This article deals with the topic of medievalism as all existing, still evolving, and future forms of reception of the Middle Ages, focusing primarily on the issues of the term itself and the ...problems that arise with its definition, its occurrence in John Ruskin’s time, various historical forms, and their variations, especially considering some of the implications of its official or academic aspect - namely, medieval studies in general. Consequently, the article shows that medievalism entails a step beyond or beneath the usual opposition between the real and false Middle Ages. In terms of objectivity as an ideal, as the search or quest for the real Middle Ages (and also as a reaction against subjective receptions, colored by presuppositions, preconceptions, and prejudice), medievalism shifts our perspective on the opposition between the objective and subjective, inaugurating a field of study that centers on the objective-subjective, which should not be seen or taken as a synthesis. Furthermore, it pinpoints a change or shift in the status of truth itself a truth with no guarantee. Primarily making reference to art history, the article emphasizes the importance of medievalist fantasies and proposes a much needed re-reading of Panofsky’s take on the scholastic habitus. Both terms, fantasy and/or habitus, permeate the field of medievalism, opening what is perhaps the most important question that of (works of art and) materiality.
In this study, we aimed to identify patients within our B-ALL cohort with altered
. Our objective was to use a comprehensive analysis approach to characterize the types of genetic changes, determine ...their origin (somatic/germline), and analyze the clinical outcomes associated with them. A consecutive cohort of 99 patients with B-ALL treated at the Children's Hospital of the UMC Ljubljana according to the ALL IC-BFM 2009 protocol was included in our study. We used RNA sequencing data for gene expression analysis, fusion gene detection and single nucleotide variant identification, multiplex-ligation dependent probe amplification for copy number variation assessment, and Sanger sequencing for germline variant detection.
was impacted in 33.3% of our patients, with the genetic alterations ranging from CNVs and rearrangements to SNVs. The most common were CNVs, which were found in more than a third of patients, followed by point mutations in 5.2%, and gene rearrangements in 4.1%. We identified eight patients with a
-associated genetic subtype that were previously classified as "B-other", and they showed intermediate outcomes. We showed higher minimal residual disease values at the end of induction and poorer event-free survival in hyperdiploid cases carrying duplications in
compared to other hyperdiploid cases. We also report an interesting case of a patient with
and a pathogenic variant in
who underwent an early relapse with a monocytic switch. In conclusion, this study provides valuable insights into the presence, frequency, and prognostic significance of diverse
alterations in B-ALL patients, highlighting the complexity of genetic factors and their impact on patient outcomes.
We investigated micro-threaded stem taper surface and its impact on premature failures, aseptic loosening, and infection in cementless hip endoprostheses. Our study focused on the fretting, and ...crevice corrosion of micro-threaded tapers, as well as the characterization of the microstructure and surface properties of two new and three retrieved Zweymüller stem tapers. The retrieved samples were selected and examined based on the head–stem taper interface being the sole source of modularity with a metallic component, specifically between the Ti alloy taper stem and the ceramic head. To determine the surface chemistry and microstructures of both new and retrieved hip endoprostheses stem taper titanium alloy, scanning -electron microscopy (SEM) was employed for morphological and microstructural analyses. Energy dispersive spectroscopy (EDS) was utilized for characterizing chemical element distribution, and electron backscattered diffraction (EBSD) was used for phase analysis. The roughness of the micro-threated stem tapers from different manufacturers was investigated using an optical profilometer, with standard roughness parameters Ra (average surface roughness) and Rz (mean peak to valley height of the roughness profile) being measured. Electrochemical studies revealed no fretting corrosion in retrieved stem tapers with ceramic heads. Consequently, three retrieved tapers and two new ones for comparison underwent potentiodynamic measurements in Hank’s solution to determine the corrosion rate of new and retrieved stem taper surfaces. The results showed a low corrosion rate for both new and prematurely failed retrieved samples due to aseptic loosening. However, the corrosion rate was higher in infected and low-grade infected tapers. In conclusion, our study suggests that using ceramic heads reduces taper corrosion and subsequently decreases the incidence of premature failures in total hip arthroplasty.
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