We report the INTernational Gamma-ray Astrophysics Laboratory (INTEGRAL) detection of the short gamma-ray burst GRB 170817A (discovered by Fermi-GBM) with a signal-to-noise ratio of 4.6, and, for the ...first time, its association with the gravitational waves (GWs) from binary neutron star (BNS) merging event GW170817 detected by the LIGO and Virgo observatories. The significance of association between the gamma-ray burst observed by INTEGRAL and GW170817 is 3.2 , while the association between the Fermi-GBM and INTEGRAL detections is 4.2 . GRB 170817A was detected by the SPI-ACS instrument about 2 s after the end of the GW event. We measure a fluence of (1.4 0.4 0.6) × 10−7 erg cm−2 (75-2000 keV), where, respectively, the statistical error is given at the 1 confidence level, and the systematic error corresponds to the uncertainty in the spectral model and instrument response. We also report on the pointed follow-up observations carried out by INTEGRAL, starting 19.5 hr after the event, and lasting for 5.4 days. We provide a stringent upper limit on any electromagnetic signal in a very broad energy range, from 3 keV to 8 MeV, constraining the soft gamma-ray afterglow flux to <7.1 × 10−11 erg cm−2 s−1 (80-300 keV). Exploiting the unique capabilities of INTEGRAL, we constrained the gamma-ray line emission from radioactive decays that are expected to be the principal source of the energy behind a kilonova event following a BNS coalescence. Finally, we put a stringent upper limit on any delayed bursting activity, for example, from a newly formed magnetar.
We report on International Gamma-Ray Astrophysics Laboratory (INTEGRAL) observations of the soft γ-ray repeater SGR 1935+2154 performed between 2020 April 28 and May 3. Several short bursts with ...fluence of erg cm−2 were detected by the Imager on-board INTEGRAL (IBIS) instrument in the 20-200 keV range. The burst with the hardest spectrum, discovered and localized in real time by the INTEGRAL Burst Alert System, was spatially and temporally coincident with a short and very bright radio burst detected by the Canadian Hydrogen Intensity Mapping Experiment (CHIME) and Survey for Transient Astronomical Radio Emission 2 (STARE2) radio telescopes at 400-800 MHz and 1.4 GHz, respectively. Its lightcurve shows three narrow peaks separated by ∼29 ms time intervals, superimposed on a broad pulse lasting ∼0.6 s. The brightest peak had a delay of 6.5 1.0 ms with respect to the 1.4 GHz radio pulse (that coincides with the second and brightest component seen at lower frequencies). The burst spectrum, an exponentially cutoff power law with photon index and peak energy , is harder than those of the bursts usually observed from this and other magnetars. By the analysis of an expanding dust-scattering ring seen in X-rays with the Neil Gehrels Swift Observatory X-ray Telescope (XRT) instrument, we derived a distance of kpc for SGR 1935+2154, independent of its possible association with the supernova remnant G57.2+0.8. At this distance, the burst 20-200 keV fluence of erg cm−2 corresponds to an isotropic emitted energy of erg. This is the first burst with a radio counterpart observed from a soft γ-ray repeater and it strongly supports models based on magnetars that have been proposed for extragalactic fast radio bursts.
Aims.
Gamma-ray burst (GRB) 190829A (
z
= 0.0785) was detected by
Fermi
and
Swift
and also at very high energy (VHE) by the High-Energy Stereoscopic System (H.E.S.S.) telescopes. The prompt emission ...displayed two emission episodes separated by a quiescent gap of ∼40 s. We present the 10.4 m Gran Telescopio Canarias (GTC) observations of the afterglow of GRB 190829A and its underlying supernova. We also compare GRB 190829A to GRB 180728A, a GRB with similar behaviour, and discuss the implications on underlying physical mechanisms producing these two GRBs.
Methods.
We present multi-band photometric data along with spectroscopic follow-up observations taken with the 10.4 m GTC telescope. Together with the data from the prompt emission, the 10.4 m GTC data are used to understand the emission mechanisms and possible progenitor.
Results.
A detailed analysis of the multi-band observations of the afterglow requires the cooling frequency to pass between the optical and X-ray bands at early epochs. The afterglow then transitions to the underlying supernova (SN) 2019oyw, which dominates later on.
Conclusions.
Although the prompt emission temporal properties of GRB 190829A and GRB 180728A are similar, the two pulses are different in the spectral domain. We find that SN 2019oyw associated with GRB 190829A is powered by Ni decay and is a Type Ic-BL SN. The spectroscopic and photometric properties of this SN are consistent with those observed for SN 1998bw, but evolved earlier.
The Laser Interferometer Gravitational Wave Observatory (LIGO) and Virgo Collaboration’s Observing Run 3 has demanded the development of widely-applicable tools for gravitational wave follow-up. ...These tools must address the main challenges of the multi-messenger era, namely covering large localisation regions and quickly identifying decaying transients. To address these challenges, we present a public web interface to assist astronomers in conducting galaxy-targeted follow-up of gravitational wave events by offering a fast and public list of targets post-gravitational wave trigger. After a gravitational wave trigger, the back-end galaxy retrieval algorithm identifies and scores galaxies based on the LIGO and Virgo computed probabilities and properties of the galaxies taken from the Galaxy List for the Advanced Detector Era V2 galaxy catalogue. Within minutes, the user can retrieve, download, and limit ranked galaxy lists from the web application. The algorithm and website have been tested on past gravitational wave events, and execution times have been analysed. The algorithm is being triggered automatically during Observing Run 3 and its features will be extended if needed. The web application was developed using the Python based
Flask
web framework.
Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy for various forms of cancer and show promise in treating HIV-1 infection. However, significant limitations are ...persistence and whether peripheral T cell-based products can respond to malignant or infected cells that may reappear months or years after treatment remains unclear. Hematopoietic Stem/Progenitor Cells (HSPCs) are capable of long-term engraftment and have the potential to overcome these limitations. Here, we report the use of a protective CD4 chimeric antigen receptor (C46CD4CAR) to redirect HSPC-derived T-cells against simian/human immunodeficiency virus (SHIV) infection in pigtail macaques. CAR-containing cells persisted for more than 2 years without any measurable toxicity and were capable of multilineage engraftment. Combination antiretroviral therapy (cART) treatment followed by cART withdrawal resulted in lower viral rebound in CAR animals relative to controls, and demonstrated an immune memory-like response. We found CAR-expressing cells in multiple lymphoid tissues, decreased tissue-associated SHIV RNA levels, and substantially higher CD4/CD8 ratios in the gut as compared to controls. These results show that HSPC-derived CAR T-cells are capable of long-term engraftment and immune surveillance. This study demonstrates for the first time the safety and feasibility of HSPC-based CAR therapy in a large animal preclinical model.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
ABSTRACT
PSR B1259-63 is a gamma-ray binary system hosting a radio pulsar orbiting around an O9.5Ve star, LS 2883, with a period of ∼3.4 yr. The interaction of the pulsar wind with the LS 2883 ...outflow leads to unpulsed broad-band emission in the radio, X-rays, GeV, and TeV domains. While the radio, X-ray, and TeV light curves show rather similar behaviour, the GeV light curve appears very different with a huge outburst about a month after a periastron. The energy release during this outburst seems to significantly exceed the spin-down luminosity of the pulsar and both the GeV light curve and the energy release vary from one orbit to the next. In this paper, we present for the first time the results of optical observations of the system in 2017, and also reanalyse the available X-ray and GeV data. We present a new model in which the GeV data are explained as a combination of the bremsstrahlung and inverse Compton emission from the unshocked and weakly shocked electrons of the pulsar wind. The X-ray and TeV emission is produced by synchrotron and inverse Compton emission of energetic electrons accelerated on a strong shock arising due to stellar/pulsar winds collision. The brightness of the GeV flare is explained in our model as a beaming effect of the energy released in a cone oriented, during the time of the flare, in the direction of the observer.
Due to the durability and persistence of reservoirs of HIV-1-infected cells, combination antiretroviral therapy (ART) is insufficient in eradicating infection. Achieving HIV-1 cure or sustained ...remission without ART treatment will require the enhanced and persistent effective antiviral immune responses. Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy and show promise in treating HIV-1 infection. Persistence, trafficking, and maintenance of function remain to be a challenge in many of these approaches, which are based on peripheral T cell modification. To overcome many of these issues, we have previously demonstrated successful long-term engraftment and production of anti-HIV CAR T cells in modified hematopoietic stem cells (HSCs) in vivo. Here we report the development and in vivo testing of second generation CD4-based CARs (CD4CAR) against HIV-1 infection using a HSCs-based approach. We found that a modified, truncated CD4-based CAR (D1D2CAR) allows better CAR-T cell differentiation from gene modified HSCs, and maintains similar CTL activity as compared to the full length CD4-based CAR. In addition, D1D2CAR does not mediate HIV infection or stimulation mediated by IL-16, suggesting lower risk of off-target effects. Interestingly, stimulatory domains of 4-1BB but not CD28 allowed successful hematopoietic differentiation and improved anti-viral function of CAR T cells from CAR modified HSCs. Addition of 4-1BB to CD4 based CARs led to faster suppression of viremia during early untreated HIV-1 infection. D1D2CAR 4-1BB mice had faster viral suppression in combination with ART and better persistence of CAR T cells during ART. In summary, our data indicate that the D1D2CAR-41BB is a superior CAR, showing better HSC differentiation, viral suppression and persistence, and less deleterious functions compared to the original CD4CAR, and should continue to be pursued as a candidate for clinical study.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
ABSTRACT
We present the results from Nordic Optical Telescope and X-shooter follow-up campaigns of the tidal disruption event (TDE) iPTF16fnl, covering the first ∼100 d after the transient discovery. ...We followed the source photometrically until the TDE emission was no longer detected above the host galaxy light. The bolometric luminosity evolution of the TDE is consistent with an exponential decay with e-folding constant t0 = 17.6 ± 0.2 d. The early-time spectra of the transient are dominated by broad He ii λ4686, H $\beta$, H $\alpha$, and N iii λ4100 emission lines. The latter is known to be produced together with the N iii λ4640 in the Bowen fluorescence mechanism. Due to the medium-resolution X-shooter spectra we have been able to separate the Bowen blend contribution from the broad He ii emission line. The detection of the Bowen fluorescence lines in iPTF16fnl place this transient among the N-rich TDE subset. In the late-time X-shooter spectra, narrow emission lines of O iii and N ii originating from the host galaxy are detected, suggesting that the host galaxy harbours a weak active galactic nucleus in its core. The properties of all broad emission lines evolve with time. The equivalent widths follow an exponential decay compatible with the bolometric luminosity evolution. The full width at half-maximum of the broad lines decline with time and the line profiles develop a narrow core at later epochs. Overall, the optical emission of iPTF16fnl can be explained by being produced in an optically thick region in which high densities favour the Bowen fluorescence mechanism and where multiple electron scatterings are responsible for the line broadening.
Abstract
Previous cognitive training research with the change-detection paradigm found only sparse effects that went beyond improvements in the training task but stressed an increase in fidelity of ...internal memory representations. Motivated by the demanding visual processing requirements of change-detection training, we extended this work by focusing on whether training on a change-detection task would improve visual processing skills. Fifty participants were randomly assigned to train on a change-detection task or on a control task for seven sessions. Participants’ visual processing skills were assessed before and after the intervention, focusing on visual search, contrast sensitivity, and contour integration. Our results suggest a general improvement in perceptual skills that was primarily driven by a conjunction search task and to a much lesser extent by a complex visual search task and a contrast sensitivity task. The data from the conjunction search task further suggest a causal link between training and improvements of perceptual as opposed to attentional processes. Since the change-detection paradigm is commonly used to assess working memory capacity, future research needs to investigate how much of its variance is explained by memory performance and how much is explained by perceptual processes.
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