The range of potential applications of compact laser-plasma ion sources motivates the development of new acceleration schemes to increase achievable ion energies and conversion efficiencies. Whilst ...the evolving nature of laser-plasma interactions can limit the effectiveness of individual acceleration mechanisms, it can also enable the development of hybrid schemes, allowing additional degrees of control on the properties of the resulting ion beam. Here we report on an experimental demonstration of efficient proton acceleration to energies exceeding 94 MeV via a hybrid scheme of radiation pressure-sheath acceleration in an ultrathin foil irradiated by a linearly polarised laser pulse. This occurs via a double-peaked electrostatic field structure, which, at an optimum foil thickness, is significantly enhanced by relativistic transparency and an associated jet of super-thermal electrons. The range of parameters over which this hybrid scenario occurs is discussed and implications for ion acceleration driven by next-generation, multi-petawatt laser facilities are explored.
The flare of radiation from the tidal disruption and accretion of a star can be used as a marker for supermassive black holes that otherwise lie dormant and undetected in the centres of distant ...galaxies. Previous candidate flares have had declining light curves in good agreement with expectations, but with poor constraints on the time of disruption and the type of star disrupted, because the rising emission was not observed. Recently, two 'relativistic' candidate tidal disruption events were discovered, each of whose extreme X-ray luminosity and synchrotron radio emission were interpreted as the onset of emission from a relativistic jet. Here we report a luminous ultraviolet-optical flare from the nuclear region of an inactive galaxy at a redshift of 0.1696. The observed continuum is cooler than expected for a simple accreting debris disk, but the well-sampled rise and decay of the light curve follow the predicted mass accretion rate and can be modelled to determine the time of disruption to an accuracy of two days. The black hole has a mass of about two million solar masses, modulo a factor dependent on the mass and radius of the star disrupted. On the basis of the spectroscopic signature of ionized helium from the unbound debris, we determine that the disrupted star was a helium-rich stellar core.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Antiferromagnets are hard to control by external magnetic fields because of the alternating directions of magnetic moments on individual atoms and the resulting zero net magnetization. However, ...relativistic quantum mechanics allows for generating current-induced internal fields whose sign alternates with the periodicity of the antiferromagnetic lattice. Using these fields, which couple strongly to the antiferromagnetic order, we demonstrate room-temperature electrical switching between stable configurations in antiferromagnetic CuMnAs thin-film devices by applied current with magnitudes of order 10⁶ ampere per square centimeter. Electrical writing is combined in our solid-state memory with electrical readout and the stored magnetic state is insensitive to and produces no external magnetic field perturbations, which illustrates the unique merits of antiferromagnets for spintronics.
This review presents an overview of the initial targeted chemical processing stages for conversion of lignocellulosic biomass to platform molecules that serve as intermediates for the production of ...carbon-based fuels and chemicals. We identify four classes of platform molecules that can be obtained in an initial chemical processing step: (i) sugars, (ii) dehydration products, (iii) polyols and (iv) lignin monomers. Special emphasis is placed on reporting and comparing parameters that affect process economics and/or sustainability, including product yields, amount of catalyst used, processing conditions, and product concentrations. We discuss the economic trade-offs associated with choices related to these parameters, depending on the product that is targeted. We also address the effects of real biomass on the ability to recover, recycle, and potentially regenerate catalysts and solvents used in the biomass conversion processes.
We review the initial targeted chemical processing stages for converting lignocellulosic biomass to bio-based fuels and chemicals.
On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an ...estimated false-alarm rate of 1 in 4900 yr using a search sensitive to generic transients. If GW190521 is from a quasicircular binary inspiral, then the detected signal is consistent with the merger of two black holes with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16}^{+28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance of the source is 5.3_{-2.6}^{+2.4} Gpc, corresponding to a redshift of 0.82_{-0.34}^{+0.28}. The inferred rate of mergers similar to GW190521 is 0.13_{-0.11}^{+0.30} Gpc^{-3} yr^{-1}.
We found that exposure of mice and rats to male but not female experimenters produces pain inhibition. Male-related stimuli induced a robust physiological stress response that results in ...stress-induced analgesia. This effect could be replicated with T-shirts worn by men, bedding material from gonadally intact and unfamiliar male mammals, and presentation of compounds secreted from the human axilla. Experimenter sex can thus affect apparent baseline responses in behavioral testing.
Blood biomarkers have great potential to advance clinical care and accelerate trials in Alzheimer's disease (AD). Plasma phospho-tau181 (p-tau181) is a promising blood biomarker however, it is ...unknown if levels increase in presymptomatic AD. Therefore, we investigated the timing of p-tau181 changes using 153 blood samples from 70 individuals in a longitudinal study of familial AD (FAD). Plasma p-tau181 was measured, using an in-house single molecule array assay. We compared p-tau181 between symptomatic carriers, presymptomatic carriers, and non-carriers, adjusting for age and sex. We examined the relationship between p-tau181 and neurofilament light and estimated years to/from symptom onset (EYO), as well as years to/from actual onset in a symptomatic subgroup. In addition, we studied associations between p-tau181 and clinical severity, as well testing for differences between genetic subgroups. Twenty-four were presymptomatic carriers (mean baseline EYO -9.6 years) while 27 were non-carriers. Compared with non-carriers, plasma p-tau181 concentration was higher in both symptomatic (p < 0.001) and presymptomatic mutation carriers (p < 0.001). Plasma p-tau181 showed considerable intra-individual variability but individual values discriminated symptomatic (AUC 0.93 95% CI 0.85-0.98) and presymptomatic (EYO ≥ -7 years) (AUC 0.86 95% CI 0.72-0.94) carriers from non-carriers of the same age and sex. From a fitted model there was evidence (p = 0.050) that p-tau181 concentrations were higher in mutation carriers than non-carriers from 16 years prior to estimated symptom onset. Our finding that plasma p-tau181 concentration is increased in symptomatic and presymptomatic FAD suggests potential utility as an easily accessible biomarker of AD pathology.
Bringing physics to life at the submesoscale Lévy, Marina; Ferrari, Raffaele; Franks, Peter J. S. ...
Geophysical research letters,
07/2012, Letnik:
39, Številka:
14
Journal Article
Recenzirano
Odprti dostop
A common dynamical paradigm is that turbulence in the upper ocean is dominated by three classes of motion: mesoscale geostrophic eddies, internal waves and microscale three‐dimensional turbulence. ...Close to the ocean surface, however, a fourth class of turbulent motion is important: submesoscale frontal dynamics. These have a horizontal scale of O(1–10) km, a vertical scale of O(100) m, and a time scale of O(1) day. Here we review the physical‐chemical‐biological dynamics of submesoscale features, and discuss strategies for sampling them. Submesoscale fronts arise dynamically through nonlinear instabilities of the mesoscale currents. They are ephemeral, lasting only a few days after they are formed. Strong submesoscale vertical velocities can drive episodic nutrient pulses to the euphotic zone, and subduct organic carbon into the ocean's interior. The reduction of vertical mixing at submesoscale fronts can locally increase the mean time that photosynthetic organisms spend in the well‐lit euphotic layer and promote primary production. Horizontal stirring can create intense patchiness in planktonic species. Submesoscale dynamics therefore can change not only primary and export production, but also the structure and the functioning of the planktonic ecosystem. Because of their short time and space scales, sampling of submesoscale features requires new technologies and approaches. This paper presents a critical overview of current knowledge to focus attention and hopefully interest on the pressing scientific questions concerning these dynamics.
Key Points
Submesoscale physics control ecology locally, but also feedback to basin scales
Strong gradients in community structure are created at the submesoscale
Despite recent innovations, sampling the submesoscale remains a major challenge
Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These ...simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus developed by the COST INFOGEST network. The method is designed to be used with standard laboratory equipment and requires limited experience to encourage a wide range of researchers to adopt it. It is a static digestion method that uses constant ratios of meal to digestive fluids and a constant pH for each step of digestion. This makes the method simple to use but not suitable for simulating digestion kinetics. Using this method, food samples are subjected to sequential oral, gastric and intestinal digestion while parameters such as electrolytes, enzymes, bile, dilution, pH and time of digestion are based on available physiological data. This amended and improved digestion method (INFOGEST 2.0) avoids challenges associated with the original method, such as the inclusion of the oral phase and the use of gastric lipase. The method can be used to assess the endpoints resulting from digestion of foods by analyzing the digestion products (e.g., peptides/amino acids, fatty acids, simple sugars) and evaluating the release of micronutrients from the food matrix. The whole protocol can be completed in ~7 d, including ~5 d required for the determination of enzyme activities.
Abstract
Determination of the lithium depletion boundary (LDB), i.e., the observational limit below which the cores of very low-mass objects do not reach high enough temperatures for Li destruction, ...has been used to obtain ages for several open clusters and stellar associations younger than 200 Myr—which until now has been considered the practical upper limit on the range of applicability of this method. In this work, we show that the LDB method can be extended to significant older ages than previously thought. Intermediate resolution optical spectra of six L-type candidate members in the Hyades cluster obtained using Optical System for Imaging and Low Resolution Integrated Spectroscopy at the 10.4 m Gran Telescopio Canarias are presented. The
670.8 nm resonance doublet is clearly detected only in the two faintest and coolest of these objects, which are classified as L3.5 to L4 brown dwarf (BD) cluster members with luminosities around 10
−4
solar. Lithium depletion factors are estimated for our targets with the aid of synthetic spectra and they are compared with predictions from evolutionary models. An LDB age of 650 ± 70 Myr for the Hyades provides a consistent description of our data using a set of state-of-the-art evolutionary models for BDs calculated by Baraffe et al.
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