Nowadays, SPOCs (Small Private Online Courses) have been used as complementary methods to support classroom teaching. SPOCs are courses that apply the usage of MOOCs (Massive Open Online Courses), ...combining classroom with online education, making them an exciting alternative for contexts such as emergency remote teaching. Although SPOCs have been continuously proposed in the software engineering teaching area, it is crucial to assess their practical applicability via measuring the effectiveness of this resource in the teaching-learning process. In this context, this paper aims to present an experimental evaluation to investigate the applicability of a SPOC in a Verification, Validation, and Software Testing course taught during the period of emergency remote education during the COVID-19 pandemic in Brazil. Therefore, we conducted a controlled experiment comparing alternative teaching through the application of a SPOC with teaching carried out via lectures. The comparison between the teaching methods is made by analyzing the students’ performance during the solving of practical activities and essay questions on the content covered. In addition, we used questionnaires to analyze students’ motivation during the course. Study results indicate an improvement in both motivation and performance of students participating in SPOC, which corroborates its applicability to the software testing teaching area.
Carbon capture and storage with porous materials is one of the most promising technologies to minimize CO
release into the atmosphere. Here, we report a family of compartmentalized coordination ...polymers (CCPs) capable of capturing gas molecules in a selective manner based on two novel tetrazole-based ligands. Crystal structures have been modelled theoretically under the Density Functional Theory (DFT) revealing the presence of discrete voids of 380 Å
. Single gas adsorption isotherms of N
, CH
and CO
have been measured, obtaining a loading capacity of 0.6, 1.7 and 2.2 molecules/void at 10 bar and at 298 K for the best performing material. Moreover, they present excellent selectivity and regenerability for CO
in mixtures with CH
and N
in comparison with other reported materials, as evidenced by dynamic breakthrough gas experiments. These frameworks are therefore great candidates for separation of gas mixtures in the chemical engineering industry.
Virtual reality therapy (VRT) is an interactive intervention that induces neuroplasticity. The aim was to evaluate the effects of VRT associated with conventional rehabilitation for an upper limb ...after stroke, and the neuroimaging predictors of a better response to VRT.
Patients with stroke were selected, and clinical neurological, upper limb function, and quality of life were evaluated. Statistical analysis was performed using a linear model comparing pre- and post-VRT. Lesions were segmented in the post-stroke computed tomography. A voxel-based lesion-symptom mapping approach was used to investigate the relationship between the lesion and upper limb function.
Eighteen patients were studied (55.5 ± 13.9 years of age). Quality of life, functional independence, and dexterity of the upper limb showed improvement after VRT (p < 0.001). Neuroimaging analysis showed negative correlations between the internal capsule lesion and functional recovery.
VRT showed benefits for patients with stroke, but when there was an internal capsule lesion, a worse response was observed.
Inflammatory bowel diseases (IBD) are chronic inflammatory affections of recurrent nature whose incidence and prevalence rates have increased, including in Brazil. In long term, they are responsible ...for structural damage that impacts quality of life, morbidity and mortality of patients.
To describe the profile of physicians who treat IBD patients as well as the characteristics of IBD care, unmet demands and difficulties.
A questionnaire containing 17 items was prepared and sent to 286 physicians from 101 Brazilian cities across 21 states and the Federal District, selected from the register of the State Commission of the "Study Group of Inflammatory Bowel Disease of Brazil" (GEDIIB).
The majority of the physicians who answered the questionnaire were gastroenterologists and colorectal surgeons. More than 60% had up to 20 years of experience in the specialty and 53.14% worked at three or more locations. Difficulties in accessing or releasing medicines were evident in this questionnaire, as was referrals to allied healthy professionals working in IBD-related fields. More than 75% of physicians reported difficulties in performing double-balloon enteroscopy and capsule endoscopy, and 67.8% reported difficulties in measuring calprotectin. With regard to the number of patients seen by each physician, it was shown that patients do not concentrate under the responsibility of few doctors. Infliximab and adalimumab were the most commonly used biological medicines and there was a higher prescription of 5-ASA derivatives for ulcerative colitis than for Crohn's disease. Steroids were prescribed to a smaller proportion of patients in both diseases. The topics "biological therapy failure" and "new drugs" were reported as those with higher priority for discussion in medical congresses. In relation to possible differences among the country's regions, physicians from the North region reported greater difficulty in accessing complementary exams while those from the Northeast region indicated greater difficulty in accessing or releasing medicines.
The data obtained through this study demonstrate the profile of specialized medical care in IBD and are a useful tool for the implementation of government policies and for the Brazilian society as a whole.
The combination of a properly designed organic linker, 3,6-N-ditriazolyl-2,5-dihydroxy-1,4-benzoquinone (trz2An), with CoII ions results in a novel 3D ultramicroporous MOF with high CO2 uptake ...capacity and separation efficiency, with particular attention to CO2/N2 and CO2/CH4 gas mixtures. This material consists of 1D chains of octahedrally coordinated CoII ions linked through anilato ligands at the equatorial positions and triazole substituents from two neighbouring chains at the two axial positions. This leads to a 3D microporous structure with voids with an affinity for CO2 molecules and channels that enable the selective entry of CO2 but not of molecules with larger kinetic diameters such as N2 or CH4. Adsorption studies revealed that (i) the MOF presents a remarkable carbon dioxide uptake, above 20% in weight; (ii) CO2 adsorptive separation is successfully performed in CO2:N2 and CO2:CH4 gas mixtures, exhibiting high selectivity in a large operation range; (iii) regeneration is easily achieved under mild conditions.
Idiopathic achalasia is a relatively infrequent esophageal motor disorder for which major histocompatibility complex (MHC) genes are well-identified risk factors. However, no information about ...HLA-achalasia susceptibility in Mexicans has previously been reported. We studied a group of 91 patients diagnosed with achalasia and 234 healthy controls with Mexican admixed ancestry. HLA alleles and conserved extended haplotypes were analyzed using high-resolution HLA typing based on Sanger and next-generation sequencing technologies. Admixture estimates were determined using HLA-B and short tandem repeats. Results were analyzed by non-parametric statistical analysis and Bonferroni correction. P-values < 0.05 were considered significant. Patients with achalasia had 56.7% Native American genes, 24.7% European genes, 16.5% African genes and 2.0% Asian genes, which was comparable with the estimates in the controls. Significant increases in the frequencies of alleles DRB1*14:54 and DQB1*05:03 and the extended haplotypes DRB1*14:54-DQB1*05:03 and DRB1*11:01-DQB1*03:01, even after Bonferroni correction (pC<0.05), were found in the achalasia group compared to those in the controls. Concluding, the HLA class II alleles HLA-DRB1*14:54:01 and DQB1*05:03:01 and the extended haplotype are risk factors for achalasia in mixed-ancestry Mexican individuals. These results also suggest that the HLA-DRB1*14:54-DQB1*05:03 haplotype was introduced by admixture with European and/or Asian populations.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Two ultramicroporous 2D and 3D iron-based Metal-Organic Frameworks (MOFs) have been obtained by solvothermal synthesis using different ratios and concentrations of precursors. Their reduced pore ...space decorated with pendant pyridine from tangling isonicotinic ligands enables the combination of size-exclusion kinetic gas separation, due to their small pores, with thermodynamic separation, resulting from the interaction of the linker with CO
2
molecules. This combined separation results in efficient materials for dynamic breakthrough gas separation with virtually infinite CO
2
/N
2
selectivity in a wide operando range and with complete renewability at room temperature and ambient pressure.
Using the commercially available isonicotinic acid and iron, we report two ultramicroporous MOFs, denoted MUV-26.
The combination of a properly designed organic linker, 3,6-
N
-ditriazolyl-2,5-dihydroxy-1,4-benzoquinone (trz
2
An), with Co
II
ions results in a novel 3D ultramicroporous MOF with high CO
2
uptake ...capacity and separation efficiency, with particular attention to CO
2
/N
2
and CO
2
/CH
4
gas mixtures. This material consists of 1D chains of octahedrally coordinated Co
II
ions linked through anilato ligands at the equatorial positions and triazole substituents from two neighbouring chains at the two axial positions. This leads to a 3D microporous structure with voids with an affinity for CO
2
molecules and channels that enable the selective entry of CO
2
but not of molecules with larger kinetic diameters such as N
2
or CH
4
. Adsorption studies revealed that (i) the MOF presents a remarkable carbon dioxide uptake, above 20% in weight; (ii) CO
2
adsorptive separation is successfully performed in CO
2
:N
2
and CO
2
:CH
4
gas mixtures, exhibiting high selectivity in a large operation range; (iii) regeneration is easily achieved under mild conditions.
A novel anilato-based 3D ultramicroporous MOF is reported, displaying a significant balance of high CO
2
separation from CO
2
:N
2
and CO
2
:CH
4
gas mixtures, high thermal stability and high regenerability, a challenge in the separation technology industry.
The combination of a properly designed organic linker, 3,6-
N
-ditriazolyl-2,5-dihydroxy-1,4-benzoquinone (trz
2
An), with Co
II
ions results in a novel 3D ultramicroporous MOF with high CO
2
uptake ...capacity and separation efficiency, with particular attention to CO
2
/N
2
and CO
2
/CH
4
gas mixtures. This material consists of 1D chains of octahedrally coordinated Co
II
ions linked through anilato ligands at the equatorial positions and triazole substituents from two neighbouring chains at the two axial positions. This leads to a 3D microporous structure with voids with an affinity for CO
2
molecules and channels that enable the selective entry of CO
2
but not of molecules with larger kinetic diameters such as N
2
or CH
4
. Adsorption studies revealed that (i) the MOF presents a remarkable carbon dioxide uptake, above 20% in weight; (ii) CO
2
adsorptive separation is successfully performed in CO
2
:N
2
and CO
2
:CH
4
gas mixtures, exhibiting high selectivity in a large operation range; (iii) regeneration is easily achieved under mild conditions.
PDF
