One side effect of the immunomodulatory effect of interferon is the possible triggering or exacerbation of systemic or cutaneous sarcoidosis. We report two new cases and offer an exhaustive review of ...the literature. A 39-year-old man with type C chronic active hepatitis developed new respiratory symptoms and pulmonary infiltrates with hilar and mediastinal adenopathy after 7 months of treatment with pegylated interferon. The evolution was favourable after stopping treatment. The second patient developed cutaneous lesions after 6 months of treatment. Resolution occurred after the discontinuation of the treatment. In these two cases ribavirin was stopped before the first signs of sarcoidosis.
Le mécanisme de formation du granulome sarcoïdosique est peu clair. L’activation des lymphocytes CD4+ et l’interféron gamma semblent jouer un rôle important. L’interféron par ses effets ...immunomodulateurs pourrait induire ou aggraver une sarcoïdose. Nous rapportons deux cas de sarcoïdose sous interféron retard. Le premier malade âgé de 39 ans développait une sarcoïdose pulmonaire (syndrome interstitiel et adénopathies médiastinales) après sept mois de traitement. L’évolution était favorable après arrêt de l’interféron. Le deuxième malade présentait une forme cutanée après six mois et demi de traitement. L’évolution était favorable à l’arrêt du traitement et sans corticothérapie.
One side effect of the immunomodulatory effect of interferon is the possible triggering or exacerbation of systemic or cutaneous sarcoidosis. We report two new cases and offer an exhaustive review of the literature. A 39-year-old man with type C chronic active hepatitis developed new respiratory symptoms and pulmonary infiltrates with hilar and mediastinal adenopathy after 7 months of treatment with pegylated interferon. The evolution was favourable after stopping treatment. The second patient developed cutaneous lesions after 6 months of treatment. Resolution occurred after the discontinuation of the treatment. In these two cases ribavirin was stopped before the first signs of sarcoidosis.
