Disordered eating behaviors (DEBs) and adolescent pregnancy are public health problems. Among adolescents, there is little evidence concerning the relationship of DEB with gestational weight gain ...(GWG) and the birth weight and length of their offspring. We aimed to determine the association between DEB with GWG and the weight and length of adolescents’ offspring. We conducted a study with 379 participants. To evaluate DEB, we applied a validated scale. We identified three factors from DEB by factorial analysis: restrictive, compensatory, and binge–purge behaviors. The main events were GWG and offspring’s birth weight and length. We performed linear regression models. We found that 50% of adolescents have at least one DEB. Excessive and insufficient GWG were 37 and 34%, respectively. The median GWG was 13 kg; adolescents with restrictive behaviors had higher GWG (13 vs. 12 kg, p = 0.023). After adjusting for pregestational body mass index and other covariables, the restrictive (β = 0.67, p = 0.039), compensatory (β = 0.65, p = 0.044), and binge–purge behaviors (β = 0.54, p = 0.013) were associated with higher GWG. We did not find an association between the birth weight and length of newborns with DEB, and suggest that DEB is associated with GWG but not with the birth weight or length of the offspring.
is a resident of the human gut. However, certain
toxigenic strains exist that secrete the nonribosomal peptide tilivalline (TV) cytotoxin. TV is a pyrrolobenzodiazepine that causes ...antibiotic-associated hemorrhagic colitis (AAHC). The biosynthesis of TV is driven by enzymes encoded by the
and NRPS operons. In this study, we determined the effect of environmental signals such as carbon sources, osmolarity, and divalent cations on the transcription of both TV biosynthetic operons. Gene expression was enhanced when bacteria were cultivated in tryptone lactose broth. Glucose, high osmolarity, and depletion of calcium and magnesium diminished gene expression, whereas glycerol increased transcription of both TV biosynthetic operons. The cAMP receptor protein (CRP) is a major transcriptional regulator in bacteria that plays a key role in metabolic regulation. To investigate the role of CRP on the cytotoxicity of
, we compared levels of expression of TV biosynthetic operons and synthesis of TV in wild-type strain MIT 09-7231 and a Δ
isogenic mutant. In summary, we found that CRP directly activates the transcription of the
and NRPS operons and that the absence of CRP reduced cytotoxicity of
on HeLa cells, due to a significant reduction in TV production. This study highlights the importance of the CRP protein in the regulation of virulence genes in enteric bacteria and broadens our knowledge on the regulatory mechanisms of the TV cytotoxin.
is a Gram-negative bacterium that colonizes the human gastric mucosa and causes peptic ulcers and gastric carcinoma.
strain 26695 has a small genome (1.67 Mb), which codes for few known ...transcriptional regulators that control bacterial metabolism and virulence. We analyzed by qRT-PCR the expression of 16 transcriptional regulators in
26695, including the three sigma factors under different environmental conditions. When bacteria were exposed to acidic pH, urea, nickel, or iron, the sigma factors were differentially expressed with a particularly strong induction of
. The regulatory genes
, and
were highly induced in the presence of urea, nickel, and iron. In terms of biofilm formation
, and
were induced in sessile bacteria. Transcriptional expression levels of
, and
were increased in contact with AGS epithelial cells. Kanamycin, chloramphenicol, and tetracycline increased or decreased expression of regulatory genes, showing that these antibiotics affect the transcription of
. Our data indicate that environmental cues which may be present in the human stomach modulate
transcription.
MTSS2-related neurodevelopmental disorder (MTSS2-related NDD) (MIM 620086) is characterized by intellectual developmental disorder with ocular anomalies and distinctive facial features (IDDOF). The ...only existing report to date described five individuals who exhibited an identical de novo c.2011C>T (p.Arg671Trp) variant in the MTSS2 gene. Herein, we report a new case of MTSS2-related NND in a male dizygotic twin who presented with IDDOF and severe intellectual disability. This patient also displayed additional clinical features, including low functioning autism, hypothyroidism, duodenal obstruction secondary to Ladd's bands, inguinal hernias, cryptorchidism, transient subperiosteal new bone formation, and short stature with delayed bone age, which had not been previously reported in association with the MTSS2-related NDD. Exome sequencing identified the recurrent c.2011C>T (p.Arg671Trp) variant in the MTSS2 gene. The mother and the other twin tested negative for the pathogenic variant, while the father's participation in the study was unavailable. This case confirms that the MTSS2-related NDD is caused by the recurrent MTSS2 missense variant p.Arg671Trp. The novel findings identified in our patient expand the phenotypic spectrum associated with this new autosomal dominant entity, but further studies on its genetic and clinical manifestations are still needed.
•MTTS2-related neurodevelopmental disorder (NDD) is characterized by NDD, and ocular and facial anomalies (IDDOF).•The five individuals known to date exhibited an identical de novo c.2011C>T (p.Arg671Trp) variant in the MTSS2 gene.•We report the sixth case of MTSS2-related NND in a male dizygotic twin who presented IDDOF and severe NDD.•This patient had additional clinical features which had not been reported previously in the MTSS2-related NDD.
En los últimos meses la llegada de migrantes a México se ha visto muy marcada, dentro de esta migración llama la atención la presencia de un nuevo oleaje extracontinental: La migración de africanos a ...México. Las guerras civiles, cuestiones de salud, pobreza, cambio climático y hambruna han obligado a gran parte de la población a salir de sus países natales, en busca de nuevas oportunidades y mejora de la calidad de vida, dándose así, una migración económica forzada de amplias magnitudes. Es por ello, que en el presente artículo se analiza el proceso migratorio del reciente y particular éxodo de africanos a México y sus implicaciones jurídicas. Asimismo, se realiza una interpretación hermenéutica de la jurisprudencia mexicana, contrastándola con los retos a los que México se enfrenta al promover el derecho al asilo, propuesto por los diferentes instrumentos de derechos humanos y la agenda global 2030. La investigación es de corte cualitativo, utilizando el método hermenéutico y basándonos en diversas teorías tales la teoría de la causación acumulativa y la teoría de redes. El objetivo del artículo es responder a la pregunta: Los derechos humanos de los migrantes africanos en México ¿Realidad o retórica?
El propósito de este estudio fue conocer si los adultos mayores, residentes en una ciudad mexicana, se consideraban "felices" y, de ser así, profundizar en los motivos, experiencias o aspectos que, a ...su juicio, los había llevado a alcanzar esa felicidad. Se trabajó con este grupo porque se consideró que su comprensión de la experiencia era mayor respecto a las diferentes etapas de la vida, y porque además podía apreciar en retrospectiva las situaciones que una persona atraviesa a lo largo de su vida. Se aplicó la Escala de la Auténtica Felicidad a 121 participantes como punto de partida, para luego realizar aleatoriamente, como complemento, entrevistas individuales a 21 de esos participantes. Los resultados muestran que los principales factores a los que los adultos mayores atribuyen su felicidad son la familia, la pareja, su forma de ser, la compañía, las actividades, la naturaleza de la felicidad, Dios y la salud.
What is happiness for women facing poverty? This article describes the ways in which rural and indigenous women, make senses of their experiences of happiness through their life histories. These ...narrations give an account of how important are harmonious, participatory and egalitarian social relationships throughout the different spheres of women’s realities to approach their sense of happiness. Building on scholar contributions from action-research, feminist ethnography, reflexive practice and decolonial propositions, we argued that women’s definitions, immersed in their daily and communitarian life, reveal a collective dimension of human well-being usually postponed in mainstream development perspectives.
Recording infraslow brain signals (<0.1 Hz) with microelectrodes is severely hampered by current microelectrode materials, primarily due to limitations resulting from voltage drift and high electrode ...impedance. Hence, most recording systems include high-pass filters that solve saturation issues but come hand in hand with loss of physiological and pathological information. In this work, we use flexible epicortical and intracortical arrays of graphene solution-gated field-effect transistors (gSGFETs) to map cortical spreading depression in rats and demonstrate that gSGFETs are able to record, with high fidelity, infraslow signals together with signals in the typical local field potential bandwidth. The wide recording bandwidth results from the direct field-effect coupling of the active transistor, in contrast to standard passive electrodes, as well as from the electrochemical inertness of graphene. Taking advantage of such functionality, we envision broad applications of gSGFET technology for monitoring infraslow brain activity both in research and in the clinic.
Aims and objectives
To explore the knowledge, attitudes and practices related to cervical cancer and its prevention in Spain.
Background
Worldwide, women's knowledge about cervical cancer is low, and ...their attitudes towards its prevention are good, but they do not correlate with the screening uptake. Although the rates of Spanish women performing cervical cancer screening are mostly acceptable, their knowledge and attitudes about it have not been explored.
Design
Qualitative descriptive study.
Methods
Three focus groups were conducted, with 21 women aged 25 to 65 years. Participants were recruited through convenience sampling. For intragroup homogeneity, women participated in age groups. The COREQ reporting guidelines were used.
Results
Women expressed their knowledge about cervical cancer was low. None of the participants identified the human papillomavirus as a cause of cervical cancer, nor did they mention the vaccine as a preventive measure. They all knew about the screening existence, but not about its frequency nor target population. About the attitudes and practice, 18 women had an appropriate screening, and they were favourable to this health check, claiming an increase in its frequency. Nineteen women claimed they had not received enough information from the healthcare system and a lack of social awareness in comparison with breast cancer. They demanded from the professionals more health education, a reminder of their appointments and a report of the Pap test results.
Conclusions
There was a self‐perceived low level of knowledge about cervical cancer risk factors and its prevention in the participants. However, they expressed favourable attitudes towards screening, and they demanded more information about cervical cancer and its prevention measures, and they regretted its low social awareness.
Relevance to clinical practice
Midwives, general nurses and other nurse specialists may have a leading position in health education for cervical cancer prevention in different population levels.
The global spread of antimicrobial resistance genes (ARGs) is a major public health concern. Mobile genetic elements (MGEs) are the main drivers of this spread by horizontal gene transfer (HGT). ...'Escherichia coli' is widespread in various environments and serves as an indicator for monitoring antimicrobial resistance (AMR). Therefore, the objective of this work was to evaluate the whole genome of multidrug-resistant 'E. coli' strains isolated from human clinical, animal, and environmental sources. Four 'E. coli' strains previously isolated from human urine (n = 2), retail meat (n = 1), and water from the Rio Grande River (n = 1) collected in northern Tamaulipas, Mexico, were analyzed. 'E. coli' strains were evaluated for antimicrobial susceptibility, followed by whole genome sequencing and bioinformatic analysis. Several ARGs were detected, including blaCTX-M-15, blaOXA-1, blaTEM-1B, blaCMY-2, qnrB, catB3, sul2, and sul3. Additionally, plasmid replicons (IncFIA, IncFIB, IncFII, IncY, IncR, and Col) and intact prophages were also found. Insertion sequences (ISs) were structurally linked with resistance and virulence genes. Finally, these findings indicate that 'E. coli' strains have a large repertoire of resistance determinants, highlighting a high pathogenic potential and the need to monitor them.
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