Bumble bees are an ecologically and economically important group of pollinating insects worldwide. Global climate change is predicted to affect bumble bee ecology including habitat suitability and ...geographic distribution. Our study aims to estimate the impact of projected climate change on 18 Mesoamerican bumble bee species. We used ecological niche modeling (ENM) using current and future climate emissions scenarios (representative concentration pathway 4.5, 6.0, and 8.5) and models (CCSM4, HadGEM2‐AO, and MIROC‐ESM‐CHEM). Regardless of the scenario and model applied, our results suggest that all bumble bee species are predicted to undergo a reduction in their potential distribution and habitat suitability due to projected climate change. ENMs based on low emission scenarios predict a distribution loss ranging from 7% to 67% depending on the species for the year 2050. Furthermore, we discovered that the reduction of bumble bee geographic range shape will be more evident at the margins of their distribution. The reduction of suitable habitat is predicted to be accompanied by a 100–500 m upslope change in altitude and 1–581 km shift away from the current geographic centroid of a species' distribution. On average, protected natural areas in Mesoamerica cover ~14% of each species' current potential distribution, and this proportion is predicted to increase to ~23% in the high emission climate change scenarios. Our models predict that climate change will reduce Mesoamerican bumble bee habitat suitability, especially for rare species, by reducing their potential distribution ranges and suitability. The small proportion of current and future potential distribution falling in protected natural areas suggests that such areas will likely have marginal contribution to bumble bee habitat conservation. Our results have the capacity to inform stakeholders in designing effective landscape management for bumble bees, which may include developing restoration plans for montane pine oak forests habitats and native flowering plants.
Global climate change poses a threat to bumble bees from Mesoamerica by reducing the current potential distribution of these bees in the region, moving their geographic centroid, shifting their altitude distribution to higher altitudes, and reducing their environmental suitability.
Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood ...pressure, lipids and insulin resistance. However, no previous epidemiological studies have evaluated the relationship between the intake of total polyphenols intake and polyphenol subclasses with overall mortality. Our aim was to evaluate whether polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk.
We used data from the PREDIMED study, a 7,447-participant, parallel-group, randomized, multicenter, controlled five-year feeding trial aimed at assessing the effects of the Mediterranean Diet in primary prevention of cardiovascular disease. Polyphenol intake was calculated by matching food consumption data from repeated food frequency questionnaires (FFQ) with the Phenol-Explorer database on the polyphenol content of each reported food. Hazard ratios (HR) and 95% confidence intervals (CI) between polyphenol intake and mortality were estimated using time-dependent Cox proportional hazard models.
Over an average of 4.8 years of follow-up, we observed 327 deaths. After multivariate adjustment, we found a 37% relative reduction in all-cause mortality comparing the highest versus the lowest quintiles of total polyphenol intake (hazard ratio (HR) = 0.63; 95% CI 0.41 to 0.97; P for trend = 0.12). Among the polyphenol subclasses, stilbenes and lignans were significantly associated with reduced all-cause mortality (HR =0.48; 95% CI 0.25 to 0.91; P for trend = 0.04 and HR = 0.60; 95% CI 0.37 to 0.97; P for trend = 0.03, respectively), with no significant associations apparent in the rest (flavonoids or phenolic acids).
Among high-risk subjects, those who reported a high polyphenol intake, especially of stilbenes and lignans, showed a reduced risk of overall mortality compared to those with lower intakes. These results may be useful to determine optimal polyphenol intake or specific food sources of polyphenols that may reduce the risk of all-cause mortality.
ISRCTN35739639.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Squatting empty properties for living or to develop public activities has lasted in European cities for more than three decades. Although local and national contexts differ significantly, there are ...also some general trends and patterns that deserve careful attention. When squatting occasionally appears in public debates, controversy is generated and many gaps open between academic, social and political perceptions. In this article I use evidence from several European cities to argue that the squatters' movement has produced an original impact in urban politics. The main feature of this impact has been to generate a relatively wide autonomous and mainly non‐institutional mode of citizen participation, protest and self‐management. How has this been possible? Which are the specific contributions made by this urban movement? These are questions that both scholars and activists continuously claim to be relevant, so that this research attempts to offer some general answers based on detailed comparisons and experiences.
ResumenLa okupación de inmuebles vacíos para residir o para desarrollar actividades públicas en ellos se ha prolongado en las ciudades europeas durante más de tres décadas. Aunque los contextos locales y nacionales difieren significativamente, existen también algunas tendencias y pautas generales que merecen una detallada consideración. Cuando la okupación aparece ocasionalmente en los debates públicos, es habitual que genere mucha controversia y percepciones académicas, sociales y políticas muy distintas. En este artículo utilizo la evidencia disponible en varias ciudades europeas para sostener que el movimiento de okupaciones ha producido un impacto original en la política urbana. La principal característica de ese impacto es la apertura de un modo de participación ciudadana, de protesta y de autogestión con una relativamente amplia autonomía al margen de las instituciones. ¿Cómo ha sido posible ese desarrollo?¿Cuáles son las contribuciones específicas realizadas por este movimiento urbano? Estas son las cuestiones que tanto investigadores/as como activistas han considerado a menudo como relevantes, de tal modo que el presente texto intenta ofrecer algunas respuestas generales a partir de comparaciones y experiencias concretas.
The voltage‐dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited proliferation. By modulating membrane ...potential, cell volume, and/or Ca2+ influx, K+ channels can influence cell cycle progression. Also, noncanonical channel functions could contribute to modulate cell proliferation independent of K+ efflux. The specificity of the requirement of Kv1.3 channels for proliferation suggests the involvement of molecule‐specific interactions, but the underlying mechanisms are poorly identified. Heterologous expression of Kv1.3 channels in HEK cells has been shown to increase proliferation independently of K+ fluxes. Likewise, some of the molecular determinants of Kv1.3‐induced proliferation have been located in the C‐terminus region, where individual point mutations of putative phosphorylation sites (Y447A and S459A) abolished Kv1.3‐induced proliferation. Here, we investigated the mechanisms linking Kv1.3 channels to proliferation exploring the correlation between Kv1.3 voltage‐dependent molecular dynamics and cell cycle progression. Using transfected HEK cells, we analyzed both the effect of changes in resting membrane potential on Kv1.3‐induced proliferation and the effect of mutated Kv1.3 channels with altered voltage dependence of gating. We conclude that voltage‐dependent transitions of Kv1.3 channels enable the activation of proliferative pathways. We also found that Kv1.3 associated with IQGAP3, a scaffold protein involved in proliferation, and that membrane depolarization facilitates their interaction. The functional contribution of Kv1.3‐IQGAP3 interplay to cell proliferation was demonstrated both in HEK cells and in vascular smooth muscle cells. Our data indicate that voltage‐dependent conformational changes of Kv1.3 are an essential element in Kv1.3‐induced proliferation.
Ion channels have been involved in proliferation in many tissues, but the underlying mechanisms remain unclear. Here, the authors demonstrate a link between Kv1.3 conformational changes and proliferation, and conclude that voltage‐dependent transitions of the channel regulate cell cycle progression.
To date, there has been no comprehensive analysis of the disperse research on the squatters’ movement in Europe. In Squatters in the Capitalist City, Miguel A. Martínez López presents a critical ...review of the current research on squatting and of the historical development of the movements in European cities according to their major social, political and spatial dimensions. Comparing cities, contexts, and the achievements of the squatters’ movements, this book presents the view that squatting is not simply a set of isolated, illegal and marginal practices, but is a long-lasting urban and transnational movement with significant and broad implications. While intersecting with different housing struggles, squatters face various aspects of urban politics and enhance the content of the movements claiming for a ‘right to the city.’ Squatters in the Capitalist City seeks to understand both the socio-spatial and political conditions favourable to the emergence and development of squatting, and the nature of the interactions between squatters, authorities and property owners by discussing the trajectory, features and limitations of squatting as a potential radicalisation of urban democracy.
Limited data exists on the interrelationships between physical activity (PA), sedentary behaviors and sleep concerning cardiometabolic risk factors in aged adults at high cardiovascular disease risk. ...Our aim was to examine independent and joint associations between time spent in leisure-time PA, sedentary behaviors and sleep on the prevalence of obesity, type 2 diabetes (T2D) and components of the metabolic syndrome (MetS) in Mediterranean individuals at high cardiovascular risk. Cross-sectional analyses were performed on baseline data from 5776 Spanish adults (aged 55-75y in men; 60-75y in women) with overweight/obesity and MetS, from October 2013 to October 2016, in the PREDIMED-PLUS trial. Employing multivariable-adjusted Cox regression with robust variance and constant time (given the cross-sectional design), higher prevalence of obesity, T2D and abdominal obesity as component of the MetS were associated with greater time in TV-viewing (Relative Risk, RR: 1.02, 95%CI: 1.01, 1.03; RR:1.04, 95%CI: 1.02, 1.06 and RR: 1.01 95%CI: 1.00, 1.02; respectively, all P < .01). Conversely, greater time in moderate-vigorous PA (MVPA) was associated with lower prevalence of obesity, T2D, abdominal obesity and low HDL-cholesterol (RR: 0.95, 95%CI: 0.93, 0.97; RR: 0.94, 95%CI: 0.89, 0.99; RR: 0.97, 95%CI: 0.96, 0.98; and RR: 0.95, 95%CI: 0.91, 0.99, respectively, all P < .05). For these outcomes, theoretically substituting 1-h/day of MVPA for 1-h/day TV-viewing was also significantly associated with lower prevalence (RR 0.91 to 0.97, all P < .05). Similar lower RR in these outcomes was observed when substituting 1-h/day of MVPA for 1-h/day of sleeping. Longer time watching TV and not meeting MVPA recommendations were jointly associated with higher RR of the prevalence of obesity and T2D. We concluded that, in senior individuals at high cardiovascular risk, greater time spent on MVPA and fewer on sedentary behaviors was inversely associated with prevalence of obesity, T2D, and some of the components of MetS.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Abstract
Background
The role of vitamin D status in COVID-19 patients is a matter of debate.
Objectives
To assess serum 25-hydroxyvitamin D (25OHD) levels in hospitalized patients with COVID-19 and ...to analyze the possible influence of vitamin D status on disease severity.
Methods
Retrospective case–control study of 216 COVID-19 patients and 197 population-based controls. Serum 25OHD levels were measured in both groups. The association of serum 25OHD levels with COVID-19 severity (admission to the intensive care unit, requirements for mechanical ventilation, or mortality) was also evaluated.
Results
Of the 216 patients, 19 were on vitamin D supplements and were analyzed separately. In COVID-19 patients, mean ± standard deviation 25OHD levels were 13.8 ± 7.2 ng/mL, compared with 20.9 ± 7.4 ng/mL in controls (P < .0001). 25OHD values were lower in men than in women. Vitamin D deficiency was found in 82.2% of COVID-19 cases and 47.2% of population-based controls (P < .0001). 25OHD inversely correlates with serum ferritin (P = .013) and D-dimer levels (P = .027). Vitamin D-deficient COVID-19 patients had a greater prevalence of hypertension and cardiovascular diseases, raised serum ferritin and troponin levels, as well as a longer length of hospital stay than those with serum 25OHD levels ≥20 ng/mL. No causal relationship was found between vitamin D deficiency and COVID-19 severity as a combined endpoint or as its separate components.
Conclusions
25OHD levels are lower in hospitalized COVID-19 patients than in population-based controls and these patients had a higher prevalence of deficiency. We did not find any relationship between vitamin D concentrations or vitamin deficiency and the severity of the disease.
Since the 2008 economic recession, state intervention in the real estate sector has strengthened. This article explains how housing financialization was reignited in Spain following key policy ...reforms in 2013. We argue that Spanish authorities managed to strategically recreate a finance-friendly environment to attract global investors. They combined financial policies, other deregulatory reforms and neoliberal measures in a coordinated manner we call a policy package. Our analysis provides evidence of the legal and political arrangements at various state levels that effectively facilitated the reanimation of a new cycle of housing financialization which caused rising inflation in prices and distress in tenants' rights. This approach contributes to the understanding of how state-led actions foster a spatial fix to overcome financial crises by granting global speculative funds extraordinary benefits. In addition, we show how this process occurred with poor democratic accountability and was also confronted by various forms of social contestation.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Availability of fixed nitrogen is a pivotal driver on primary productivity in the oceans, thus the identification of key processes triggering nitrogen losses from these ecosystems is of major ...importance as they affect ecosystems function and consequently global biogeochemical cycles. Denitrification and anaerobic ammonium oxidation coupled to nitrite reduction (Anammox) are the only identified marine sinks for fixed nitrogen. The present study provides evidence indicating that anaerobic ammonium oxidation coupled to the reduction of sulfate, the most abundant electron acceptor present in the oceans, prevails in marine sediments. Tracer analysis with
15
N-ammonium revealed that this microbial process, here introduced as Sulfammox, accounts for up to 5 μg
15
N
2
produced g
−1
day
−1
in sediments collected from the eastern tropical North Pacific coast. Raman and X-ray diffraction spectroscopies revealed that elemental sulfur and sphalerite (ZnFeS) were produced, besides free sulfide, during the course of Sulfammox. Anaerobic ammonium oxidation linked to Fe(III) reduction (Feammox) was also observed in the same marine sediments accounting for up to 2 μg
15
N
2
produced g
−1
day
−1
. Taxonomic characterization, based on 16S rRNA gene sequencing, of marine sediments performing the Sulfammox and Feammox processes revealed the microbial members potentially involved. These novel nitrogen sinks may significantly fuel nitrogen loss in marine environments. These findings suggest that the interconnections among the oceanic biogeochemical cycles of N, S and Fe are much more complex than previously considered.
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