A correct definition of the most adequate strategies and/or course of action to improve the sustainability of the wine industry must start with an evaluation, as objective and accurate as possible, ...of the sustainability performance of its products and processes. The main goal of this work is to perform a comparative sustainability evaluation of two Portuguese wines: a high market value “terroir” wine produced in small quantities, using grapes from a single vineyard, and a branded wine with lower market value, produced in large quantities using grapes from various regions. The evaluation follows a life cycle perspective and is based on seven sustainability indicators, selected taking into account the main issues pertinent to the wine industry. The functional unit is 0.75 L of wine produced that is the most common capacity of the wine bottles. The environmental and economic information used for the evaluation is mainly primary data obtained from the company, and complemented whenever necessary with secondary data from the literature or life cycle inventory databases. Results show that the main differences between the two wines are their water intensity and wastewater generated, being the values of the branded wine more than double those of the “terroir” wine, which is attributable to differences in the winemaking process, in particular the need to remove the SO2 added in the branded wine production. The calculated values for the carbon emissions are in good agreement with literature works. Some recommendations for improvement of the process sustainability are given.
•A comparative sustainability assessment of two Portuguese wines is performed.•Wines differ in terms of winemaking process, produced volume and market value.•System boundary includes winemaking, transportation of must and grapes, bottling and packaging.•Sustainability indicators use data mainly from real industrial practice.
Patients with polycythemia vera (PV) or essential thrombocythemia (ET) presenting with splanchnic vein thrombosis (SVT) might have a specific clinico-biological profile. To investigate this ...hypothesis, 3705 PV/ET patients from three national registers, 118 of them presenting with SVT, were reviewed. After correction for age and sex, PV/ET patients with SVT showed an increased risk of death (HR 2.47, 95% CI 1.5–4.01,
p
< 0.001), venous thrombosis (IRR 3.4, 95%CI 2.1–5.5, p < 0.001), major bleeding (IRR 3.6, 95%CI 2.3–5.5,
p
< 0.001), and second cancer (IRR 2.37, 95%CI 1.4–4.1,
p
= 0.002). No case of acute leukemia was documented among patients with PV/ET presenting with SVT and seven of them (6%) progressed to myelofibrosis. SVT was not associated with lower risk of MF after correction by age and sex. Patients with SVT more frequently died from complications related to hepatic disease, major bleeding, or second cancer, resulting in a 5-year reduction of age- and sex-adjusted median survival. In conclusion, PV and ET patients presenting with SVT have shorter survival than patients with PV and ET of the same age and sex. This excess mortality is related to liver disease, major bleeding, and second cancer rather than to the natural evolution of the MPN.
This study uses the process simulator ASPEN Plus
® and Life Cycle Assessment (LCA) to compare three process design alternatives for biodiesel production from waste vegetable oils that are: the ...conventional alkali-catalyzed process including a free fatty acids (FFAs) pre-treatment, the acid-catalyzed process, and the supercritical methanol process using propane as co-solvent. Results show that the supercritical methanol process using propane as co-solvent is the most environmentally favorable alternative. Its smaller steam consumption in comparison with the other process design alternatives leads to a lower contribution to the potential environmental impacts (PEI’s). The acid-catalyzed process generally shows the highest PEI’s, in particular due to the high energy requirements associated with methanol recovery operations.
Ultraviolet radiation (UVR) induces damage in a variety of organisms, and cells may adapt by developing repair or tolerance mechanisms to counteract such damage; otherwise, the cellular fate is cell ...death. Here, the effect of UVR-induced cell damage and the associated signalling and repair mechanisms by which cells are able to survive was studied in Dunaliella tertiolecta. UVR did not cause cell death, as shown by the absence of SYTOX Green-positive labelling cells. Ultrastructure analysis by transmission electron microscopy demonstrated that the cells were alive but were subjected to morphological changes such as starch accumulation, chromatin disaggregation, and chloroplast degradation. This behaviour paralleled a decrease in F v/F m and the formation of cyclobutane–pyrimidine dimers, showing a 10-fold increase at the end of the time course. There was a high accumulation of the repressor of transcriptional gene silencing (ROS1), as well as the cell proliferation nuclear antigen (PCNA) in UVR-treated cells, revealing activation of DNA repair mechanisms. The degree of phosphorylation of c-Jun N-terminal kinase (JNK) and p38-like mitogen-activated protein kinases was higher in UVR-exposed cells; however, the opposite occurred with the phosphorylated extracellular signal-regulated kinase (ERK). This confirmed that both JNK and p38 need to be phosphorylated to trigger the stress response, as well as the fact that cell division is arrested when an ERK is dephosphorylated. In parallel, both DEVDase and WEHDase caspase-like enzymatic activities were active even though the cells were not dead, suggesting that these proteases must be considered within a wider frame of stress proteins, rather than specifically being involved in cell death in these organisms.
Diatoms are very diverse and highly productive organisms, found in a wide variety of environments. This study aims to analyze the growth and lipid composition of Phaeodactylum tricornutum, cultured ...in an outdoor pilot-scale bubble column photobioreactor under natural conditions in Chile for biodiesel production. Results showed that P. tricornutum cultures reached their highest biomass concentration (0.96 ± 0.04 kg m−3) after 14 days of culturing, at the stationary phase, with a volumetric productivity of 0.13 kg m−3 d−1. Biomass samples showed a total lipid content of 9.08 ± 0.38 wt %. The fatty acid methyl ester analysis revealed a composition of 24.39% C16-C18 fatty acids, 42.34% saturated fatty acids, 21.91% monounsaturated fatty acids and 31.41% polyunsaturated fatty acids. These findings suggest that P. tricornutum oil can be used as an alternative raw material for the production of biodiesel capable of meeting international quality standards.
This work aims to calculate the carbon footprint of the ICB produced by a Portuguese company and to compare it with other insulation materials available in the market. A Life Cycle Thinking approach ...and the ISO/TS 14067 (2013) requirements were followed in this work to perform a “cradle-to-gate” life cycle analysis. The inventory analysis mainly uses primary data collected from a Portuguese ICB producing company, complemented with secondary data from commercial life cycle databases and literature concerning respectively, the external transportation of the cork raw-material and the emission factors of electricity and fuel production and use. Results of this study show that ICB has a carbon footprint of −116.229 kg CO2 equivalent per m3 of ICB. It is the only insulation material present in the market with a negative carbon footprint, which is mainly due to the utilization of cork, a renewable raw material, the proximity of its source to the factory, and the use of biomass for generating the steam needed for its production process. To the authors’ knowledge, this is the first study to report the carbon footprint of ICB and to compare it with other building insulation materials.
•The carbon footprint of Insulation Cork Board, ICB, is determined following a Life Cycle Thinking approach and the ISO/TS 14067 (2013) requirements.•A “cradle-to-gate” life cycle analysis is done showing that ICB is carbon negative, due to the utilization of cork, a renewable raw material.•A comparison with other insulation materials showed the superiority of ICB from a carbon footprint point of view.
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Photodynamic therapy (PDT) is an established anticancer treatment that combines the use of a photosensitiser (PS) and a light source of a specific wavelength for the generation of ...reactive oxygen species (ROS) that are toxic to the tumour cells. Foscan® (mTHPC) is a clinically-approved chlorin used for the PDT treatment of advanced head and neck, prostate and pancreatic cancers but is characterized by being photochemically unstable and associated with prolonged skin photosensitivity. Herein, we report the synthesis of new 4,5,6,7-tetrahydropyrazolo1,5-apyridine-fused chlorins, having the meso-tetra(3-hydroxyphenyl)macrocycle core of mTHPC, by exploring the 8π + 2π cycloaddition of a meso-tetra(3-hydroxyphenyl)porphyrin derivative with diazafulvenium methides. These chlorins have photochemical properties similar to Foscan® but are much more photostable. Among the novel compounds, two chlorins with a hydroxymethyl group and its azide derivative present in the 4,5,6,7-tetrahydropyrazolo1,5-apyridine-fused system, are promising photodynamic agents with activity in the 100 nM range against triple-negative breast cancer cells and, in the case of azidomethyl chlorin, a safer phototherapeutic index compared to Foscan®.
Low indoor air quality is an increasingly important problem due to the spread of urbanization. Because people spend most of their time inside, poor indoor air quality causes serious human health ...issues, resulting in significant economic losses. In this work, the current state of affairs is presented and analyzed, focusing on the current problems and the available solutions to improve the quality of indoor air, and the use of nature-based solutions. These involve the cultivation of microalgae in closed photobioreactors. In these systems, photosynthetic organisms can capture CO2 and other pollutants generated in indoor environments, which they use to grow and develop biomass. Several possible layouts for the implementation of microalgae-based indoor air cleaning systems are presented, taking into account the systems that are currently available at a commercial scale. A critical analysis of the microalgae indoor purification systems is presented, highlighting their advantages and disadvantages, and suggesting potential improvements and future lines of research and development in the area.
Energy has been the engine of nations’ development, and this has driven mankind towards growing energy needs, in particular for transportation, agricultural and industrial activities and buildings. ...Energy for transportation is based on oil derived fuel, whereas energy in buildings consists mainly of electricity, which is produced from fossil fuels, nuclear power and/or from renewable energy sources, such as hydro and solar. Agricultural and industrial activities use a combination of fossil fuels and electric energy. To increase the sustainability of energy production and efficient energy use, it is urgent that better monitoring and control systems are used, and increase the energy production from renewable sources. This drives the energy sector towards the need for Life Cycle Analysis of energy processes to support the selection and implementation of more sustainable energy systems, as well as to develop better and more intelligent electric energy grids, where storage energy systems plays an essential role. These questions will be briefly discussed in this paper, focusing in the current situation, existing problems and potential solutions, and expected developments.
The world population is ageing, in particular in the developed world, with a significant increase in the percentage of people above 60 years old. They represent a segment of the population that is ...more vulnerable to adverse environmental conditions. Among them, indoor air quality is one of the most relevant, as elders spend comparatively more time indoors than younger generations. Furthermore, the recent COVID-19 pandemic contributed immensely to raising awareness of the importance of breathing air quality for human health and of the fact that indoor air is a vector for airborne infections and poisoning. Hence, this work reviews the state of the art regarding indoor air quality in elderly centers, considering the type of pollutants involved, their emission sources, and their health effects. Moreover, the influence of ventilation on air quality is also addressed. Notwithstanding the potential health problems with the corresponding costs and morbidity effects, only a few studies have considered explicitly indoor air quality and its impacts on elderly health. More studies are, therefore, necessary to objectively identify what are the impacts on the health of elderly people due to the quality of indoor air and how it can be improved, either by reducing the pollutants emission sources or by more adequate ventilation and thermal comfort strategies.
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