Trachyxiphium, including the species T. guadalupense (Pilotrichaceae), is reported for the first time for the moss flora of Uruguay. This study provides a description of its morphological ...characteristics and highlights its novel habitat within the region. Additionally, comments and illustrations are provided.
Cohesin exists in two variants carrying either STAG/SA1 or SA2. Here we have addressed their specific contributions to the unique spatial organization of the mouse embryonic stem cell genome, which ...ensures super-enhancer-dependent transcription of pluripotency factors and repression of lineage-specification genes within Polycomb domains. We find that cohesin-SA2 facilitates Polycomb domain compaction through Polycomb repressing complex 1 (PRC1) recruitment and promotes the establishment of long-range interaction networks between distant Polycomb-bound promoters that are important for gene repression. Cohesin-SA1, in contrast, disrupts these networks, while preserving topologically associating domain (TAD) borders. The diverse effects of both complexes on genome topology may reflect two modes of action of cohesin. One, likely involving loop extrusion, establishes overall genome arrangement in TADs together with CTCF and prevents excessive segregation of same-class compartment regions. The other is required for organization of local transcriptional hubs such as Polycomb domains and super-enhancers, which define cell identity.
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•Cohesin variants have distinct effects on mESC chromatin architecture and transcription•Cohesin-SA1 preferentially contributes to TAD boundary strength•Cohesin-SA2 facilitates Polycomb domain compaction through PRC1 recruitment•Cohesin-SA1 impedes and cohesin-SA2 promotes aggregation of distal Polycomb domains
The unique chromatin architecture of mESCs ensures high transcription of pluripotency factors and repression of lineage-specification genes. Cuadrado et al. report that besides their differential contribution to genome organization in TADs, cohesin variants SA1 and SA2 have antagonistic effects on the establishment of long-range contacts between Polycomb-bound genes that are essential for repression.
Psoriasis is a common inflammatory skin disease involving a cross‐talk between epidermal and immune cells. The role of specific epidermal stem cell populations, including hair follicle stem cells ...(HF‐SCs) in psoriasis is not well defined. Here, we show reduced expression of c‐JUN and JUNB in bulge HF‐SCs in patients with scalp psoriasis. Using lineage tracing in mouse models of skin inflammation with inducible deletion of c‐Jun and JunB, we found that mutant bulge HF‐SCs initiate epidermal hyperplasia and skin inflammation. Mechanistically, thymic stromal lymphopoietin (TSLP) was identified in mutant cells as a paracrine factor stimulating proliferation of neighboring non‐mutant epidermal cells, while mutant inter‐follicular epidermal (IFE) cells are lost over time. Blocking TSLP in psoriasis‐like mice reduced skin inflammation and decreased epidermal proliferation, VEGFα expression, and STAT5 activation. These findings unravel distinct roles of HF‐SCs and IFE cells in inflammatory skin disease and provide novel mechanistic insights into epidermal cell interactions in inflammation.
Synopsis
Lineage tracing in models of skin inflammation reveals that thymic stromal lymphopoietin (TSLP) activates pro‐inflammatory cues in mutant hair follicle stem cells (HF‐SCs) and keratinocytes (KCs) (1). Primed non‐mutant HF‐SCs also produce TSLP, thus contributing to the disease (2).
Scalp psoriasis was associated with a reduction of c‐JUN/JUNB in bulge hair follicle stem cells (HF‐SCs) in psoriatic patients.
Specific deletion of c‐Jun/JunB in bulge HF‐SCs (mutantGFP HF‐SCs) was sufficient for the development of psoriasis‐like disease in mice.
Keratinocytes derived from mutantGFPHF‐SCs survived, while keratinocytes from mutantGFP inter‐follicular epidermal cells (IFE) were lost during psoriasis progression.
TSLP was an important mediator for epidermal hyper‐proliferation and pro‐inflammatory signaling in keratinocytes. Neutralization with anti‐TSLP reduced epidermal cell proliferation and psoriasis‐like progression in mice.
TSLP was highly expressed in the epidermis and hair follicles of scalp psoriasis.
Lineage tracing in models of skin inflammation reveals that thymic stromal lymphopoietin (TSLP) activates pro‐inflammatory cues in mutant hair follicle stem cells (HF‐SCs) and keratinocytes (KCs). Primed non‐mutant HF‐SCs also produce TSLP, thus contributing to the disease.
Clinical pharmacy is a health discipline in which pharmacists provide patient care that optimizes rational medication use and promotes health, wellness and disease prevention. The beginnings of ...clinical pharmacy in Chile were inspired by the origin in the School of Pharmacy of the University of California, San Francisco (UCSF), in the mid-1960s. However, the historical development in our country, both in teaching and in the professional field, was accompanied by difficulties and success, which became a long and winding road. This article shares the events that gave rise to its beginnings in Chile, first through teaching, then in pharmacovigilance and clinical pharmacokinetics, to later describe its professional expansion and recognition as a specialty of pharmacy. This article briefly recounts the history of the Chilean clinical pharmacy to this day. Some names of people or institutions were not mentioned. Therefore the authors apologize in advance to pharmacists and organizations whose contribution cannot be recognized in this way. However, we know that this specialty has not been forged only by the names that appear, but by all those who love and respect the work of the clinical pharmacy.
Although there are different proposals in Spain to apply cooperative learning in physical education, they are focused on specific physical-sport activities or on very specific cooperative structures. ...In our country, there is a lack of comprehensive proposals aimed at facilitating the implementation of this pedagogical model in an extensive way, including all the motor action domains imposed by the education regulations. This article provides a model to apply cooperative learning in the area of physical education within the educational stages of primary and secondary school including all existing approaches up to now. The program is structured in four phases: 1) trust – group cohesion, 2) familiarization 3) consolidation and 4) performance, which embraces the five motor action domains that are established for the P.E. and the variables to take into account in the design of the activity: timing, number of lessons and activities, rules, group dynamics, roles, practice spaces, cooperative learning principles, teamwork skills, cooperative structures and techniques.
Embora existam diferentes propostas na Espanha para aplicar a aprendizagem cooperativa na educação física, estas se concentram em atividades físico-desportivas específicas ou em estruturas cooperativas muito específicas. Em nosso país faltam propostas abrangentes que visem facilitar a implantação desse modelo pedagógico de forma ampla, abrangendo todos os domínios da ação motora impostos pelas normas educacionais. Este artigo fornece um modelo de aplicação da aprendizagem cooperativa na área de educação física nas etapas educacionais do ensino fundamental e médio que engloba todas as abordagens existentes até o momento. Um programa estruturado em quatro fases: 1) confiança - coesão do grupo, 2) familiarização 3) consolidação e 4) desempenho, que abrange os cinco domínios da ação motora que se estabelecem para a E.F. e as variáveis a ter em conta na concepção da atividade: tempo, número de sessões e atividades, regras, dinâmica de grupo, papéis, espaços de prática, princípios de aprendizagem cooperativa, habilidades de trabalho em equipe, técnicas e estruturas cooperativas.
Aunque existen en España diferentes propuestas para aplicar el aprendizaje cooperativo en la educación física estas se centran en actividades físico-deportivas específicas o en estructuras cooperativas muy concretas. Faltan en nuestro país propuestas integrales destinadas a facilitar la implantación de este modelo pedagógico de forma extensiva abarcando todos los dominios de acción motriz que impone la normativa educativa. En este artículo se aporta un modelo para aplicar el aprendizaje cooperativo en el área de la educación física dentro de las etapas educativas de primaria y secundaria que engloba todos los enfoques existentes hasta el momento. Un programa estructurado en cuatro fases: 1) confianza–cohesión grupal, 2) familiarización 3) consolidación y 4) rendimiento, que abarca los cinco dominios de acción motriz que se establecen para la E.F. y las variables a tener en cuenta en el diseño de la actividad: Temporalización, número de sesiones y actividades, reglas, dinámica de las agrupaciones, roles, espacios de práctica, principios de aprendizaje cooperativo, destrezas de trabajo en equipo, técnicas y estructuras cooperativas.
The severity of hallux rigidus depends on the degree of joint involvement, from local pain to stress fractures of other bones of the foot due to hyper-support. Radiology is mandatory to have an ...accurate diagnosis and gives us a parameter of joint injury. We use the Coughlin and Shurnas classification as the gold standard for treatment. Level of Evidence IV.
Three new species of the genus Syllis Savigny in Lamarck, 1818, from the Chilean Patagonia are described, figured and discussed. The specimens were collected in boulders, sediment bottoms, ...Macrocystis pyrifera holdfasts, and inside tubes of Chaetopterus cf. variopedatus. Syllis patagonica n. sp., is characterized by its color pattern, short, fusiform dorsal cirri, plenty of hyaline inclusions, acuminate posterior acicula, and compound chaetae with slightly bidentate falcigers. Syllis terraeignium n. sp., has similar compound chaetae, but dorsal cirri are longer than those of the above mentioned species, a long proventricle, and the posterior acicula are straight, pointed. Finally, Syllis patersoni n. sp., has a slender, elongated body, with moderately long dorsal cirri, plenty of hyaline inclusions, acuminate posterior acicula, and compound chaetae composed by falcigers and short spiniger-like.
Abstract
A new genus of ectoparasitic marine annelids living on ctenophores, Ctenophoricola gen. nov., is described and its feeding behaviour, reproduction and developmental stages are discussed. Its ...unusual morphology challenged its placement within the known marine families. However, analyses of mitochondrial and nuclear sequence data showed the new genus as member of the Alciopini, a group of holopelagic annelids included within the Phyllodocidae. Ctenophoricola masanorii sp. nov. from Japan and Ctenophoricola rousei sp. nov. from the Canary Islands (Spain) are described. A third species from the Gulf of California is not formally described because the specimens are in poor condition. The new genus is characterized by having: 1) two distinctive body regions, the anterior with reduced parapodia lacking chaetae, and the posterior with long parapodia and chaetae and 2) a pair of large, elongate lensed eyes. These eyes are here described using histology and 3D reconstruction based on a Californian specimen. The two new species mainly differ in colour pattern, shape of parapodia, number of chaetae and body ciliation.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Syllis Savigny in Lamarck, 1818, the type genus of Syllidae, is the largest and most diverse within the family. This genus presents many taxonomic and phylogenetic problems due mainly to the lack of ...molecular data and morphological synapomorphies for many of the species, but also to poor or inadequate descriptions. In order to improve the knowledge of the genus, we have undertaken a morphological revision of Australian species, based on type material and material from the Australian Museum. Sixteen species are herein described, of which four are new and twelve are redescriptions of alreadyknown species, with six new combinations: Syllis boggemanni, n. sp.; S. joaoi, n. sp.; S. karlae, n. sp.; S. marceloi, n. sp.; S. albanyensis (Hartmann-Schröder, 1984) n. comb.; S. erikae (Hartmann-Schröder, 1981) n. comb.; S. krohnii Ehlers 1864; S. lunaris (Imajima, 1966) n. comb.; S. lutea (Hartmann-Schröder, 1960); S. macrodentata (Hartmann-Schröder, 1982) n. comb.; S. monilaris Savigny in Lamarck, 1818; S. nigropunctata Haswell, 1886; S. pectinans Haswell, 1920; S. rosea (Langerhans, 1879); S. warrnamboolensis (Hartmann-Schröder, 1987) n. comb.; and S. yallingupensis (Hartmann-Schröder, 1982), n. comb.
During a study of fauna associated with a shallow-water Zostera (Zosterella) noltei bed from the southern part of the Romanian Black Sea coast, among the identified material collected in 2015, a ...syllid polychaete belonging to the subfamily Exogoninae, Sphaerosyllis taylori Perkins, 1981, represents a new record for the Black Sea. Re-examination of available specimens previously identified as Sphaerosyllis bulbosa Southern, 1914 revealed that they belong to an unknown species, described herein as Sphaerosyllis pontica sp. nov. The new species is characterized by the median antenna inserted more posteriorly than the lateral antennae, dorsal cirri with bulbous bases and very short tips, shorter than the parapodial lobes, dorsal cirri absent on chaetiger 2, parapodial glands with fibrillar material from chaetiger 4 onwards, compound chaetae with short blades and smooth shafts, anterior parapodia with two aciculae each, one straight and one with bent tip. Descriptions of both species are provided together with a key to all Sphaerosyllis species known from the Black Sea.
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