We report a case of smoldering adult T-cell leukemia (ATL) with B-cell lymphoma and early gastric cancer. A 64-year-old man was admitted to our hospital because of proteinuria and ...hypergammaglobulinemia. Systemic lymphadenopathy, "flower cells" in peripheral white blood cells, and hypergammaglobulinemia with monoclonal gammopathy (IgA, λ type) were found. As Southern blot analysis revealed monoclonal integration of human T-lymphotrophic virus type I proviral DNA in peripheral blood mononuclear cells, he was diagnosed as having smoldering ATL. The tissue specimen of an inguinal lymph node showed proliferation of abnormal lymphocytes which were stained with anti-λ antibody, indicating B-cell lymphoma. A polypoid lesion in the stomach was histologically diagnosed as early gastric cancer. (Internal Medicine 34:118-121, 1995)
A 56-year-old man with left anterior chest pain showed two well-defined tumors in the left anterior chest wall and left parietal region. A large osteolytic lesion in the parietal bone and several ...punched-out lesions in the temporal bone were revealed by a skull X-ray examination. He showed monoclonal gammopathy (IgG, kappa type) and Bence Jones proteinuria, but no proliferation of plasma cells was observed in the bone marrow. The tissue specimens from both lesions consisted of abnormal plasma cells, indicating plasmacytoma. Although a bulky intracranial plasmacytoma was present, the patient did not exhibit intracranial hypertensive symptoms, or neurological abnormalities. (Internal Medicine 33: 376-379, 1994)
Verification Program of BWR 9×9 Fuel MIYASHITA, Toshiyasu; NAKAE, Nobuo; OGATA, Keizo ...
Transactions of the Atomic Energy Society of Japan,
2008, Letnik:
7, Številka:
4
Journal Article
Odprti dostop
The high-burnup BWR 9×9 lead use fuel assemblies (LUAs), which are designed for a maximum assembly burnup of 55 GWd/t in Japan, have been examined after irradiation in a commercial BWR to confirm the ...reliability of the current safety evaluation methodology and to accumulate data for judging the adequacy of its application to the future higher burnup fuel. The irradiation performance of 9×9 LUAs for two different designs, types A and B, is generally on the extended trend of 8×8 fuel, but some new findings in terms of fuel performance have been addressed after 5 cycle irradiations. Accelerated corrosion of cladding for the corner rods in Type-B fuel assemblies and spacers in both types is observed after 5 cycle irradiations. The increasing trend of high hydrogen concentration seems to be an issue, which should be paid much attention with respect to fuel integrity during high-burnup irradiation. The large difference in fission gas release rate between two types of fuel is confirmed after 3 and 5 cycle irradiations, and the release rate of Al-Si-O doped pellets is particularly higher than the others.
We report a case of chronic hepatitis C presenting insulin-dependent diabetes mellitus (IDDM) associated with various autoantibodies including possible anti-insulin receptor antibody (AIRA) during ...interferon (IFN) therapy. A 57-year-old man having chronic hepatitis C virus (HCV) infection with chronic thyroiditis received IFN therapy. The thyroid function was well-controlled by administration of thyroid hormone, although thyroid autoantibodies were positive. At 15 weeks after starting IFN (reaching 530 million units of total dose), marked thirst happened, with increased fasting plasma glucose level (488 mg/dl) and decreased daily urinary C peptide immunoreactivity level (less than 4.2 μg/day). IDDM occurred with anti-nuclear antibody (ANA), anti-DNA antibody and possible AIRA, and thyroid autoantibodies titers increased, but without pancreatic islet cell antibody and anti-glutamic acid decarboxylase antibody. Administration of IFN was stopped and insulin treatment was started, but plasma glucose level was not controlled well. AIRA became negative 2 months later, however, insulin antibody (IA) was positive when tested after 18 months. Serum HCV RNA has been negative, and a normal level of serum transaminase has been observed since IFN therapy. It is likely that IFN therapy induced the immunological disturbance and resulted in occurrence of various autoantibodies and IDDM in the patient.
Abstract
The formation, variation and conversion of isospecific active sites were investigated, based on the isotacticity distribution of the polypropenes analyzed by the temperature rising elution ...fractionation (TREF) method. Stopped‐flow polymerization of propene was carried out with a MgCl
2
‐supported Ziegler catalyst in the absence or presence of an internal or external electron donor so that the effects and roles of the electron donors could be clarified. The results showed that various kinds of active sites with different isospecificities, including the highest isospecific active sites responsible for producing the highest isotactic fraction (elution temperature: > 112°C) existed, even in the electron donor‐free catalyst system. The isospecificity of the active sites in the donor‐free catalyst might have originated from a surface monolayer multinuclear titanium species, namely an “island” of titanium species. The addition of the external electron donor converted a part of the aspecific and/or low isospecific active sites into the second highest isospecific active sites, but showed no effect on the formation of the highest isospecific active sites, whereas the addition of an internal donor played an important role in creating the highest isospecific active sites as well as suppressing the formation of the aspecific active sites.
The stopped‐flow technique, by which a quasi‐living polymerization process can be performed within an extremely short period (ca. 0.2s), is a powerful method for kinetic investigation in Ziegler ...catalysis. Significant understanding of many controversial problems was achieved, such as arguments concerning the nonuniformity of the active sites, the accurate kinetic parameters, the active sites formed in the different stages, the role of cocatalyst, the effects of hydrogen and electron donors, etc..
The stomatitis accompanying chemotherapy reduces a patient's QOL. Many reports have suggested that some kinds of gargling agents for oral mucositis shorten the duration and severity of symptoms. This ...study tested the prevention and efficacy against stomatitis of a herbal medicine (Syousaikotou) as a gargling agent for patients receiving chemotherapy. Compared to gargling with providone-iodine and amphotericin B, the Syousaikotou gargle showed a significantly decreased incidence of stomatitis, and a painkilling effect. Stomatitis occurred in about 17.4% among 23 chemotherapy cycles with the Syousaikotou gargle, against about 40.8% among 71 chemotherapy cycles without the Syousaikotou gargle. Among the patients suffering stomatitis pain after 22 chemotherapy cycles, the painkilling effect was seen to be 76.2%, and continues for about 2 hours. Critical side effects were not seen, but in 4 cases there were complaints about foul smells, such as oil and grass smells. Syousaikotou gargle was considered to be one of the useful methods against the stomatitis prevention and sharp pain mitigation from the chemotherapy.
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