The process-based evaluation of adsorbents is considered the most foolproof method with respect to a particular application, as it provides data about the separation effectiveness in authentic ...operating conditions. This paper presents empirically obtained performance results of the kinetically-controlled air separation on multiple carbon molecular sieves carried out in a twin-bed pressure swing adsorption unit. The effect of adsorbent pellet size on nitrogen productivity and air demand is studied at different product purity levels (10–10,000 ppm O
2
of the residual oxygen concentration), operating temperatures (25–45 °C), and half-cycle times (35–70 s). The selected process conditions correspond to the majority of practical applications. Guidelines for the suitable particle size depending on the desired nitrogen purity are given.
With increasing nitrogen purity, PSA plants require an over-proportional air demand with the consequence that high-purity PSA systems engender a distinct interest in energy-saving measures. This ...paper presents process intensification strategies with the focus on a reduced energy consumption. Therefore, the influence of PSA configuration and cycle organisation on process performance was investigated. Results are presented at two product purity levels (10 ppm/1000 ppm O
2
) and two operating temperatures (25 °C/45 °C) in a lab-scale twin bed PSA (2 × 2 L). It is shown that dedicated strategies are available to intensify the PSA process; however, their effects are dependent on ambient conditions and product purity levels.
There has recently been tremendous progress in the development of wearable technologies for monitoring stress. The majority of wearable stress devices are based on continuous monitoring of the heart ...rate. An increased heart rate is a normal physiological response to acute emotional stress or physical exercise. It seems unlikely that such responses will directly translate to negative consequences caused by stress. More recently, wearable stress devices have been developed based on heart rate variability (HRV).3 This approach seems more rational for the assessment of vascular consequences caused by stress, particularly in the healthy population. However, the measured HRV can be attenuated in individuals suffering from diseases affecting the vascular system, such as diabetes, CVD, hypercholesterolemia, or hypertension. Therefore, HRV may not be a reliable measure of stress.
Small-scale pressure swing adsorption (PSA) plants, also referred to as pilot plants, are commonly exploited for studying separation processes in favour of the development of mathematical models and ...scale-up strategies. The applicability of a lately presented mathematical model, which was developed based on experimental data acquired from a high-purity twin-bed N
2
-PSA pilot plant, is verified in this paper for the design of large-scale systems by an analysis of the mass transfer zone development at different PSA cycle times. Effects of the PSA scale-up factor, adsorber aspect ratio, packed-bed density, and flow resistances along the piping system on the process performance are studied numerically. These considerations are particularly relevant for the scale-up of bank-type PSA units as well as for skid-mounted systems fitted to local space limitations, where the standard scale-up concept of keeping the gas velocity constant often cannot be fully realised. It is demonstrated that the sensitivity of the PSA performance to studied factors increases along with the required product purity level. Therefore, recommendations for adequate dimensions of pilot plants depending on the desired gas purity level can be derived. Limitations of the gas velocity through the adsorber shall be observed to generate reliable simulation data. The agreement between experimental results obtained from an industrial-scale system on one hand, and the outcome of a dynamic simulation on the other hand, is confirmed—provided that realistic pressure profiles are generated by a proper adjustment of flow resistances along the piping.
At present, nitrogen production from air by pressure swing adsorption (PSA) is simulated almost exclusively at low product purity levels (< 99% N
2
). However, with increasing global demand for ...highly purified gases provided by energy-efficient separation processes the requirement for either extensive experimental research in the high-purity range or predictive computer simulations arises. This paper presents a mathematical model of a twin-bed PSA plant equipped with a carbon molecular sieve (Shirasagi MSC CT-350) for the generation of high-purity nitrogen (99.9–99.999% N
2
). The model is implemented in the process simulator Aspen Adsorption™. The influence of operating conditions as well as the cycle organisation on the process performance is validated, especially the influence of pressure, temperature, half-cycle time, purge flow rate, and cutting time. The precision of the performance prediction by numerical simulations is critically discussed. Based on the new insights efficiency improvement strategies with a focus on reduced energy consumption are introduced and discussed by means of radar charts.
The global demand on highly purified gases provided by energy-efficient separation processes grows steadily since decades. An example of particular industrial relevance is nitrogen generated by ...pressure swing adsorption from compressed air. A kinetically based separation of oxygen from nitrogen is possible by means of carbon molecular sieves (CMS) since oxygen adsorbs remarkably faster in CMS than nitrogen. Even high product purities (5–1000 ppm O
2
) are easily achievable in commercial generators. However, only a few studies present experimental findings in this purity range. That comes as no surprise, since experimental conditions are not standardised and the determination of N
2
-PSA performance indicators still creates an experimental challenge. Moreover, the design of the set-up remarkably influences the experimental results. Thus it is the motivation of this study to develop a multi-step strategy, comprising the definition of a reference process, the derivation of explicit and implicit performance indicators based on either flow meter readings or macroscopic material balances, a verification strategy for experimentally obtained data, and an error consideration, which advices accuracy requirements for analysers and flow meters. The effect of cycle time and operating temperature on the performance indicators is exemplarily studied at high purities by means of the proposed strategy.
This note describes a newly developed technique for evaluation of cutaneous microcirculation. The technique called Flow Mediated Skin Fluorescence (FMSF) is based on monitoring of NADH fluorescence ...intensity emitted from the skin tissue cells of a forearm. The changes in fluorescence intensity as a function of time in response to blocking and releasing of blood flow in a forearm are used as a measure of oxygen transport with blood to the tissue, which directly correlates with the skin microcirculation status. Preliminary results collected for healthy volunteers and patients experiencing serious cardiovascular problems indicated a usefulness of FMSF technique for evaluation of health related perturbations in cutaneous microcirculation.
Purpose: The pathophysiology of chronic fatigue associated with post-COVID syndrome is not well recognized. It is assumed that this condition is partly due to vascular dysfunction developed during an ...acute phase of infection. There is great demand for a diagnostic tool that is able to clinically assess post-COVID syndrome and monitor the rehabilitation process. Patients and Methods: The Flow Mediated Skin Fluorescence (FMSF) technique appears uniquely suitable for the analysis of basal microcirculatory oscillations and reactive hyperemia induced by transient ischemia. The FMSF was used to measure vascular circulation in 45 patients with post-COVID syndrome. The results were compared with those for a group of 26 amateur runners before and after high-intensity exercise as well as for a control group of 32 healthy age-matched individuals. Results: Based on the observed changes in the NOI (Normoxia Oscillatory Index) and RHR (Reactive Hyperemia Response) parameters measured with the FMSF technique, it was found that chronic fatigue associated with post-COVID syndrome is comparable with transient fatigue caused by high-intensity exercise in terms of vascular effects, which are associated with vascular stress in the macrocirculation and microcirculation. Acute and chronic fatigue symptomatology shared similarly altered changes in the NOI and RHR parameters and both can be linked to calcium homeostasis modification. Conclusion: The NOI and RHR parameters measured with the FMSF technique can be used for non-invasive clinical assessment of post-COVID syndrome as well as for monitoring the rehabilitation process. Keywords: COVID-19, post-COVID syndrome, chronic fatigue, vascular circulation, FMSF technique
We investigate a mathematical model describing the growth of tumor in the presence of immune response of a host organism. The dynamics of tumor and immune cells populations is based on the generic ...Michaelis-Menten kinetics depicting interaction and competition between the tumor and the immune system. The appropriate phenomenological equation modeling cell-mediated immune surveillance against cancer is of the predator-prey form and exhibits bistability within a given choice of the immune response-related parameters. Under the influence of weak external fluctuations, the model may be analyzed in terms of a stochastic differential equation bearing the form of an overdamped Langevin-like dynamics in the external quasi-potential represented by a double well. We analyze properties of the system within the range of parameters for which the potential wells are of the same depth and when the additional perturbation, modeling a periodic treatment, is insufficient to overcome the barrier height and to cause cancer extinction. In this case the presence of a small amount of noise can positively enhance the treatment, driving the system to a state of tumor extinction. On the other hand, however, the same noise can give rise to return effects up to a stochastic resonance behavior. This observation provides a quantitative analysis of mechanisms responsible for optimization of periodic tumor therapy in the presence of spontaneous external noise. Studying the behavior of the extinction time as a function of the treatment frequency, we have also found the typical resonant activation effect: For a certain frequency of the treatment, there exists a minimum extinction time.