-glucoside, and quercetin 3-glucuronide significantly reduced reactive oxygen species accumulation in all investigated cancer cells compared to the control. Methanolic leaf extracts and identified polyphenols showed antiproliferative and cytotoxic activities against cancer cells, which may be attributed to necrotic cell accumulation during apoptotic periods. Antibacterial activities were also found in both species leaf extracts and were twice as high in
than
due to the high composition of rutoside and other polyphenols. Finally, strong antifungal activities were detected, which were associated with specific phenols such as rutoside, hyperoside, apigenin 5-glucoside and
-coumaric acid. This is the first study exploring the polyphenolic composition of
and
natural populations in northern Saudi Arabia and aiming at the detection of their biological activities.
Plasma potential is a key parameter in plasma discharge or fusion plasma to control plasma-wall interaction or ExB drift. The magnitude of plasma potential depends on the overall energy transmitted ...to the plasma via direct current (dc) or radio frequency (RF) devices such as electrodes or antennas. Knowing the plasma potential from the exciting source is useful to prevent high energetic fluxes to the wall or to improve the plasma confinement or explaining shear velocity. The aim of the present model is to calculate this plasma potential with respect to a dc or RF source in a magnetized or unmagnetized plasma. This double saturated probe (DSP) model takes into account the electron saturation current and is able to derive the plasma potential as a function of the electrode/wall area ratio for a dc or RF discharge in a helium/argon plasma with or without a magnetic field. The results of the model are compared with Aanesland's model in the case of unmagnetized capacitive sheath and particle-in-cell (PIC) simulations. The magnetized model is applied to a plasma column with a perpendicular capacitive current in an RF discharge. It appears that the plasma potential can increase to almost the RF potential value at a low wall/electrode area ratio (<inline-formula> <tex-math notation="LaTeX">A_{\text {wall}}/A_{\text {el}} </tex-math></inline-formula> lower than 5), while the same potential collapses as soon as the area ratio (perpendicular over the parallel current area) is higher than the electron/ion saturation current ratio. This is directly due to the saturation of electron current, preventing the plasma potential from following the imposed RF potential by the electrode, so that the maximum value can be as lower as the floating potential. The perpendicular current involved is mainly a conduction current modeled as a resistive collisional current. In fusion plasma, the maximum plasma potential can rise to higher values than in plasma discharges, but the collapse of the potential still occurs for long collisional biased flux tubes.
Purpose. Smoking has a negative effect on health and ocular tear film. The purpose of the current study is to investigate the correlation between the TearLab and I-Pen osmolarity scores in smokers ...and compare them with those of non-smoking healthy males. Methods. Thirty male smokers (25.3 ± 2.2 years) participated in the study. An age-matched (22.9 ± 2.0 years) control group of non-smoking healthy males (N = 30) was also recruited for comparison purposes. The ocular surface disease index (OSDI) was completed first, followed by the TearLab and I-Pen osmolarity measurements. Results. The median TearLab osmolarity score was lower (P < 0.001) than that obtained using the I-Pen in both the study and the control groups. The OSDI scores and osmolality measurements were higher (P < 0.001) in smokers than in the control subjects. In the smoker group, there were moderate correlations between the OSDI scores and the measurements obtained using the TearLab (Spearman’s correlation coefficient, r = 0.463; P = 0.010) and I-Pen (r = 0.449; P = 0.013) systems. In addition, there was a strong correlation between the osmolarity scores obtained from the TearLab and I-Pen systems in smokers (r = 0.911; P < 0.001). Conclusion. The I-Pen scores in smokers were significantly higher than those obtained using TearLab. The TearLab scores showed small variations compared with those obtained using I-Pen. A strong correlation was found between the TearLab and I-Pen scores in smokers. The osmolarity TearLab and I-Pen scores were significantly higher in smokers compared with normal eye subjects.
Artemisia absinthium—wormwood (Asteraceae)—is a very important species in the history of medicine, formerly described in medieval Europe as “the most important master against all exhaustions”. It is ...a species known as a medicinal plant in Europe and also in West Asia and North America. The raw material obtained from this species is Absinthii herba and Artemisiae absinthii aetheroleum. The main substances responsible for the biological activity of the herb are: the essential oil, bitter sesquiterpenoid lactones, flavonoids, other bitterness-imparting compounds, azulenes, phenolic acids, tannins and lignans. In the official European medicine, the species is used in both allopathy and homeopathy. In the traditional Asian and European medicine, it has been used as an effective agent in gastrointestinal ailments and also in the treatment of helminthiasis, anaemia, insomnia, bladder diseases, difficult-to-heal wounds, and fever. Today, numerous other directions of biological activity of the components of this species have been demonstrated and confirmed by scientific research, such as antiprotozoal, antibacterial, antifungal, anti-ulcer, hepatoprotective, anti-inflammatory, immunomodulatory, cytotoxic, analgesic, neuroprotective, anti-depressant, procognitive, neurotrophic, and cell membrane stabilizing and antioxidant activities. A. absinthium is also making a successful career as a cosmetic plant. In addition, the importance of this species as a spice plant and valuable additive in the alcohol industry (famous absinthe and vermouth-type wines) has not decreased. The species has also become an object of biotechnological research.
We present the clustering of galaxy clusters as a useful addition to the common set of cosmological observables. The clustering of clusters probes the large-scale structure of the Universe, extending ...galaxy clustering analysis to the high-peak, high-bias regime. Clustering of galaxy clusters complements the traditional cluster number counts and observable-mass relation analyses, significantly improving their constraining power by breaking existing calibration degeneracies. We use the maxBCG galaxy clusters catalogue to constrain cosmological parameters and cross-calibrate the mass-observable relation, using cluster abundances in richness bins and weak-lensing mass estimates. We then add the redshift-space power spectrum of the sample, including an effective modelling of the weakly non-linear contribution and allowing for an arbitrary photometric redshift smoothing. The inclusion of the power spectrum data allows for an improved self-calibration of the scaling relation. We find that the inclusion of the power spectrum typically brings a ∼50 per cent improvement in the errors on the fluctuation amplitude σ8 and the matter density Ωm. Finally, we apply this method to constrain models of the early universe through the amount of primordial non-Gaussianity of the local type, using both the variation in the halo mass function and the variation in the cluster bias. We find a constraint on the amount of skewness f
NL = 12 ± 157 (1σ) from the cluster data alone.
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