After a previous analysis that did not detect clear differences in the results of three conditioning regimens used for autologous stem cell transplantation (ASCT) in patients from the Spanish ...Registry for Transplant in Multiple Myeloma (MM), we have updated the registry, including a larger number of cases and a fourth conditioning regimen with a longer follow-up. We evaluate 472 MM patients treated with 200 mg/m 2 melphalan (MEL200), 135 patients treated with 140 mg/m 2 melphalan plus total body irradiation (MEL140 + TBI), 186 patients treated with 12 mg/kg busulphan plus 140 mg/m 2 melphalan (BUMEL) and 28 patients treated with 14 mg/kg busulphan followed by cyclophosphamide 120 mg/kg (BUCY). There were no significant differences in respect to either transplant related death or haematological recovery, regardless of growth factor use, between the four conditioning programs. Nevertheless, hospitalization time with MEL200 was less than with BUMEL when growth factors were used (19 ± 9 vs. 25 ± 9 days, P =0.009) and less than with MEL140 + TBI without growth factors (20 ± 8 days vs. 27 ± 9 days, P =0.002). In patients with measurable disease at ASCT (non-complete remission CR), BUMEL achieved a 51% CR vs. 43%-31% in the other groups (P =0.007). The response rate for patients in partial remission (PR) at ASCT was 100% with BUMEL vs. 93%-86% in the other groups (P between 0.02 and 0.0007). The median overall survival (OS) for the BUMEL group was 57 months (95% confidence interval CI: 51-78) as compared to 45 (CI: 36-64) months for the MEL200 group and 39 (CI: 28-72) months for the MEL140 + TBI and BUCY groups. The median event free survival (EFS) was longer in the BUMEL group 30 (CI: 22-44) mo than in the MEL200 22 (CI: 18-26) mo, BUCY 23 (CI: 11-50) mo or MEL140 + TBI groups 20 (CI: 15-29) mo. Nevertheless, the differences in OS and EFS did not reach statistical significance in either the univariate analysis or the multivariate analysis adjusted with other high prognostic weight factors. As in the initial study, differences in regards to the anti-myeloma effect of the conditioning regimens are not conclusive. However, the better response rates associated with the favorable tendency in outcome achieved with BUMEL, continue to justify further prospective studies.
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Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Objective: To assess classical psychometric properties of the Spanish versions of the Bech‐Rafaelsen’s mania (MAS) and melancholia (MES) scales.
Method: Observational, prospective, and multicentric ...study in bipolar out‐patients. Convergent validity was assessed against the Young Mania Rating Scale and the Montgomery‐Åsberg Depression Rating Scale. Discriminant validity, reliability, and sensitivity to change, were also assessed.
Results: One hundred and thirteen bipolar patients with a manic episode and 102 bipolar patients with a depressive episode were included. Both the MAS and the MES showed appropriate convergent validity (r > 0.90), discriminant validity (P < 0.0001), internal consistency (Cronbach’s alpha >0.80), test–retest reliability intraclass correlation coefficient (ICC) = 0.69 for the MAS and 0.94 for the MES, inter‐rater reliability (ICC > 0.80), and sensitivity to change at 4 weeks since inception (P < 0.0001; within‐group effect size ≥1.8).
Conclusion: The Spanish versions of both scales present appropriate psychometric estimates in bipolar patients treated in ambulatory care.
Endometrial cancer (EC) is the second most common gynecologic malignancy worldwide in the peri and postmenopausal period. Most often for the endometrioid variety. In early clinical stages long-term ...survival is greater than 80%, while in advanced stages it is less than 50%. In our country there is not a standard management between institutions. GICOM collaborative group under the auspice of different institutions have made the following consensus in order to make recommendations for the management of patients with this type of neoplasm.
The following recommendations were made by independent professionals in the field of Gynecologic Oncology, questions and statements were based on a comprehensive and systematic review of literature. It took place in the context of a meeting of four days in which a debate was held. These statements are the conclusions reached by agreement of the participant members.
Screening should be performed women at high risk (diabetics, family history of inherited colon cancer, Lynch S. type II). Endometrial thickness in postmenopausal patients is best evaluated by transvaginal US, a thickness greater than or equal to 5 mm must be evaluated. Women taking tamoxifen should be monitored using this method. Abnormal bleeding in the usual main symptom, all post menopausal women with vaginal bleeding should be evaluated. Diagnosis is made by histerescopy-guided biopsy. Magnetic resonance is the best image method as preoperative evaluation. Frozen section evaluates histologic grade, myometrial invasion, cervical and adnexal involvement. Total abdominal hysterectomy, bilateral salpingo oophorectomy, pelvic and para-aortic lymphadenectomy should be performed except in endometrial histology grades 1 and 2, less than 50% invasion of the myometrium without evidence of disease out of the uterus. Omentectomy should be done in histologies other than endometriod. Surgery should be always performed by a Gynecologic Oncologist or Surgical Oncologist, laparoscopy is an alternative, especially in patients with hypertension and diabetes for being less morbid. Adjuvant treatment after surgery includes radiation therapy to the pelvis, brachytherapy, and chemotherapy. Patients with Stages III and IV should have surgery with intention to achieve optimal cytoreduction because of the impact on survival (51 m vs. 14 m), the treatment of recurrence can be with surgery depending on the pattern of relapse, systemic chemotherapy or hormonal therapy. Follow-up of patients is basically clinical in a regular basis.
Screening programme is only for high risk patients. Multidisciplinary treatment impacts on survival and local control of the disease, including surgery, radiation therapy and chemotherapy, hormonal treatment is reserved to selected cases of recurrence. This is the first attempt of a Mexican Collaborative Group in Gynecology to give recommendations is a special type of neoplasm.
This study searched for mutations in the MLH1 and MSH2 genes in 23 unrelated Colombian families with suspected hereditary nonpolyposis colorectal cancer (HNPCC). The families were grouped according ...to the fulfillment of the Amsterdam II criteria or the Bethesda guidelines. We screened all probands by single-strand conformational polymorphism (SSCP) and direct DNA sequencing. Eleven families fulfilled the Amsterdam criteria II and 12 families the Bethesda guidelines. Germline mutations were detected in 11 families, which corresponds to a mutation detection rate of 48%. When only families fulfilling the Amsterdam II criteria were analyzed, the mutation detection rate rose to 82%. Only 8% of the mutation detection rate was found in families following the Bethesda guidelines. Three mutations were shared by two different families, which corresponds to a total of eight different mutations, seven of them found in the MLH1 gene and one in the MSH2 gene. We have identified four mutations that have not been previously reported to the International Collaborative Group of HNPCC. Three of these are pathogenic, a single base substitution (C > T) at codon 640, exon 17, a G deletion at codon 619, exon 16 and in the MLH1 gene and a two-nucleotide deletion (TG) at codon 184, exon 3 in the MSH2. Also, an unclassified variant, a substitution (C > G) at the codon 141, exon 5 of the MLH1, was detected.
We present a kinematical study of 29 spiral galaxies included in the Spitzer Survey of Stellar Structure in Galaxies, using H alpha Fabry-Perot (FP) data obtained with the Galaxy H alpha Fabry-Perot ...System instrument at the William Herschel Telescope in La Palma, complemented with images in the R band and in H alpha . The primary goal is to study the evolution and properties of the main structural components of galaxies through the kinematical analysis of the FP data, complemented with studies of morphology, star formation and mass distribution. In this paper we describe how the FP data have been obtained, processed and analysed. We present the resulting moment maps, rotation curves, velocity model maps and residual maps. Images are available in FITS format through the NASA/IPAC Extragalactic Database and the Centre de Donnees Stellaires. With these data products we study the non-circular motions, in particular those found along the bars and spiral arms. The data indicate that the amplitude of the non-circular motions created by the bar does not correlate with the bar strength indicators. The amplitude of those non-circular motions in the spiral arms does not correlate with either arm class or star formation rate along the spiral arms. This implies that the presence and the magnitude of the streaming motions in the arms is a local phenomenon.
El objetivo de este estudio es el análisis del poder predictivo de los diferentes tipos de metas académicas sobre el rendimiento académico en cinco áreas curriculares. Para ello, se ha aplicado el ...Cuestionario de Metas Académicas a una amplia muestra de adolescentes que cursaban los cuatro cursos de la Enseñanza Secundaria en España (12 a 16 años). Los resultados obtenidos indican que el rendimiento se encuentra explicado, en primer lugar, positiva y significativamente por motivos de adquisición de competencia y control así como de obtención de un buen trabajo futuro y, en segundo lugar, negativamente por motivos muy relacionados con la protección de la autoestima. Son presentadas y discutidas algunas implicaciones de los datos para el proceso de aprendizaje.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
497.
First seco-C Oleananes from Nature Román, Luisa U; Guerra-Ramírez, Diana; Morán, Gerardo ...
Organic letters,
01/2004, Letnik:
6, Številka:
2
Journal Article
Recenzirano
The triterpenes 8,14-seco-oleana-8(26),13-dien-3β-ol (1) and its acetyl derivative 2 were isolated from Stevia viscida and Stevia eupatoria, respectively. Their structures were elucidated by 2D NMR, ...including carbon−carbon connectivity experiments, and confirmed by X-ray diffraction analysis of ketone 3. The absolute configuration was determined by NMR analysis of the Mosher esters of 1. The biogenetic implications of the new substances are discussed.
Solitary fibrous tumors (SFTs) are rare spindle cell neoplasms that are mostly found arising from the pleura. Although SFTs recently have been reported in other regions, they are rare in the head and ...neck and have often been misdiagnosed due to their rarity. SFTs are benign in most cases. Clinically, SFTs usually manifest as well-circumscribed, slow-growing, smooth and painless masses. Symptoms are often minimal, although they may include sore throat, difficulty in swallowing, change of voice or trismus. CT-Scan and MRI are the most sensitive imaging procedures used. The treatment of choice is complete surgical excision of the lesion. Because recurrences have been noted up to 30 years after surgery, long-term follow up is mandatory. In this article, we present a case of a Solitary Fibrous Tumor arising in the parapharyngeal space in a 20-year-old man, involving the carotid sheath, treated by surgical excision with no recurrence after 1 year. The clinical presentation, surgical management and pathological findings are described.
Common snook (Centropomus undecimalis) is a marine species with high aquaculture potential; although its digestive physiology is still unknown and knowledge of that could allow the development of a ...balanced feed for commercial culture of this fish. The objective of this study was to partially characterize the digestive proteases in C. undecimalis using electrophoretic and biochemical techniques. A total of 50 wild snook juveniles were used to determine the optimal values of pH stability and temperature as well as the effect of inhibitors on digestive, gastric and intestinal proteases. The optimal pH for gastric proteases was obtained to be 2 with stability obtained between 2 and 8; the optimal temperature was detected at 75ºC for in vitro test, and the thermal stability was between 25 and 45ºC. Intestinal proteases showed two peaks of activity at a pH of 7 and 11; meanwhile, the greatest stability was found between a pH of 4 and 10; the optimal temperature was at 65ºC, and the greatest stability was detected between 35 and 45ºC. Up to 86% of the gastric protease activity was inhibited by pepstatin A; meanwhile, the intestinal proteases TPCK, TLCK, 1-10 Phenanthroline, SBT1, EDTA, PMSF and ovalbumin reduced the activity by 17%, 68%, 85%, 41%, 40.5%, 60% and 59%, respectively.
Tobacco smoking is the only established risk factor for pancreatic cancer. Results from several epidemiologic studies have
suggested that increased body mass index and/or lack of physical activity ...may be associated with an increased risk of this
disease. We examined the relationship between anthropometry and physical activity recorded at baseline and the risk of pancreatic
cancer in the European Prospective Investigation into Cancer and Nutrition ( n = 438,405 males and females age 19-84 years and followed for a total of 2,826,070 person-years). Relative risks (RR) were
calculated using Cox proportional hazards models stratified by age, sex, and country and adjusted for smoking and self-reported
diabetes and, where appropriate, height. In total, there were 324 incident cases of pancreatic cancer diagnosed in the cohort
over an average of 6 years of follow-up. There was evidence that the RR of pancreatic cancer was associated with increased
height RR, 1.74; 95% confidence interval (95% CI), 1.20-2.52 for highest quartile compared with lowest quartile ( P trend = 0.001). However, this trend was primarily due to a low risk in the lowest quartile, as when this group was excluded, the
trend was no longer statistically significant ( P = 0.27). A larger waist-to-hip ratio and waist circumference were both associated with an increased risk of developing the
disease (RR per 0.1, 1.24; 95% CI, 1.04-1.48; P trend = 0.02 and RR per 10 cm, 1.13; 95% CI, 1.01-1.26; P trend = 0.03, respectively). There was a nonsignificant increased risk of pancreatic cancer with increasing body mass index (RR,
1.09; 95% CI, 0.95-1.24 per 5 kg/m 2 ), and a nonsignificant decreased risk with total physical activity (RR, 0.82; 95% CI, 0.50-1.35 for most active versus inactive).
Future studies should consider including measurements of waist and hip circumference, to further investigate the relationship
between central adiposity and the risk of pancreatic cancer. (Cancer Epidemiol Biomarkers Prev 2006;15(5):879–85)
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